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gigimom

Member Since 22 Sep 2004
Offline Last Active Aug 11 2006 09:29 AM
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Topics I've Started

Other Causes For Cd Symptoms?

03 November 2005 - 11:40 AM

I have 3 kids who have been tested for celiac disease. All had very high AG IgG. Only one had a positive biopsy. We did the HLA gene test through Kimball Genetics. No one had DQ2 or DQ8. Neither did my husband or I. I probably will try to go through Enterolab to see if we have gluten sensitivity genes (although the medical bills are really adding up). I actually asked an expert in this field about our situation and he said to be careful because "all that atrophies is not celiac disease." What I want to know is if anybody has heard of any other factors that can temporarily cause a sensitivity to gluten (or other allergens) such as exposure to molds, etc. The kids have been gluten-free (except one) but the symptoms were so mild to begin with that I keep wondering if we are barking up the wrong tree. I'm afraid that they may have some silent form of gluten sensitivity and don't want them to have unnecessary damage by putting them back on gluten. I'm also worried that the doc that we have seen isn't being thorough enough to check out other possibilities.

My father, who is a physician, and willingly admits that he knows virtually nothing about celiac disease also says to be careful that the dx wasn't made too quickly. He says that the saying "if you have a hammer, everything looks like a nail" may apply in this dx. I'm confused, concerned and just want to be sure that I'm not doing the wrong things with my children.

Kimball Genetics Testing

28 August 2005 - 08:03 PM

I've been reading past posts about Enterolab testing and the genetic testing but haven't seen much about Kimball Genetics. We had the celiac disease DNA test done hoping it would give us some answers -- it did, but ended up giving us more questions. Three of my children had very high IgG levels in their initial bloodwork. Only one came back with a positive biopsy. One of the children with a negative biopsy has frequent headaches with vomiting so I put her on the gluten-free diet hoping it would take care of the headaches. It didn't seem to change anything (maybe 3-4 months wasn't long enough?) To give us answers, we thought we'd find out if she carried the gene for celiac disease but hadn't developed full blown celiac disease.

We tested me, my husband and this one child. My husband and daughter tested negative for DQ2 (DQA1*05/DQB1*02) and DQ8 (DQB1*0302). They detected one of the DQA1*05 alleles in me but that alone was not enough to result in celiac disease. So...according to Kimball Genetics, neither me nor my husband has the celiac disease associated molecules necessary to result in celiac disease and therefore our children do not posess the necessary genes for celiac disease. My doctor doesn't want to put full faith in these tests and so celiac disease remains the diagnosis for my biopsy positive child.

Can anybody tell me if the Enterolab testing is more specific for possible gluten intolerance genes? (There seem to be more gene types with Enterolab).Has anybody else had a positive biopsy without a celiac gene?
I know people will say to just follow the gluten-free diet and if it works let that be enough. But I keep thinking that there may be some other factors making my children sick.
Can anything else elevate an IgG level other than gluten?

Enterolab Vs. Kimball Genetics

15 April 2005 - 11:26 AM

I need help deciding which company to go through for genetic testing. Her IgG was high, all else was within normal. Her biopsy was inconclusive. Two brothers have celiac disease. She has a 4 year history of migraines with nausea and vomiting. She is gluten-free but has been getting her migraines at least every other week. We need to determine if she has other indicators of celiac disease and would like a genetic test for her and possibly other family members. What lab would work best for us? Any ideas? I can't determine any great differences between the companies that U've been reading about.

Genetic Testing Questions

20 December 2004 - 08:19 PM

Two of my children have recently been diagnosed with celiac disease. They had obvious symptoms and obvious improvements on a gluten-free diet. My third child often had bad headaches and joint aches so I thought she would probably test positive too. But, she had an IgG of 64 and other tests were negative. Her biopsy was negative (no flattened villi but superficial congestion -- whatever that means). I started her on a gluten-free diet. I think she seems okay on the diet but her symptoms are so much more vague than the other kids. I'm considering some genetic testing for her and maybe my husband and me. I need some input on what is the best option. I've heard of Kimball Genetics and Enterolab. Are they really reliable and worth the money? My doc told me to save my money and not do the tests. I just need more strong evidence for my third child because she does not think she needs to stick with the diet -- mostly because she really doesn't have the same digestive reactions that my other two children have. Any suggestions?