Jump to content
  • Sign Up
Celiac.com Sponsor:


Celiac.com Sponsor:


  • Join Our Community!

    Get help in our celiac / gluten-free forum.

  • Jefferson Adams

    Can Probiotics Help Prevent Celiac Disease and IBD in Pediatrics?

    Jefferson Adams


    Reviewed and edited by a celiac disease expert.

      ​​​​​​​Beyond a few teaser studies, we don’t know enough about whether the individual microbiome to celiac disease and inflammatory bowel disease, says top celiac disease researcher Alessio Fasano.


    Caption: Image: CC--Honza Soukup

    Celiac.com 12/28/2018 - Beyond a few teaser studies, we don’t know enough about whether the individual micro-biome might play a role in the development of celiac disease and inflammatory bowel disease.

    Top celiac researcher Alessio Fasano, together with colleague G. Serena, recently presented an overview of current knowledge regarding the contribution of the individual micro-biome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.



    Celiac.com Sponsor:




    They are both affiliated with the Mucosal Immunology and Biology Research Center and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children - Harvard Medical School, Boston, MA, USA.

    As part of their presentation, they write that, globally, cases of chronic inflammatory diseases (CIDs) are undergoing a steep rise. This rise, together with limited effective strategies for slowing these disease explosions demands deeper knowledge of their physical mechanisms in order to reduce the adverse effects of the diseases on children. 

    Several cross-sectional studies have shown a connection between intestinal microbial imbalance and active disease.  Unfortunately, they note, these studies do not demonstrate any connection between changes in microflora as a factor in disease development, and so do not suggest any promising directions to explore for possible treatments. 

    Fasano and Serena say that additional studies are needed to show conclusively whether intestinal dysbiosis plays a part in triggering CIDs. Furthermore, given the complexity of the microflora interaction with the host, it is necessary to design a systems-level model of interactions between the host and the development of disease by integrating micro-biome, metagenomics, metatranscriptomics, and metabolomics with either clinical or environmental data.

    In their overview, Fasano and Serena discuss the current knowledge regarding the contribution of the individual microbiome to celiac disease and inflammatory bowel disease. Their discussion includes a particular focus on how probiotics may be used as potential preventive therapy for CIDs.

    The article includes a paywall, but you may find it at:
    Adv Exp Med Biol. 2018 Dec 20. doi: 10.1007/5584_2018_317


    User Feedback

    Recommended Comments

    There are no comments to display.



    Join the conversation

    You are posting as a guest. If you have an account, sign in now to post with your account.
    Note: Your post will require moderator approval before it will be visible.

    Guest
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoji are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

  • Related Articles

    Jefferson Adams
    Celiac.com 03/17/2014 - Researchers know a great deal about the function of human digestive proteases in gluten proteins, but they know very little about the role of intestinal microbes in metabolizing those proteins.
    A team of researchers recently set out to examine the isolation and characterization of human gut bacteria involved in the metabolizing gluten proteins.

    Jefferson Adams
    Celiac.com 04/13/2015 - Celiac disease is associated complications in the small bowel, but also with problems outside the GI tract. Celiac disease affects small bowel mucosal immunity via exposure to infectious agents; therefore, it is likely that patients with untreated celiac disease are more susceptible to infectious diseases. It is possible that sensitivity to gluten increases...

    Jefferson Adams
    Celiac.com 12/25/2017 - In the very near future, your personal microbiome may be the key to creating a customized treatment for celiac disease.
    That's because new advances in genome studies are promising to help create a customized, individual approach for treating numerous disorders, including celiac disease. Such individualized treatments may also help to reduce adverse events...

    Jefferson Adams
    Celiac.com 04/16/2018 - A team of researchers recently set out to investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease onset in infants with family risk for the disease.
    The research team included Marta Olivares, Alan W. Walker, Amalia Capilla, Alfonso Benítez-Páez, Francesc Palau, Julian Parkhill, Gemma Castillejo, ...

  • Celiac.com Sponsor:

  • Forum Discussions

    CB, sorry to hear you're still having problems.  Deficiency of Vitamin B12 can cause diarrhea.  It's a frequently overlooked symptom.  Did you discuss with your doctor what to do about the B12 deficiency? Shots or oral supplements?  ...
    I think you should consider getting tested for celiac disease in order to help rule out gluten ataxia.  Why?  I just had anemia.  No GI issues with gluten.  I never would have guessed that I had celiac disease.  
    My mom has Graves.  I much prefer Hashimoto’s!  I had a few thyroid swings and it is easier to be hypo than hyper.  My Mom has permanent eye damage as a result.  If you have Graves, get treatment which may include surgery.  Her ferritin levels a...
×
×
  • Create New...