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Ninja

Member Since 15 Feb 2012
Offline Last Active Oct 17 2014 06:17 PM
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Posts I've Made

In Topic: How To Determine Hla-Dq* ?

07 May 2014 - 06:30 AM

Hi there,

 

Here are two really good links (particularly the second one) that may help explain 23andme's weird reporting system as it relates to the more common DQ type nomenclature: 

 

http://snpedia.com/i.../Celiac_Disease

 

http://www.ncbi.nlm....es/PMC2386975/#!po=53.1250 – This is actually a study. Very informative and interesting if you choose to read through the whole thing. However, if you skip to page 10 and click on table 3, you'll find a list of the celiac related DQ types, their SNP tags as well as risk alleles. I'm not sure if 23andme is still testing for all of these SNP tags, but the DQ2.2, DQ2.5 and DQ8 tags still work for me (my chip is from last September/October). I suggest referencing the first link for DQ2.2, because I think they've since updated one of the tags.

 

As others have said, 23andme only looks for DQ2.5 when establishing celiac disease risk, however they are also reporting on a few other SNP's (from different chromosomes or different parts of chromosomes, so non HLA-DQ types) that may be associated with celiac. Their studies and any they cite on these other genes/risk factors have yet to be validated. 

 

Best wishes,

Ninja :)


In Topic: Questions Regarding Enterolab Results/gene Test

01 May 2014 - 01:52 PM

HLA-DQB1 Molecular analysis, Allele 1      0303   

HLA-DQB1 Molecular analysis, Allele 2      0603   

Serologic equivalent: HLA-DQ   3,1  (Subtype 9,6)
 

 

Hi there,

 

It looks like you have HLA-DQ9 as well as HLA-DQ6. The problem with the enterolab genetic tests is that they are not fully comprehensive as they only look for the beta unit (the B1 part) of a particular gene and not the alpha unit, therefore they cannot be used to determine whether celiac can be ruled out on the basis of genetics. In other words, the beta unit and alpha units tend to correspond (beta DQ9 tends to go with alpha DQ9 so on and so forth..), but that is not always the case: one could have beta DQ9 and alpha DQ8 (DQ8 being a 'celiac gene').

 

In some studies DQ9 has been found to be associated with celiac in the asian population, but I'm not sure if those studies have been replicated or where they are with it. You might do some googling if you are interested. :)

 

You are correct that NCGI does not result in an autoimmune reaction (per current knowledge). Unfortunately there is very little known about the role of elevated TTG antibodies in the stool, thus making it hard to draw accurate conclusions from as kareng mentioned above.

 

Family history can sometimes be helpful in situations where the diagnosis is unclear, particularly if you have other autoimmune diseases or if they run in your family. If you don't care so much about getting the 'right' diagnosis and plan to be 100% gluten free, I'd try eliminating some of those foods and see how you feel. I'd also add a good probiotic if you haven't and maybe think about digestive enzymes. Both of those were tremendously helpful to me along the way!

 

Best wishes,

Ninja


In Topic: Non-Gold Standard Dx Or No Dx--Which Is Better?

29 April 2014 - 06:29 PM

Potentially not. Though I imagine it might be if you were to end up positive for one or more of the celiac genes! A shot in the dark, kinda. Even so, if you have the resources and would prefer to avoid going through a doctor (which it sounds like), I would encourage you to get it done: it could end up being an important piece of the puzzle.


In Topic: Non-Gold Standard Dx Or No Dx--Which Is Better?

29 April 2014 - 04:59 PM

Usually the beta and alpha units correspond with each other: if you have beta DQ2 present you are more likely to have alpha DQ2 present as well, however that doesn't always happen. Celiac can be observed in individuals with positive alpha and beta 'celiac genes' (DQ2, DQ8) or positive for either the beta portion or the alpha portion of those celiac genes. So theoretically, if you go through enterolab and it shows that you do not possess the beta units of DQ2 or DQ8 that does not exclude the possibility of having either of the alpha portions of those genes. In other words: it does not rule out celiac. 

 

On the other hand, if you do come up 'positive' through enterolab there's really no need to know the alpha portion, IMO. Does that help at all?


In Topic: Non-Gold Standard Dx Or No Dx--Which Is Better?

29 April 2014 - 04:27 PM

Does it do the complete testing, though, alpha and beta?

 

I went through enterolab and no, they do not report on both the alpha and beta units – only beta.