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    Risk of Duodenal Adenoma in Celiac Disease


    Scott Adams


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    Scand J Gastroenterol. 2003 Aug;38(8):831-3.

    Celiac.com 09/29/2003 - In the following abstract the authors point out that in endoscopic screenings, adenocarcinoma is found less often than statistics from studies suggest it should be, implying that routine endoscopic examinations are not adequate to detect it. If this interpretation of the study is correct, other methods of screening for it need to be utilized or developed. Another possible way to look at this is that celiac patients do not have an elevated risk of adenocarcinoma when compared to the normal population, but given the numerous studies that have shown otherwise this possibility seems unlikely. I would also like to point out that the 60- to 80-fold increased risk of small bowel adenocarcinoma in patients with celiac disease that the author mentions is true for untreated celiacs. -Scott Adams

    Here is the abstract:

    Rampertab SD, Fleischauer A, Neugut AI, Green PH.

    Dept. of Medicine and Herbert Irving Comprehensive Cancer Center, Columbia

    University College of Physicians and Surgeons, New York, USA.

    BACKGROUND: There is a 60- to 80-fold increased risk of small bowel adenocarcinoma in patients with celiac disease. While the adenoma-carcinoma sequence appears to operate in the small bowel as in the large bowel, the risk of duodenal adenomas in celiac patients is unknown.

    METHODS: The records of 381 patients (245 F, 136 M) with biopsy-proven celiac disease were reviewed to determine the prevalence of duodenal adenoma found during esophagogastroduodenoscopy (EGD). We conducted an extensive literature review to find data for estimates of the prevalence of duodenal adenoma in a comparable general population; we used data from a study at another New York City medical center of 7,346 EGDs conducted between 1976 and 1982 (Ghazi et al., 1984). We estimated the relative risk, expressed as a standard morbidity ratio (SMR), by calculating the observed to expected (O/E) ratio.

    RESULTS: Duodenal adenomas were found in 3 celiac patients (0.78%), with 24 adenomas (0.33%) in the reference population, giving an SMR of 2.39 (95% CI 0.67-8.48).

    CONCLUSION: We did not find a significantly increased risk of duodenal adenoma in celiac patients compared to a non-celiac endoscoped population. Thus, despite the previously described elevated risk of small bowel adenocarcinoma in these patients, routine endoscopic examination of the duodenum may not be adequate for screening.

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  • About Me

    In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I founded The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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    Scott Adams
    Eur J Gastroenterol Hepatol 2000;12:645-648.
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    Jefferson Adams
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    Their data showed clearly that celiac disease is not associated with an increased risk of colorectal neoplasia. They also note that the lack of increased risk of colorectal cancer seen in population studies reflects a genuine average risk of colorectal neoplasia, rather than an increase in colonoscopies and associated polypectomies in people with celiac disease.
    Source:

    Aliment Pharmacol Ther. DOI: 10.1111/j.1365-2036.2010.04440.x

    Jefferson Adams
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