Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams

    Are New Wheat Breeds Driving Up Celiac Disease Rates?

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

    Caption: New research on wheat varieties and celiac disease

    Celiac.com 09/06/2010 - Celiac disease rates have risen some 400% in the last fifty years. Some of that is due to advances in diagnostic technology, and increased awareness, but scientists also consider increased wheat and gluten consumption to be a major cause.

    Proper celiac disease diagnosis takes over a decade for about one in four sufferers, so clearly a significant portion of that increase reflects an alarming rise in celiac disease rates over the last decades.



    Celiac.com Sponsor:




    According to a new study by a team of plant researchers from The Netherlands, it's possible that modern wheat breeding habits have promoted an increase in celiac disease epitopes, and thus a proliferation of celiac disease.

    The research team set out to compare the presence of celiac disease epitopes in modern and old hexaploid wheat varieties. The team included H. C. van den Broeck, H. C. de Jong, E. M. Salentijn, L. Dekking, D. Bosch, R. J. Hamer, L. J. Gilissen, I. M. van der Meer, and M. J. Smulders, all affiliated with Plant Research International, Wageningen, The Netherlands.

    It's well-known that gluten proteins from wheat can induce celiac disease in genetically susceptible individuals. This happens when antigen presenting cells expose gluten-sensitive T-cell lymphocytes to specific gluten peptides.

    To analyze whether wheat breeding contributed to the increase of the prevalence of celiac disease, the team compared genetic diversity of gluten proteins for the presence of two celiac disease epitopes (Glia-alpha9 and Glia-alpha20).

    They examined samples of 36 modern European wheat varieties and 50 older varieties grown up to the beginning of the 20th century. Glia-alpha9 is a major (immunodominant) epitope that triggers sensitivity in most celiac disease patients. The minor Glia-alpha20 is included as a technical reference.

    Generally, the modern wheat varieties showed higher levels of Glia-alpha9 epitope, and lower levels of Glia-alpha20 epitope compared to the older varieties.

    This indicates that modern wheat breeding methods may have promoted an increase in celiac disease epitopes, and thus a proliferation of celiac disease.

    On  more positive note, there are both modern and older varieties that are known to have relatively low contents of both epitopes.

    The team conceives a scenario in which such varieties serve as breeding stock for farmers to one day breed wheat specifically designed to eliminate proteins and other substances that promote and trigger celiac disease. On a large-scale, such varieties might help to reduce fast-increasing rates of celiac disease.

    Source:


    User Feedback

    Recommended Comments



    Guest
    This is now closed for further comments

  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Celiac.com Sponsor:

  • Forum Discussions

    My bad.  My hair did get fuller and gotten back some forehead balding.  Hair grows back fast, and fingernails growth is better than in the past years.  Compared to the same age of my father.   I would have a complete head of hair, he was b...
    My hair was light/thin and also balding.  Been taking extra amino acids and other supplements (Glutathione (has 3 amino's in it Cysteine, Glycine, glutamic acid) Lysine, Horsetail. Just google search others.  I also use gluten free shampoo w...
    Hello All Thank you once again for the replies. I'm grateful. I'd sure love to get another GI scope but I cannot get in to see my GI doc  until May at the earliest. I basically get to see him once a year now, so it's borderline ...
×
×
  • Create New...