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Ninja

Member Since 15 Feb 2012
Offline Last Active Oct 29 2014 05:14 PM
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Posts I've Made

In Topic: The Beginning - Good Enough Of A Diagnosis

28 October 2014 - 11:35 AM

Hi ezgoindude,

 

I am on the fly and will come back with a more thorough reply but a few things. . .

 

Yes, I am on a sort of hybrid paleo/Mediterranean/anti-inflammatory diet. I do not eat any grains, which made a huge difference for me all the way around, but I do eat yogurt (all other dairy I avoid). It's been quite a journey to figure out what my body does and does not tolerate and it certainly sounds like your experience is similar in that regard. I am still continuing to learn and sort things out; luckily these days I am getting foods back versus the opposite.

 

It does sound like your SIBO hydrogen breath test was botched unfortunately. Those sorts of tests are kind of iffy to begin with so it is never a bad idea to re-evaluate periodically!

 

Reading your signature, I see that you have noticed some improvement on a low histamine diet? Out of curiosity have you ever had food allergy (IgE) skin tests (aka scratch tests)? If so, do you remember if you might've reacted to the 'control'? The control is typically just concentrated histamine, and thus may shed some light on a possible connection.


In Topic: The Beginning - Good Enough Of A Diagnosis

25 October 2014 - 12:01 PM

The elevated eosinophils in your colon are certainly suspect. . . Is your new doctor by chance willing to do a repeat colonoscopy with biopsy to look for further evidence of eosinophil infiltration (or lack thereof given your elimination diet)? Otherwise, would s/he repeat the colonoscopy + biopsy after a trial course of steroids/immunosuppressives? 


In Topic: Eating Out In Vancouver Bc

22 October 2014 - 05:44 PM

How far are you willing to travel? There is a wonderful restaurant in White Rock, BC (5-10 minutes from the border and near the water: beautiful!) called Uli's. I've been there many times and have had no issues, despite being super sensitive to gluten CC. It is one of only a handful of places I can eat with no ill-effects. They do a fantastic job! http://www.ulisrestaurant.com

 

If you decide to try it, I highly recommend their flourless chocolate torte. . .  :wub:


In Topic: How To Determine Hla-Dq* ?

07 May 2014 - 06:30 AM

Hi there,

 

Here are two really good links (particularly the second one) that may help explain 23andme's weird reporting system as it relates to the more common DQ type nomenclature: 

 

http://snpedia.com/i.../Celiac_Disease

 

http://www.ncbi.nlm....es/PMC2386975/#!po=53.1250 – This is actually a study. Very informative and interesting if you choose to read through the whole thing. However, if you skip to page 10 and click on table 3, you'll find a list of the celiac related DQ types, their SNP tags as well as risk alleles. I'm not sure if 23andme is still testing for all of these SNP tags, but the DQ2.2, DQ2.5 and DQ8 tags still work for me (my chip is from last September/October). I suggest referencing the first link for DQ2.2, because I think they've since updated one of the tags.

 

As others have said, 23andme only looks for DQ2.5 when establishing celiac disease risk, however they are also reporting on a few other SNP's (from different chromosomes or different parts of chromosomes, so non HLA-DQ types) that may be associated with celiac. Their studies and any they cite on these other genes/risk factors have yet to be validated. 

 

Best wishes,

Ninja :)


In Topic: Questions Regarding Enterolab Results/gene Test

01 May 2014 - 01:52 PM

HLA-DQB1 Molecular analysis, Allele 1      0303   

HLA-DQB1 Molecular analysis, Allele 2      0603   

Serologic equivalent: HLA-DQ   3,1  (Subtype 9,6)
 

 

Hi there,

 

It looks like you have HLA-DQ9 as well as HLA-DQ6. The problem with the enterolab genetic tests is that they are not fully comprehensive as they only look for the beta unit (the B1 part) of a particular gene and not the alpha unit, therefore they cannot be used to determine whether celiac can be ruled out on the basis of genetics. In other words, the beta unit and alpha units tend to correspond (beta DQ9 tends to go with alpha DQ9 so on and so forth..), but that is not always the case: one could have beta DQ9 and alpha DQ8 (DQ8 being a 'celiac gene').

 

In some studies DQ9 has been found to be associated with celiac in the asian population, but I'm not sure if those studies have been replicated or where they are with it. You might do some googling if you are interested. :)

 

You are correct that NCGI does not result in an autoimmune reaction (per current knowledge). Unfortunately there is very little known about the role of elevated TTG antibodies in the stool, thus making it hard to draw accurate conclusions from as kareng mentioned above.

 

Family history can sometimes be helpful in situations where the diagnosis is unclear, particularly if you have other autoimmune diseases or if they run in your family. If you don't care so much about getting the 'right' diagnosis and plan to be 100% gluten free, I'd try eliminating some of those foods and see how you feel. I'd also add a good probiotic if you haven't and maybe think about digestive enzymes. Both of those were tremendously helpful to me along the way!

 

Best wishes,

Ninja