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  • Jefferson Adams
    Jefferson Adams

    Can Probiotics Delay Gluten Intolerance in Children?

    Reviewed and edited by a celiac disease expert.

      Results show that the probiotic strains had a suppressing effect on celiac autoimmunity and may delay the onset of the disease


    Caption: Can probiotics delay onset of gluten intolerance in children? Photo: CC--Ryan Schneider

    Celiac.com 10/09/2017 - New trial data suggests that the probiotic strains Lactobacillus plantarum Heal 9 and Lactobacillus paracasei 8700:2 may provide support for the immune system and delay the onset of gluten intolerance in children.

    The findings, recently presented at the International Celiac Disease Symposium in New Delhi, suggest that Probi's patented probiotic strains have a 'surprisingly consistent' effect on suppressing coeliac autoimmunity and may delay the onset of the disease in children who are genetically pre-disposed to the condition.

    "To our knowledge this is the first time a probiotic study has been performed on this specific population and the results show immune-supporting properties of these probiotics as well as a potential preventive effect on the development of celiac disease," said Dr Daniel Agardh of Lund University.

    Agardh and colleagues identified and recruited 78 children with a genetic pre-disposition to coeliac disease. The children were as a subpopulation in a multinational and multiyear autoimmunity study with thousands of children.

    The randomized, double-blind, placebo-controlled trial lasted six months and found that disease-related antibodies were significantly reduced in the probiotic group and significantly increased in the placebo group during the course of the study.

    Results show that the probiotic strains had a suppressing effect on celiac autoimmunity and may delay the onset of the disease – with tissue transglutaminase autoantibodies (tTGA) decreased in the treatment group, but increased in the placebo group.

    In addition, several significant differences were observed between the groups on a cellular level indicating that the probiotic may counteract coeliac disease-associated ongoing immunological and inflammatory response.

    "This is an excellent example of a well working collaboration between academia and the industry" commented Probi CEO Peter Nählstedt.

    "We see a growing interest in children's probiotics and these results enable Probi to build a product platform for children."

    Read more at: Nutraingredients.com


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    This sounds like great news, however when I researched the original article that disseminated this news, the original referenced article link is broken: the page has been removed from the internet: "https://www.nutraingredients-usa.com/Suppliers2/Probiotic-could-delay-onset-of-gluten-intolerance-in-children-RCT-data" The researcher additionally has no article about this study published (as of yet). Can someone verify with the researcher and also verify conflict of interest? The vendor, Probi, has an article on this probiotic and celiac (http://probi.se/sites/all/files/attachment_files/press_release_cd_and_probiotics.pdf) however, I am concerned that the vendor rather than the clinical researcher is publishing the results... so it's not peer reviewed.

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    The information is simply an update on topics presented at the 2017 Celiac Disease Symposium in New Delhi. As such, it is not intended as a report an a peer reviewed article. I would expect that to come later as research develops further.

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,000 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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