Jump to content
  • Sign Up
  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams
    Jefferson Adams

    Brain Abnormalities in Patients with Celiac Disease and Neurological Issues

    Reviewed and edited by a celiac disease expert.

    Caption: Image: CC--jsmjr

    Celiac.com 09/17/2012 - Many aspects of celiac disease simply have not been well studied, so they remain poorly understood. For example, researchers have not done enough study on people with celiac disease to understand if they show any readily available serological markers of neurological disease.

    Image: CC--jsmjrTo better understand this issue, a research team recently assessed the amount of brain abnormality in patients with celiac disease, along with looking into MR imaging sequences as biomarkers for neurological dysfunction.

    The study team included S. Currie, M. Hadjivassiliou, M.J. Clark, D.S. Sanders, I.D. Wilkinson, P.D. Griffiths, and N. Hoggard, of the Academic Unit of Radiology at University of Sheffield, Royal Hallamshire Hospital, in Sheffield, UK.

    For their study, they conducted a retrospective examination of a consecutive group of 33 patients with biopsy proven celiac disease, who had been referred for neurological opinion. The group ranged in age from 19 to 64 years old, with an average of 44±13 years.

    Researchers divided the group into subgroups based on their main neurological complaints of balance disturbance, headache and sensory loss.

    They used 3T MR to evaluate variations in brain grey matter density, cerebellar volume, cerebellar neurochemistry and white matter abnormalities (WMAs) between celiac patients and control subjects.

    The results showed that the celiac patients had a significantly lower cerebellar volume than did control subjects. Celiac patients had 6.9±0.7% of total intracranial volume, compared with 7.4±0.9% for control subjects (p<0.05).

    Celiac patients also showed significantly less grey matter density in multiple brain regions, both above and below the tentorium cerebelli, compared with the control subjects (p<0.05).

    The data showed that 12 (36%) patients demonstrated WMAs unexpected for the patient's age, with the highest incidence occurring in the headache subgroup.

    This group of patients averaged nearly double the number of WMAs per MR imaging session than the subgroup with balance disturbance, and six times more than the subgroup with sensory loss.

    The MR images of celiac patients who have neurological symptoms show significant brain abnormality on MR imaging, which means that MR imaging may serve as valuable biomarkers of disease in celiac patients.

    Source:


    User Feedback

    Recommended Comments

    Although I appreciate the medical terms and speech, I'm still not sure what it all means. We don't need it to be written at a 3rd grade level, but some explanation for those who did not attend med school would be helpful.

     

    Thanks!

    Share this comment


    Link to comment
    Share on other sites

    Jessica dear, I suppose this is another nice article that tells us we are stupider than normal people on top of being generally doomed. Well, me I have graduated 2 European universities, had a successful career and am fluent in 5 foreign language. I am over 50 and have been diagnosed celiac and following up a gluten-free diet only in the last 5 years. Thank God I am celiac or otherwise I would have been a genius, according to this research.

    Share this comment


    Link to comment
    Share on other sites
    Jessica dear, I suppose this is another nice article that tells us we are stupider than normal people on top of being generally doomed. Well, me I have graduated 2 European universities, had a successful career and am fluent in 5 foreign language. I am over 50 and have been diagnosed celiac and following up a gluten-free diet only in the last 5 years. Thank God I am celiac or otherwise I would have been a genius, according to this research.

    Valeria - agreed. I went about 28 years of my life without being on a proper/pure gluten-free diet and was diagnosed with everything under the sun besides what was actually the root of what was wrong with me. During my time as a celiac consuming gluten, I earned both a Bachelor's and a Master's degree from two of the most world-renowned music conservatories. Without having been hindered by debilitating pain and ill health most of my life, I could have been a prodigy or at least at the very top of my field.

    Share this comment


    Link to comment
    Share on other sites
    Valeria - agreed. I went about 28 years of my life without being on a proper/pure gluten-free diet and was diagnosed with everything under the sun besides what was actually the root of what was wrong with me. During my time as a celiac consuming gluten, I earned both a Bachelor's and a Master's degree from two of the most world-renowned music conservatories. Without having been hindered by debilitating pain and ill health most of my life, I could have been a prodigy or at least at the very top of my field.

    I have been diagnosed as having signs of dementia. I was

    forty years old when I found a doctor who cared enough to test me for celiac disease. Now I have to find a doctor that understands that celiac disease is affecting my brain.

    Share this comment


    Link to comment
    Share on other sites

    I have refractory coeliac disease and was told many years ago that women with this illness very often have children that then grow up to suffer from mental illness. My own son suffers from schizophrenia. I was told it might be something to do with not enough nutrition in the womb. Should we not be screening pregnant women for coeliac, I am trying to get publicity around this subject?

    Share this comment


    Link to comment
    Share on other sites
    Guest Lucille Cholerton

    Posted

    I have refractory coeliac disease and was told many years ago that women with this illness very often have children that then grow up to suffer from mental illness. My own son suffers from schizophrenia. I was told it might be something to do with not enough nutrition in the womb. Should we not be screening pregnant women for coeliac, I am trying to get publicity around this subject?

    Yes, June, I believe every pregnant mother should be screened for celiac. I had 3 children who have all turned out to be celiac, as I am. I did not realize that I was a celiac until 20 years later! All of my children suffered from a myriad of health issues for many years. My middle daughter was born jaundiced. I was told it was caused by "immature" liver enzymes. I realize now it was an autoimmune reaction against the liver, caused by gluten. That daughter suffered other autoimmune disorders (Sjogren's syndrome is one of them) as she grew up. I have learned that schizophrenia is caused by the peptides released by gluten and casein in dairy products, that upset brain chemicals.

    Share this comment


    Link to comment
    Share on other sites


    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in biology, anatomy, medicine, science, and advanced research, and scientific methods. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

×
×
  • Create New...