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    Capsule Endoscopy in the Management of Refractory Celiac Disease

    Jefferson Adams
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    Reviewed and edited by a celiac disease expert.   eNewsletter: Get our eNewsletter

      Can repeat small bowel capsule endoscopy help spot refractory celiac disease in patients following treatment with steroids and/or immunosuppressants?

    Caption: Image: CC BY-SA 2.0--pixelthing

    Celiac.com 02/10/2020 - There are no articles in the medical literature about the role of repeat small bowel capsule endoscopy (SBCE) in patients with refractory celiac disease (RCD) following treatment with steroids and/or immunosuppressants.

    A team of researchers recently set out to compare the findings on SBCEs from a group of 23 patients with histologically proven RCD against the results of 48 patients with uncomplicated celiac disease. All patients had concurrent duodenal histology and serology taken at the time of SBCE.

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    The team included Stefania Chetcuti Zammit, David S. Sanders, Simon S. Cross, and Reena Sidhu. They are variously associated with Academic Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield; and the Academic Unit of Pathology, Department of Neuroscience, Faculty of Medicine, Dentistry & Health, The University of Sheffield, Sheffield, UK.

    SBCE revealed refractory celiac disease patients to have greater mucosal involvement than patients with uncomplicated celiac disease. After steroid and/or immunosuppressant treatment, refractory celiac disease patients showed an improvement in the extent of affected small bowel mucosa. 

    Statistically, both histology and serology were the same for first and second SBCE in refractory celiac disease patients. The study data indicates that SBCE is useful in documenting the degree of mucosal involvement in refractory celiac disease patients. 

    The team notes that this is the first study to demonstrate the value of a second look SBCE to assess the degree of improvement in celiac disease in the small bowel following treatment. However, more study is needed to more firmly establish these results.

    Read more in J Gastrointestin Liver Dis, March 2019 Vol. 28 No 1: 15-22

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    I myself am a patient of David Sanders and I have been for the last 5years. He is a brilliant man especially in Gastroenterology. I have had RCD2 for the last 5 years and I am currently doing well and that is with the help of David Sanders and his team.. I also had 5 endoscopies and without those I wouldn't have known that I had RCD2 

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  • About Me

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University, and has authored more than 2,500 articles on celiac disease. His coursework includes studies in science, scientific methodology, biology, anatomy, medicine, logic, and advanced research. He previously served as SF Health News Examiner for Examiner.com, and devised health and medical content for Sharecare.com. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of the book "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

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