Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Newbie Here With One Celiac Test To Be Positive-Need Help!
0

7 posts in this topic

Hi, I have stalked around on this forum for a while and finally decided to sign up today and ask all of you seasoned celiacers a question about my lab work. I have had some serious neurological issues, mainly my eyes being very sensitive to light and feeling dizzy, so my neurologist ran a panel of blood work on me and besides a low Vit. D, a slight titer of dsDNA which is so low considered neg. only one came back positive. This was the Deamidated Gliadin Peptide IgG. It was weakly positive at 24. 30 being strong postive. So I googled what Deamidated Gliadin Peptide was and a whole slew of celiac articles popped up. I had a biopsy in 2008 which I was told was negative for celiac disease, but I think my Gastro only took one biopsy. I want to be realistic here and not keep barking up the same tree if I don't have celiac disease, but I was shocked to see the DGP IgG positive. Do you guys think this test could correlate with other possible diseases? They did do other celiac tests like the IgA and Ttg test which were in normal ranges.Endomysial test also normal.

I guess what I want to know is, with this one test being positive, should I look further into celiac disease or should I not worry about it? Thanks for any input in advance. :rolleyes:

0

Share this post


Link to post
Share on other sites


Ads by Google:

Was this one of the articles you read?: (excerpted in part)

http://drrodneyford.com/extra/documents/279-gliadin-antibody-confusion-same-name-different-test.html

"The old gliadin test. In the 1990s, the gliadin antibody test was developed. Although most celiacs had a positive IgG-gliadin antibody test, high levels of this antibody were found in about 10% of the normal population. Consequently, gliadin testing was considered non-specific” from the point of view of diagnosing celiac disease. Mistakenly, this led to IgG-gliadin being maligned as a useless and non-specific test .

Gluten sensitivity. The reality, however, is that an elevated IgG-gliadin antibody specifically means that the person is immunologically reacting to gluten. International research, including my own, has demonstrated that high gliadin anybody levels are frequently associated with clinical disease without the gut damage of celiac disease. This is now known as non-celiac gluten sensitivity, or the gluten syndrome.

Because of the poor predictive value of IgG-gliadin antibodies to detect celiac disease, this old gliadin test has been widely abandoned in the medical community – to the extent that most laboratories do not offer to do this test. But this is about to change.

DGP. This new deamidated gliadin peptide (DGP) antibody is the next big step along the journey. It is more sensitive and specific than EMA or tTG for the diagnosis of celiac disease. Unfortunately, its name is now being confused with the early old gliadin test.

Nicknames

Shortening names is universal, we call these nicknames. Whenever I am in Australia, I introduce myself as Rodney, but my friends call me Rod .

The same name strategy is being used for the DGP test. Instead of its full name, it has been shortened to the gliadin test – the identical name for the old gliadin test. But they test for very different things:

The new DGP gliadin test accurately indicates the gut damage of celiac disease.

The old IgG-gliadin antibody test indicates immunological reaction to gluten, and can help diagnose the gluten syndrome.

This is how to interpret what these gliadin antibodies mean:

A positive old test (IgG-gliadin antibody) usually means gluten sensitivity.

A positive new test (DGP-IgG and DGP-IgA) means celiac disease.

A negative old test usually means that gluten is unlikely to be a problem.

A negative new test means that celiac disease is unlikely at the time of the test, but it does not rule out gluten sensitivity."

I have heard Dr. Ford speak, and I believe that with a weakly positive DGP you should have another Endoscopy, this time with enough biopsy samples to have a hope of finding the disease. This is if you absolutely have to have the official diagnosis. If it were me, I would consider that I had celiac disease and put an end to it. I would definitely not dismiss it.

0

Share this post


Link to post
Share on other sites

Wow, thats alot more cut and dry, and seems to be very specific for celiac. I am a little shocked to be quite honest and thought with the neg biopsy from 5 years ago that I had a different unknown disease. I haven't gone completely gluten-free because I think I have been in denial somewhat. I honestly don't know if I could go through another biopsy, and maybe I should just really accept that I should cut out the gluten and be serious about it. I don't mean to sound like a baby here, but going gluten free has been harder than I thought it would be and so I waiver with cutting it out. I guess this article really explains what my blood test meant. I just wish my doctor who ran the test would have taken the result seriously and talked to me about it. Thank you for such an in depth answer, it was extremely helpful.

0

Share this post


Link to post
Share on other sites

hi! i had a full celiac panel done by Labcorp, and my DGP igG was also the only thing that came back positive. For my lab, a strong positive was greater than 30 and I scored a 43. I've been researching info to get ready for my follow-up GI appointment and found this article to be very helpful http://www.worldgastroenterology.org/assets/export/userfiles/2012_Celiac%20Disease_long_FINAL.pdf

page 8 gives a clear cut diagram that says if you test positive for either ttG igA/EMA or DGP igG, a small bowel biopsy is warranted. I plan on giving my GI a copy at my next apt. Hope you find it helpful!

0

Share this post


Link to post
Share on other sites

hi! i had a full celiac panel done by Labcorp, and my DGP igG was also the only thing that came back positive. For my lab, a strong positive was greater than 30 and I scored a 43. I've been researching info to get ready for my follow-up GI appointment and found this article to be very helpful http://www.worldgast..._long_FINAL.pdf

page 8 gives a clear cut diagram that says if you test positive for either ttG igA/EMA or DGP igG, a small bowel biopsy is warranted. I plan on giving my GI a copy at my next apt. Hope you find it helpful!

Thanks for the info, I am excited to read it! Have you gone gluten-free and feel better and do you have any symptoms?

0

Share this post


Link to post
Share on other sites




here's a link to the thread about my test results and questions

my main one is continuous bloating and frequent constipation, but in the WGO paper, they are listed in the non-classic symptoms portion on pg. 7.

i've tried gluten free for three weeks and things started to improve, but then I read that you needed to be on gluten for the testing, so i started eating it again.

0

Share this post


Link to post
Share on other sites

Jen, what did you end up being diagnosed with?  Did you get an EGD done?  Hope you're feeling better!!

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,681
    • Total Posts
      921,724
  • Topics

  • Posts

    • Ok, I can't seem to find my first lot of blood tests that were done for Celiac screening, they did include TTG I remember that much, and I am getting another copy of it but another test did come in today.  I don't know how different tests are done around the world and I don't get all the medical jargon but this is what it states, ******************************************************************************* HLA DR/DQ Genotyping for Coeliac Disease, Specimen type : EDTA blood Method : Detection of sequence-specific oligonucleotides (Gen-Probe). HLA-DR - 1, 13          DRB1 - 01, 13 HLA-DQ - 5,6        HLA-DQA1 - 5,6      HLA-DB1 - 05, 06 Interpretation : No genotype susceptibility for coeliac disease.  The DQ2 and DQ8 antigens associated with increased risk of coeliac disease were not identified in this patient.  In the absence of these antigens, coeliac disease is extremely unlikely.   *******************************************************************************   I have read the horror stories of blood tests and scope biopsies not be done right or flawed but here is what I do know as of now, At the moment the most non invasive test I can have done say negative.  I have double scopes (endoscopy and colonoscopy) booked for the 12th of October with results from biopsies expected a week or two after. Chances are they will show, a) signs of coeliac disease (even if the odds are low it can still happen), b) show signs of something else entirely and we will be busy dealing with the ramifications of that or c) it will show no signs of coeliac but I will still be suffering from gluten sensitivity (which is harder/impossible to measure clinically). My GP has told me that stress and anxiety can be a cause of all the symptoms I have been experiencing and suggests if the scopes show nothing that I may benefit from something to treat anxiety, i.e. antidepressants.  Not in a, "Oh we don't know what it is so have these," kind of way, he agrees with the thought that the scopes could indeed show coeliac, something else or even be negative. I did tell him that I could have a sensitivity and that even without benefit of clinical results, some people have gone on a gluten elimination diet for a period of time to see if they get any relief.  My question is this, if the scopes come up negative and I try eliminating gluten, how long would it be before I saw any results or improvements?  I have read enough here and elsewhere to know that everybody is different, some see results within days, some see results longer but are there any guidelines for how long a test like this should be undertaken for?  I have heard everything thing from two weeks to two months.  All of this is entirely moot at this point but I know that even if the results said clear, there would always be a little part of me that wonders if it could be a sensitivity that is the problem.  Any thoughts or advice greatly appreciated, and a thank you to all those who have taken the time to respond and offer advice and encouragement so far.        
    • We don't delete accounts but can delete any personal information and change your screen name if you would like. Just send me a personal message with three possible screen names. For the record you can edit most things in your account area with the exception of your screen name.
    • Thanks I never heard of that dye before, I guess I have to find more natural meat thanks for the suggestion. 
    • Yes, I only eat one meal a day. Sometimes salad or fries or whatever I can find. And thanks for the replies again.
    • A colonoscopy is not used to diagnose celiac disease.  An endoscopy is used to obtain biopsies in the small intestine.  
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,680
    • Most Online
      3,093

    Newest Member
    Misalina
    Joined