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      Frequently Asked Questions About Celiac Disease   09/30/2015

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to FREE Celiac.com email alerts What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease? - list blood tests, endo with biopsy, genetic test and enterolab (not diagnostic) Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet Free recipes: Gluten-Free Recipes Where can I buy gluten-free stuff? Support this site by shopping at The Celiac.com Store.

Gene Test Results Negative
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8 posts in this topic

Here are my gene test results, so it seems it is NOT celiac. Which is good news for my relatives. :) I guess this narrows what I have down to NCGI, but my GI doc is doing an endo in a couple weeks anyway....

I'm not doubting the interpretation, but can anyone decipher what this means? I get what the first two are and am lost after that.

---------------------------------

Interpretation --- The patient does not have the HLA-DQ variants associated with celiac disease.

More than 97% of celiac patients carry either HLA-DQ2(DQA1*05/DQB1*02) or HLA-DQ8(DQA1*03/DQB1*0302) or both.

Hla-Dq2 Negative

Hla-Dq8 Negative

Hla-Dqa1 -- 01

Hla-Dqa1 -- 02

Hla-Dqb1 -- 0303

Hla-Dqb1 -- 0603

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Unless you are in the 3% that don't have the genes they test for?

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Oh.... I didn't think of that. Maybe that's why he's doing the scope anyway. <_<

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I was told if I don't have the genes, I ain't celiac (I don't have the genes). Does anyone have any information about the other 3%?

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I was told if I don't have the genes, I ain't celiac (I don't have the genes). Does anyone have any information about the other 3%?

ravenwoodglass belongs in that 3%. You can find out what it did to her :wacko:

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So my GI seems to be sure I am celiac negative, given my blood tests were also neg. I'm at a loss as to why he's doing the endo, plus I'm supposed to start a gluten challenge on Sunday. Why would I do a gluten challenge and biopsy if he is convinced I'm negative anyway?

I tend to think that I'm probably not in that "less than 3 percent" group -- I mean those are pretty slim odds. I have to accept that all of the most sophisticated tests say I'm not celiac. I guess the biopsy will be the last test.

I'm kind of freaking out about what to do next because I still can't eat gluten and I seem to have a wheat allergy, as in the puffy face and all. So little is known about NCGI... Are all the potential complications the same? Do I need to be as strict? I don't mind being gluten-strict in my own home, but I do sometimes feel bad giving friends and family the once-over in their own kitchens. Can I lay off them a little if I don't have celiac?? :(

----

Also, does anybody know what the last four gene tests mean, if anything?

Hla-Dqa1 -- 01

Hla-Dqa1 -- 02

Hla-Dqb1 -- 0303

Hla-Dqb1 -- 0603

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Actually, I've read studies wherein they've found up to 6-8% (I think) being negative for both the alpha and beta chains of DQ2 and DQ8 (which includes, by default, DQ7.5), the study had a very large cohort as well. Let me see if I can dig it up...

EDIT: Here are a couple I've read a long the way.... still digging for the study that showed only 93% of the celiac cohort showed DQ2 and/or DQ8.

http://www.ncbi.nlm....pubmed/12651074

http://celiacdisease...tic-Testing.htm

http://www.glutenfre...o_interview.pdf - In this article Dr. Fasano acknowledges that 2-3% of people diagnosed with Celiac do not have the genes.

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