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mle_ii

Member Since 07 Jul 2005
Offline Last Active Sep 14 2006 05:56 PM
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Topics I've Started

Mechanisms Behind The Leaky Gut

12 September 2006 - 02:11 PM

Haven't seen this here yet, so I thought I'd post this. I was doing some research on zonulin and came across this document:
http://www.autismone...Owens Susan.doc

Haven't examined all the science/research, but a quick look at a few parts of the science look very sound.

Mike

Diseases In Europe

06 September 2006 - 12:20 PM

Ok, for those who know history of Europe, and perhaps some of Asia.

What diseases in the past oh, say 500,000 years have decimated the European population in the past? Of those diseases, which aren't now causing large amounts of the European population to die of? Finally which of those diseases still might or do run rampant in Asia, South Africa and among Native Americans?

I'm currently reading "Guns, Germs, and Steel" - by Jared Diamond, but I'm not to the Germs chapter. I'm sure I'll get a good idea of what these might be, but I thought I'd ask as I'm sure one or two or more might know the answer.

Where I'm going with this is what I've talked about in the past. That our HLA-2 and 8 (perhaps some of the others, except HLA-4 were selected because we (with those genes) survived some disease, pathogen or whatever. Those that did not have the genes died. Others who were more isloated from Europe, namely Asia, South Africa and the Americas don't have these genes. Unfortuneatly for us there are foods that we eat that also have the protein signature recognized by these genes as a pathogen.

For more on gene's read this article:
Understanding the Genetics of Gluten Sensitivity by Dr. Scot Lewey

For more information to those left reading. :)

So our immune systems get turned on and fight back. Part of the fight back is the attack on our own body tissues. The reason for this is that Tissue Transglutaminase binds to the gliadin protein, in some cases it just changes the protein, in other cases it binds to other things. Some of those other things include other body tissues. When the B-Lymphycyte sees this foreign matter it checks it out, this is done by basically engesting the object (including the ttg and bound body tissues) and breaks it down into parts. The gliadin gets recognized as foreign (due to the HLA-2 and 8 genes) after talking with a T-Cell. And thus the B-Lymphocyte creates antibodies for all the proteins it enjested. Including ttg (ttg is the same thing that tests to find the antibodies for found in Celiac Disease) and other body tissues. Normally the body would ignore the self tissues but due to disease or other reasons, perhaps even the mechanism which tells the body that it's infected (with gliadin or a similar pathogen) turns off this mechanism of not recognizing self as foreign. Once the body sees self as foreign it doesn't stop until the pathogen is gone. And since the body sees self as foreign it attacks self as well and thus more bad things happen.

Thanks,
Mike

Celiac Disease Could Be A Frequent Disease In Mexico

31 August 2006 - 08:30 PM

If this has already been posted then please delete. Otherwise take a look at these stats!

http://www.ncbi.nlm....l=pubmed_DocSum

On the basis of a well-recognized serologic screening method performed to blood donor samples, we demonstrated an unexpectedly high prevalence of tTGA positivity (2.6%) in the adult Mexican Mestizo population. Thus, the prevalence of celiac disease in Mexico could be higher or similar to that observed in other countries. This observation contributes to increase the awareness for this under diagnosed disease in clinical practice and to consider celiac disease as a global health problem.


2.6% that is getting close to 3 in 100 people.

Questions About Lab Tests...

28 August 2006 - 10:43 AM

I saw a GI Dr today and I'm curious about some lab tests I'm getting done.

One is for Lactose Intollerance and it's a blood test. What does this entail and how does it work in comparison to the breath test?

How do they test for Bacterial Overgrowth?

Has anyone done an upper GI x-ray where you drink barium? What was this like?

Finally I'm getting a Dexa scan as well, what's this like?

I have a bunch of other tests, though I know about them.

Oh and it still seems like the GI Drs don't know much about Microscopic Colitis :( Still seem to be grasping at straws. Talked about high fiber, pepto bismol and endocort (sp). The usual. Seem to be even clueless about celiac/gluten sensitivity. Didn't seem very impressed with the stool testing other than the gene test, nor did they seem to care much about the IgG test. Talk about heads in the sand. :(

Mike

My Elisa Food Test For Igg Antibodies Is Back

22 August 2006 - 03:07 PM

Most everything showed no reaction, but let's look at what showed a reaction.

Low Reaction - Whey (protein in dairy) and Almond
Moderate Reaction - Gliadin (Wheat) and Whole Wheat - Both were closer to High than Low reaction
High Reaction - Gluten (Wheat), and Rye

And what, quite curiously, is missing with regards to reaction. Barley and Oat. Given more info about celiac/gluten and oats not being a problem, I might just have to try an oat that is known for being gluten free (no cross contamination). I thought for sure my reaction to dairy would be higher though, perhaps it's only a lactose reaction or perhaps I'm just sensitive to the low reaction of whey.

It's pretty cool that it matches very well with the data from Enterolab. Being that I showed reaction to gluten, but no reaction to soy, egg, casein in both this test and in the stool test via Enterolab.

It also appears that I might have to give eggs another chance now and test soy again.

Here's info on what all I had tested:
http://www.usbiotek....s-96General.htm
http://www.usbiotek....es-Add15Veg.htm
http://www.usbiotek....cesAndHerbs.htm

More info on the testing:
http://www.usbiotek....elevenceIgG.htm
http://www.usbiotek....alReviewIgG.htm

Thanks,
Mike