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    Adverse Gluten Reactions Impact Oral Mucosa in Celiac Patients


    Jefferson Adams

    Celiac.com 07/31/2014 - Although the adverse mucosal reaction in celiac disease occurs mainly in the small intestine, other mucosal surfaces in the gastrointestinal tract and the gut-associated lymphoid tissue are also affected. To better understand the impact, a research team recently set out to examine histopathological findings in the oral mucosa of celiac disease patients.


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    Photo: Tasmanian Devil--Wikimedia Commons--Wayne McLeanSpecifically, based on the assumption that the oral mucosa could reflect the histopathological intestinal inflammation seen in celiac disease patients, they wanted to determine the pattern of T-cell subsets in the oral mucosa of young adults with celiac disease. The research team included E. Bardellini, F. Amadori, A. Ravelli, M. Salemme, S. Lonardi, V. Villanacci, and A. Majorana.

    For their study, they enrolled a group of 37 patients with celiac disease, ranging in age from 20-38 years. Twenty-eight were female, nine male. The team broke the 37 subjects into two groups. The nineteen patients of group A were following a gluten free diet (GFD); two patients for less than one year; 6 patients between 1 and 5 years; 11 patients more than 5 years. The 18 patients (group B) remained untreated.

    Meanwhile, fifteen healthy volunteers (age range 18-35 years, 11 females and 4 males served as controls. Because the study involved observing untreated celiac patients, the team sought and received ethical approval for the research from the Ethics Committee.

    The team took biopsy specimens from normal looking oral mucosa. They conducted immunohistochemical investigation with monoclonal antibodies to CD3, CD4, CD8, and gamma/delta-chains T cell receptor (TCR).

    They found T-lymphocytic inflammatory infiltrate significantly higher in group B (p < 0.0001); as compared with group A and with the control group.

    Their results confirm that the oral cavity is involved with adverse reactions to celiac disease triggers, and might offer potential for celiac diagnosis.

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    I have been on a gluten-free diet for 12 years and can tell when I have been glutened by the outbreak of canker sores the next day.

     

    It seems if a correlation could be made between oral mucosa and the small intestine biopsies, that an oral swab test could be enough for a celiac disease diagnosis

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    Guest R.Borg

    Posted

    The article did not define and explain oral mucosa nor its symptoms.

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    Guest Diana Barnes

    Posted

    This is great to know, but I have a question. Maybe you can help me or tell me who I can talk to. I have celiac disease and I eat gluten-free but I still get sores in my mouth, WHY?

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    Guest Jefferson

    Posted

    The article did not define and explain oral mucosa nor its symptoms.

    Are you serious? Oral mucosa is simply the lining of the mouth. Please look things up before commenting.

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    Guest Jefferson

    Posted

    This is great to know, but I have a question. Maybe you can help me or tell me who I can talk to. I have celiac disease and I eat gluten-free but I still get sores in my mouth, WHY?

    First, I'm not a doctor, so definitely consult one. However, two possibilities are: 1) You may have sensitivities to things besides wheat gluten. 2) You may be getting cross-contamination.

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    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
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    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023