Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Doctor Said Anti-Gliadin Test Not Necessary!
0

5 posts in this topic

so we saw the pedi GI specialist today. i asked him to order the full celiac panel for my son and youngest daughter and he said no. that it wasn't necessary. he only wants to oder ttg IgG and ttg IgA. i said "but my son doesn't have the genetics for celiac, like my daughter does, but i want to know if he has anti-gliadin antibodies to see if he is gluten-sensitive". and he refuses to order the full celiac panel. ugh. comments?! am i right...

0

Share this post


Link to post
Share on other sites


Ads by Google:

Those are the two tests that most doctors think are the only tests necessary; some will only order the IgA tTG. They order these on the premise that those are the tests which will pick up damage in the small intestine (the anti-tissue transglutaminase) and this is their definition of celiac disease, that there must be damage to the intestinal lining. The total serum IgA is an important test because it is a control to see if he is a normal IgA producer; it is not quite so important if he is running the IgG version of the tTG as well because if he is not a normal IgA producer they run the IgG versions of the tests. Some, however, are low producers of both types of antibodies, which invalidates the testing. However, the new DGP test (both IgA and IgG versions if he is not running the total IgA) is a test very specific to celiac (the tTG can be elevated by things other than gluten) and it is very accurate, more so than tTG, in picking up celiac in children, specifically if the gut has not incurred much or any damage yet.

As far as gluten sensitivity, there is no blood test currently available which will measure this. In fact non-celiac gluten sensitivity has only recently been recognized as existing by the medical profession and researchers, let alone there being a test devised to measure it. They haven't really defined what it is yet :blink: The genetic testing can show what are labelled as gluten sensitivity genes (those associated with symptoms but not celiac diagnosis). However, in the rest of the world there are additional genes that have been associated with celiac other than the DQ2 and DQ8 genes recognized in USA, so if you are saying that your son doesn't have either of these and therefore doesn't have celiac that is not strictly accurate. There are posters on this board with diagnosed celiac who do not possess either DQ2 or DQ8.

So, in summary, we all produce IgA and IgG antibodies; the tests measure whether we are producing excessive amounts of these. People can test positive (and have celiac) while still testing negative on the tTG. Your doctor obviously does not subscribe to this. But I listened to Dr. Rodney Ford, a foremost pediatric celiac specialist, speak on the subject, and it is his belief that those children will eventually go on to develop full-blown intestinal damage if you let them eat gluten long enough, and the DGP is a kind of "head them off at the pass" test before too much damage and suffering occurs.

I hope I have clarified this a little for you. See if you can persuade him to at least run both versions of the DGP as well. :)

2

Share this post


Link to post
Share on other sites

wow! thank you so much!!! i've never heard of the dcp test. must go look into this. i don't think it's part of the celiac panel that my pedi runs. darn! anyway, what are other causes of ttg igG being high? my oldest daughter has negative everything on the panel, but positive ttg IgG. since she has been very gluten-reduced for 3 years, and only ate gluten for 2-3 weeks before the test was run, the specialist wants her to to get retested for ttg igG in a couple weeks, so she would be on it for 2 months at that point. he said that if the test came back higher, she's almost certain to have celiac disease, but if it comes back the same or lower, then we still don't know. his opinion is that since we have the genetics for it, and she shows signs for gluten-sensitivty, she should just go gluten-free. i agree, but i also wanted the stool test done and he said no, that it's not necessary. i tried telling him that it's becoming the gold standard, that if we want to see what's going on in her intestines, we should look at her stool. he said no. i'm getting it done anyway, and payingout of pocket.

also, perhaps you, or someone else, can help me with a genetics question. my hubby is DQ8 heterozygous. me, and my 2 daughters are DQ2 heterozygous (HLA DQA1*05/DQB1*02). my son is "DQ2-, DQ8-" (which my doctor said that means he does not have DQ2 or DQ8). but on top of the paper it says "HLA DQA1*0201 detected". what is that allele?!

0

Share this post


Link to post
Share on other sites

wow! thank you so much!!! i've never heard of the dcp test. must go look into this. i don't think it's part of the celiac panel that my pedi runs. darn! anyway, what are other causes of ttg igG being high? my oldest daughter has negative everything on the panel, but positive ttg IgG. since she has been very gluten-reduced for 3 years, and only ate gluten for 2-3 weeks before the test was run, the specialist wants her to to get retested for ttg igG in a couple weeks, so she would be on it for 2 months at that point. he said that if the test came back higher, she's almost certain to have celiac disease, but if it comes back the same or lower, then we still don't know. his opinion is that since we have the genetics for it, and she shows signs for gluten-sensitivty, she should just go gluten-free. i agree, but i also wanted the stool test done and he said no, that it's not necessary. i tried telling him that it's becoming the gold standard, that if we want to see what's going on in her intestines, we should look at her stool. he said no. i'm getting it done anyway, and payingout of pocket.

also, perhaps you, or someone else, can help me with a genetics question. my hubby is DQ8 heterozygous. me, and my 2 daughters are DQ2 heterozygous (HLA DQA1*05/DQB1*02). my son is "DQ2-, DQ8-" (which my doctor said that means he does not have DQ2 or DQ8). but on top of the paper it says "HLA DQA1*0201 detected". what is that allele?!

From:

http://americanceliac.org/celiac-disease/diagnosis/

TTG false positivity has been described in patients with both type I diabetes and autoimmune hepatitis. Theoretically, it can also be falsely positive in other autoimmune disease.

It is also known to occur with dairy intolerance in the absence of celiac disease.

0

Share this post


Link to post
Share on other sites

thank you SO much!!! and btw, she had a fasting/tolerance glucose test and she does not have diabetes.

dairy intolerance huh? so should i test her stool for dairy antibodies also? i was just going to do gluten. but will add in dairy if i get more answers to the puzzle.

you are SO much help to me... thank you so much!!!!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,642
    • Total Posts
      921,566
  • Topics

  • Posts

    • Hello I'm happy to join, any help is greatly appreciated as it can be difficult by times for sure. Unfortunately, I have been told my doctor has definitely not been doing anything correctly and very backwards about Alot of things. I live in canada, and there are celiac support groups I have found but I am about 2 hours away from any. I live in a pretty rural area. Although,  I have still received some help from them , they prefer a diagnosis before helping out to much. My doctor has me on a waiting list to see a gastrointestinal specialist but whenever I called her office to inquire about an appointment time I was told there was a very long wait and that I was considered to be a non emergency. So I am waiting to get an appointment. I have seen a dermatoligist for some of my rashes and she said it was dermatitis and gave me different creams for them.  It is frustrating because I don't know how to go about getting a actual diagnosis besides this biopsy. I was told to request a different specialist, but supposedly there is a waiting period for most in our area. 
    • Thanks for all of the replies. I've just found out I'm not getting to see a dietician because of not having a definite diagnosis which is another blow. I've had loads of bloods done but they just say they're all normal. I did have low vitamin D and high parathyroid but it's sorted itself out after a course of high dose vitamin D and they're not checking it again for a year. No chance of getting referred to endocrinology, gastro won't do it and neither will my gp. I've tried giving up coffee and all fizzy juice and it hasn't made a difference. I'm exhausted and scared and still have no clue what to do next. My gp has zero experience dealing with this type of thing - last time I was there she said it could be because I've restricted my diet too much and I should eat more gluten-free replacement products - everything I've read online says this is the worst thing to do! I'm asking for a copy of the last blood results this week so I can go through them myself but other than that I'm pretty stuck. 
    • I really am iffy on talking about this side of my gluten issues, I think I am about to ruin my reputation on this forum coming about as some extreme crazy guy saying this but I wanted to get this off my chest and perhaps see if anyone else might share a similar trauma. I get emotional recalling it, this side of my reactions, as it is most ingrained and very traumatizing experience, and I am not proud of it as the mentality I have now disgust me but I am going to come out about it. One of the scariest things in this world is when your own mind turns against you, when you can not think about what you want to think about, when you can not do what you know you should be able to do. When I got glutened really bad these where things I felt with my own mind would start looping, and thoughts would not come together. I would loose comprehension, feel like I know I should be able to think about something but my mind was not working. The same thing looped over and over and over like a broken record, This led to anger, anxiety, depression, panic, top it off with loss of feeling in my hands and feet, and the pains in the gut......it was a nightmare. I would go as far as beating my head against walls and punching them out of frustration as to why my own body and mind where not working, I just wanted it to end the pain to stop. I still have scars on my fist from punching into a nail in a stud once and kept going.....I scared everyone and myself distanced my self from loved ones. And started running a bucket list accepting that I was going to die soon. Hell to this day parts of the brain damage seem to be permanent as I can no longer do computer programing or some forms of math, they just no longer make any sense or connect. Then we learned what was causing it, and once the symptoms started to fade, I would get very angry if someone in the shared house did something stupid and got me sick again. The fear of going back to that caused violent and drastic actions to get away from what was making me sick. The sheer fear of my own mind turning on me led me to drastic actions to prevent it, throwing everything away I thought could make me sick, making sure no one else used that kitchen, used freezer paper and gloves when fixing my foods and working in there. I really destroyed and burned all bridges I had then and alienated myself from others. In the end it motivated me to learn how to cook, to get and renovate my own apartment in a building downtown, and start a business to pay for my new diet, by selling safe food to others with this issues locally at farmer markets. But it changed me on a very deep level, that traumatic experience to this day I have a issue looking at others and dealing with other humans who eat that stuff.......the stuff that breaks my mind and body so horrifically. If I have to compare it to something its like watching aliens drinking antifreeze and eating poison.....it causes a subconscious level of disgust and slight envy. I really can not even look at the stuff without recall what it does and feeling a twitch. I know I am the alien here, but it feels vise versa, and I look down on the normal people as odd creatures.  I go to the store and find myself overly avoiding contamination, keeping stuff in my own bags, asking the cashier to scan and bag it as I pass it not letting it touch that flour I see on the belt. I am hyper sensitive to the stuff I know and that fear semi dominates my mind as crazy as it sounds.  I am recovering and am forcing myself to try to mingle with other humans overlooking that one thing, but that deep rooted trauma still flares up as a protective measure especially around foods.  I could talk on and on about the other side effects but this one is the hardest to talk about it, and I feel others might be able to relate to it.    
    • Time.  You need time to heal.  Yeah, I am like a broken record!  😄 So...Lycra is your best friend for now (that and old baggy sweats!).  Hang in there!  Hugs!     
    • So far dairy seems to be OK, as are eggs. I like canned chickpeas so will carry on with those. Beans I had ruled out at one point with the doctor's recommendation to go with the low FODMAPs diet but will reintroduce those now I know it probably wasn't that causing the problems.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,647
    • Most Online
      3,093

    Newest Member
    iFitCeliac
    Joined