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  • Scott Adams
    Scott Adams

    Antibodies to Oat Prolamines Found in Children with Celiac Disease

    Reviewed and edited by a celiac disease expert.

    Scand J Gastroenterol. 2003 Jul;38(7):742-6

    Celiac.com 08/25/2003 – A recent study published in the July edition of the Scandinavian Journal of Gastroenterology demonstrates that avenin oat prolamines can be detected at higher levels in children with celiac disease compared to those without celiac disease. The researchers prepared a crude avenin extract using an ethanol and salt solution, and used it as an antigen in a three step ELISA test. The blood of 81 children, including 34 with celiac disease, were analyzed for both IgA and IgG antibodies to avenin and gliadin. The researchers found that: Children with coeliac disease on a normal diet had significantly higher levels of antibodies to avenin, both IgG and IgA, than reference children (P

    The researchers conclude: Children with coeliac disease have antibodies to oat proteins at significantly higher levels than reference children. The absorption test did not indicate a cross-reactivity between the prolamines of wheat and oats. The method will be employed for repeated sampling of anti-avenin antibodies during a prospective interventional study with a gluten-free diet supplemented with oats. An emphasis should be added to the last sentence, as it appears that they will now perform a study on celiac children who actually eat oats, and most other major studies of this type have shown no intestinal damage caused by the avenin oat prolamines in people with celiac disease. It is interesting that this study shows a different response to oats in those with celiac disease, but it remains to be seen if this response is actually harmful to celiacs.


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    I miss oatmeal ? Is there anyway to be tested for the prolamines mentioned in this article . I stopped eating oatmeal in 1990 - as I finally realized my face and feet were reacting to the oatmeal - my feet and sometimes my face were swollen each morning after consuming oatmeal in the past week . I have celiac and Dermatitis Herpetiformis. The swelling was so bad I couldn't get my shoes on and as far as my face it could be so bad that my neighbors didn't recognize me.

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    Guest marilyn mcmahon

    Posted

    I miss oatmeal ? Is there anyway to be tested for the prolamines mentioned in this article . I stopped eating oatmeal in 1990 - as I finally realized my face and feet were reacting to the oatmeal - my feet and sometimes my face were swollen each morning after consuming oatmeal in the past week . I have celiac and Dermatitis Herpetiformis. The swelling was so bad I couldn't get my shoes on and as far as my face it could be so bad that my neighbors didn't recognize me.

    I have the same problem. I would love to try the assorted oatmeal they have out, but just getting cleared up by my great doctor after three years.

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  • About Me

    Celiac.com's Founder and CEO, Scott was diagnosed with celiac disease  in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. Scott launched the site that later became Celiac.com in 1995 "To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives."  In 1998 he founded The Gluten-Free Mall which he sold in 2014. He is co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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