Celiac.com 07/12/2018 - Previous research has shown that the oral administration of Biﬁdobacterium infantis Natren Life Start super strain (NLS-SS) reduces of gastro-intestinal symptoms in untreated celiac disease patients. The reduction of symptoms was not connected with changes in intestinal permeability or serum levels of cytokines, chemokines, or growth factors. Therefore, researchers suspected that the reduction of symptoms might be related to the modulation of innate immunity.
To test that hypothesis, a team of researchers set out to assess the potential mechanisms of a probiotic B.infantis Natren Life Start super strain on the mucosal expression of innate immune markers in adult patients with active untreated celiac disease compared with those treated with B. infantis 6 weeks and after 1 year of gluten-free diet.
The team determined the numbers of macrophages and Paneth cells, along with the expression of a-defensin-5 expression via immunohistochemistry in duodenal biopsies.
Their results showed that a gluten-free diet lowers duodenal macrophage counts in celiac disease patients more eﬀectively than B. infantis, while B. infantis lowers Paneth cell counts and reduces expression of a-defensin-5.
This study documents the diﬀerential innate immune eﬀects of treatment with B. infantis compared with 1 year of gluten-free diet. The team calls for further study to better understand the synergistic eﬀects of gluten-free diet and B. infantis supplementation in celiac disease.