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mle_ii

Member Since 07 Jul 2005
Offline Last Active Sep 14 2006 05:56 PM
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Posts I've Made

In Topic: Mechanisms Behind The Leaky Gut

14 September 2006 - 01:54 PM

Ok, I've been reading a lot more about zonulin and what I've read thus far is pretty darn amazing.

Of course we all know by now that Zonulin causes these tight junctions, the barrier from the contents of the GI to the other side of the cells, to open.

It appears that in folks with celiac disease and even treated celiac disease folks that the tjs are open a lot more than normal folks. And that when exposed to gliadin that zonulin causes these tjs to open even more, a lot more in celiac disease and celiac disease-treated, but also (news to me) in folks without celiac disease. It also appears that bacteria that reside in the gut also opens these tjs (even newer news to me).

http://gut.bmjjourna...t/full/48/4/503

BACKGROUND AND AIMSAltered intestinal permeability is a key pathogenetic factor of idiopathic bowel inflammation. We investigated in the rat if changes in the composition of the bowel flora can alter colonic permeability.
METHODSA colonic segment was surgically excluded from faecal transit and brought out as a loop to the abdominal wall through two colostomies. The loop was used for colonisation with specific bacterial strains after eradication of the native flora with antibiotics. Lumen to blood clearance of dextran (molecular weight 70 000) and mannitol (molecular weight 182) was measured in rats recolonised with a single bacterial strain from rat colonic origin, and in control rats whose colonic loop was kept free of bacteria by antibiotics. Actual colonisation was confirmed by culture of segment effluents.
RESULTSColonisation with Escherichia coli, Klebsiella pneumoniae, and Streptococcus viridans significantly increased lumen to blood clearance of mannitol. Colonisation with Lactobacillus brevis had the opposite effect and reduced permeability to mannitol. Bacteroides fragilis did not induce significant changes. Permeability to dextran was not altered by any of the strains tested.
CONCLUSIONSCertain commensal bacteria can modify colonic wall permeability to luminal substances.


Didn't realize that even bacteria had the key to our bodies.

Here's this one that shows that zonulin was part of the key for the bacteria.
http://www.ncbi.nlm....t_uids=12404235

Once the tjs are open more than normal this allows stuff to pass through, in some cases gliadin and in others other food proteins or even bacteria. Once they pass through we develop the antibodies to these pathogens and all heck breaks loose.

Now I'm wondering why the gut would allow this bacteria to do this. Perhaps gliadin looks to what ever is turning on the zonulin like the bacteria and thus lets stuff on in.

Mike

In Topic: Cleansing?

14 September 2006 - 08:48 AM

Is there any science or research behind these cleanses? Colon, liver, etc?

Fasting, absolutely I've seen some research and see the benefit.

As for cleansing, I've not seen anything yet that leads me to believe that there is any basis in fact here.

After having the ultimate colon cleanse (prep for a colonoscopy) I didn't see anything that even closely resembled what these cleanses show to be in the GI. I think it's all just the contents of the cleanse formula binding up the GI contents that you see and not what is "stuck" to your insides.

Honestly I'm a sceptic, but I'm open to hear differently. About the only cleanse that makes sense to me is water and lots of it. And perhaps a massage for getting the "gunk" out of the muscle tissue.

Thanks,
Mike

In Topic: A Question About Enterolab

13 September 2006 - 02:00 PM

A light just went off in my head ... I have felt bad ever since I eliminated casein, which I showed a sensitivity to. So, now I'm off all opiods. Am I feeling this bad for the past three months from withdrawal? Can it take that long?


What do you mean by feeling bad? What are your symptoms?

As far as how long, 3 months seems like too long for withdrawal symptoms, but this isn't something I know much about.

Here's more on what I'm taking about:
http://en.wikipedia..../Opioid_peptide

In Topic: A Question About Enterolab

13 September 2006 - 01:02 PM

And here's another. Why do folks get depressed or sad during the fall/winter? Is this physical or mental?

In Topic: A Question About Enterolab

13 September 2006 - 12:51 PM

By the way, I wasn't aware lactose intolerance is linked to depression, or did you mean fructose intolerance.

http://www.ncbi.nlm....l=pubmed_docsum
Full text here:
http://www.jpgn.org/pt/re/jpgn/fulltext.00...#33;8091!-1

Depression is rarely the only symptom of malnutrition. For example B12 deficiency produces megaloblastic anemia before it produces depression. Thiamine deficiency produces paresthesias, angina, peripheral neuropathy. So I guess my point is that when there are physical causes of depression (which is uncommon), they always produce other charatherisitc signs besides just the depression and can be easily identified in the vast majority of the cases.


I don't agree, but that's ok. :)

Actually I can prove it. Most patients, about 65-70%, who are depressed improve significantly with their first antidepressant trial or therapy. 35% do not improve significantly with one antidepressant and for these agumentation therapy has been used. Also switching to another class of antidepressants is also helpful. This reduces the number of people who are treatement resistant to about 5% or less. These people (the 5%) usually have physical causes of depression.


All you proved to me was that Drs know how to cover up problems by taking care of the symptoms with drugs. Something I already know. Plus this is all subjective, perhaps folks just gave up on therapy because they weren't being helped and told the Dr they were cured. Give me a measurement one way or the other and I'll agree, otherwise you can't prove it.

Also, you do know that 2 of the top foods in the american diet are dairy and grains. I bet you also know that those two foods are broken down by the body to produce opioids. What happens when you give someone opoids or take them away, or take them chronically? What organs does this affect? What is this doing to our bodies long term? Can one get addicted to the opioids in these foods? If addicted to these foods does this explain why some folks cannot stop eating them? Is this addiction physical or mental? When this addicted person overeats, gets overweight and then depressed is this physical or mental?

Where does physical stop and mental begin? Again we don't know enough to say.

Mike