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Help Interpreting Lab Work, Please
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7 posts in this topic

Good afternoon, all!

So, I've had some bloodwork done, Dr. says I am positive for Celiac, but I would like a better understanding of my lab results, I have typed the results exactly as seen on lab report.

I knew before the tests that I was having a problem with gluten, and went gluten-free 5 days before the test (I didn't know!), then I read that one should be consuming gluten for the test, so I panicked and gluten loaded 2 days before....so maybe this threw off some of the results. I will be seeing the gastroenterologist Monday for a consult. I have been feeling so much better since being gluten-free for a few days now, so I am definitely questioning whether I need a biopsy or not, although I understand that biopsy is the "gold standard". I do feel better having some validation from the lab work, but It seems pretty clear to me.

1. Deami. Gliadin Abs, IgA - 46

Neg. 0-19, Weak pos. 20-30, Mod. to Strong pos. 30+

2. Deami. Gliadin Abs, IgG - 97

Same values as above

3. t-Transglutiminase, IgA - 5

Neg. 0-3, weak pos. 4-10, positive 10+

4. t-Transglutiminase, IgG - 3

Same values as above

5. Endomysial Ab, IgA - Positive

positive or negative

6. Immunoglobulin A - 406

Lab report only shows a range of 91-414,

Thanks in advance for any advice.

Edited by ChrisMcD
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Because every lab uses a different " scale", could you post the reference ranges from the lab sheet. Something like:

ABC 12. (0-6 neg, 7-9 weak positive, >p high)

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Because every lab uses a different " scale", could you post the reference ranges from the lab sheet. Something like:

ABC 12. (0-6 neg, 7-9 weak positive, >p high)

Post edited, thank you!

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I see you added the ranges. Looks positive. Others who know more about the test will probably chime in.

Whether you have an endoscopy is up to you. I had one and a colonoscopy at the same time. Here's why: we were really checking for anything else that might be going on with the Celiac - ulcers, colitis, polyps etc and how advanced the Celiac is.

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Yes, those are definite positive results for celiac. We always tell people that cramming gluten in the last couple of days won't affect the results, so, no, that didn't have any bearing on your positive tests. Your tests show that you make a normal amount of antibodies (Immunoglobulin A) so the tests are valid. Your Endomysial Antibodies and Deamidated Gliadin Peptide were both positive and these two tests are the most specific for celiac, so unless you want to find out the level of damage in your small intestine there is no actual reason for the confirmation the biopsy gives that this is, in fact, celiac disease (in my book anyway).. Doctors always like to do it because it is a moneymaker and because of that old gold standard saw, but that was before the blood testing was refined to its present level. Doctors are now coming to accept: symptoms, positive blood results, resolution of symptoms on gluten-free diet, as being diagnostic, although some would want to toss in the genetic testing just to be sure. So it is up to you whether or not you have the biopsy.

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Thanks, Mushroom...I was a little worried, I consulted with a Nutritionist yesterday, and she told me the results were probably altered since I went gluten-free for a few days. Now to have the kids tested, ages 4 and 7. Runs in my family on mother's side. Grandfather was positive and mom has never been tested. Thanks for the quick replies.

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Gluten free would make the results lower. So if these are your results from a few days gluten-free, think how high they might have been on a full gluten diet!

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    • Thankyou both! I was wondering if my high levels left much doubt on the diagnosis. I don't see the GI until the 15th Sep and I don't think I can stand to eat gluten in that time. If he tells me to I will do so after then. After 25 years of symptoms I don't think there is much chance of healing my bowel In a couple of weeks. I'm actually terrified of the damage they might find. But I think I will need the endo since there may be other things going on with me. So great they didn't put your son through the biopsy! Once I have a formal diagnosis I have my kids to worry about also. I can't even stand the thought of my daughter having a blood test. I think she would need to be sedated as she is so fearful and pain sensitive. My son is not yet 2 so I don't think they will test him. I'm feeling so off at the moment. I think I have some anxiety and reflux going on complicating things quite a bit.
    • My son's antibodies were 300. Based on his extremely high levels, his pediatric GI suggested genetic testing instead of the biopsy. Genetic testing can't diagnose celiac on its own but combined with such high levels, the gi dr was confident a positive genetic test would confidently diagnose celiac. He warned that biopsies are small snapshots of the intestine and can miss damage. He said this is an approach used very often in Europe but not as much in the US. What sold me on that approach was the ability to put my son directly on a gluten free diet instead of waiting three weeks for the biopsy, during which time he would continue to eat gluten and feel terrible. I'm not sure if this is more common with younger patients though (our son is two), based on the idea that he's had less time to inflict damage that would show in a biopsy? We are very happy that we immediately started the gluten free diet and chose the genetic testing. Our son got the proper diagnosis and his recent number shows a drop to 71 after only 4.5 months gluten free! Not sure if this helps. Good luck and I hope you feel better soon!
    • We have been off gluten for a while now, and symptoms return when I've allowed gluten full meals… so something still isn't sitting right with me.  Checking with her doc about seeing a pediactric GI although I'm not sure how long that will take since we live in small town America. I know she didn't get at least one of the recommended full panel tests but maybe two, can someone help clarify, or is she missing two? DGP for sure and possibly EMA? And if I understand what I'm reading in other posts that the DGP can be more accurate? Thanks Her blood panel results: Ttg ab iga <.5u/ml ttg igg <.8u/ml aga ab iga <.2 u/ml aga an igg <.7u/ml iga 61mg/dL  
    • I was tested for the full panel, I believe. I had normal values for t-transglutaminase (ttg) igg,t-transglutaminase (ttg) iga, deamidated gliadin abs igg, deamidated gliadin abs iga, and immunoglobulin a qn serum.  
    • Going gluten free may be beneficial if you're among the roughly 10 percent of people who suffer from celiac disease, a genetic immune disorder, ... View the full article
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