Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Help With Lab Result Interpretation
0

6 posts in this topic

Morning All,

While using my limited Google-Fu skills to find a way of deciphering the results of my Enterolab stool testing, I saw several results pointing me to this forum. While I consider myself a reasonable intelligent person, this seems sort of Greek to me so, I thought I'd try to ask someone who might be more of a 'subject matter expert'. If I'm reading this correctly, I do not really have Celiac disease but, I do have sensitivity to both gluten and eggs (the later completely threw me for a loop!) - am I correct in my understanding?

I also don't know if I really understand the genetic results but, again, sounds like I do not have the genes for Celiac but, do have two genes which indicate a predisposition to gluten sensitivity, does that sound right? Any input or guidance would be greatly appreciated. I'd like to be able to explain this to my other half who's pretty much said he won't be changing the way he cooks, with regard to the elimination of gluten, until I can show him there's a legitimate reason why he should (e.g., results showing that I have a sensitivity to wheat products).

Thanks in advance for your time and information!

Best,

C.

Edit - Realized I never included the actual results....

B) Gluten/Antigenic Food Sensitivity Stool/Gene Panel

Fecal Anti-gliadin IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-casein (cow’s milk) IgA 7 Units (Normal Range is less than 10 Units)

Fecal Anti-ovalbumin (chicken egg) IgA 13 Units (Normal Range is less than 10 Units)

Fecal Anti-soy IgA 4 Units (Normal Range is less than 10 Units)

HLA-DQB1 Molecular analysis, Allele 1 0301

HLA-DQB1 Molecular analysis, Allele 2 0609

Serologic equivalent: HLA-DQ 3,1 (Subtype 7,6)

I wasn't sure if the narrative bits were also important to include but if so, please let me know and I'll happily update the information.

Edited by cwredden
0

Share this post


Link to post
Share on other sites


Ads by Google:

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. :).

I don't believe scientists have identified any genes for gluten sensitivity as that is a fairly new area of study.

Also read this link and the link T the bottom of it:

http://www.cureceliacdisease.org/archives/faq/why-dont-you-recognize-tests-stool-tests-or-otherwise-for-gluten-sensitivity-that-are-currently-available-through-companies-like-enterolab-or-cyrex

"Why don’t you recognize tests (stool tests or otherwise) for non-celiac gluten sensitivity that are currently available through companies like Enterolab or Cyrex?

We only embrace tests that have endured rigorous scientific evaluations. So far, these tests have received no evidence-based support.

Enterolab has never successfully published anything on the accuracy of stool tests (nor have any other stool test manufacturers, to our knowledge) making it difficult to confirm the research results. Because of this, we must make our decisions based on what has been published; Harvard, UCSD, and the American College of Gastroenterology all agree that stool tests are simply not sensitive or specific enough methods in screening for celiac disease.

Further reading: “Detection of secretory IgA antibodies against gliadin and human tissue transglutaminase in stool to screen for coeliac disease in children: validation study” at BMJ.com"

0

Share this post


Link to post
Share on other sites

Curious....why didn't you go to a doctor and get a blood test? from what I have seen with Enterolabs, everyone gets a positive result. :).

Primarily because from searching around the internet, it sounded as though blood tests were not as reliable (a link from an article on this site) and in my mind it did seem reasonable that if there was an issue with something related to the antibodies in the digestive tract, it made more sense to look there before those made their way into the blood stream. In my case, I don't think the test showed a positive for Celiac, which I'm quite happy about. With regard to everyone getting a positive result from Enterolab, I think a reasonable answer might be that individuals who have symptoms which align with gluten intolerance/sensitivity are the ones requesting the test. Could there be false positives? Possible. From my readings, I've seen a lot of information about false negatives from blood tests as well.

If the results from the stool testing had indicated Celiac then my next step would have been to move to the blood testing and/or the biopsy testing.

0

Share this post


Link to post
Share on other sites

Updated....realized I didn't actually include the information from the test.... :wacko:

0

Share this post


Link to post
Share on other sites

The only test you did that tests for celiac (as far as I can tell) is your anti-gliadin IgA whish is positive at 13. As you said, your next step is to try blood testing. The most common tests are:

ttg IgA and IgG

EMA IgA

total serum IgA

DGP IgA and IgG

I'm not sure how accurate the enterolab tests are (did not do them) but I have heard they tend to have a LOT of positives. The blood work done in your typical lab will err the other way: they have approximately a 25% false positive rate, but biopsies seem to catch those who appear to have normal blood.

I don't know anything about the DNA testing. I tested positive on blood work so I never bothered learning about the DNA tests since it's a moot point for me.

Good luck with your future testing if you choose to go tha direction. I hope you feel well soon.

0

Share this post


Link to post
Share on other sites




I do believe that the blood testing has a 25% false negative rate. There are very very few false positives on blood work. :-)

It looks like you have DQ7 and DQ6. Currently, DQ7 is not recognized as a celiac gene but there is some research starting to come out which points otherwise, especially in the case of no DQ2 or DQ8.

Laura

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,091
    • Total Posts
      920,311
  • Topics

  • Posts

    • Thanks for posting this Adrien, it's a great list and I and others will appreciate the effort and the thought behind it. I loved my time in Malaysia and I'm glad I sampled all the food I could whilst I was still on an unrestricted diet. The good thing is that, like you say, some of the nice Malay foods are still ok. As a backpacker I survived on a lot of nasi goreng and laksa, nice to think if I return there I could still do the same Terima kasih!
    • I have posted on here before. DQ2, brother with celiac, DGP iGA was the only mildly elevated test. Was gluten-free so did 6 week challenge last winter. Negative biopsy. I am gluten-free now but do go out to eat. Prior to the challenge my health was good. Since then I have: Chest pain, pain between shoulder blades, periods of shortness of breath, heart palpitations, one instance of a heart arrythmia episode, neck is tender to touch on one side (they kept saying sinuses or TMJ which my dentist vetoed) ear ache, bowels never sink. Numbness and tingling. Blood pressure variations. Could be doing chores and feel dizzy and it might be 84/52.  not super low, but not typical for me if I'm running around the house.While other days I am mildly hypertensive. Recently lost 5 lbs in 8 days without trying. Recently electrolytes were low, alkaline phosphatese was low. Ferritin started dropping so started liquid iron 2-3 times per day 4 months ago. Primary watching that, I am not anemic but we are nowhere near iron overload either.  GI doc was a dick. Did not even know DGP replaced older tests and he was very condescending When I begged him for help recently and told me to get a second opinion which is exactly what I plan on doing.  I now have pain in my upper GI area. It is tender to touch. I had my gallbladder out in 97 along with a stone and infection in my bile duct. It hurts in this area. Pancreatic enzymes look fine, liver enzymes fine. Pancreatic ultrasound fine. I will now be doing a EUS Soon to look at bile duct, pancreas and liver.   so a typical day for me is that I might feel fine for a while and then suddenly feel like I'm going to pass out. really dizzy, numbness in odd places, like my body has been hijacked. I will typically eat a bunch of food something high protein and in about an hour or so I start to feel better. However, then my upper stomach starts to hurt in place of the passing out feeling. blood sugars are also normal. After getting the " it must be panic attacks" and condescending looks a million times my primary finally ordered an ultrasound of my sore neck and there is an abnormality in my thyroid which she says looks like possibly Hashti's. Except for one time, all my serum TSH tests were normal. We have more blood work on Monday. As I have not put on any weight and there are other symptoms that are closer to Graves.  Has anyone else had any thyroid issues that followed doing a gluten challenge?  where is your stomach pain? Do you have it above or below your belly button? Mine feels like it's in the pancreas area, like 2-3 inches above the belly button and when I push on it it's tender, but not all the time. sometimes i feel it in my back. 
    • Thanks for sharing with me.  I really appreciate it.  Honestly, after a glutening last summer (still do not know what glutened me), I did not eat out for a year!  The risk was too great as my healing time took 3 months (for symptoms to subside) and six months to regain lost weight.  Our recent vacation to Europe was worth the risk  as we traveled with our entire extended family, but we were extra cautious and ate only at celiac-approved places.  Otherwise, we "dined" at markets or ate the food we brought from home.  Thankfully, we did not get glutened (at least we don't think so!)  
    • I do not struggle with this and I was brought up the same way as you. I don't struggle because for many years off & on we didn't have a bathtub, only showers as well as this being therapy or medicinal for the skin - heck even for the muscles as I age. I figure I've earned my right to luxuriate or medicate with baths any time I've a mind to. My husband saw just how bad my dh got & NEVER begrudges me a nice long soak in the big soaking tub we now have.
    • Hi, No, I do not have celiac  disease. I have an ankylosing spondylitis which is an auto-immune disease provoking an inflammation of the joints. Under the advice and supervision of my doctor and the professor at the hospital I follow a gluten free & casein free diet, which is extremely successful in preventing inflammatory events. And I've been doing so, strictly, for more than 6 years. So I'm not Celiac, but I can tell you that I react strongly every time I take gluten even in small amounts. Even soya sauce, which according to this website has an almost zero dose of gluten, is a lot too much for me. Nevertheless I allow myself to eat food which has been processed in a factory which processes gluten. To conclude, I would say that when you are travelling, especially in a country where celiac disease is scarcely known, you should be twice as careful as when you're going out at home. In the end you can never guarantee that the cook has cleaned his pan after using soya sauce and so on... You can only bet
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,121
    • Most Online
      1,763

    Newest Member
    Sambud
    Joined