Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Autoimmune Diseases And Gluten
0

16 posts in this topic

Just curious:

I've seen a lot of information about the connection between celiac disease and other autoimmune diseases. But I was wondering if there is also a connection between non-celiac gluten intolerance (NCGI) and autoimmune diseases?

It's difficult to research this via search engines. Does anyone know?

0

Share this post


Link to post
Share on other sites


Ads by Google:

Since non-celiac gluten intolerance has only recently been recognized as actually existing, there is very little research on it yet; but there are studies under way. Logic (in my pea brain) would say that celiac disease is just another form of gluten intolerance :P

0

Share this post


Link to post
Share on other sites

I'm intolerant of peas, but second mushroom's logic :)

1

Share this post


Link to post
Share on other sites

I'm intolerant of peas, but second mushroom's logic :)

Well, I am too, so there ya go -- problem solved -- new brain on order :D

0

Share this post


Link to post
Share on other sites

It is fairly common for a person with one autoimmune disease to also have another. This increased susceptibility is probably genetic. There is no evidence that one causes the other—in other words, gluten has not been shown to be a trigger for other autoimmune diseases, other than celiac disease.

0

Share this post


Link to post
Share on other sites




Gluten can be a "trigger" food for Eosinophilic Esophagitus, another auto-immune disease. There is a known connection between Celiac and EoE. New diagnosed cases of EoE should be automatic testing for Celiac.

0

Share this post


Link to post
Share on other sites

It is fairly common for a person with one autoimmune disease to also have another. This increased susceptibility is probably genetic. There is no evidence that one causes the other—in other words, gluten has not been shown to be a trigger for other autoimmune diseases, other than celiac disease.

Gluten is suspected in making some AI diseases worse though. Patients with RA, lupus, Hashimotos, and uveitis are advised to go gluten-free to help alleviate symptoms.

0

Share this post


Link to post
Share on other sites

Psoriatic arthritis was the impetus for me (from arthritis patients and from what I had read) to stop eating gluten. The disappearance of my GI symptoms was an unexpected bonus :blink:

0

Share this post


Link to post
Share on other sites

Gluten is suspected in making some AI diseases worse though. Patients with RA, lupus, Hashimotos, and uveitis are advised to go gluten-free to help alleviate symptoms.

Hi nvsmom,

Do you have any more information about this? I haven't come across this idea before—I try to stay up to date with the research, but this is unfamiliar.

0

Share this post


Link to post
Share on other sites

Hi nvsmom,

Do you have any more information about this? I haven't come across this idea before—I try to stay up to date with the research, but this is unfamiliar.

I'm afraid I'm really bad about quoting authors; I probably should write this stuff down... I've read a bunch of books over the past 6 months on thyroid problems because of my own health issues. I would estimate that a quarter of them recommended that patients try the gluten-free diet to see if it helps with symptoms. I remember reading in one book about the possibility of mild hypothyroidism resolving itself on the gluten-free diet based on a some patients' experiences. Same thing with Lupus; I've read in a few books that the gluten-free diet can help prevent flares. That was applied to RA as well.

My SIL has uveitis (sp?) and her specialist also told her to follow the gluten-free diet to help slow the disease; she' had some mild improvements.

Wheat Belly by Davis also mentions how going gluten-free can help in AI diseases, the most obvious being diabetes. He discusses how genetically modified wheat is and how this could be the cause of many problems. It's a really good book, and an entertaining read.

...But with your credentials, I'm sure you are much more knowledgeable than I am in this area.

1

Share this post


Link to post
Share on other sites

I have heard of a gluten free diet can be helpful for any auto-immune disease.

Take gluten and the top 8 allergens list, these are the hardest known proteins for the human body to handle. It would make sense that an already compromised immune system may have more difficulty handling these proteins in the diet. There is not a medical test "proving" this food "intolerance" , but there has been studies and research collected. So I don't have a link to any test, but there are studies of diet change helping auto-immune diseases.

You can search some of cases of MS and improvement, or are you interested in one other auto-immune disease specifically?

It may be like the advice to new gluten free peeps, "keep a food journal" to identify another food intolerance. We do assume (from many cases discussed here) the damaged gut is going to have difficulty with another food (most likely casein from the similarity of the protein chain and the location of the damaged villi to the area of digestion.)

0

Share this post


Link to post
Share on other sites

Just heard back from the Chicago center (they are super sweet, by the way!) for a specific version of this, namely: whether the gluten-free diet has any impact on autoimmune thyroid disorders.

Dr. Guandalini informs us that there are no current studies yet concerning the link between the two in *non* celiac patients. So, as it stands, it would seem that we just don't know.

I am still barely 1/3 through the gluten-free period they prescribed me, but in my specific case I can't say much regarding the gluten-thyroid connection in non-celiacs. I have (right now) hyperthyroidism, and my FT and FT4 spiked up even more after the gluten-free diet. I could bottle some of my hormones and sell them at the black market right now! :D I am starting a new therapy today, and it'll be a few months till I know how it goes.

But the gluten-free diet alleviates my GI symptoms (and some others), which appear to be not directly connected to my thyroid problems, so I will just stick with it.

0

Share this post


Link to post
Share on other sites

I scour the medical literature on a regular basis and I just came across an editorial in which it was postulated that non celiac gluten sensitivity is caused by activation of our "innate" immune system...it works by a different pathway than most other autoimmune diseases, but is still autoimmune in the sense that our bodies are recognizing gluten as "foreign" invader and then attacking ourselves. I need to go back and find the reference myself. There was similarly a recent article about "wheat sensitive" IBS, and the researchers discussed a subgroup of IBS sufferers whose symptoms were worsened with gluten exposure and who also were intolerant to dairy and miltiple other foods. Again, activation of the innate immune system was discussed. My understanding of the innate immune system is that it is our primitive, no frills defense against bacteria and viruses (not highly involved and does not involve the complex antibody response). I need to read and learn more about this and report back.

0

Share this post


Link to post
Share on other sites

Thankfully -- we will be hearing more and more of our Innate Immune System - the best researchers are getting closer to what we all have figured out individually.

For now - if you are here and other places researching possible solutions from your food - you are way ahead of the most advanced research ... IMHO.

0

Share this post


Link to post
Share on other sites

Question for those of you in the know - does the presence of more than one autoimmune disorder leave one more susceptible for another? For example, I tested negative for celiac (blood test and endoscopy), but I have two other auto immune disorders - does this mean that the possibility of developing celiac in the future is greater for me?

0

Share this post


Link to post
Share on other sites

I often ask the same question. Since I didn't have any testing, but have hypothyroidism and psoriatic arthritis, does that make it more likely that I have celiac disease rather than gluten intolerance. Since my oldest sister was gluten intolerant but her daughter celiac, would that likely make us both celiac? It is something to ponder but, for me, not to know for sure. Regardless, neither of us should eat gluten. :)

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,352
    • Total Posts
      920,503
  • Topics

  • Posts

    • I already did. Thats how i found the place. Its amazing to actually go to a restraunt again.
    • This is EXACTLY what happens to me. It has twice now and both times was after both glutening episodes but once it was the day after and the other time it was a week and a half. So I'm still not sure if it's related or strange bug bites...

      Did they stop happening when she stopped being glutened? Did you decide they were definitely related? I'm really confused by this and would love to know whether to insecticide my house or....
    • Thankyou both! I was wondering if my high levels left much doubt on the diagnosis. I don't see the GI until the 15th Sep and I don't think I can stand to eat gluten in that time. If he tells me to I will do so after then. After 25 years of symptoms I don't think there is much chance of healing my bowel In a couple of weeks. I'm actually terrified of the damage they might find. But I think I will need the endo since there may be other things going on with me. So great they didn't put your son through the biopsy! Once I have a formal diagnosis I have my kids to worry about also. I can't even stand the thought of my daughter having a blood test. I think she would need to be sedated as she is so fearful and pain sensitive. My son is not yet 2 so I don't think they will test him. I'm feeling so off at the moment. I think I have some anxiety and reflux going on complicating things quite a bit.
    • My son's antibodies were 300. Based on his extremely high levels, his pediatric GI suggested genetic testing instead of the biopsy. Genetic testing can't diagnose celiac on its own but combined with such high levels, the gi dr was confident a positive genetic test would confidently diagnose celiac. He warned that biopsies are small snapshots of the intestine and can miss damage. He said this is an approach used very often in Europe but not as much in the US. What sold me on that approach was the ability to put my son directly on a gluten free diet instead of waiting three weeks for the biopsy, during which time he would continue to eat gluten and feel terrible. I'm not sure if this is more common with younger patients though (our son is two), based on the idea that he's had less time to inflict damage that would show in a biopsy? We are very happy that we immediately started the gluten free diet and chose the genetic testing. Our son got the proper diagnosis and his recent number shows a drop to 71 after only 4.5 months gluten free! Not sure if this helps. Good luck and I hope you feel better soon!
    • We have been off gluten for a while now, and symptoms return when I've allowed gluten full meals… so something still isn't sitting right with me.  Checking with her doc about seeing a pediactric GI although I'm not sure how long that will take since we live in small town America. I know she didn't get at least one of the recommended full panel tests but maybe two, can someone help clarify, or is she missing two? DGP for sure and possibly EMA? And if I understand what I'm reading in other posts that the DGP can be more accurate? Thanks Her blood panel results: Ttg ab iga <.5u/ml ttg igg <.8u/ml aga ab iga <.2 u/ml aga an igg <.7u/ml iga 61mg/dL  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,417
    • Most Online
      1,763

    Newest Member
    Suzette Porter
    Joined