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Iga Deficient With Igg Subclass Deficiency And Postive Ana
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Hello everyone, this is my first post and I am SO confused. I have had the typical Celiac blood test twice over last few years and both were negative. I have been IgA deficient, its always been in my records but I did not realise that it could render me with a false negative. My Immunologist did IgG subclass test and I was deficient in IgG subclass 2 (explains the bronchitis and pneumonia frequent colds/flu) I also tested positive for ANA. My liver function is always high.

Ok here is the question..........do I biopsy or not? I have been gluten free in past and felt absolutely wonderful. I haven't been eating gluten-free as my Immunologist said if I am not gluten intollerant or allergy then if I go gluten-free it could lead to cancer because even just a tiny bit of accidental gluten would be harmful. He recommended glutening up and then biopsy. I would prefer to go back to gluten-free diet and follow it strictly, no cheats here and there and make family members understand this is not something I can cheat at.

Thank you for taking the time to read my question and I hope someone will be able to shed some light or someone else here is in same situation...IgA deficienty and IgG subclass deficient.

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Read this and show it to your doc. Its from a medical center so he will be more likely to go for it. He can run these blood tests.

http://www.cureceliacdisease.org/medical-professionals/screening

"For most people, the serum anti-tissue transglutaminase (tTG-IgA) is the best antibody blood test for screening for celiac disease; however, it is important to also get a total serum IgA. Having this total serum test will help bolster the reliability of the tTG test. The reason for this is that while the tTG test is very reliable, its reliability is dependent on the premise that the person being tested adequately produces IgA. If the individual does not produce sufficient amounts of IgA and is instead IgA deficient, then tTG-IgG should be tested instead.

There is also a newer version of the old screening test that checked the levels of anti-gliadin antibodies, called DPG (for deamidated gliadin peptides). While evidence shows these tests to be as reliable as the tTG, they are not necessarily better than the tTG."

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Kat, keep eating gluten until the testing is done or you may get another false negative.

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Thank you very very much for this information. Whom should I get to do this test? Rheumatologist, Immunologist, Oncologist (yes forgot to say I also have Mgus) Family Dr. and I live in Ontario does anyone know if this is covered under OHIP or cost? I pay about $45. for the standard blood test for Gluten Allergy. I can see my Family Dr. faster than any of my specialists so maybe I will just take it to her...she is wonderful and very quick on the ball so I am fortunate that way. I ate gluten free today, was to be my New Years Resolution but if I need to eat a bit every day until this test is done then I will. Also I heard there can be genetic testing of some sort?

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If it were me I would eat more than a "bit" each day. You want the best chance you can of getting an accurate result. 2-4 slices of gluten bread per day or 2 good bowls of pasta is what I would do.

Your Family Dr. can run the blood work for you. As to what the rules are in Canada on your insurance I have no clue as I am in the U.S.

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    • I think the posters above have given you very good information and I will throw in my 2 cents worth.  I am surprised that they did not test her DGP IgA also.  I am sure that would have been positive.  They switched off with antibody classes and usually they do both tests for both antibodies.  IgA is more specific to Celiac but the IgG is also useful.  The testing shows your daughter is producing antibodies to the gluten in her diet. (DGP IGG). THe tTg shows positive for some damage or inflammation. You know........your daughter is only 4.  She hasn't been on the planet or eating gluten that long. It can take years for enough damage to occur for it to be able to be found on biopsy.  I would say it is highly likely that this is Celiac, especially with her symptoms. But because the damage hasn't graduated to bad enough yet, they won't diagnose her. I think you need to do what others have said and get all copies of testing and find someone else who will take a look and give a diagnosis, especially if they have you do a dietary trial and her symptoms go away.  That might be the only recourse if you want faster proof. I know I would want faster.  I would not really be happy if I thought I had to keep feeding her something that was making her sick.  If you keep her on gluten long enough, the diarrhea will probably show up. BTW.........the criteria mentioned regarding diagnosis does not apply to kids.  I know it's silly and stupid but most leading Celiac specialists do not go by this criteria for kids.......adults only.  Keep that in mind because it might come up.  You could recognize it but they might not. Have you considered gene testing, to help bolster a diagnosis? As far as false positives go, it's the other way around. False negatives happen more frequently than many people think.  It's a recurring theme here.  With her symptoms, which is what I had, a bloated belly and tummy aches are telling.  Have they tested her for lactose intolerance?  That can cause similar symptoms, although it sure won't raise those 2 blood tests.  Keep looking for Celiac because there are many red flags here.
    • This 4 out of 5 criteria does not apply to children. I was never given a reason why, but it isn't.     That said, you may try to get a second opinion from another GI who may be willing to give her a firm dx.  We were in your boat 6 years ago and while I'm sure I'll get slammed for it, I wish we had kept gluten in our kiddos diet till he scoped positive for a variety of reasons.  Again, even family is different and you have to find what is best for you!
    • Mnoosh, I had swollen lymph nodes prior to celiac dx and for a while after going gluten free. My neck as well as groin. The groin ones were the worst. Guess what? All gone! It's hard to recall a time line & consider that everyone is different but I think mine completely resolved within a year.  You've been given great information. Just breathe and then again, breathe. You're going to be fine. 
    • It is the only thing you have eaten, so it can't be anything else?  I eat it with no issues so I am not sure how you can be certain that is the problem.  All I am saying is that its sort of "your word against mine and the company's word".  
    • Thanks cyclinglady & manasota! I appreciate it. I came to give an update...... I'm still 99% itch free. I get a "place" like a bug bite once in a while that itches and I just use the prescription steroid cream on it & that takes care of the itch. My rash is healing up rapidly everywhere. Almost clear skin now! Yaaaaayyyyyyyyyy! Now for a rundown of the "treatment". For 20 days I took a 100mg doxycycline twice a day. Then we upped it to two 100mg doxy twice per day. I took those for 5 days & made rapid progress and the itching stopped. The doxy was getting my tummy though. It was getting really rough despite my eating yogurt. So on day 6 and day 7, I took two 100mg doxy in the am but in the pm I just took 1 of them. On day 7, I was nauseous for hours on end. So since I was still doing well without itching and the rash was healing everywhere, I decided to cut back some more. On days 8, 9, & 10 I have only taken two 100mg doxy in the am and none at night. I'm doing good and my tummy is much, much happier! No more nausea!  I'll update as things go along.
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