Get email alerts Get E-mail Alerts Sponsor: Sponsor:

Ads by Google:

   Get email alerts  Subscribe to FREE email alerts

Blood Test - Help With Results

3 posts in this topic


I need your help with my wife´s blood test. First of all, I like to thank for this amazing forum, I´ve learned a lot about celiac disease. And apologize because my english is not good.

Backing to the problem, my wife´s mother has C.D and she asked to my wife to do the blood test to check if her has too. But here, in Brazil, this disease isn´t very known by the people, and the doctors are included. So, i would like some help to interpret the test.

The result of blood test is following:

Total Serum IgA - 208,00 mg/dL (normal)

Anti-Tissue Transglutaminase IgA and IgG 54 EliA U/mL(reactive)and 0,0 U/mL(not reactive)

Anti-Endomysial IgA and IgG 1/20(not reactive)and 0 (not reactive)

And she don't have symptoms. So, what do you think? She will do the endoscopy and biopsy, but I´d like some help to interpret this result.

Thanks for the help again!!

Edited by C.H.

Share this post

Link to post
Share on other sites

Ads by Google:


Hopefully other people will reply, besides me.

Here's what I can tell you so far - first of all, it seems (to me at least) that the doctor did some good tests. The anti-endomysial tests are among the most sensitive and the most specific.

Regarding this test (anti-endomysial), these are some notes I compiled recently:

EMA stands for antiendomysial antibodies, which are antibodies produced by the body that attack the body's own tissue. when the EMA-IgA is positive, the patient almost certainly has celiac disease. However, the test also can produce false negative results in patients with celiac disease but only partial villous atrophy.

Highly specific, and 90% sensitive. The EMA antibodies correlate to degree of villous atrophy. Observer-dependent."

The total serum IgA levels means your wife is not IgA-deficient. This is important to establish prior to doing testing for these anti-bodies. It's not necessarily a part of the celiac blood test, though (again, from what I understand). In other words, the results of your wife's total serum IgA level does not really say anything about whether or not she has celiac disease.

From looking at the results, it appears that the only positive result that might be suggestive of celiac disease is the tTG-IgA, right? If that is the case, then, me personally, I would do more blood tests before getting an endoscopy.

Also - this is very important: your wife must be eating her normal diet up to the date of the blood test, which would include gluten in order to get an accurate reading. One should not stop eating gluten before getting the blood tests.

I was in Brazil for the first time about two years ago. I must say that gluten (or wheat in general) did not seem to be such a heavy part of the diet as it is here in the USA.

Please let me know if there is anything that I was not clear about. And again, there are some REAL experts here in reading the blood tests. Hopefully you will hear from them soon.



Share this post

Link to post
Share on other sites

It looks like your wife has a positive anti-tissue transglutamase IgA (TTG IgA) test but I'm not sure because the reference range was not given. Did the lab tell what the "normal ranges" were that they compared your wife's results with? For example, a patient might have a result of 34 on a test; if the reference range is 0-20 then it is positive but if the range is 0-40 then it is not positive. Knowing the reference range makes it easier to interpret the results.

If her TTG IgA is positive (I assume that is what reactive means?) then she probably has celiac disease, but other intestinal infections or disorders can sometimes cause that result too... but it is not common.

There are many celiac patients who have no symptoms, or mild symptoms so do not rule out celiac disease as a possibility based on that. There is a strong genetic link so if her mother has it, she is more likely to have it than a person outside of their family would be.

I wish her luck on the endoscopy. Make sure she does not stop eating gluten before the test. Best wishes to you both.


Share this post

Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Forum Statistics

    • Total Topics
    • Total Posts
  • Topics

  • Posts

    • I understand. Poor thing, made doubly rough because 13 is a really hard age even in the best of times. OK, at 13 she should show the damage in the biopsies. I didn't know if she was 2 or 3 yrs. old & in those cases sometimes they just plain haven't lived long enough to be damaged where the biopsies pick it up - it can be so patchy then.  Gosh, I'm really feeling for her & you both and I so want to say take her off gluten the moment the endoscopy is over but I'm afraid to say that b/c I've seen some pretty weird things go on that you would never expect. Docs can be so uninformed! Please let us know how things turn out & send your daughter some hugs from me and tell her I believe her. Please let her know that most of us had been told by doctors they think it's all in our heads, didn't believe us, blew us off so we know exactly how she feels. Remind her her pedi believes her & he's been more helpful than the GI has.  Press the GI for 6-8 biopsies but a bare minimum of 6.  {{{{{{{{{{{{{{{{{{{{{{HUGS}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}
    • I have seen articles linking celiac to Barretts and esophagitis.  I've actually been subtly hinting to my boyfriend to get tested for celiac as well because he has some strange Autoimmune arthritis as well as Barrett's  and some white spots on brain MRI Not MS). One of the articles I read on Celiac and Barrett's actually suggested that most of the patient did not have actual acid reflux symptoms. Not sure if you ever did antibody testing for celiac, but sounds like you certainly want to avoid gluten. 
    • Ahh good point! She is 13 and has been miserable for over two years. It started with chronic hives. We have been to a dermatologist, and a allergist and they brushed it off to her seasonal allergies and now she has joint pain,bloating,constipation,fatigue,headaches just all around miserable. I just want answers quick. she is getting depressed and says she hates her life cause she doesn't think anyone believes her. It's heart breaking . I hope we get answer soon. Thanks for the advice I will keep her on gluten. She is just miserable and I figured the sooner she is off gluten the sooner she will feel better. 
    • Welllllllll, in this particular case it would be best to keep her on gluten until the results come back. The reason I say this is b/c this GI seems whacky. There's a chance you may need to go to a different GI & have the endoscopy redone. I was going to say get a new GI but since the endoscopy is on Monday then I would go forth with it rather than waiting the time it would take to get a new GI & schedule an endoscopy. This GI seems set that it's not celiac & when they get that in their brain it's usually pretty darn hard for them to admit they were wrong. My concern is that she won't take enough biopsies from the right places b/c she's either dumb about how many & where or letting her personal (already formed) opinion influence what she will do. The problem is that you can't be there in the OR with them standing on the GI's shoulders making her do the right thing. Not knowing your daughters age, the other concern is that there may not be "enough" damage just yet, it may be patchy, etc..... that with the mindset this doc has, she will poo poo the dx.  Let me say that it would be a travesty & wholly awful IF you had to put your daughter through another endoscopy but we know how very important it is for her to have an official, dyed in the wool dx. So I'm just trying to think down the line & prevent problems before they come up. I mean, this doc may not even take any biopsies. That sounds insane I realize, but really, it happens more often than you would think. I can't tell you the number of times we've had people come on here after having an endoscopy for celiac where the doc didn't take any biopsies b/c the doc is so stupid as to think they can see the damage & doesn't realize there MUST be biopsies! If you take her off gluten & heaven forbid, you have to end up putting her back on it to get further testing then chances are she's going to get much, much sicker when she's put back on gluten. That most often happens with us and I'm talking about radically sick. See, I'm basing all my thinking on the fact that despite ALL the positive celiac blood work, this dimwit doc doesn't think it's celiac & instead it's all related to the constipation. That is just so far out there, it's NUTS! She's flying in the face of hard evidence! Every test you listed was positive. I can't even begin to understand how this GI comes to her insane conclusion. THAT'S why I am so concerned. 
    • Thanks for your reply. That's what my husband and I thought too. She has a ton of symptoms that's fit celiac. Also I was going to start her gluten free diet after her biopsy on Monday cause the dr said the results take two weeks. Is there a reason I should keep her eating gluten until we get the results? Thanks for your help.
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
    • Most Online

    Newest Member