• Join our community!

    Do you have questions about celiac disease or the gluten-free diet?

  • Ads by Google:
     




    Get email alerts Subscribe to Celiac.com's FREE weekly eNewsletter

    Ads by Google:



       Get email alertsSubscribe to Celiac.com's FREE weekly eNewsletter

  • Member Statistics

    71,837
    Total Members
    3,093
    Most Online
    TFreckles
    Newest Member
    TFreckles
    Joined
  • Announcements

    • admin

      Frequently Asked Questions About Celiac Disease   04/07/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
  • 0

    ANXIETY AND DEPRESSION IN ADULTS WITH CELIAC DISEASE ON A GLUTEN-FREE DIET


    Jefferson Adams

    Celiac.com 07/13/2010 - More and more, researchers are showing connections between inflammatory diseases, like celiac disease, and complex disorders, such as anxiety and depression. There's also a good amount of anecdotal evidence to suggest that people with celiac disease have higher rates of anxiety and depression than the general population.


    Ads by Google:




    ARTICLE CONTINUES BELOW ADS
    Ads by Google:



    A study of the German population is the first to show that female adults following a gluten-free diet for celiac disease show higher levels of anxiety than do members of the general population.

    The researchers are recommending that female celiacs on a gluten-free diet be screened for anxiety. The researchers included W. Häuser, K. H. Janke, B. Klump, M. Gregor, and A. Hinz of the Department of Internal Medicine I of the Klinikum Saarbrücken, Winterberg in Saarbrücken, Germany.

    The team set out to examine levels of depression and anxiety between adults with celiac disease following a gluten-free diet (GFD), and in control subjects drawn from the general population.

    For their study, the team used the Hospital Anxiety and Depression Scale to measure levels of anxiety, depression, and likely anxiety or depressive disorder, in 441 adult patients with celiac disease recruited by the German Celiac Society. They then conducted the same assessments on 235 comparable patients with inflammatory bowel disease (IBD), either in remission or with slight disease activity. They did the same for the cross-sample control group of 441 adults from the general population.

    The team used regression analysis to test possible demographic and disease-related predictors of anxiety and depression in celiac disease. Demographic predictors included age, sex, social class, and family status. Disease-related predictors included latency to diagnosis, duration of GFD, compliance with GFD, thyroid disease.

    The team found that female gender (P = 0.01) was the main predictor (R(2) = 0.07) of anxiety levels in patients with celiac disease. Female patients had a higher risk for a probable anxiety disorder (OR = 3.6, 95% CI: 1.3-9.4, P = 0.01)  Patients who lived alone (OR = 0.5, 95% CI: 0.2-0.9, P = 0.05) enjoyed a lower risk of anxiety disorder. None of the demographic and medical variables for which the team screened predicted either depression levels or risk for a probable depressive disorders.

    Patients with celiac disease showed anxiety levels of 6.6 +/- 3.4, and those with IBD, anxiety levels of 6.9 +/- 3.7, both higher than the general population's level of 4.6 +/- 3.3 - (both P < 0.001). Depression levels were similar for people with celiac disease (4.2 +/- 3.4), IBD (4.6 +/- 3.4) and the general population (4.2 +/- 3.8) (P = 0.3). Rates of likely anxiety disorders in people with celiac disease were 16.8%, and 14.0% for IBD, both higher than the rates of 5.7% in the general population (P < 0.001). All three groups showed similar rates of probable depressive disorder (P = 0.1).

    Their results provide strong indications that adult women with celiac disease on a gluten-free diet suffer higher rates of anxiety than persons of the general population. They encourage clinicians to provide anxiety screens for adult women with celiac disease on a gluten-free diet.

    Source:




    Image Caption: Anxiety and Depression in Adults with Celiac Disease on a Gluten-free Diet
    0


    User Feedback

    Recommended Comments

    Guest kelly fordon

    Posted

    I'm surprised by this. I think following the gluten-free diet lowers anxiety levels rather than increases it. I would like to know if their anxiety levels were higher before they started following the diet, or if they decreased over time....

    Share this comment


    Link to comment
    Share on other sites
    Guest Samantha

    Posted

    I'm surprised by this. I think following the gluten-free diet lowers anxiety levels rather than increases it. I would like to know if their anxiety levels were higher before they started following the diet, or if they decreased over time....

    Good question, yet, I still can identify with the researcher's analysis. Following a gluten-free diet brings about dietary and social demands that non-celiacs never need to imagine. Unfortunately, this way of life is quite demanding for young females wanting to "fit in". Note that those living alone did not display similar results.

    Share this comment


    Link to comment
    Share on other sites
    Guest BarbaraDH

    Posted

    I had a very high level anxiety disorder before getting the Celiac diagnosis and going gluten-free. While my anxiety levels did get better on some levels (no more panic attacks, no free-floating anxiety), I have certainly noticed a level of anxiety that in some ways is worse and hits me harder, although I can usually find a trigger. I don't have it all the time anymore, but when I do have it, it seems to be a deeper anxiety than I usually had before getting my diagnosis and going gluten-free.

    Share this comment


    Link to comment
    Share on other sites
    Guest dotslady

    Posted

    My experience is that gluten-free diet helped depression and anxiety. Four years later I can say that dairy-free added to that. What else are these people eating? Lots of gluten-free specialty foods,with empty calories and no nutrients? Healthy fats? Do they have kids w/their own undiagnosed neurological disorders? That increases anxiety.

    Share this comment


    Link to comment
    Share on other sites

    These numbers are confusing to me.

    But, I agree with the anxiety piece. Most of the time, I can link it to when I eat out so I could guess it was cross contamination and I ate a trace of gluten. Other times, I can't find a trigger to it.

    But, my anxiety definitely only started when I started a gluten-free diet.

    Share this comment


    Link to comment
    Share on other sites
    Guest Heddi

    Posted

    I had much less anxiety while living alone. No contamination worries. Didn't eat out as much. I usually consume gluten containing foods, mistakenly, while eating out, being social. People/restaurants say their food is gluten-free, but many times it's not, or contaminated. This challenges my trust, which can cause anxiety. I have to have very strict boundaries, decide what is really best for me.

    Share this comment


    Link to comment
    Share on other sites
    Guest Barbara

    Posted

    This diagnosis of Celiac disease is the worst thing that has ever happened to me. I believe that living alone would make this a lot easier. Being married means conflicts with your spouse over the Celiac not wanting to bring food to a barbecue/party where you do not know the hosts. Even if you do know the hosts it still is very awkward and not fun at all. Traveling is really stressful also.

     

    Everyone says to me that there is a lot of Gluten-Free food now. Well most of it is awful. Before being Celiac I could buy bread that is 40 calories a slice and the average caloric count of gluten-free bread is about 150 calories a slice.

    Share this comment


    Link to comment
    Share on other sites
    This diagnosis of Celiac disease is the worst thing that has ever happened to me. I believe that living alone would make this a lot easier. Being married means conflicts with your spouse over the Celiac not wanting to bring food to a barbecue/party where you do not know the hosts. Even if you do know the hosts it still is very awkward and not fun at all. Traveling is really stressful also.

     

    Everyone says to me that there is a lot of Gluten-Free food now. Well most of it is awful. Before being Celiac I could buy bread that is 40 calories a slice and the average caloric count of gluten-free bread is about 150 calories a slice.

    I have followed a gluten-free diet for 13 years and felt physically and personally healthier every year up until the past 3 years. I am now married and have 2 little kids. I often have a hard time eating well (I sometimes avoid eating simply because it is so much effort to find healthy, quick gluten-free foods, or I eat questionable foods out of necessity) and uncharacteristic anxiety affects some areas of my life quite noticeable.

    Share this comment


    Link to comment
    Share on other sites
    Guest Vesta Coffey

    Posted

    I think if you wanted to you could blame alot of things on the celiac disease. I was diagnosed one - half years ago. I feel much better and my anxiety level is almost nothing, since I have been eating gluten free.

     

    If I eat badly (gluten-free junk) I don't feel as well. Also, most of the gluten free bake goods are not that good for you.

    Share this comment


    Link to comment
    Share on other sites
    Guest jdiemert

    Posted

    This diagnosis of Celiac disease is the worst thing that has ever happened to me. I believe that living alone would make this a lot easier. Being married means conflicts with your spouse over the Celiac not wanting to bring food to a barbecue/party where you do not know the hosts. Even if you do know the hosts it still is very awkward and not fun at all. Traveling is really stressful also.

     

    Everyone says to me that there is a lot of Gluten-Free food now. Well most of it is awful. Before being Celiac I could buy bread that is 40 calories a slice and the average caloric count of gluten-free bread is about 150 calories a slice.

    I am 60 years old and got diagnosed 1 year ago. I fully agree that the celiac diet tastes awful. It is no wonder women living with a spouse are depressed and have anxiety. They must make two types of meals everyday and smell it cooking knowing that they cannot eat it. Eating out is so frustrating when you have to pick and choose what you can and cannot eat from the menu or tying to find a restaurant that is gluten-free and will not cross-contaminate food. Family gatherings are the worst, watching everyone having what you cannot have.

    Share this comment


    Link to comment
    Share on other sites
    Guest EBgirl

    Posted

    Interesting article, but it leaves a lot of unanswered questions -- let's hope for more studies on this.

     

    My anxiety levels spiked too on the gluten-free diet (although I also had anxiety before). My anxiety has slowly gone down over the past 6 month (I have been gluten-free for 2 years). I was found to have really weak adrenals, probably from the years of inflammation and pain from Celiac. Since supporting my adrenals over the past 6 months I have improved a lot.

     

    I think gluten contributes to anxiety, but I am very curious as to why. I have heard that the serotonin receptors in your gut can become damaged with Celiac, which can increase anxiety. I also wonder why it seems to have gotten worse when I first went gluten-free, detox reaction maybe? I have also heard that wheat can act as an opiate sometimes, so maybe it was a withdrawal of some kind?

     

    Lots of interesting possibilities -- let's hope that more research can help with this problem that so many of us have.

    Share this comment


    Link to comment
    Share on other sites
    Guest Shellie

    Posted

    I can testify that my anxiety and depression were significantly reduced after being diagnosed. It was seriously like having a brand new life once I had been correctly diagnosed. I had been living with this since childhood and had been diagnosed with numerous other diseases; however, once I had been diagnosed, all of the other things went away. Yes! I'm not anxious at all. Happy as a new born lamb and a lil adjustment is all I needed.

    Share this comment


    Link to comment
    Share on other sites
    Guest kirstenandkevin@gmail.com

    Posted

    I know I am feeling Blue in regards to my celiac. My family eats normal and we have active social lives but I feel like just not eating at all because the only things I can eat seem to be either gross, or too expensive to buy, or the same boring thing I eat day after day. So I feel like just starving myself or giving up. I hate the feeling! I don't have or know celiac friends so I am struggling through this alone and its not fun. I have a dinner to attend today, and tomorrow and I will have to bring all my own food and I don't want to eat... I don't feel like eating at all.

    Share this comment


    Link to comment
    Share on other sites

    I am just starting a gluten free diet to see if it will help before I do all the expensive testing. So far I am seeing amazing results. I have incredibly high anxiety levels and they have subsided dramatically. Also my gastrointestinal problems are going away in a hurry. This may be the best thing I ever do for myself.

    Share this comment


    Link to comment
    Share on other sites
    Guest Exercise

    Posted

    Anxiety attacks can happen to anyone. Exercise is one other thing that you can do to improve your mental state. Exercise helps to increase the serotonin levels in your brain's chemistry. These serotonin levels enhance a sense of well-being. Finding an exercise routine and sticking to it will enable you to better your day-to-day anxiety levels. It will also help you to feel better about yourself and your body in general.

    Share this comment


    Link to comment
    Share on other sites
    Guest Someone

    Posted

    I'm a male diagnosed with social anxiety disorder after I quit school because of it, I've also suffered with depression for most of my life. I recently discovered I have celiac too.

    Share this comment


    Link to comment
    Share on other sites

    Due to malabsorption in the gut, and diagnosed with celiac after years of anxiety and depression (GAD), I recently came across articles related to 5-MTHFR Deficiency. Folic acid as we all know it, is not metabolised properly by some individuals. Latest research is showing that we need the more active form folic acid - and bio-identical form of folinic acid. Unfortunately, the high dose form of this folate is only available in certain countries in high doses - the product is called Deplin. Battling with anxiety and depression and celiac including borderline iron deficiency all relates back to inefficient absorption. It's not easy exercising when your high homocysteine levels cause chronic fatigue and very low energy which makes you more susceptible to inflammation.

    Share this comment


    Link to comment
    Share on other sites


    Your content will need to be approved by a moderator

    Guest
    You are commenting as a guest. If you have an account, please sign in.
    Add a comment...

    ×   Pasted as rich text.   Paste as plain text instead

      Only 75 emoticons maximum are allowed.

    ×   Your link has been automatically embedded.   Display as a link instead

    ×   Your previous content has been restored.   Clear editor

    ×   You cannot paste images directly. Upload or insert images from URL.


  • Popular Contributors

  • Ads by Google:

  • Who's Online   5 Members, 0 Anonymous, 1,105 Guests (See full list)

  • Related Articles

    admin

    BMC Psychiatry 2005, 5:14 Celiac.com 05/09/2005 – Past studies have linked depression and behavioral disorders in teenagers with untreated celiac disease. Researchers in Finland conducted a study that was designed to determine what effect a gluten-free diet has on the psychiatric symptoms of adolescents with celiac disease, and specifically on the hormone prolactin (thyroid function) and on large neutral amino acid serum concentrations. Nine 12 to 16 –year-old adolescents with celiac disease were evaluated using the semi-structured K-SADS-Present and Lifetime Diagnostic interview, and seven were followed up after 1-2, 3 and 6 months on a gluten-free diet.
    The researchers found that pre-gluten-free diet adolescents with celiac disease and depression had significantly lower tryptophan competing amino-acid ratios and free tryptophan concentrations, and had significantly higher biopsy morning prolactin levels compared to those without depression. After three months on a gluten-free diet the researchers noted a significant decrease in the patients psychiatric symptoms that coincided with a decrease in celiac disease symptoms and prolactin levels, and a sharp increase in serum concentrations of tryptophan competing amino-acid ratios.
    The researchers conclude that their findings support the idea that untreated celiac disease in adolescents can create serotonergic dysfunction due to the impaired availability of tryptophan, and this may play a role in depressive and behavioral disorders.

    Jefferson Adams
    Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers.
    A team of researchers recently used a Web-mediated survey to assess a range of physical, behavioral and emotional experiences in 177 U.S. adult women, who reported a physician-provided diagnosis of celiac disease.
    The team was led by Josh Smyth, professor of biobehavioral health and medicine at Pennsylvania State University, and included members from  Syracuse University and Drexel University.
    The survey gathered information about how closely people follow a gluten-free diet and assessed various symptoms of celiac disease from physical symptoms to the respondents' experience and management of stressful situations, along with charting symptoms of clinical depression and frequency of thoughts and behaviors associated with eating and body image.
    Perhaps unsurprisingly, many women with celiac disease suffer from disordered eating, given that the management of celiac disease requires careful attention to diet and food, Smyth said.
    "What we don't know is what leads to what and under what circumstances," Smyth said. "It's likely that the disease, stress, weight, shape and eating issues, and depression are interconnected."
    The findings are forthcoming in the journal of Chronic Illness.
    Source:

    http://www.upi.com/Health_News/2011/12/28/Celiac-ups-depression-risk-for-women/UPI-75401325131984/#ixzz1iQynze9k.

  • Recent Articles

    Jefferson Adams
    Celiac.com 04/20/2018 - A digital media company and a label data company are teaming up to help major manufacturers target, reach and convert their desired shoppers based on dietary needs, such as gluten-free diet. The deal could bring synergy in emerging markets such as the gluten-free and allergen-free markets, which represent major growth sectors in the global food industry. 
    Under the deal, personalized digital media company Catalina will be joining forces with Label Insight. Catalina uses consumer purchases data to target shoppers on a personal base, while Label Insight works with major companies like Kellogg, Betty Crocker, and Pepsi to provide insight on food label data to government, retailers, manufacturers and app developers.
    "Brands with very specific product benefits, gluten-free for example, require precise targeting to efficiently reach and convert their desired shoppers,” says Todd Morris, President of Catalina's Go-to-Market organization, adding that “Catalina offers the only purchase-based targeting solution with this capability.” 
    Label Insight’s clients include food and beverage giants such as Unilever, Ben & Jerry's, Lipton and Hellman’s. Label Insight technology has helped the Food and Drug Administration (FDA) build the sector’s very first scientifically accurate database of food ingredients, health attributes and claims.
    Morris says the joint partnership will allow Catalina to “enhance our dataset and further increase our ability to target shoppers who are currently buying - or have shown intent to buy - in these emerging categories,” including gluten-free, allergen-free, and other free-from foods.
    The deal will likely make for easier, more precise targeting of goods to consumers, and thus provide benefits for manufacturers and retailers looking to better serve their retail food customers, especially in specialty areas like gluten-free and allergen-free foods.
    Source:
    fdfworld.com

    Jefferson Adams
    Celiac.com 04/19/2018 - Previous genome and linkage studies indicate the existence of a new disease triggering mechanism that involves amino acid metabolism and nutrient sensing signaling pathways. In an effort to determine if amino acids might play a role in the development of celiac disease, a team of researchers recently set out to investigate if plasma amino acid levels differed among children with celiac disease compared with a control group.
     
    The research team included Åsa Torinsson Naluai, Ladan Saadat Vafa, Audur H. Gudjonsdottir, Henrik Arnell, Lars Browaldh, and Daniel Agardh. They are variously affiliated with the Institute of Biomedicine, Department of Microbiology & Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; the Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; the Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University Hospital and Division of Pediatrics, CLINTEC, Karolinska Institute, Stockholm, Sweden; the Department of Clinical Science and Education, Karolinska Institute, Sodersjukhuset, Stockholm, Sweden; the Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden; the Diabetes & Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; and with the Nathan S Kline Institute in the U.S.A.
    First, the team used liquid chromatography-tandem mass spectrometry (LC/MS) to analyze amino acid levels in fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls. They then crafted a general linear model using age and experimental effects as covariates to compare amino acid levels between children with celiac disease and non-celiac control subjects.
    Compared with the control group, seven out of twenty-three children with celiac disease showed elevated levels of the the following amino acids: tryptophan; taurine; glutamic acid; proline; ornithine; alanine; and methionine.
    The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects.
    This study shows that amino acids can influence inflammation and may play a role in the development of celiac disease.
    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764

    Jefferson Adams
    Celiac.com 04/18/2018 - To the relief of many bewildered passengers and crew, no more comfort turkeys, geese, possums or other questionable pets will be flying on Delta or United without meeting the airlines' strict new requirements for service animals.
    If you’ve flown anywhere lately, you may have seen them. People flying with their designated “emotional support” animals. We’re not talking genuine service animals, like seeing eye dogs, or hearing ear dogs, or even the Belgian Malinois that alerts its owner when there is gluten in food that may trigger her celiac disease.
    Now, to be honest, some of those animals in question do perform a genuine service for those who need emotional support dogs, like veterans with PTSD.
    However, many of these animals are not service animals at all. Many of these animals perform no actual service to their owners, and are nothing more than thinly disguised pets. Many lack proper training, and some have caused serious problems for the airlines and for other passengers.
    Now the major airlines are taking note and introducing stringent requirements for service animals.
    Delta was the first to strike. As reported by the New York Times on January 19: “Effective March 1, Delta, the second largest US airline by passenger traffic, said it will require passengers seeking to fly with pets to present additional documents outlining the passenger’s need for the animal and proof of its training and vaccinations, 48 hours prior to the flight.… This comes in response to what the carrier said was a 150 percent increase in service and support animals — pets, often dogs, that accompany people with disabilities — carried onboard since 2015.… Delta said that it flies some 700 service animals a day. Among them, customers have attempted to fly with comfort turkeys, gliding possums, snakes, spiders, and other unusual pets.”
    Fresh from an unsavory incident with an “emotional support” peacock incident, United Airlines has followed Delta’s lead and set stricter rules for emotional support animals. United’s rules also took effect March 1, 2018.
    So, to the relief of many bewildered passengers and crew, no more comfort turkeys, geese, possums or other questionable pets will be flying on Delta or United without meeting the airlines' strict new requirements for service and emotional support animals.
    Source:
    cnbc.com

    admin
    WHAT IS CELIAC DISEASE?
    Celiac disease is an autoimmune condition that affects around 1% of the population. People with celiac disease suffer an autoimmune reaction when they consume wheat, rye or barley. The immune reaction is triggered by certain proteins in the wheat, rye, or barley, and, left untreated, causes damage to the small, finger-like structures, called villi, that line the gut. The damage occurs as shortening and villous flattening in the lamina propria and crypt regions of the intestines. The damage to these villi then leads to numerous other issues that commonly plague people with untreated celiac disease, including poor nutritional uptake, fatigue, and myriad other problems.
    Celiac disease mostly affects people of Northern European descent, but recent studies show that it also affects large numbers of people in Italy, China, Iran, India, and numerous other places thought to have few or no cases.
    Celiac disease is most often uncovered because people experience symptoms that lead them to get tests for antibodies to gluten. If these tests are positive, then the people usually get biopsy confirmation of their celiac disease. Once they adopt a gluten-free diet, they usually see gut healing, and major improvements in their symptoms. 
    CLASSIC CELIAC DISEASE SYMPTOMS
    Symptoms of celiac disease can range from the classic features, such as diarrhea, upset stomach, bloating, gas, weight loss, and malnutrition, among others.
    LESS OBVIOUS SYMPTOMS
    Celiac disease can often less obvious symptoms, such fatigue, vitamin and nutrient deficiencies, anemia, to name a few. Often, these symptoms are regarded as less obvious because they are not gastrointestinal in nature. You got that right, it is not uncommon for people with celiac disease to have few or no gastrointestinal symptoms. That makes spotting and connecting these seemingly unrelated and unclear celiac symptoms so important.
    NO SYMPTOMS
    Currently, most people diagnosed with celiac disease do not show symptoms, but are diagnosed on the basis of referral for elevated risk factors. 

    CELIAC DISEASE VS. GLUTEN INTOLERANCE
    Gluten intolerance is a generic term for people who have some sort of sensitivity to gluten. These people may or may not have celiac disease. Researchers generally agree that there is a condition called non-celiac gluten sensitivity. That term has largely replaced the term gluten-intolerance. What’s the difference between celiac disease and non-celiac gluten-sensitivity? 
    CELIAC DISEASE VS. NON-CELIAC GLUTEN SENSITIVITY (NCGS)
    Gluten triggers symptoms and immune reactions in people with celiac disease. Gluten can also trigger symptoms in some people with NCGS, but the similarities largely end there.

    There are four main differences between celiac disease and non-celiac gluten sensitivity:
    No Hereditary Link in NCGS
    Researchers know for certain that genetic heredity plays a major role in celiac disease. If a first-degree relative has celiac disease, then you have a statistically higher risk of carrying genetic markers DQ2 and/or DQ8, and of developing celiac disease yourself. NCGS is not known to be hereditary. Some research has shown certain genetic associations, such as some NCGS patients, but there is no proof that NCGS is hereditary. No Connection with Celiac-related Disorders
    Unlike celiac disease, NCGS is so far not associated with malabsorption, nutritional deficiencies, or a higher risk of autoimmune disorders or intestinal malignancies. No Immunological or Serological Markers
    People with celiac disease nearly always test positive for antibodies to gluten proteins. Researchers have, as yet, identified no such antobodies or serologic markers for NCGS. That means that, unlike with celiac disease, there are no telltale screening tests that can point to NCGS. Absence of Celiac Disease or Wheat Allergy
    Doctors diagnose NCGS only by excluding both celiac disease, an IgE-mediated allergy to wheat, and by the noting ongoing adverse symptoms associated with gluten consumption. WHAT ABOUT IRRITABLE BOWEL SYNDROME (IBS) AND IRRITABLE BOWEL DISEASE (IBD)?
    IBS and IBD are usually diagnosed in part by ruling out celiac disease. Many patients with irritable bowel syndrome are sensitive to gluten. Many experience celiac disease-like symptoms in reaction to wheat. However, patients with IBS generally show no gut damage, and do not test positive for antibodies to gliadin and other proteins as do people with celiac disease. Some IBS patients also suffer from NCGS.

    To add more confusion, many cases of IBS are, in fact, celiac disease in disguise.

    That said, people with IBS generally react to more than just wheat. People with NCGS generally react to wheat and not to other things, but that’s not always the case. Doctors generally try to rule out celiac disease before making a diagnosis of IBS or NCGS. 
    Crohn’s Disease and celiac disease share many common symptoms, though causes are different.  In Crohn’s disease, the immune system can cause disruption anywhere along the gastrointestinal tract, and a diagnosis of Crohn’s disease typically requires more diagnostic testing than does a celiac diagnosis.  
    Crohn’s treatment consists of changes to diet and possible surgery.  Up to 10% of Crohn's patients can have both of conditions, which suggests a genetic connection, and researchers continue to examine that connection.
    Is There a Connection Between Celiac Disease, Non-Celiac Gluten Sensitivity and Irritable Bowel Syndrome? Large Number of Irritable Bowel Syndrome Patients Sensitive To Gluten Some IBD Patients also Suffer from Non-Celiac Gluten Sensitivity Many Cases of IBS and Fibromyalgia Actually Celiac Disease in Disguise CELIAC DISEASE DIAGNOSIS
    Diagnosis of celiac disease can be difficult. 

    Perhaps because celiac disease presents clinically in such a variety of ways, proper diagnosis often takes years. A positive serological test for antibodies against tissue transglutaminase is considered a very strong diagnostic indicator, and a duodenal biopsy revealing villous atrophy is still considered by many to be the diagnostic gold standard. 
    But this idea is being questioned; some think the biopsy is unnecessary in the face of clear serological tests and obvious symptoms. Also, researchers are developing accurate and reliable ways to test for celiac disease even when patients are already avoiding wheat. In the past, patients needed to be consuming wheat to get an accurate test result. 
    Celiac disease can have numerous vague, or confusing symptoms that can make diagnosis difficult.  Celiac disease is commonly misdiagnosed by doctors. Read a Personal Story About Celiac Disease Diagnosis from the Founder of Celiac.com Currently, testing and biopsy still form the cornerstone of celiac diagnosis.
    TESTING
    There are several serologic (blood) tests available that screen for celiac disease antibodies, but the most commonly used is called a tTG-IgA test. If blood test results suggest celiac disease, your physician will recommend a biopsy of your small intestine to confirm the diagnosis.
    Testing is fairly simple and involves screening the patients blood for antigliadin (AGA) and endomysium antibodies (EmA), and/or doing a biopsy on the areas of the intestines mentioned above, which is still the standard for a formal diagnosis. Also, it is now possible to test people for celiac disease without making them concume wheat products.

    BIOPSY
    Until recently, biopsy confirmation of a positive gluten antibody test was the gold standard for celiac diagnosis. It still is, but things are changing fairly quickly. Children can now be accurately diagnosed for celiac disease without biopsy. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide.

    WHY A GLUTEN-FREE DIET?
    Currently the only effective, medically approved treatment for celiac disease is a strict gluten-free diet. Following a gluten-free diet relieves symptoms, promotes gut healing, and prevents nearly all celiac-related complications. 
    A gluten-free diet means avoiding all products that contain wheat, rye and barley, or any of their derivatives. This is a difficult task as there are many hidden sources of gluten found in the ingredients of many processed foods. Still, with effort, most people with celiac disease manage to make the transition. The vast majority of celiac disease patients who follow a gluten-free diet see symptom relief and experience gut healing within two years.
    For these reasons, a gluten-free diet remains the only effective, medically proven treatment for celiac disease.
    WHAT ABOUT ENZYMES, VACCINES, ETC.?
    There is currently no enzyme or vaccine that can replace a gluten-free diet for people with celiac disease.
    There are enzyme supplements currently available, such as AN-PEP, Latiglutetenase, GluteGuard, and KumaMax, which may help to mitigate accidental gluten ingestion by celiacs. KumaMax, has been shown to survive the stomach, and to break down gluten in the small intestine. Latiglutenase, formerly known as ALV003, is an enzyme therapy designed to be taken with meals. GluteGuard has been shown to significantly protect celiac patients from the serious symptoms they would normally experience after gluten ingestion. There are other enzymes, including those based on papaya enzymes.

    Additionally, there are many celiac disease drugs, enzymes, and therapies in various stages of development by pharmaceutical companies, including at least one vaccine that has received financial backing. At some point in the not too distant future there will likely be new treatments available for those who seek an alternative to a lifelong gluten-free diet. 

    For now though, there are no products on the market that can take the place of a gluten-free diet. Any enzyme or other treatment for celiac disease is intended to be used in conjunction with a gluten-free diet, not as a replacement.

    ASSOCIATED DISEASES
    The most common disorders associated with celiac disease are thyroid disease and Type 1 Diabetes, however, celiac disease is associated with many other conditions, including but not limited to the following autoimmune conditions:
    Type 1 Diabetes Mellitus: 2.4-16.4% Multiple Sclerosis (MS): 11% Hashimoto’s thyroiditis: 4-6% Autoimmune hepatitis: 6-15% Addison disease: 6% Arthritis: 1.5-7.5% Sjögren’s syndrome: 2-15% Idiopathic dilated cardiomyopathy: 5.7% IgA Nephropathy (Berger’s Disease): 3.6% Other celiac co-morditities include:
    Crohn’s Disease; Inflammatory Bowel Disease Chronic Pancreatitis Down Syndrome Irritable Bowel Syndrome (IBS) Lupus Multiple Sclerosis Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Psoriasis Rheumatoid Arthritis Scleroderma Turner Syndrome Ulcerative Colitis; Inflammatory Bowel Disease Williams Syndrome Cancers:
    Non-Hodgkin lymphoma (intestinal and extra-intestinal, T- and B-cell types) Small intestinal adenocarcinoma Esophageal carcinoma Papillary thyroid cancer Melanoma CELIAC DISEASE REFERENCES:
    Celiac Disease Center, Columbia University
    Gluten Intolerance Group
    National Institutes of Health
    U.S. National Library of Medicine
    Mayo Clinic
    University of Chicago Celiac Disease Center

    Jefferson Adams
    Celiac.com 04/17/2018 - Could the holy grail of gluten-free food lie in special strains of wheat that lack “bad glutens” that trigger the celiac disease, but include the “good glutens” that make bread and other products chewy, spongey and delicious? Such products would include all of the good things about wheat, but none of the bad things that might trigger celiac disease.
    A team of researchers in Spain is creating strains of wheat that lack the “bad glutens” that trigger the autoimmune disorder celiac disease. The team, based at the Institute for Sustainable Agriculture in Cordoba, Spain, is making use of the new and highly effective CRISPR gene editing to eliminate the majority of the gliadins in wheat.
    Gliadins are the gluten proteins that trigger the majority of symptoms for people with celiac disease.
    As part of their efforts, the team has conducted a small study on 20 people with “gluten sensitivity.” That study showed that test subjects can tolerate bread made with this special wheat, says team member Francisco Barro. However, the team has yet to publish the results.
    Clearly, more comprehensive testing would be needed to determine if such a product is safely tolerated by people with celiac disease. Still, with these efforts, along with efforts to develop vaccines, enzymes, and other treatments making steady progress, we are living in exciting times for people with celiac disease.
    It is entirely conceivable that in the not-so-distant future we will see safe, viable treatments for celiac disease that do not require a strict gluten-free diet.
    Read more at Digitaltrends.com , and at Newscientist.com