Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Help With Lab Result Interpretation
0

6 posts in this topic

Morning All,

While using my limited Google-Fu skills to find a way of deciphering the results of my Enterolab stool testing, I saw several results pointing me to this forum. While I consider myself a reasonable intelligent person, this seems sort of Greek to me so, I thought I'd try to ask someone who might be more of a 'subject matter expert'. If I'm reading this correctly, I do not really have Celiac disease but, I do have sensitivity to both gluten and eggs (the later completely threw me for a loop!) - am I correct in my understanding?

I also don't know if I really understand the genetic results but, again, sounds like I do not have the genes for Celiac but, do have two genes which indicate a predisposition to gluten sensitivity, does that sound right? Any input or guidance would be greatly appreciated. I'd like to be able to explain this to my other half who's pretty much said he won't be changing the way he cooks, with regard to the elimination of gluten, until I can show him there's a legitimate reason why he should (e.g., results showing that I have a sensitivity to wheat products).

Thanks in advance for your time and information!

Best,

C.

Edit - Realized I never included the actual results....

B) Gluten/Antigenic Food Sensitivity Stool/Gene Panel

Fecal Anti-gliadin IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 7 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 4 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0609

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6)

I wasn't sure if the narrative bits were also important to include but if so, please let me know and I'll happily update the information.

Edited by cwredden
0

Share this post


Link to post
Share on other sites


Ads by Google:

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. :).

I don't believe scientists have identified any genes for gluten sensitivity as that is a fairly new area of study.

Also read this link and the link T the bottom of it:

http://www.cureceliacdisease.org/archives/faq/why-dont-you-recognize-tests-stool-tests-or-otherwise-for-gluten-sensitivity-that-are-currently-available-through-companies-like-enterolab-or-cyrex

"Why don’t you recognize tests (stool tests or otherwise) for non-celiac gluten sensitivity that are currently available through companies like Enterolab or Cyrex?

We only embrace tests that have endured rigorous scientific evaluations. So far, these tests have received no evidence-based support.

Enterolab has never successfully published anything on the accuracy of stool tests (nor have any other stool test manufacturers, to our knowledge) making it difficult to confirm the research results. Because of this, we must make our decisions based on what has been published; Harvard, UCSD, and the American College of Gastroenterology all agree that stool tests are simply not sensitive or specific enough methods in screening for celiac disease.

Further reading: “Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study” at BMJ.com"

0

Share this post


Link to post
Share on other sites

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. :).

Primarily because from searching around the internet, it sounded as though blood tests were not as reliable (a link from an article on this site) and in my mind it did seem reasonable that if there was an issue with something related to the antibodies in the digestive tract, it made more sense to look there before those made their way into the blood stream. In my case, I don't think the test showed a positive for Celiac, which I'm quite happy about. With regard to everyone getting a positive result from Enterolab, I think a reasonable answer might be that individuals who have symptoms which align with gluten intolerance/sensitivity are the ones requesting the test. Could there be false positives? Possible. From my readings, I've seen a lot of information about false negatives from blood tests as well.

If the results from the stool testing had indicated Celiac then my next step would have been to move to the blood testing and/or the biopsy testing.

0

Share this post


Link to post
Share on other sites

Updated....realized I didn't actually include the information from the test.... :wacko:

0

Share this post


Link to post
Share on other sites

The only test you did that tests for celiac (as far as I can tell) is your anti-gliadin IgA whish is positive at 13. As you said, your next step is to try blood testing. The most common tests are:

ttg IgA and IgG

EMA IgA

total serum IgA

DGP IgA and IgG

I'm not sure how accurate the enterolab tests are (did not do them) but I have heard they tend to have a LOT of positives. The blood work done in your typical lab will err the other way: they have approximately a 25% false positive rate, but biopsies seem to catch those who appear to have normal blood.

I don't know anything about the DNA testing. I tested positive on blood work so I never bothered learning about the DNA tests since it's a moot point for me.

Good luck with your future testing if you choose to go tha direction. I hope you feel well soon.

0

Share this post


Link to post
Share on other sites




I do believe that the blood testing has a 25% false negative rate. There are very very few false positives on blood work. :-)

It looks like you have DQ7 and DQ6. Currently, DQ7 is not recognized as a celiac gene but there is some research starting to come out which points otherwise, especially in the case of no DQ2 or DQ8.

Laura

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,125
    • Total Posts
      919,500
  • Topics

  • Posts

    • I am so confused right now.... 6 years ago I went on gluten free diet... after being on it for the first yr I was 100%better up until 5 months ago in got the "flu" the doctors told me to cut out dairy sonic did and my diarrhea  became better but not completely gone would not have it every day tho. I went to the gi doctor and they said to cut out fructose and dairy and keep gluten out... yesterday I went to the dietitian to see what I can eat and she gave me the list for fructose... she said it should have been on a antibiotic for sibo.... eventually I will be able to add dairy back and maybe gluten.... I said how can I add gluten back when this was my first problem... she goes well through fructose goes hand in hand with it... I said with gluten I vomit and am sick for weeks.... fructose isn't that bad I vomit sometimes but I'm not sick for weeks.... I'm just confused on really what is going on and was wondering if you or someone you know had sibo from gluten and or fructose and how Is this all related?
    • I see no one has responded to your query.  Unfortunately I have yet to try making a pie crust.  It was something I never mastered before going gluten free.  Have you looked on Pinterest?  You might find something there.
    • I honestly feel like both doctors think it's all in my head even though there is proof.  Yeah there was a point when I felt crazy.  That was when I was being shuffled from dr to dr being given individual diagnoses of my problems.  None of those diagnoses ever made me get better.  Seriously I was diagnosed with heart palpitations, neurocardiogenic syncope, I was given a butt load of steroids because a dr felt like I was producing too much adrenaline, freaking had a few tell me I was depressed, and the good ol IBS.  It seemed most wanted to push pills.  It's all just ridiculous!
    • I can't believe your doctors!!! You have a daughter who is dx'd already! Yet the ped doesn't want to test your other kids unless you have a dx????!!! Are you kidding me???!!! That's absurd!!! They have a first degree relative who has been dx'd with celiac already. There is no need to wait to see what you turn out to be!! And then, and then, and then....don't even get me started on your doctor!!! Does he have brain damage? Oh this is insane & ridiculous!  I have never heard of a disease that doctors are so unwilling to consider or test for OR to diagnose as this one! Usually they are hot to trot to make a dx but say the word celiac & they shake in their boots. Grrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrrr!!!!!!!!!!!!!!!!!!
    • I had a negative biopsy and was still diagnosed with Celiac. My GI ran a bunch of tests looking for the cause of my 15+ years of diarrhea and the only thing that came back positive was the entire Celiac panel. All very high. So he performed an endoscopy with biopsy. The biopsy was negative. So he ordered a genetic test. When that came back as "high risk" he decided a trial gluten free diet was in order. After 8 weeks my symptoms resolved and my antibodies were back to normal. Since then, follow up testing had shown I have osteoporosis. I am a 40 year old male.  So yes, you can definitely still have it and have significant damage with a negative biopsy. 
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,161
    • Most Online
      1,763

    Newest Member
    Jashan8534
    Joined