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  • Jefferson Adams
    Jefferson Adams

    Can a Gluten-Free Diet Help People with Bipolar Disorder?

    Reviewed and edited by a celiac disease expert.

    There’s growing evidence that autoimmune disorders and bipolar disorder are closely connected.

    Can a Gluten-Free Diet Help People with Bipolar Disorder? - Image: CC BY-SA 2.0-- Christiaan Tonnis
    Caption: Image: CC BY-SA 2.0-- Christiaan Tonnis

    Celiac.com 08/14/2019 - One question we get often is whether a gluten-free diet can help treat bipolar disorder. There’s growing evidence that autoimmune disorders and bipolar disorder are closely connected. 

    It's also true that celiac disease and bipolar disorder are linked. People with celiac disease are many times more likely to have bipolar disorder than those without celiac.

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    About 1% of the population has celiac disease. However, nearly 4.3% of celiacs are diagnosed with bipolar disorder, compared a 0.4% bipolar rate for the non-celiac control group.

    Having a mood disorder can have a major negative impact on quality of life in people with celiac disease. One study suggests that the negative impact on quality of life in people with celiac disease and bipolar disorder is second only to that of people with bipolar and MS.

    While there's been some study connecting gluten sensitivity and acute mania, there really hasn't been much research on a gluten-free diet for people with bipolar disorder. That means much of the information is anecdotal, and needs to be taken with a grain of salt.

    The topic thread on the Celiac.com forum contains robust commentary on the gluten-free diet and bipolar disorder.

    In his blog, Getting Older With Bipolar, George Hofmann shares his own experiences on being bipolar with celiac disease, and the benefits of a gluten-free diet.

    On going gluten-free, Hofmann says "I had gut problems for decades.  I thought it was normal to feel like crap after I ate.  Then I was diagnosed with celiac disease and my life completely changed. Please understand, though, that my bipolar disorder is still medically treated as it was before I knew I had celiac disease.  Removing gluten from my diet has not led to the removal of my psych meds...My bipolar disorder is not cured.  I just feel a lot better."

    Celiac disease increases immune activation, which many researchers think is an important factor in the onset of bipolar disorder.

    Many researchers suggest celiac disease screening for people with bipolar disorder who show some key symptoms or have a family history of celiac disease. Many of those same researchers suggest screening people with celiac disease for a mood disorders.

    To close, the current answer to the question whether a gluten-free diet can help treat bipolar disorder would be that there's a good amount of anecdotal evidence that a gluten-free diet can help to improve the general well-being of people with bipolar and other mood disorders.

    However, there's not much in the way of actual science to support those claims. Still, for people with bipolar disorder, there's likely not much of a downside to following a gluten-free diet, as long make sure you get adequate nutrition and fiber. As always, check with your doctor before adopting any treatment or change that may have an influence on your condition of symptoms. Also, consider getting tested for celiac disease.

    Read more at NIH

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    Huh, interesting. I recently started having stomach issues, about over a month. It's really been on/off for a little but I didn't think anything of it until it lasted a month straight. My doctor suspects that I have celiac disease. I'm trying an elimination process and so far it's been helping then she recommended eating gluten for a few weeks and doing test to confirm, but anywho. I'm bipolar so it's interesting to know that there's a common link between the two. It gives me hope that this is what I have, because I'd rather know than... not know I guess? Either way at least it'll help manage my bipolar a little as well.

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    Brittany, I too was like you. I got an endoscopy and colonoscopy done after two months of experiencing severe symptoms turns out I have celiac and Crohn’s. It’s been hard mentally dealing with bipolar disorder and two autoimmune diseases but makes me feel better there’s a reason for all of the pain! I would definitely recommend getting checked for celiac and even a gluten allergy. Even if it’s negative you should consider changing your diet, it may help!

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    I wonder how many people with gluten sensitivity also have MTHFR SNPs and problems with their methylation cycle?  Bipolar disorder is strongly linked to problems with methylation and the production of neurotransmitters.  Getting rid of folic acid consumption might be a great first step for those struggling with bipolar disorder.

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  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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    Jefferson Adams
    Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers.
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    The team was led by Josh Smyth, professor of biobehavioral health and medicine at Pennsylvania State University, and included members from  Syracuse University and Drexel University.
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    Jefferson Adams
    Celiac.com 05/29/2014 - Many people with celiac disease report symptoms of depression, which usually subside upon treatment with a gluten-free diet. But a new study out of Australia suggests that gluten can cause depression in people with non-celiac gluten-sensitivity.
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    Jefferson Adams
    Celiac.com 06/23/2016 - Digestive Disease Week 2016 took place in San Diego from May 21-24. Among the presentations given was one that stood out for its obvious health impacts. That presentation was given by Jonathan Cordova, DO, pediatric gastroenterologist at the University of Chicago Medical Center. His presentation tied celiac disease to major depressive disorder in adolescents, and stated that most adolescents with celiac disease have symptoms consistent with the disorder.
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    Cordova J, et al. Abstract #844. Presented at: Digestive Disease Week; May 21-24, 2016; San Diego

    Jefferson Adams
    Celiac.com 08/05/2019 - The relationship between mental health, gluten sensitivity, and celiac disease has not been well researched. Some studies have shown that people with schizophrenia and bipolar disorder have elevated levels of antibodies to gliadin.
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    Psychiatry Research. Volume 196, Issue 1, 30 March 2012, Pages 68-71.

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