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Member Since 31 Aug 2012
Offline Last Active Oct 29 2012 10:52 AM

Posts I've Made

In Topic: Conflicting Test Results--What Do I Do Now

25 October 2012 - 12:20 PM

Thank you for all the responses. We go back to see the GI in 2 weeks. I have been trying to do alot of research on the topic and do ask questions here because everyone seems so knowledgeable. I have been reading the testing "algorithms" from different studies and they all seem to say to draw the ttg first, then if that is positive, draw the deamidated gliadin. In my son's case, they drew the deamidated gliadin first which then led to the ttg testing. So I am wondering if that really matters at all (which is done first). If the doc would have just run the ttg first, then he wouldn't have looked any further and thus never knowing the deamidated gliadin was even high. Just some thoughts as I try to educate myself before we see him. If his AGA levels are normal, what does the igg levels show? Thanks again for all of your help :)

In Topic: Conflicting Test Results--What Do I Do Now

25 October 2012 - 08:57 AM

Yes, he ruled it out based on the negative ttg. My son had a total IGA drawn at the same time which was normal so he isn't deficient. Has anyone else had conflicting results like this ? The doc said the gliadin test isn't very reliable. I did tell him it was the deamidated because I believe that makes a big difference (my son's regular ped drew had that drawn just based on his symptoms)

In Topic: Conflicting Test Results--What Do I Do Now

25 October 2012 - 08:52 AM

The deamidated gliadin is an antibody created in reaction to gluten, it is SUPPOSE to be very specific for celiac. I say suppose because it only came into play in 2008 and there are still many studies being done on it. However it is very likely that your son is having reactions to gluten with a level that high.

The TTG IgA looks for damage in the small intestine, perhaps your son is reacting to gluten but has not yet received substantial damage in his intestines to show up on the test?

With a DGP that high I would look for a second opinion, I really think you may be onto the diagnosis of celiacs, you don't want to wait until your son gets worse to look into it. Some doctors won't do anything until you are obviously being destroyed by the disease, members on this forum want early detection so that people like your son do not have to go through the horrible years of symptoms many of our members had to get diagnosed. Also early detection will prevent further development of other autoimmune diseases such as Hashimoto's Disease. Not to mention that your son's growth can be hindered if he has celiac and it goes ignored.

You need a to get the entire celiac panel done, here it is:
Deamidated gliadin IgG
Deamidated gliadin IgA
Ttg IgA
Endomysial Ab
Total serum IgA

The first two are the bodies reaction to gluten, the second two are markers of damage in the intestine. The last test is used to rule out false positives on the IgA scale.

Question- Did your doctor rule out celiac just because the TTG was negative or was there more to it? If he ruled it out because of a negative TTG I wonder how he even obtained his medical license let alone a specialist one.

Yes, the doctor ruled it out based on the ttg. He said the gliadin test isn't very reliable. My son's total IGA was normal, so he is not IGA deficient. The doc said we don't have to test further because the ttg was negative. From everthing I have read, I'm wondering if I should ask for and endoscopy. Has anyone else had conflicting results like that?

In Topic: Ttg Results....what Do I Make Of This?

13 September 2012 - 05:22 AM

Hi there,

About to head to get some sleep, but a quick note: there are a LOT of false negatives for the TTG. In fact, I never had a positive TTG (out of three times I tested) but I did do the endoscopy and clearly have damage to my sm intestine = a difinitive diagnosis for Celiac. Also, one of my daughters tested negative 2 out of 3 of her TTG tests (our other daughter was a very clear positive TTG). A positive TTG is a very accurate indicator of Celiac.

- Yes, I believe it's possible he could be in the beginning stages of Celiac. If this is the case, you might consider testing him annually to see if the TTG is triggered sometime in the not too distant future.

- I believe I had a low TTG because I had (over 40+ years) developed enough food aversions to effectively take myself off gluten inadvertantly and unknowingly (I avoided pasta, beer, pizza...). You may consider (heavily) gluten loading him for 3+ to 6 months and see if his TTG changes (this is how we triggered one daughter's TTG to a positive result).

All this said, I believe there is a lot to subjectively consider in looking at Celiac disease. Here is the list of things we considered as inputs for diagnosing our kids (and then me):

- Bloodwork (TTG, etc)
- Genetic testing
- Endoscopy
- Symptoms while eating gluten
- Easing of symptoms once off gluten (don't do this until you're done testing)
- Family history of Celiac, GI cancers, other related disorders etc.

Celiac can be easily definitive (in the case of one daughter with positive TTG, positive genetics, positive endoscopy, symptomatic, better off gluten) or more of an art (another daughter with eventual positive TTG, positive genetics, inconclusive endoscopy, symptomatic, better off gluten).

Hope this helps!

Thanks so much for the information. I am going to talk to the GI doc at more length about early stage celiac when we see him in November. I just think something must be going on if his gliadin IGA is high. Thanks again!!

In Topic: Blood Tests......what Is Correct?

10 September 2012 - 04:48 AM

Thanks for your replies. He did not order any nutrient tests and he didnt offer any explanation to the high result if it isn't celiac. He pretty much blew off that he thought it could be celiac, but he said we needed to "contend" with the high DGP. He did very briefly mention that if the tTG comes back negative, he may do a biopsy, but he said it so quickly and brushed over it and on to other things. My son had his tTG drawn this weekend, I will let you know what is was. I am very interested to see what it is and where we proceed from there. Can and elevated DGP indicate anything else?? Thanks for your time!

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