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    Connection Seen Between Celiac and Addison's Disease


    Jefferson Adams

    Celiac.com 12/14/2007 - Celiac & Addison's patients seem to be at greater risk for both diseases. People with celiac disease have a higher risk of developing Addison’s disease, and those with Addison's have a higher risk of developing celiac disease. In both cases, the numbers are far higher than for the general population at large.


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    Doctors are advising that people with Addison's be screened for celiac disease. However, as Addison’s is still rare overall, they are holding off recommending screening of celiac patients for Addison's. Instead, they are advocating that doctors treating celiac patients maintain a heightened awareness for signs of Addison’s, and to react accordingly.

    This latest evidence is the result of a case history review of 15,000 people with celiac disease. The review was conducted by a team of doctors led by one Dr. Peter Elfstrom of Sweden‘s Orebro University Hospital.

    A number of studies have shown a link between celiac disease and Addison’s disease, but little has been done to elucidate that connection. And, while this review goes farther than most, the doctors emphasize that the data is strictly preliminary, as they have looked at a relatively small number of cases and tested patients with Addison’s for celiac disease, but not vice versa.

    The data show a significant connection between celiac and later development of Addison's disease, citing a hazard ratio of 11.4. The results were the same for both adults and children with celiac, and remained so even after adjustment for diabetes, and the socio-economic conditions of the patients.

    Patients with existing Addison's had a significantly higher risk of celiac disease, citing a hazard ratio of 8.6.

    The connection between celiac and Addison's was shown to exist both pre- and post-diagnosis for celiac disease. The researchers don’t feel that celiac causes Addison's disease or vice versa, but that they might have related or common genetic traits.

    Journal of Endocrin. Metabol. 2007: 3595-3598.

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    Guest Michelle A

    Posted

    I have celiac disease and was just diagnosed with Addison's disease. They are both autoimmune and I was thinking that they might have something in common. Thanks for the article.

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    OK, we get it, Addison's and celiac are linked. But what is Addison's disease? What symptoms should we be aware of?

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    Knowing what Addison's is and how to educate ourselves would be of great help!

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    To those who want to know what Addison's disease is - Google it

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    I've had Addison's for 21 years. I recently read about the link to celiac disease and recently discovered that celiac runs in my family. I am presently awaiting test results. But I will not be surprised if further studies indicate that a lot of the primary Addison's cases currently attributed to 'autoimmune' causes turn out to be the result of some type of chronic malnutrition caused by years of undiagnosed celiac disease.

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    I've had Addison's for 21 years. I recently read about the link to celiac disease and recently discovered that celiac runs in my family. I am presently awaiting test results. But I will not be surprised if further studies indicate that a lot of the primary Addison's cases currently attributed to 'autoimmune' causes turn out to be the result of some type of chronic malnutrition caused by years of undiagnosed celiac disease.

    Excellent! Thank you so much. This is what I have thought over the last year but no doctor will listen while I waste away from no nutrition. I know I am celiac even tho test results say no and now I have no cortisol and lipase and post menopause. I don't know what to do now but thanks again for confirmation of what i been saying too!

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    to Lea

     

    mine happened the same way. no doctor will listen, test say no but I know i am, no cortisol(autoimmune adrenal inff,) and post meno too. NO NUTRITION THO I EAT AND EAT. and waste away everyday. i get it, they don't oh yeah no lipase either. Why?????

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    Hi Lea

     

    The same thing happened to me. No doctor will listen, NO Nutrition. I know I am celiac and the tests say no. No cortisol ( autoimmune adrenal insuff) No lipase, post meno too. would love to gain 30 lbs. THANK YOU

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    I've had Addison's for 21 years. I recently read about the link to celiac disease and recently discovered that celiac runs in my family. I am presently awaiting test results. But I will not be surprised if further studies indicate that a lot of the primary Addison's cases currently attributed to 'autoimmune' causes turn out to be the result of some type of chronic malnutrition caused by years of undiagnosed celiac disease.

    I would agree. I guessed I had celiac disease due to some symptoms. I did not test positive for the blood test, but my intestines show a different story. My parents were told I was wheat, milk and red meat sensitive when I was 14. They ignored the doctor. Now I have Addison's. I believe there is a direct connection between my "un-diagnosed" celiac disease and getting Addison's as Addison's is in 70% of the cases caused by an auto-immune disorder. Just because the blood tests are negative, it does not mean you don't have a milder form of celiac disease which will worsen over time if left untreated. They also diagnosed me as bi-polar. I am not. The mood disorder was related to the celiac disase.

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    I had to tell the doctor about celiac disease! I also have Addison's. After taking cortisone and getting moon faced and arthritis from the toxic medicine, I studied and now take only herbs and food. I am a Certified Holistic Health Counselor.

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    Guest Jenna

    Posted

    I have confirmed Addison's (dx at age 33- I'm 38 now). It took 15 years & several misdiagnoses (Fibromyalgia/Chronic fatigue (along w/chronic migraine) before I self-referred to an endocrinologist- who finally ordered the right test.

     

    About 2 years ago, I started developing skin rashes & infections. I did my research and learned the rash may be Derm. H. resulting from gluten intolerance. I've now avoided gluten for 3 months (I had two incidents where I accidentally ingested it though).

     

    To anyone with gluten issues (esp. if you also have Addison's), assuming you've gone gluten-free, how long did it take to feel better? Did you avoid gluten alone or gluten/dairy, etc?

     

    Thanks!!

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    Guest Lorraine

    Posted

    I had to tell the doctor about celiac disease! I also have Addison's. After taking cortisone and getting moon faced and arthritis from the toxic medicine, I studied and now take only herbs and food. I am a Certified Holistic Health Counselor.

    I was diagnosed with a gluten problem several years ago and have always suspected Addision's. Doctors said no but I never had testing to confirm. I am soon to see an endocrynologist however my concerns are the same as yours BJ. I don't want meds with side affects. Being certified in Holistic Health what do you suggest if I test positive for Addison's?

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    Interesting article. I have had Addison's Disease for 11 years, and for 5 years I have had diarrhea constantly. I have been checked for celiac and I have tested negative. I am thinking maybe I should try a celiac diet.

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    Guest adrienne

    Posted

    Hi Lea

     

    The same thing happened to me. No doctor will listen, NO Nutrition. I know I am celiac and the tests say no. No cortisol ( autoimmune adrenal insuff) No lipase, post meno too. would love to gain 30 lbs. THANK YOU

    Because of gluten intolerance/celiac it can cause stress on the body= low cortisol blood serum levels. it happened to me, but i do not have Addison's, just adrenal fatigue, which is dealt with having a strict diet and sleep/ wake cycle. up at 7 walk at 9 in bed by 10. do this for 6 months and you will feel better and get your cortisol back on track. also, i'm seeing two specialists, a G.I dr and an endocrinologist dr...i have not been diagnosed with gluten intolerance, but the elimination diet says i do, i get dermatitis herpeformus. i am about to go back to the G.I dr for a checkup, he wants to see me again, I bet he will finally diagnose me. I went on a gluten free diet before the scope and biopsy, he saw a lot of scarring but tested negative for celiac, hence gluten intolerance is what I have. my mom has it too.

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    Guest Linda Orr

    Posted

    I just discovered this article and I am crying with joy, it is so wonderful when you finally have great information and then you can put everything together and have the information it takes to get well and live a much better life, I was diagnosed with Addison's last Nov and thought I was dying, my Dr. suggested there might be a link to celiac so he wanted me to start going gluten free, so in my search I found this website, I thank God for this website and all the writers that contribute to it, thank you.

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    Guest Joe

    Posted

    I figured this out on my own too. I have self treated my adrenal insufficiency for years (daily salt plus Dr Wilson's adrenal rebuilder). Over the years I developed a mucus reaction to gluten and finally went on a gluten free diet. And something remarkable happened - my sleep dramatically improved. I think part of the benefit I have experienced is from better nutrient absorption. But also my breathing is better and that contributes to better sleep. This connection between the two disorders is important.

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    Guest Lynn

    Posted

    I figured this out on my own too. I have self treated my adrenal insufficiency for years (daily salt plus Dr Wilson's adrenal rebuilder). Over the years I developed a mucus reaction to gluten and finally went on a gluten free diet. And something remarkable happened - my sleep dramatically improved. I think part of the benefit I have experienced is from better nutrient absorption. But also my breathing is better and that contributes to better sleep. This connection between the two disorders is important.

    I have been having symptoms of diarrhea for years. I had no idea, until I finally went to the doctor and today I found out that I have celiac disease. My mother had Addison's disease but it was not diagnosed until she was in the late stages where she started losing the function of her organs. She ended up on Prednisone and passed away due to the complications from Addison's. All the research I have done today confirms my suspicions that these two diseases are related and that if I don't get my celiac disease under control then I could develop Addison's as well. Great article.

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    I've had Addison's for 21 years. I recently read about the link to celiac disease and recently discovered that celiac runs in my family. I am presently awaiting test results. But I will not be surprised if further studies indicate that a lot of the primary Addison's cases currently attributed to 'autoimmune' causes turn out to be the result of some type of chronic malnutrition caused by years of undiagnosed celiac disease.

    Before I found out I had celiac, every tooth in my mouth was loose from malabsorption and my hair was falling out like crazy. I started gluten-free and am feeling much better! I'm going to have my doctor check for Addison's also, just to rule in or rule out. I want my health back even if I am the one doing all the work to fix it.

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    I had to tell the doctor about celiac disease! I also have Addison's. After taking cortisone and getting moon faced and arthritis from the toxic medicine, I studied and now take only herbs and food. I am a Certified Holistic Health Counselor.

    It would help if you mentioned the kind of herbs you take. I am writing from Switzerland and therefore have to look for them locally. Thanks.

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    Thanks for all the comments from people. I was tested about 5-6 yrs ago for celiac and test was negative. I went on a gluten free diet and have lost weight, feel better and gotten rid of diahrrhea for the most part.

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    I came here to learn more about Addison's Disease because I suffer from Lyme and noticed that most of the people who have Lyme suffer from this and celiac disease. I did not expect the two to be connected in some way. This was very interesting. I am going to share this information because many of the people in my Lyme group are still having health problems and have been tested for one but not the other if they see these have a connection it might help them find a solution to their health problems.

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    Guest Brittany

    Posted

    OK, we get it, Addison's and celiac are linked. But what is Addison's disease? What symptoms should we be aware of?

    Addison's disease is when your adrenal glands don't function. so you would need to get a type of steroid medication for that. it means that whenever your body is under stress or something like that you would need more meds. some symptoms include being lethargy and super tired and out of it. you appetite decreases (when I was diagnosed I lost 30 pounds in less then a month), you will want to sleep a lot and if you're diabetic your sugar levels will low frequently. I hope this helps.

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    Guest Cayt

    Posted

    better late than never.  My doctor has actually been pretty good.  He told me that even though my  blood tests were coming back with no indication of celiac that he believed l was suffering from it.  Our insurance does not cover the decisive test for celiac  because it requires a biopsy and out of pocrt expense for the test is $880.00 plus fees for the biopsy administrator.  Doc put me on a psychiatric medication to help me sleep and gain weight and had me go completely gluten free; told me to make sure l ate no "may contain" products.  Within 4 months l gained a much needed 40 pounds but have had to fight to keep it on.  all went well for a few years, then my teeth began breaking and so did my bones.  with 15 broken bones in two years, l was placed on a bone builder, and this year not a single break despite having five falls.  Now l am having all the Addison symptoms and will make an appointment to see my good doctor this week.

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    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

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    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023