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Help Interpreting Lab Work, Please
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7 posts in this topic

Good afternoon, all!

So, I've had some bloodwork done, Dr. says I am positive for Celiac, but I would like a better understanding of my lab results, I have typed the results exactly as seen on lab report.

I knew before the tests that I was having a problem with gluten, and went gluten-free 5 days before the test (I didn't know!), then I read that one should be consuming gluten for the test, so I panicked and gluten loaded 2 days before....so maybe this threw off some of the results. I will be seeing the gastroenterologist Monday for a consult. I have been feeling so much better since being gluten-free for a few days now, so I am definitely questioning whether I need a biopsy or not, although I understand that biopsy is the "gold standard". I do feel better having some validation from the lab work, but It seems pretty clear to me.

1. Deami. Gliadin Abs, IgA - 46

Neg. 0-19, Weak pos. 20-30, Mod. to Strong pos. 30+

2. Deami. Gliadin Abs, IgG - 97

Same values as above

3. t-Transglutiminase, IgA - 5

Neg. 0-3, weak pos. 4-10, positive 10+

4. t-Transglutiminase, IgG - 3

Same values as above

5. Endomysial Ab, IgA - Positive

positive or negative

6. Immunoglobulin A - 406

Lab report only shows a range of 91-414,

Thanks in advance for any advice.

Edited by ChrisMcD
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Because every lab uses a different " scale", could you post the reference ranges from the lab sheet. Something like:

ABC 12. (0-6 neg, 7-9 weak positive, >p high)

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Because every lab uses a different " scale", could you post the reference ranges from the lab sheet. Something like:

ABC 12. (0-6 neg, 7-9 weak positive, >p high)

Post edited, thank you!

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I see you added the ranges. Looks positive. Others who know more about the test will probably chime in.

Whether you have an endoscopy is up to you. I had one and a colonoscopy at the same time. Here's why: we were really checking for anything else that might be going on with the Celiac - ulcers, colitis, polyps etc and how advanced the Celiac is.

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Yes, those are definite positive results for celiac. We always tell people that cramming gluten in the last couple of days won't affect the results, so, no, that didn't have any bearing on your positive tests. Your tests show that you make a normal amount of antibodies (Immunoglobulin A) so the tests are valid. Your Endomysial Antibodies and Deamidated Gliadin Peptide were both positive and these two tests are the most specific for celiac, so unless you want to find out the level of damage in your small intestine there is no actual reason for the confirmation the biopsy gives that this is, in fact, celiac disease (in my book anyway).. Doctors always like to do it because it is a moneymaker and because of that old gold standard saw, but that was before the blood testing was refined to its present level. Doctors are now coming to accept: symptoms, positive blood results, resolution of symptoms on gluten-free diet, as being diagnostic, although some would want to toss in the genetic testing just to be sure. So it is up to you whether or not you have the biopsy.

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Thanks, Mushroom...I was a little worried, I consulted with a Nutritionist yesterday, and she told me the results were probably altered since I went gluten-free for a few days. Now to have the kids tested, ages 4 and 7. Runs in my family on mother's side. Grandfather was positive and mom has never been tested. Thanks for the quick replies.

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Gluten free would make the results lower. So if these are your results from a few days gluten-free, think how high they might have been on a full gluten diet!

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    • Thank you! I will call and ask for a full panel and see where it leads!!
    • I think the idea of grinding your own at home stems from the thought that flavored coffees might be ground on the same machines.  The grinders in the grocery are not cleaned between uses.  However, I have not found a flavored coffee bean that had gluten, so it's probably not a real concern.  For coffee that comes from a factory ground, I wouldn't worry at all.   Machines would be cleaned between flavors and nothing but coffee could be made on the machines or even in the same building ( everything made would taste/ smell like coffee). if you still have doubts - I went to the International Celiac Disease Symposium a few years back.  This is held every few years in different countries for medical professionals that study and treat Celiac.  They present research, etc.  All food served was gluten-free.  We drank a lot of plain, already ground, coffee!  A lot!   Coffee is not on any lists as a gluten containing food.  Talking legitimate organizations - not some blogger or pseudo- science website.   After all this, if you still doubt that coffee is gluten free...... Then don't drink it!  It leaves more for me!    
    • To answer some of your questions.... Non celiac gluten sensitivity does not cause any damage to the small intestine so that is not the source of the "little holes or bumps".  You need to get her records including the report of the endoscopy to see exactly what it says as well as the pathology report of the biopsies. You should always get medical records anyway & keep a copy for yourself. How many biopsies did he take? There should be a minimum of 4, ideally 6. The small intestine is very vast even in a small child. An adults is the size of a tennis court! That's a whole lot of territory so biopsies can miss damage especially when enough of them are not taken! She has 2 positives on the serum panel. This crap about "weak" positives should be thrown out of the nomenclature! A positive is a positive, weak or not! Her DgP IGG is way over the range and extremely telling. As far as my knowledge goes, there is nothing else that causes a positive DgP IGG other than celiac disease. False positives are really rare and to have 2 false positives would be astronomically rare! You are right & smart that she really does need an official diagnosis! IMHO, keep her on gluten for right now. Get a second opinion pronto & I believe you'll be able to get her a dx based on the 4 out of 5 rule if nothing else. I wouldn't think it's going to take more than a month to get to see another doc for a second opinion. Then you can take her off gluten. Kids heal up really fast, way faster than us old geezers! I'm sure as others  wake up & get on their computers they will be along to voice their knowledge. I am in the eastern time zone & rise before the birds so I was on here early. Hang in there mom! You're doing the right thing!
    • Now that my initial rage has calmed a tad.... your daughter has to fulfill 4 out of 5 of the diagnostic criteria. Second opinion can do a gene test. If positive, then she will have4 out of 5 of the dx criteria to dx without a positive biopsy. See: http://www.gastro.org/news_items/a-biopsy-should-not-be-required-to-make-the-diagnosis which says in part: The presence of signs and symptoms compatible with celiac disease. Positive serology screening (high serum levels of anti-TTG and/or EMA). Presence of the predisposing genes HLA-DQ2 and/or –DQ8. Histological evidence of auto-insult of jejunal mucosa typical of celiac disease. Resolution of the symptoms and normalization of serology test following the implementation of a gluten-free diet.   Also see: http://www.tenderfoodie.com/blog/2014/5/1/dr-fasano-on-new-gut-autoimmune-research-autism-clearing-up.html She can get a dx after her symptoms resolve on a gluten-free diet!
    • OMG!!!! The doc wants her to get sicker & sicker & do further damage so he can diagnose her? Don't do me any favors doc!!! I'm so spitting med right now I can't even speak! Find a new doc, take the records & get a second opinion. Maybe the next doc will have a freaking brain & dx your daughter. She should be dx'd! This is absurd in the extreme. The very least that should happen is the doc give her a dx now & then in a year or 2 have her do a gluten challenge & do a biopsy all over again but seriously, that would be just as cruel as what he's doing now. He's an ASS!
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