Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Study Shows High Rates of Celiac Disease Antibodies in Adult Rheumatology Patients

    Reviewed and edited by a celiac disease expert.

    High rates of celiac disease antibodies in adult rheumatology patients suggest that celiac screening might be a good idea for people with rheumatological issues.

    Study Shows High Rates of Celiac Disease Antibodies in Adult Rheumatology Patients - Image: CC BY-SA 3.0--Doc James
    Caption: Image: CC BY-SA 3.0--Doc James

    Celiac.com 09/24/2019 - Currently, physicians do not routinely conduct celiac disease screening in patients with rheumatological diseases, as these people are not considered to have high risk for celiac disease.

    A team of researchers recently set out to determine rates of celiac disease serological markers in a group of patients with rheumatological issues. The research team included Giacomo Caio, Roberto De Giorgio, Francesco Ursini, Silvia Fanaro, and Umberto Volta.

    Celiac.com Sponsor (A12):
    They are variously affiliated with the Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy; the Mucosal Immunology and Biology Research Center, Massachusetts General Hospital – Harvard Medical School, Boston, Massachusetts, USA; the Department of Medical Sciences, University of Ferrara, Ferrara, Italy; the Department of Health Sciences, University of Catanzaro “Magna Graecia”; and the Centre of Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London.

    The team screened blood from 230 rheumatological patients for celiac disease by testing IgA antitransglutaminase (TTG IgA), IgG deamidated gliadin peptides (DGP IgG) and IgA antiendomysium (EMA) antibodies.

    Of the 230 total patients, the team found 67 patients with rheumatoid arthritis (RA), 52 with Sjögren’s syndrome (SjS), 42 with systemic sclerosis (SCL), 35 with systemic lupus erythematosus (SLE), 15 with mixed connective tissue disease, 11 with polymyositis and 10 with dermatomyositis.

    The results showed TTG IgA antibodies in a total of 7 out of 230 cases, or 3%. They also showed such antibodies in 3 of 42 SJS cases, 2 of 42 SCL cases, 1 of 67 RA cases, and 1 of 35 SLE sera. All seven samples were also positive for DGP IgG and EMA IgA. DGP IgG antibodies were the most common, showing up in 16 total samples.

    High rates of celiac disease antibodies in adult rheumatology patients suggest that celiac disease screening might be a good idea for people with rheumatological issues.

    Read more at Gastroenterology Hepatology Bed Bench. 2018 Summer; 11(3): 244–249.


    User Feedback

    Recommended Comments

    Guest Tammy

    Sadly I have both Celiac and Rheumatoid Arthritis- diagnosed within one year of each other. I’m not really sure which came first though. 

    Link to comment
    Share on other sites
    Guest Annette

    Posted

    It actually was a Rheumatologist that discovered my Celiac Disease after sending me for a blood work up.  He diagnosed me with Rheumatoid Arthritis and then called and told me I tested positive for Celiac Disease.  Which I had tests and my Endocrinologist confirmed it.  I am in constant pain from the Arthritis.  It is a daily struggle dealing with the Celiac and Arthritis, causing me to stay at home feeling like I live the life of a recluse.

    Link to comment
    Share on other sites
    Guest miguel54b

    Posted

    12 hours ago, Guest Annette said:

    It actually was a Rheumatologist that discovered my Celiac Disease after sending me for a blood work up.  He diagnosed me with Rheumatoid Arthritis and then called and told me I tested positive for Celiac Disease.  Which I had tests and my Endocrinologist confirmed it.  I am in constant pain from the Arthritis.  It is a daily struggle dealing with the Celiac and Arthritis, causing me to stay at home feeling like I live the life of a recluse.

    Did you go in a 100% gluten-free diet after the diagnosis? I was having pain and swelling in my joints (hands and knees), it was difficult to open a jar. That problem and many more went away once in a 100% gluten-free diet.  

    Link to comment
    Share on other sites
    Guest Wayne williams,

    Posted

    14 hours ago, Guest Annette said:

    It actually was a Rheumatologist that discovered my Celiac Disease after sending me for a blood work up.  He diagnosed me with Rheumatoid Arthritis and then called and told me I tested positive for Celiac Disease.  Which I had tests and my Endocrinologist confirmed it.  I am in constant pain from the Arthritis.  It is a daily struggle dealing with the Celiac and Arthritis, causing me to stay at home feeling like I live the life of a recluse.

    Our family took the 23&me DNA test nearly 10 years ago. We found after suffering with numerous symptoms, that we were all high for celiac. At 60, I was breaking out with weird rashes on my scalp, groin and other areas, my kidneys and joints were giving out, doctors had no answers. My adult daughter was always sick and would get rashes and acne on her face, and our granddaughter would get rashes on around her elbows and back of the knees and well as stomachaches, we all had more constipation, than the diarrhea most seem to get. Within days of trying the gluten-free diet our symptoms minimized. It has taken years to figure out gluten is in everything, but with today's new products, growing our own garden and eggs, we are all doing much better. It is hard to eat out, many don't understand gluten can be in vinegar's and other condiments, even being in a restaurant that serves a lot of gluten products can create problems, because of cross-contamination and flour can get air-born if they make their own breads, so we stay clear or get as far from the kitchen as possible... There are some great books, recipes and other sources. If one researches, they find they are not alone and there are many options available, we still believe celiac is way under diagnosed, because of so many variable symptoms. My wifes rheumatoid arthritis, is nearly symptom-less. I suggested the gluten-free diet to a friend who's fingers were totally bent sideways, she basically  quit breads and pasties, but it was enough to unbend her bent fingers of over 20 years... She still eats gluten in moderation, but feels much better. You are not alone and there are many good products coming out.

    Link to comment
    Share on other sites
    MariaFisher

    Is 3% really considered a high rate?  

    Link to comment
    Share on other sites
    Guest Joan
    On 9/25/2019 at 2:22 PM, Guest Tammy said:

    Sadly I have both Celiac and Rheumatoid Arthritis- diagnosed within one year of each other. I’m not really sure which came first though. 

    I had Celiac first then within 9 months diagnosed w RA.  I was, and have been told, RA is a major one of many side effects of Celiac.  Also, within couple years diagnosed with IBS and I was classed as a “high sensitive” celiac I am unable to have gluten-free oats or be around flour if it even gets up my nose from breathing it in my stomach gets upset and using lotions with oat or wheat sends my system into flare up.  I wish you well with your RA there are a lot of medicines to help you such as Enbrel Humira, Remicade as long as you haven’t been vaccinated for TB then, like me who was,  you will be unable to have them cos of the high risk of a non curable TB.

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 06/08/2007 - In the first study, doctors Ibrahim S. Alghafeer, and Leonard H. Sigal conducted a routine gastroenterology follow-up of 200 adult celiac patients. Arthritis was present in 52 of 200 patients, or 26%. The arthritis was peripheral in 19 patients, Axial in 15 patients, and an overlap of the two in 18 patients. The doctors found that joint disease was much less common in those patients who were following a gluten-free diet (1).
    A related study by Usai, et al found that 63% of patients with celiac disease show axial joint inflammation (2).
    In that study, doctors conducted bone scintigraphy using 99m Tc methylene diphosphonate. 14 of these patients (65%) signs compatible with sacroiliitis. 11 of the 14 suffered from low back pain. In five of the 11 patients...


    Jefferson Adams
    Celiac.com 02/24/2016 - Rosacea is a common inflammatory skin condition that shares the same genetic risk location as autoimmune diseases such as type 1 diabetes mellitus (T1DM) and celiac disease.
    Researchers have noted a clustering of autoimmune diseases in patients with rosacea. In fact, a recent genomewide association study found 90 genetic areas associated with T1DM, celiac disease, multiple sclerosis, and/or rheumatoid arthritis, but did not address a possible association with rosacea.
    A team of researchers recently set out to assess any connections between rosacea and T1DM, celiac disease, multiple sclerosis, and rheumatoid arthritis, respectively. The research team included Alexander Egeberg, MD, Peter Riis Hansen, MD, PhD, DMSci, Gunnar Hilmar Gislason, MD, PhD, Jacob Pontoppidan...


    Jefferson Adams
    Celiac.com 03/16/2017 - When screening arthritis patients for celiac disease, should HLA be done before serology? During the past decades, an accumulating evidence shows a dramatic rise in the frequency of autoimmune diseases, including rheumatoid arthritis and gastrointestinal conditions, such as celiac disease.
    HLA genes have been shown to be strongly associated with numerous autoimmune diseases, including rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA) and celiac disease. A team of researchers recently set out to assess the performance of celiac disease associated serology in face of a rheumatologic patient, when gluten enteropaty is suspected.
    The research team included Hakim Rahmoune, Nada Boutrid, Mounira Amrane, and Belkacem Bioud. They are variously affiliated...


    Jefferson Adams
    Celiac.com 07/03/2018 - The vast majority of celiac disease remain undiagnosed, and clinical testing is usually done on a case by case basis. Factor in vague or atypical symptoms, and you have a recipe for delayed diagnosis and unnecessary suffering. What determines who gets tested, and are current screening methods working?
    A team of researchers recently set out to assess the factors that determine diagnostic testing, along with the frequency of clinical testing in patients with undiagnosed celiac disease. The research team included I. A. Hujoel, C. T. Van Dyke, T. Brantner, J. Larson, K. S. King, A. Sharma J. A. Murray, and A. Rubio‐Tapia. They are variously affiliated with the Division of Biomedical Statistics and Informatics, the Division of Internal Medicine, at the Division of...


  • Recent Activity

    1. - trents replied to AlyO's topic in Parents, Friends and Loved Ones of Celiacs
      3

      Possible gluten exposure in 4yo

    2. - AlyO replied to AlyO's topic in Parents, Friends and Loved Ones of Celiacs
      3

      Possible gluten exposure in 4yo

    3. - trents replied to Hannah24's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Negative Test but I have All the Symptoms!

    4. - knitty kitty replied to Hannah24's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Negative Test but I have All the Symptoms!

    5. - trents replied to Linedancegal's topic in Introduce Yourself / Share Stuff
      2

      25 year biopsy confirmed/ate pizza with no ill effects?


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,458
    • Most Online (within 30 mins)
      7,748

    RUTHANN BRANOFF
    Newest Member
    RUTHANN BRANOFF
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):




  • Who's Online (See full list)


  • Celiac.com Sponsor (A21):



  • Popular Now

    • Hannah24
    • jessiemariecar
    • Rhonda H
    • HayleyC123
    • Touche
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...