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Iga Deficient With Igg Subclass Deficiency And Postive Ana
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Hello everyone, this is my first post and I am SO confused. I have had the typical Celiac blood test twice over last few years and both were negative. I have been IgA deficient, its always been in my records but I did not realise that it could render me with a false negative. My Immunologist did IgG subclass test and I was deficient in IgG subclass 2 (explains the bronchitis and pneumonia frequent colds/flu) I also tested positive for ANA. My liver function is always high.

Ok here is the question..........do I biopsy or not? I have been gluten free in past and felt absolutely wonderful. I haven't been eating gluten-free as my Immunologist said if I am not gluten intollerant or allergy then if I go gluten-free it could lead to cancer because even just a tiny bit of accidental gluten would be harmful. He recommended glutening up and then biopsy. I would prefer to go back to gluten-free diet and follow it strictly, no cheats here and there and make family members understand this is not something I can cheat at.

Thank you for taking the time to read my question and I hope someone will be able to shed some light or someone else here is in same situation...IgA deficienty and IgG subclass deficient.

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Read this and show it to your doc. Its from a medical center so he will be more likely to go for it. He can run these blood tests.

http://www.cureceliacdisease.org/medical-professionals/screening

"For most people, the serum anti-tissue transglutaminase (tTG-IgA) is the best antibody blood test for screening for celiac disease; however, it is important to also get a total serum IgA. Having this total serum test will help bolster the reliability of the tTG test. The reason for this is that while the tTG test is very reliable, its reliability is dependent on the premise that the person being tested adequately produces IgA. If the individual does not produce sufficient amounts of IgA and is instead IgA deficient, then tTG-IgG should be tested instead.

There is also a newer version of the old screening test that checked the levels of anti-gliadin antibodies, called DPG (for deamidated gliadin peptides). While evidence shows these tests to be as reliable as the tTG, they are not necessarily better than the tTG."

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Kat, keep eating gluten until the testing is done or you may get another false negative.

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Thank you very very much for this information. Whom should I get to do this test? Rheumatologist, Immunologist, Oncologist (yes forgot to say I also have Mgus) Family Dr. and I live in Ontario does anyone know if this is covered under OHIP or cost? I pay about $45. for the standard blood test for Gluten Allergy. I can see my Family Dr. faster than any of my specialists so maybe I will just take it to her...she is wonderful and very quick on the ball so I am fortunate that way. I ate gluten free today, was to be my New Years Resolution but if I need to eat a bit every day until this test is done then I will. Also I heard there can be genetic testing of some sort?

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If it were me I would eat more than a "bit" each day. You want the best chance you can of getting an accurate result. 2-4 slices of gluten bread per day or 2 good bowls of pasta is what I would do.

Your Family Dr. can run the blood work for you. As to what the rules are in Canada on your insurance I have no clue as I am in the U.S.

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