Celiac.com 03/09/2009 - Due to seemingly low rates of beta-cell autoimmunity among children with celiac disease, there is no need to screen these children for beta-cell autoimmunity markers, according to a report by Italian doctors in the February issue of Diabetes Care.
The doctors confirmed gluten-free diet compliance by testing for anti-endomysial antibodies and endomysial tissue transglutaminase antibodies.
Nine of the children (4.8%) tested positive for diabetes-related auto-antibodies. However, all of these children showed normal fasting blood glucose and A1C levels and, after 36 months of follow-up, none developed type 1-diabetes.
The researchers note that there is, between celiac disease and juvenile diabetes, a shared prodromic stage, with “auto-antibodies to islet or gut antigens.” Still, they note that their findings support those of other investigators, and that routine screening for diabetes-related antibodies in children with celiac disease is not warranted.
Diabetes Care 2009; 32:254-256.