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Help With Cp Results?


Rgd

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Rgd Newbie

My daughter had a celiac panel done in 2010. I was told the results were neg. so we left it at that. She has been having API s again so I had them run another panel, new doctor. I don't have the new results back yet but here are the ones from 2010. Can you tell me what you think?

Gliadin Antibody IgA - H 83 normal high Less 20

Gliadin Antibody IgG - 19 normal,high less 20

Tissue Trans AB IgA - H 28 normal high less 20

Tissue Trans AB IgG - 18 normal high less 20

And yes I did bring these results to the new doctor -though her doctor was more consernd about the urinalysis report so she focused on that. They are supposed to be calling me,with an appointment for a GI referral today Also

I had my son tested in 2010, all his results were less than 20 excepts for the Gliadin Antibody IgA which was 27. I will be bring him back to have him rested. He has been having increased stomach pains for the past month. My son also was dx with leukemia at the age of 21, received chemotherapy for 3 years, is now cancer free. My youngest daughter also had leukemia, dx at the age of 3 1/2 , passed away 2007 at the age of 11 due to complication from the bone marrow transplant. My oldest daughter has had a few stomach issues, nothing too bad, will also have her tested. All my labs were normal. We have suspected celiac or crohns with my husband though he has never been tested

The panel was ran on Friday afternoon, I'm not sure how long it takes for results. I will be calling when they open this morning. .

H. Pylori AB Negative

My daughter is also having some kidney issues the last few weeks, currently waiting on repeating an urinalysis. I won't list those labs unless someone here knows something about those results. From the searching I've done this weekend I found that celiac can be linked to kidney disease?

Thank you!

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guest134 Apprentice

Uhm those results are not negative, two are clearly flagged as "H" for high. Can you post the reference range of the tests? I am assuming the tests are the standard negative under 20, your IgA specific antibody reaction to gluten is high positive, and the tissue transglutaminase is also positive showing there is damage in the intestine. Put that together and you have a damaged intestine due to a negative reaction to gluten. I bet your new results will be much higher, hopefully they tested the deamidated versions this time, let us know the results.

I am just throwing this out there but because those results were obviously positive (especially the gliadin IgA) and your doctor never reported that to you, upon your daughter actually being diagnosed, you could have a malpractice law suit in your hands. Especially if you can link further complications due to being misdiagnosed.

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shadowicewolf Proficient

Can you give us the range of the tests? What is considered normal, and whatnot? All labs are a bit different.

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ravenwoodglass Mentor

Have you brought those test results to her new doctor? Do bring those to that doctors attention. She should have been diagnosed when the tests you posted were run. Yes celiac can impact kidney function (and many other organs) but once she goes gluten free her kidney function can return to normal. I hope you are able to get her diagnosed quickly and do test every other family member as well.

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Rgd Newbie

Can you give us the range of the tests? What is considered normal, and whatnot? All labs are a bit different.

I added the normal range above. I'm not sure if they added the "deamidated" version, not sure what that is?

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guest134 Apprentice

The deamidated version is more specific to celiac, the older anti-gliadin tests are not very accurate, especially the IgG version. However the IgA is still sensitive to celiac which is what came back high positive.

These tests would be necessary for a more accurate diagnosis:

Deamidated gliadin IgA

Deamidated gliadin IgG

Endomysial Ab

As I said before, your daughters results were strong positive in reaction to gluten and positive to the gut damage test, you are going to need to run the three tests I just posted as well as possibly an endoscopy if it is necessary.

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Rgd Newbie

The deamidated version is more specific to celiac, the older anti-gliadin tests are not very accurate, especially the IgG version. However the IgA is still sensitive to celiac which is what came back high positive.

These tests would be necessary for a more accurate diagnosis:

Deamidated gliadin IgA

Deamidated gliadin IgG

Endomysial Ab

As I said before, your daughters results were strong positive in reaction to gluten and positive to the gut damage test, you are going to need to run the three tests I just posted as well as possibly an endoscopy if it is necessary.

My daughter had a celiac panel done in 2010. I was told the results were neg. so we left it at that. She has been having API s again so I had them run another panel, new doctor. I don't have the new results back yet but here are the ones from 2010. Can you tell me what you think?

Gliadin Antibody IgA - H 83 normal high Less 20

Gliadin Antibody IgG - 19 normal,high less 20

Tissue Trans AB IgA - H 28 normal high less 20

Tissue Trans AB IgG - 18 normal high less 20

And yes I did bring these results to the new doctor -though her doctor was more consernd about the urinalysis report so she focused on that. They are supposed to be calling me,with an appointment for a GI referral today Also

I had my son tested in 2010, all his results were less than 20 excepts for the Gliadin Antibody IgA which was 27. I will be bring him back to have him rested. He has been having increased stomach pains for the past month. My son also was dx with leukemia at the age of 21, received chemotherapy for 3 years, is now cancer free. My youngest daughter also had leukemia, dx at the age of 3 1/2 , passed away 2007 at the age of 11 due to complication from the bone marrow transplant. My oldest daughter has had a few stomach issues, nothing too bad, will also have her tested. All my labs were normal. We have suspected celiac or crohns with my husband though he has never been tested

The panel was ran on Friday afternoon, I'm not sure how long it takes for results. I will be calling when they open this morning. .

H. Pylori AB Negative

My daughter is also having some kidney issues the last few weeks, currently waiting on repeating an urinalysis. I won't list those labs unless someone here knows something about those results. From the searching I've done this weekend I found that celiac can be linked to kidney disease?

Thank you!

I got the results of my daughters cp panel. I don't have a copy of them yet, nurse said it was negative. She read a few values off to me, the ttIgA was less than 2 , Gliadin IgA was 5 last time was 83. Now she was on flagly and serious for 1 day- would that effect the results at all ?? I'm happy if those are the true results but the results are way different than the ones taken in 2010, something doesn't seem right?

Sorry that should have said steriods not serious, she had 30 mg of steriods in her system and took 2 doses of flagyl , each tablet 500 mg, the day before the blood draw. The little searching I did does show that steriods can show a false neg, but would 30 mg be enough to mess up the results?

Just got off phone with nurse, they have schechduled an appoint for next week with a GI doctor. I did call that doctor and ask about the steriod issues, they want the labs drawn again so I will have that done next monday and hopefully have the results by Thursday. Does anyone see a GI doctor at st Louis children's ?

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guest134 Apprentice

Steroids in prolonged use can effect the results, I doubt that one time before would but I can't be sure on that. Flagyl would not cause false negatives, if anything it would cause false positives since it is notoriously hard on the small intestine.

I am at a loss at this point, I am not sure what to make of results being so high than dropping, perhaps your daughter is an example of how inaccurate Gliadin AB's are. If your daughter had celiac and was eating gluten there is no reason for the antibodies to drop like that, active disease simply does not do that.

My only suggestion would be to retest using the methods I posted above as well as being off steroids for a week. Also did she get tested for IgA sufficiency? What led you guys to celiac to begin with?

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Rgd Newbie

Steroids in prolonged use can effect the results, I doubt that one time before would but I can't be sure on that. Flagyl would not cause false negatives, if anything it would cause false positives since it is notoriously hard on the small intestine.

I am at a loss at this point, I am not sure what to make of results being so high than dropping, perhaps your daughter is an example of how inaccurate Gliadin AB's are. If your daughter had celiac and was eating gluten there is no reason for the antibodies to drop like that, active disease simply does not do that.

My only suggestion would be to retest using the methods I posted above as well as being off steroids for a week. Also did she get tested for IgA sufficiency? What led you guys to celiac to begin with?

In 2010 she was having constant bad stomach pains, missing lots of school. My husband has had horrible stomach problems all his life. we're always assumed that he had colitis. He has never been tested for it though, stubborn. So they tested her knowing my husband has some thing going on. She has been eating gluten all this time. I don't know what to think with those results. She will be retested next week. So I guess I'll just have to wait and see. thank you for your help.

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