Celiac.com 03/15/2008 - For the first time, medical researchers have shown that an activation of the inflammatory response system accompanies major depression and that pro-inflammatory cytokines and lipopolysaccharide (LPS) may trigger symptoms of depression. In the face of the study results, researchers are recommending that patients with depression be screened for leaky gut using IgM and IgA panels.
Compared to the non-depressive control groups, patients with major depression (MDD) showed significantly greater prevalences and median values for serum IgM and IgA against LPS of enterobacteria. Increased levels of IgM and IgA are associated with fatigue, autonomic and gastro-intestinal symptoms and a subjective feeling of infection.
Leaky Gut a Factor in Major Depression
The results demonstrate that intestinal mucosal dysfunction marked by an elevated translocation of gram-negative bacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression.
Researchers are suggesting that IgM and IgA panels be used to screen people who suffer from depression for leaky gut.
Neuro Endocrinol Lett. 2008 Feb;29(1):117-24.