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  • Jefferson Adams
    Jefferson Adams

    Bifidobacterium infantis NLS Super Strain Reduces a-Defensin-5 in Active Celiac Disease Patients

    Reviewed and edited by a celiac disease expert.

      Certain bacteria strains show promise against celiac disease.

    Caption: Can certain bacteria strains help treat celiac disease? Photo: CC--D26B73

    Celiac.com 12/29/2016 - Researchers have documented a reduction of gastrointestinal symptoms in untreated celiac disease patients after oral administration of Bifidobacterium infantis Natren Life Start super strain (NLS-SS). The reduction of symptoms was not connected with and changes in intestinal permeability or serum levels of cytokines, chemokines, or growth factors. That led the team to hypothesize that the benefits observed in celiac patients treated with B. infantis may be connected to the modulation of innate immunity.

    A team of researchers recently set out to investigate the potential mechanisms of a probiotic B. infantis Natren Life Start super strain on the mucosal expression of innate immune markers in adult patients with active untreated celiac disease compared with those treated with B. infantis 6 weeks and after 1 year of gluten-free diet. The research team included Maria I. Pinto-Sanchez, MD, Edgardo C. Smecuol, MD, Maria P. Temprano, RD, Emilia Sugai, BSBC, Andrea Gonzalez, RD, PhD, Maria L. Moreno, MD, Xianxi Huang, MD, PhD, Premysl Bercik, MD, Ana Cabanne, MD, Horacio Vazquez, MD, Sonia Niveloni, MD, Roberto Mazure, MD, Eduardo Maurino, MD, Elena F. Verdu´, MD, PhD, and Julio C. Bai, MD.

    They are variously affiliated with the Medicine Department, Farcombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada; Small Intestinal Section, Department of Medicine; Department of Alimentation, Dr. C. Bonorino Udaondo Gastroenterology Hospital and Research Institute at the Universidad del Salvador in Buenos Aires, Argentina.

    They first used immunohistochemistry to assess the numbers of macrophages and Paneth cells, and the expression a-defensin-5 in duodenal biopsies. They found that a gluten-free diet reduces duodenal macrophage counts in celiac patients more effectively than B. infantis. In contrast, B. infantis decreases Paneth cell counts and expression of a-defensin-5 in celiac disease (P< 0.001).

    The results identify differential innate immune effects of treatment with B. infantis compared with 1 year of gluten-free diet.

    The team is calling for further study to determine synergistic effects of gluten-free diet and B. infantis supplements in celiac disease.


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    Guest AWOL cast iron stomach


    Thanks for the information I found the article interesting. In my long history of GI and gluten issues in the mid 1990's when I was diagnosed with IBS by symptoms, having bouts of gastroenteritis in the hospital, and terrible muscle aches of the sacroilliac and back. I begged my mom to help me find someone to help me. My mom through a friend's husband got me to a chiropractor who put me on a probiotic 2 strains and calcium/magnesium. Now 20 years later I realize as I struggle to get a diagnosis for celiac or ncgs and my IBS is not found/ruled out, I see how this chiropractor helped me. Then she helped improved the symptoms , perhaps that's why I'm a challenge to diagnose now. I don't regret it. I always felt the best when she was in my life, she has moved, but I wonder today these many years later is the reason I'm so challenging to diagnosis because despite numerous symptoms etc. Is my immune system more regulated and not showing celiac on serum because I was using probiotics early in the past long before they arrived on store shelves/mainstream?. I've always known they helped me and I over the years went on and off them. The brand I take is purchased through holistic Drs. I had to go off them during my gluten challenge, all I could think of during my gluten challenge is I want this over and I NEED my probiotic!!. It does not stop every celiac/NCGS symptom I get, they have increased over the years, but I feel better when on them. So it was interesting to see it doesn't stop the leaky gut because that is exactly my personal experience. However it keeps things immunological in check.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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