Get email alerts Get Celiac.com E-mail Alerts  




Celiac.com Sponsor:
Celiac.com Sponsor:




Ads by Google:






   Get email alerts  Subscribe to FREE Celiac.com email alerts

Totally Confused On Genetic Test Results- Please Help?
0

4 posts in this topic

Hi,

I'm in the middle of a horrifyingly bad gluten challenge in preparation for my biopsy, etc., so please excuse any confused-sounding bits of this.

Before subjecting me to a gluten challenge, I had the genetic testing done. I don't entirely understand the results, but the gist is that I'm positive for one of the types:

HLA-DQ2 (DQA*05/DQB1*02) - Positive

HLA DQ8 (DQA*03/DQB1*0302) - Negative

HLA-DQA1* - 02

HLA-DQA1* - 05

HLA-DQB1* - 0201

HLA-DQB1* - 0202

If anyone out there actually understands this, I would really appreciate more insight.

The real confusion is coming from my parents. My dad also demonstrates symptoms similar to mine. The cause of my symptoms HAS been diagnosed as EITHER celiac or non-celiac gluten intolerance.

However, when my dad went in to get tested, too, they had him also do the HLA test and he came back negative. (My mom is negative, too.) I wanted to know how it's possible for both my parents to be negative, but then I'm positive. Does anyone understand the genetic component better?

I'm trying to encourage my dad to pursue this because he's having some symptoms that are troubling (i.e. serious brain fog) and I would like to see if I can get him some help before it gets worse.

0

Share this post


Link to post
Share on other sites


Ads by Google:

Hi lobbyart - Did your parents go through the same doctor/lab for testing that you went through? You seem to have 1 copy (alpha and beta chains) of DQ2.5 and 1 copy (alpha and beta chains) of DQ2.2. Each parent has the capacity to give you 1 copy. Since you have 2 copies, both of your parents have at least 1 copy of DQ2. They cannot skip generations! Somewhere along the line, I'd wonder about the validity of tests... and whether you could get your hands on the exact results of your parents' gene tests...?

Good luck, keep us posted!

Laura

0

Share this post


Link to post
Share on other sites

Hi lobbyart - Did your parents go through the same doctor/lab for testing that you went through? You seem to have 1 copy (alpha and beta chains) of DQ2.5 and 1 copy (alpha and beta chains) of DQ2.2. Each parent has the capacity to give you 1 copy. Since you have 2 copies, both of your parents have at least 1 copy of DQ2. They cannot skip generations! Somewhere along the line, I'd wonder about the validity of tests... and whether you could get your hands on the exact results of your parents' gene tests...?

Good luck, keep us posted!

Laura

Thank you so much, Laura. Those results were unreadable to me! I really appreciate your help on this. So that would make me homozygous for DQ2?

I wish they'd just give us plain english... :)

0

Share this post


Link to post
Share on other sites

Yes, you are homozygous for DQ2.

To be honest, I don't think many doctors know how to read the results, either. :ph34r: For the ones that do know how, I think it makes them feel good to be able to read the jargon... :lol:

0

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now
0

  • Forum Statistics

    • Total Topics
      104,091
    • Total Posts
      920,311
  • Topics

  • Posts

    • Thanks for posting this Adrien, it's a great list and I and others will appreciate the effort and the thought behind it. I loved my time in Malaysia and I'm glad I sampled all the food I could whilst I was still on an unrestricted diet. The good thing is that, like you say, some of the nice Malay foods are still ok. As a backpacker I survived on a lot of nasi goreng and laksa, nice to think if I return there I could still do the same Terima kasih!
    • I have posted on here before. DQ2, brother with celiac, DGP iGA was the only mildly elevated test. Was gluten-free so did 6 week challenge last winter. Negative biopsy. I am gluten-free now but do go out to eat. Prior to the challenge my health was good. Since then I have: Chest pain, pain between shoulder blades, periods of shortness of breath, heart palpitations, one instance of a heart arrythmia episode, neck is tender to touch on one side (they kept saying sinuses or TMJ which my dentist vetoed) ear ache, bowels never sink. Numbness and tingling. Blood pressure variations. Could be doing chores and feel dizzy and it might be 84/52.  not super low, but not typical for me if I'm running around the house.While other days I am mildly hypertensive. Recently lost 5 lbs in 8 days without trying. Recently electrolytes were low, alkaline phosphatese was low. Ferritin started dropping so started liquid iron 2-3 times per day 4 months ago. Primary watching that, I am not anemic but we are nowhere near iron overload either.  GI doc was a dick. Did not even know DGP replaced older tests and he was very condescending When I begged him for help recently and told me to get a second opinion which is exactly what I plan on doing.  I now have pain in my upper GI area. It is tender to touch. I had my gallbladder out in 97 along with a stone and infection in my bile duct. It hurts in this area. Pancreatic enzymes look fine, liver enzymes fine. Pancreatic ultrasound fine. I will now be doing a EUS Soon to look at bile duct, pancreas and liver.   so a typical day for me is that I might feel fine for a while and then suddenly feel like I'm going to pass out. really dizzy, numbness in odd places, like my body has been hijacked. I will typically eat a bunch of food something high protein and in about an hour or so I start to feel better. However, then my upper stomach starts to hurt in place of the passing out feeling. blood sugars are also normal. After getting the " it must be panic attacks" and condescending looks a million times my primary finally ordered an ultrasound of my sore neck and there is an abnormality in my thyroid which she says looks like possibly Hashti's. Except for one time, all my serum TSH tests were normal. We have more blood work on Monday. As I have not put on any weight and there are other symptoms that are closer to Graves.  Has anyone else had any thyroid issues that followed doing a gluten challenge?  where is your stomach pain? Do you have it above or below your belly button? Mine feels like it's in the pancreas area, like 2-3 inches above the belly button and when I push on it it's tender, but not all the time. sometimes i feel it in my back. 
    • Thanks for sharing with me.  I really appreciate it.  Honestly, after a glutening last summer (still do not know what glutened me), I did not eat out for a year!  The risk was too great as my healing time took 3 months (for symptoms to subside) and six months to regain lost weight.  Our recent vacation to Europe was worth the risk  as we traveled with our entire extended family, but we were extra cautious and ate only at celiac-approved places.  Otherwise, we "dined" at markets or ate the food we brought from home.  Thankfully, we did not get glutened (at least we don't think so!)  
    • I do not struggle with this and I was brought up the same way as you. I don't struggle because for many years off & on we didn't have a bathtub, only showers as well as this being therapy or medicinal for the skin - heck even for the muscles as I age. I figure I've earned my right to luxuriate or medicate with baths any time I've a mind to. My husband saw just how bad my dh got & NEVER begrudges me a nice long soak in the big soaking tub we now have.
    • Hi, No, I do not have celiac  disease. I have an ankylosing spondylitis which is an auto-immune disease provoking an inflammation of the joints. Under the advice and supervision of my doctor and the professor at the hospital I follow a gluten free & casein free diet, which is extremely successful in preventing inflammatory events. And I've been doing so, strictly, for more than 6 years. So I'm not Celiac, but I can tell you that I react strongly every time I take gluten even in small amounts. Even soya sauce, which according to this website has an almost zero dose of gluten, is a lot too much for me. Nevertheless I allow myself to eat food which has been processed in a factory which processes gluten. To conclude, I would say that when you are travelling, especially in a country where celiac disease is scarcely known, you should be twice as careful as when you're going out at home. In the end you can never guarantee that the cook has cleaned his pan after using soya sauce and so on... You can only bet
  • Upcoming Events

  • Blog Entries

  • Recent Status Updates

  • Who's Online (See full list)

  • Member Statistics

    • Total Members
      61,121
    • Most Online
      1,763

    Newest Member
    Sambud
    Joined