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  • Scott Adams

    Can Bifidobacterium Lead to Better Celiac Disease Treatments?

    Scott Adams

    By Scott Adams •

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    Reviewed and edited by a celiac disease expert.

      A recent study shows that bifidobacterium digests intact gluten proteins, and reduces cytotoxicity and inflammatory responses. Can it help treat celiac disease?


    Wall art in Bologna. Image: CC BY 2.0--Antonella Morrone
    Caption: Wall art in Bologna. Image: CC BY 2.0--Antonella Morrone

    Celiac.com 06/03/2020 - Bifidobacterium breaks down gluten in the gut, and reduces toxicity and inflammation. Could bifidobacteria-based probiotics could play a role in the treatment of celiac disease?

    When people with celiac disease eat gluten, they usually experience inflammation, and, if untreated, damage to the gut. Recent studies indicate that people with celiac disease may have lower levels of bifidobacteria in the intestinal lumen. A team of researchers recently set out to investigate the digestion of intact gluten proteins by various species of bifidobacterium.


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    The research team included Natália Ellen Castilho de Almeida, Franciele Grego Esteves, José Roberto Aparecido dos Santos-Pinto, Carla Peres de Paula, Anderson Ferreira da Cunha, Iran Malavazi, Mario Sergio Palma, and Edson Rodrigues-Filho. They are variously affiliated with the Federal University of São Carlos, São Carlos, São Paulo, Brazil.; Department of Chemistry, Federal University of São Carlos (UFSCar), São Carlos, São Paulo, Brazil; Center of Study of Social Insects, Department of Biology, Institute of Biosciences of Rio Claro, São Paulo State University (UNESP), Rio Claro, São Paulo, Brazil; and the Department of Genetics and Evolution, Biotechnology Graduate Program (PPGBiotec), Federal University of São Carlos, São Carlos, São Paulo, Brazil.

    In their paper, the research team describes the ways in which Bifidobacterium bifidum, Bifidobacterium longum, Bembidion breve, Bifidobacterium animalis, alone and also a Bifidobacterium combination, influence the digestion of complete gluten proteins, and also affect the related immunomodulatory responses caused by the generated peptides. 

    The team assessed cytotoxicity and proinflammatory responses by studying NF-kB p65 activation, and TNF-α and IL-1β cytokine expression in Caco-2 cell cultures exposed to gluten-derived peptides. 

    The peptides successfully reduced cytotoxic action and proinflammatory marker levels compared with gluten fragments created during non-inoculated digestion. These results indicate that bifidobacteria-based probiotics could play a future role in the treatment of celiac disease.

    Read more in the Journal of Agricultural and Food Chemistry, 2020, 68, 15, 4485-4492


     

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    Guest dappy

    bifidobacteria-based probiotics: I take this probiotic daily. It helped me tremendously before diagnosis was complete. I could not leave the house before beginning the regimen. HOWEVER, it does not protect from gluten reaction. If I am contaminated unknowingly, the severe reactions are just as quick and just as severe with the probiotic as without.....

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    Guest ANTHONY COLATRELLA

    Guest ANTHONY COLATRELLA

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    Certainly worthy to report, Scott, but certainly not anything new---the ability of gut bacteria, including Bifidobacteria, to  degrade gluten and their anti-inflammatory properties have been known for over a decade---in fact over the years scores of GI and oral bacteria have been shown to possess this capability---in 2013, 2014, and 2015 there were already done 3 RCTs in HUMANS each one using different species/strains of Bifidobacteria (including those in this study)--none reported statistically significant beneficial results and called for additional studies---and indeed since then and up to 2019, 6 other studies have been done with similar as well as other bacteria---without major clinical benefits--with one exception----a systematic review and meta -analysis of this field --from McGill University-- is due to be published very soon---we will see what that analysis finds. 

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    Awol cast iron stomach
    On 6/9/2020 at 11:15 AM, Guest dappy said:

    bifidobacteria-based probiotics: I take this probiotic daily. It helped me tremendously before diagnosis was complete. I could not leave the house before beginning the regimen. HOWEVER, it does not protect from gluten reaction. If I am contaminated unknowingly, the severe reactions are just as quick and just as severe with the probiotic as without.....

    I agree. 

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    Scott Adams

    Scott Adams was diagnosed with celiac disease in 1994, and, due to the nearly total lack of information available at that time, was forced to become an expert on the disease in order to recover. In 1995 he launched the site that later became Celiac.com to help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives.  He is co-author of the book Cereal Killers, and founder and publisher of the (formerly paper) newsletter Journal of Gluten Sensitivity. In 1998 he founded The Gluten-Free Mall which he sold in 2014. Celiac.com does not sell any products, and is 100% advertiser supported.

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