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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    CELIAC DISEASE TIED TO DEPRESSION IN ADOLESCENTS

    Jefferson Adams

    By Jefferson Adams

    Celiac.com 06/23/2016 - Digestive Disease Week 2016 took place in San Diego from May 21-24. Among the presentations given was one that stood out for its obvious health impacts. That presentation was given by Jonathan Cordova, DO, pediatric gastroenterologist at the University of Chicago Medical Center. His presentation tied celiac disease to major depressive disorder in adolescents, and stated that most adolescents with celiac disease have symptoms consistent with the disorder.


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    Dr. Cordova said that "...interim analysis does suggest that a majority of adolescents living with celiac disease may have symptoms consistent with major depressive disorder," and that the depression has a negative impact on their quality of life, "but does not appear to be associated with their celiac disease state." That is, the depression does not seem to be impacted by how well their celiac disease is doing. Healthy gut and gluten-free diet, or unhealthy gut, with symptoms, it doesn't seem to matter. The depression levels seem about the same whatever the case.

    A number of recent studies indicate that depression and anxiety are the main reasons people with celiac disease report decreased quality of life, Dr. Cordova and his colleagues wrote. But, most of these studies were done on adults, almost none used adolescents, and adolescents may be more susceptible to depression.

    The research team was able to connect celiac disease with mental health disorders in adolescents by administering questionnaires to adolescents and their parents. Average age of adolescents was 14.6 years at the time of survey and 11.2 years at the time of diagnosis.

    The researchers found no correlation between celiac disease and depression, anxiety, ADHD, age at survey, quality of life, age at diagnosis or length of time on a gluten free diet. However, the majority of adolescents and parental reports screened positive for major depressive disorder.

    Interestingly, a parent's perception of the state of their child's celiac disease impacted their perception of depression in their child.

    Dr. Cordova says that "the data suggests that early screening for depression in any adolescent with celiac disease is crucial to help optimize behavioral health,"

    Dr. Cordova's team plans to follow these patients into young adulthood, and aims to re-screen them again in 5 years.

    Reference: 

    • Cordova J, et al. Abstract #844. Presented at: Digestive Disease Week; May 21-24, 2016; San Diego
    Image Caption: Teens with celiac disease often have symptoms of depression. Image: CC--Rui Barros
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    Guest Heather

    Guest Heather

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    As an adult diagnosed with celiac, I began to feel much better after about a year on the gluten free diet, and was pleased that the major depression subsided. However, a new sadness and anxiety was ushered in when food choices became a tense exercise in label-reading, and when I could no longer participate the same way in social gatherings that were centered around group meals, or as it's said "breaking bread" together. Being that teens are at the most social point in their lives, I wonder if some of the depression is caused by the extra and sometimes sudden challenges of having to majorly change their diets, having to feel singled-out and "different", feeling excluded from various food-centered activities they once shared with friends, etc. As many of us know, depending on the amount of or lack of family and friend support regarding the gluten-free diet, it can be a very tough and scary time when you learn that foods you formerly enjoyed are now "the enemy". Pile this on top of all the unique social issues celiac teens must grapple with along with just the normal social issues all teens must tackle and you have a ripe environment for depression, it would seem.

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    admin
    Psychosomatics 45:325-335, August 2004
    Celiac.com 07/30/2004 - Past studies have reported a higher prevalence of depressive symptoms in adults with celiac disease, perhaps due to serotonergic dysfunction, and an increased prevalence of depressive and disruptive behavioral disorders in adolescence with the disease, especially before treatment. In an effort to further study any possible connections, researchers looked at 29 adolescents with celiac disease and 29 matched controls. The researchers used semi-structured psychiatric interviews and symptom measurement scales to examine all subjects. Their findings indicate that the subjects with celiac disease had significantly higher prevalence of major depressive disorder compared to the controls--31% versus 7%, and a significantly higher prevalence of disruptive behavior disorders--28% versus 3%. The researchers also found that most of the mental disorders occurred before the patients were diagnosed and treated with a gluten-free diet. The prevalence of current mental disorders was similar in both of the groups studied.
    Jefferson Adams
    Celiac.com 07/13/2010 - More and more, researchers are showing connections between inflammatory diseases, like celiac disease, and complex disorders, such as anxiety and depression. There's also a good amount of anecdotal evidence to suggest that people with celiac disease have higher rates of anxiety and depression than the general population.
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    The researchers are recommending that female celiacs on a gluten-free diet be screened for anxiety. The researchers included W. Häuser, K. H. Janke, B. Klump, M. Gregor, and A. Hinz of the Department of Internal Medicine I of the Klinikum Saarbrücken, Winterberg in Saarbrücken, Germany.
    The team set out to examine levels of depression and anxiety between adults with celiac disease following a gluten-free diet (GFD), and in control subjects drawn from the general population.
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    The team used regression analysis to test possible demographic and disease-related predictors of anxiety and depression in celiac disease. Demographic predictors included age, sex, social class, and family status. Disease-related predictors included latency to diagnosis, duration of GFD, compliance with GFD, thyroid disease.
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    Source:

    World J Gastroenterol. 2010 Jun 14;16(22):2780-7. PMID 20533598
    Jefferson Adams
    Celiac.com 10/03/2011 - A number of studies show that people with celiac disease have higher risk of depression and death from external causes, but there are no conclusive studies on death from suicide.
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    Source:

    Dig Liver Dis. 2011 Aug;43(8):616-22.
    Jefferson Adams
    Celiac.com 01/09/2012 - Women with celiac disease face a higher risk for depression than the general population, even once they have adopted a gluten-free diet, according to U.S. researchers.
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    Source:

    http://www.upi.com/Health_News/2011/12/28/Celiac-ups-depression-risk-for-women/UPI-75401325131984/#ixzz1iQynze9k.

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    J Clin Gastroenterol. 2018 Mar 1. doi: 10.1097/MCG.0000000000001018.
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    fdfworld.com