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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    BRAIN ABNORMALITIES IN PATIENTS WITH CELIAC DISEASE AND NEUROLOGICAL ISSUES


    Jefferson Adams

    Celiac.com 09/17/2012 - Many aspects of celiac disease simply have not been well studied, so they remain poorly understood. For example, researchers have not done enough study on people with celiac disease to understand if they show any readily available serological markers of neurological disease.


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    Image: CC--jsmjrTo better understand this issue, a research team recently assessed the amount of brain abnormality in patients with celiac disease, along with looking into MR imaging sequences as biomarkers for neurological dysfunction.

    The study team included S. Currie, M. Hadjivassiliou, M.J. Clark, D.S. Sanders, I.D. Wilkinson, P.D. Griffiths, and N. Hoggard, of the Academic Unit of Radiology at University of Sheffield, Royal Hallamshire Hospital, in Sheffield, UK.

    For their study, they conducted a retrospective examination of a consecutive group of 33 patients with biopsy proven celiac disease, who had been referred for neurological opinion. The group ranged in age from 19 to 64 years old, with an average of 44±13 years.

    Researchers divided the group into subgroups based on their main neurological complaints of balance disturbance, headache and sensory loss.

    They used 3T MR to evaluate variations in brain grey matter density, cerebellar volume, cerebellar neurochemistry and white matter abnormalities (WMAs) between celiac patients and control subjects.

    The results showed that the celiac patients had a significantly lower cerebellar volume than did control subjects. Celiac patients had 6.9±0.7% of total intracranial volume, compared with 7.4±0.9% for control subjects (p<0.05).

    Celiac patients also showed significantly less grey matter density in multiple brain regions, both above and below the tentorium cerebelli, compared with the control subjects (p<0.05).

    The data showed that 12 (36%) patients demonstrated WMAs unexpected for the patient's age, with the highest incidence occurring in the headache subgroup.

    This group of patients averaged nearly double the number of WMAs per MR imaging session than the subgroup with balance disturbance, and six times more than the subgroup with sensory loss.

    The MR images of celiac patients who have neurological symptoms show significant brain abnormality on MR imaging, which means that MR imaging may serve as valuable biomarkers of disease in celiac patients.

    Source:



    Image Caption: Image: CC--jsmjr
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    Although I appreciate the medical terms and speech, I'm still not sure what it all means. We don't need it to be written at a 3rd grade level, but some explanation for those who did not attend med school would be helpful.

     

    Thanks!

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    Guest Valeria Todd

    Posted

    Jessica dear, I suppose this is another nice article that tells us we are stupider than normal people on top of being generally doomed. Well, me I have graduated 2 European universities, had a successful career and am fluent in 5 foreign language. I am over 50 and have been diagnosed celiac and following up a gluten-free diet only in the last 5 years. Thank God I am celiac or otherwise I would have been a genius, according to this research.

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    Jessica dear, I suppose this is another nice article that tells us we are stupider than normal people on top of being generally doomed. Well, me I have graduated 2 European universities, had a successful career and am fluent in 5 foreign language. I am over 50 and have been diagnosed celiac and following up a gluten-free diet only in the last 5 years. Thank God I am celiac or otherwise I would have been a genius, according to this research.

    Valeria - agreed. I went about 28 years of my life without being on a proper/pure gluten-free diet and was diagnosed with everything under the sun besides what was actually the root of what was wrong with me. During my time as a celiac consuming gluten, I earned both a Bachelor's and a Master's degree from two of the most world-renowned music conservatories. Without having been hindered by debilitating pain and ill health most of my life, I could have been a prodigy or at least at the very top of my field.

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    Valeria - agreed. I went about 28 years of my life without being on a proper/pure gluten-free diet and was diagnosed with everything under the sun besides what was actually the root of what was wrong with me. During my time as a celiac consuming gluten, I earned both a Bachelor's and a Master's degree from two of the most world-renowned music conservatories. Without having been hindered by debilitating pain and ill health most of my life, I could have been a prodigy or at least at the very top of my field.

    I have been diagnosed as having signs of dementia. I was

    forty years old when I found a doctor who cared enough to test me for celiac disease. Now I have to find a doctor that understands that celiac disease is affecting my brain.

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    Guest JUNE LEADER

    Posted

    I have refractory coeliac disease and was told many years ago that women with this illness very often have children that then grow up to suffer from mental illness. My own son suffers from schizophrenia. I was told it might be something to do with not enough nutrition in the womb. Should we not be screening pregnant women for coeliac, I am trying to get publicity around this subject?

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    Guest Lucille Cholerton

    Posted

    I have refractory coeliac disease and was told many years ago that women with this illness very often have children that then grow up to suffer from mental illness. My own son suffers from schizophrenia. I was told it might be something to do with not enough nutrition in the womb. Should we not be screening pregnant women for coeliac, I am trying to get publicity around this subject?

    Yes, June, I believe every pregnant mother should be screened for celiac. I had 3 children who have all turned out to be celiac, as I am. I did not realize that I was a celiac until 20 years later! All of my children suffered from a myriad of health issues for many years. My middle daughter was born jaundiced. I was told it was caused by "immature" liver enzymes. I realize now it was an autoimmune reaction against the liver, caused by gluten. That daughter suffered other autoimmune disorders (Sjogren's syndrome is one of them) as she grew up. I have learned that schizophrenia is caused by the peptides released by gluten and casein in dairy products, that upset brain chemicals.

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    admin
    Celiac.com 06/25/2003 - The Neuropathy Association -- On May 27, 2003 a link between Peripheral Neuropathy and Celiac Disease was reported by physicians at the Weill Medical College of Cornell University and New York Presbyterian Hospital, according to The Neuropathy Association. Peripheral Neuropathy, which affects up to 20 million people in the U.S., can cause pain, numbness and weakness in the arms and legs and, when left untreated, can progress to debilitation.
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    Contact information:
    Media Contact: Jeanne Abi-Nader
    Tel: 212-484-7954
    E-mail: jabi-nader@rlmnet.com
    Norman Latov, M.D., Ph.D., Professor of Neurology and
    Neuroscience, Weill Medical College of Cornell
    University, and Medical and Scientific Director, The
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    Tel: 212-888-8516
    E-mail: nol2002@med.cornell.edu.
     

    admin

    Pediatrics 2004;113:1672-1676.
    Celiac.com 07/12/2004 – According to Dr. Nathaniel Zelnik and colleagues from the Technion-Israel Institute of Technology, in Haifa, Israel, the spectrum of neurological disorders among those with celiac disease are greater than previously thought. The researchers studied 111 responses to questionnaires that probed for the presence of neurological disorders and symptoms, and reviewed the respondents medical records. Those who reported neurological symptoms underwent neurological examination and brain imaging or electroencephalogram, and the results were compared with that of 211 matched controls.
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    admin

    Dig Liver Dis. 2004 Aug;36(8):513-8.
    Celiac.com 12/11/2004 - An Italian study was carried out to determine the incidence of brain perfusion abnormalities in those with celiac disease, and whether gluten intake and associated autoimmune diseases may be considered risk factors in causing cerebral impairment. The researchers used brain single-photon emission computed tomography to examine the brains of 34 adult celiac patients--16 on a gluten-free diet, 18 on a gluten-containing diet, and 18 with other autoimmune diseases--and compared them to 10 age and sex-matched controls with normal jejunal mucosa. The researchers found that 24 out of the 34 in the study--a full 71%--had brain tomography abnormalities. The most significant brain abnormalities were found in the patients with untreated celiac disease (74%), and in those with associated autoimmune disease (69%). The abnormalities mainly affected the frontal region of the brain. The researchers conclude that brain perfusion seems common in celiac disease, but does not appear to be related to associated-autoimmunity, and the condition may be improved by a gluten-free diet.

    Jefferson Adams
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    You can find my Gluten Free Emergency Food Bags and other useful products at www.allergynavigator.com.  

    Jefferson Adams
    Celiac.com 04/23/2018 - A team of researchers recently set out to learn whether celiac disease patients commonly suffer cognitive impairment at the time they are diagnosed, and to compare their cognitive performance with non-celiac subjects with similar chronic symptoms and to a group of healthy control subjects.
    The research team included G Longarini, P Richly, MP Temprano, AF Costa, H Vázquez, ML Moreno, S Niveloni, P López, E Smecuol, R Mazure, A González, E Mauriño, and JC Bai. They are variously associated with the Small Bowel Section, Department of Medicine, Dr. C. Bonorino Udaondo Gastroenterology Hospital; Neurocience Cognitive and Traslational Institute (INECO), Favaloro Fundation, CONICET, Buenos Aires; the Brain Health Center (CESAL), Quilmes, Argentina; the Research Council, MSAL, CABA; and with the Research Institute, School of Medicine, Universidad del Salvador.
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    Source:
    J Clin Gastroenterol. 2018 Mar 1. doi: 10.1097/MCG.0000000000001018.

    Connie Sarros
    Celiac.com 04/21/2018 - Dear Friends and Readers,
    I have been writing articles for Scott Adams since the 2002 Summer Issue of the Scott-Free Press. The Scott-Free Press evolved into the Journal of Gluten Sensitivity. I felt honored when Scott asked me ten years ago to contribute to his quarterly journal and it's been a privilege to write articles for his publication ever since.
    Due to personal health reasons and restrictions, I find that I need to retire. My husband and I can no longer travel the country speaking at conferences and to support groups (which we dearly loved to do) nor can I commit to writing more books, articles, or menus. Consequently, I will no longer be contributing articles to the Journal of Gluten Sensitivity. 
    My following books will still be available at Amazon.com:
    Gluten-free Cooking for Dummies Student's Vegetarian Cookbook for Dummies Wheat-free Gluten-free Dessert Cookbook Wheat-free Gluten-free Reduced Calorie Cookbook Wheat-free Gluten-free Cookbook for Kids and Busy Adults (revised version) My first book was published in 1996. My journey since then has been incredible. I have met so many in the celiac community and I feel blessed to be able to call you friends. Many of you have told me that I helped to change your life – let me assure you that your kind words, your phone calls, your thoughtful notes, and your feedback throughout the years have had a vital impact on my life, too. Thank you for all of your support through these years.