Jump to content

Follow Us:  Twitter Facebook RSS Feed            




   arrowShare this page:
   

   Get email alerts  Subscribe to FREE Celiac.com email alerts

 
Celiac.com Sponsor:                                    


simply

Member Since 03 Feb 2004
Offline Last Active Mar 03 2004 07:57 AM
-----

Posts I've Made

In Topic: Confused By Test Results

20 February 2004 - 02:36 PM

Yesterday, I spent a lot of time reading through what the various tests meant, Entrolab, etc.

Is it possible to test positive on the EMA and tissue transglutamaise without having blood in the stool? It seems like most of the anti-bodies are actually in the small intestine, a place were I have no blood (at least according to all the stool tests performed last semeter). So I'm curious how the anti-bodies get to the blood from the small intestine if the small intestine has no blood. Any help will be greatly appreciated.

Just curious.

Simply

P.S. Note to gf4life...I'm very happy that your husband has OK'd the money for the tests. Hopefully, you can get some answers.

In Topic: Confused By Test Results

19 February 2004 - 08:04 PM

I was just reading some of the FAQ's, here on Celiac.com.

One of the FAQs said something that totally contradicts everything I've been reading today.

Here it is:


One case I know of had elevated gliadins (both types) but normal EMA and ARA, plus an inconclusive biopsy. Do you see this often?**

Vijay Kumar, M.D., Research Associate Professor at the University of Buffalo and President and Director of IMMCO Diagnostics: If the tests are performed using well standardized tests with known positive and negative predictive values then you can make the statement that if the serological tests are negative celiac disease can virtually be ruled out. The problem is that some of these assays, especially the gliadin, can give you false positive results. In our laboratory we rarely see positive AGA results in the absence of EMA and ARA antibodies.


Is this true? I thought that if the EMA and transglutamaise (sp?) tests were positive, you can be 100% certain that you have celiac and that the damage to your small intestine is fairly advanced. However, if they are negative. you may have celiac, you may be gluten intolerant, you may have nothing...it would be hard to say.

Am I right about this?

Thanks,

Simply.

In Topic: What Do You Think?

19 February 2004 - 07:24 PM

Yeah...

I'm going through the same thing right now. I have all the symptoms...bloating, diarrhea, upset stomach, floating stools, hair falling out...everything except being underweight. Except the Gliadin IgG, which was a weak positive, all the lab tests have come back negative.

However, after reading some information on the www.enterolab.com site, it appears as though the EMA test is very specific but not very sensitive. This means that if it is positive, there is no possible way it is a false-positive...you have Celiac. However, it being negative doesn't mean much.

It being negative only means that the villi in the small intestine have not yet totally atrophied. This is because it is a blood test, and for the antibodies to get from your small intestine to the blood there must be some major, major damage. Only 30% of the people with partial villi-atrophy tested positive on the EMA / transglutamine tests even though there was, indeed, some damage to the villi.

I may be spelling some of these words wrong (sorry about that), but if you go the thread I started today (I'm Simply), gf4life has posted some links that give more details.

You ought to check them out.

Simply

In Topic: Confused By Test Results

19 February 2004 - 06:42 PM

gf4life,

Since the way he tests is still so new, will mainstream doctors accept the diagnosis?

Like most people on this board, this is not my only medical problem. I'm positive that sometime in my future, I'm going to have to go on yet another drug, and there is a strong possibility that the drug will not be gluten free.

If I tell a doctor that I have to be gluten free based on one of these tests, will he buy it? Will pharmacies buy it?

I'm asking all the questions because $400 is a lot of money (at least to me right now, I'm of course hoping that in the future it won't be, but c'est la vie). I want to know all the ins and outs before I commit to it.

Thanks for all your help in answering these questions...it's nice that those who have gone before are willing to spend all the time helping those that follow.

Simply

In Topic: Confused By Test Results

19 February 2004 - 03:55 PM

I have some questions about enterolab.

First, I read through some of the information Dr. Fine provided on the site, and it seems to make sense. However, since I am about to be an attorney (if I can get my brain working long enough to pass the bar) and am not anywhere close to being a doctor, I know I don't have the expertise to determine whether he is a quack. What he's written sounds good, seems logical, but he could just write well.

Second, how does the Enterolab process actually work? I've collected stool samples (all last semester, so my doctor could figure out my Diarrhea)...does Enterolab send the container, and then you send it back? How do they keep all the little cells that they will look at alive during the shipping process? Or do I actually need to get myself there so that I can collect the stool using their toilet, then hand it off to them?

Third...I think the tissue transglutimase that was ordered was of the IgG variety. I'm thinking that even with a negative EMA, the tissue one may be positive even if I'm one of the lucky few with selective IgA deficiency.

Thanks for all your help!!!

Simply