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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    EARLY PREGNANCY LOSS IN CELIAC WOMEN: THE ROLE OF GENETIC MARKERS OF THROMBOPHILIA


    Jefferson Adams

    10/05/2009 - Pregnant women with celiac disease suffer early pregnancy loss more often than women without celiac disease. A team of Italian researchers recently set out to look at a possible role of genetic pro-thrombotic variants in early pregnancy loss in women with celiac disease.


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    The research team was made up of C. Ciacci, R. Tortora, O. Scudiero, R. Di Fiore, F. Salvatore, and G. Castaldo. The team looked at 39 women with celiac disease, who had experienced at least two early pregnancy losses within the first 3 months of pregnancy, a control group of 72 celiac women with a history of one or more normal pregnancies with no pregnancy loss.

    Each of the women were enrolled in the study immediately upon diagnosis for celiac disease, whereupon, the researchers obtained a clinical history obtained from each woman.

    The researchers then screened leukocyte DNA for factor V Leiden (mutation G1691A), factor V R2 (H1299R), factor II (G20210A), methylenetetrahydrofolate reductase
    (MTHFR) (C677T and A1298C), beta-fibrinogen (−455 G>A), PAI-1 alleles 4G/5G, factor XIII (V34L), and HPA-1 (L33P).

    Women with pregnancy losses were notably older (p = 0.002) among the celiacs than in controls. Of the gene variants examined, the allelic frequency of 4G variant of PAI-1, and the frequency of mutant genotypes were significantly more frequent in the group of celiac women with early pregnancy loss (p = 0.00003 and 0.028, respectively).

    Interestingly, the beta-fibrinogen −455 G>A genotype distribution differs substantially between the two groups, though frequency of the variant allele remains the same. The control group showed more frequent variant genotypes (p = 0.009).

    Based on these data, the research team believes the 4G variant of the PAI-I gene may predispose some celiac women who carry the gene to early pregnancy loss, though they note that their data should be confirmed on larger populations.


    Digestive and Liver DiseaseVolume 41, Issue 10, October 2009, Pages 717-720


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    Guest Elizabeth Belfiore

    Posted

    I had 2 premature births in my 20's & 30's. I am 62 & was

    diagnosed with celiac at 51. First premature ended after 36 hours and second one my daughter is now 31 years of age.

    She was born at the beginning of the 7 month and weighed

    2lbs 13ozs.

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    Guest Lisa Wu

    Posted

    I have 2 comments:

    1. Thank you for summarizing peer reviewed journal articles related to celiac disease! I appreciate hearing about the latest research and your articles always prompt me to look further, and obtain the full article if possible!

     

    2. I think you should make an important distinction in the 5th paragraph of your article. As I interpret the research article, the researchers noted a significant difference in age of diagnosis between the two groups, not age at which the pregnancy loss occurred. This does not come across as currently stated in your summary, and I think it is a critical point!

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    I totally agree with Marcia! I am 30 years old and was diagnosed a year ago with celiac. We have been trying to conceive for a year and a half now and I just had my first miscarriage and I would like more information on the connection between celiac and miscarriages and problems with conception. I read that once our bodies heal that it would become easier but it's been almost a year since my diagnosis.

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    Guest sabrina

    Posted

    Mandy my nutritionist told me that it takes 2-3 years to heal completely and there are certain things in your diet to change to help the healing.

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    Article a little hard to understand for the average person but still helpful. My story short and sweet. Started trying to get pregnant after marriage at 35. 8 pregnancies..3 births. All miscarriages around 11-14 weeks. After last baby was born which was 4 years ago I was so tired, so tired of looking pregnant all the time and always having stomach troubles. Was diagnosed with celiac disease in February of 2013.

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    admin

    Lancet 2000;356:399-400.
    (Celiac.com 08/13/2000) According to a recent study by Dr. Antonio Gasbarrini and colleagues from Gemelli Hospital, Catholic University, in Rome, celiac disease may play a role in recurrent spontaneous abortion and intrauterine fetal growth retardation. The researchers studied 44 patients who had a history of spontaneous abortion, 39 patients who had fetuses with intrauterine growth retardation and 50 normal controls. For each group the researchers measured serum concentrations of IgA anti-endomysial and IgG anti-transglutaminase.
    According to Dr. Antonio Gasbarrini: The patients with recurrent spontaneous abortion and those with intrauterine fetal growth retardation had a significantly higher frequency of serological markers of celiac disease than controls, as reported in the July 29th issue of The Lancet. Further, they found that three patients with recurrent spontaneous abortion (8%) and six patients whose fetuses had growth retardation (15%) tested positive for celiac disease. In addition, nine of the patients also underwent an endoscopy (jejunal biopsy), and eight were positive for celiac disease. Of the positive endoscopy group three patients showed duodenal mucosa with chronic inflammation and
    subtotal villous atrophy and five patients presented with severe mucosal atrophy.
    The researchers also point out that while about 1 in 1000 people in Europe have some symptomatic gluten-sensitivity, it is now becoming clear that a greater proportion of individuals have a clinically silent form of the
    disease, and probably many others have a minor form of enteropathy. Their research shows that it is important to recognize celiac disease as a possible risk factor for recurrent spontaneous abortion and intrauterine fetal growth retardation, but it remains to be seen whether the removal of gluten from the diet will decrease the incidence of both problems for women with celiac disease.

    admin

    Gastroenterology, 2005; 128: 849-855
    Celiac.com 04/29/2005 – In contrast to previous studies, the findings of a study by researchers in the United Kingdom indicate that women with celiac disease do not have an increased risk of infertility. Their study compared computerized primary care data on 1,521 women with celiac disease, and, unlike past studies, compared that data with 7,732 age and practice-matched women without celiac disease. They found that fertility rates were 48.2 live births per 1,000 person-years for women without celiac disease, while those with the disease had 47.7 live births. Interestingly the researchers found that women with celiac disease had lower fertility rates when they were younger, and higher rates when they were older, compared to the non-celiac group, and the increase in fertility seen in older women with the disease was not affected by whether they were on a gluten-containing vs. gluten-free diet. The researchers noted a slightly higher risk of miscarriage and delivery by cesarean section in the group of women with celiac disease, while all other negative outcomes occurred at a level similar to that of the healthy control group. The researchers conclude that women with celiac disease have similar fertility rates to that of the normal female population, and they tend to have their babies at an older age.

    Jefferson Adams
    Celiac.com 09/30/2011 - A new study indicates that women who suffer unexplained infertility suffer higher rates of undiagnosed celiac disease than those who do not experience unexplained infertility.
    The study appeared in the May-June issue of the Journal of Reproductive Medicine.
    Using serologic screening for celiac disease as well as routine infertility testing, Janet M. Choi, M.D., of Columbia University in New York City, led a study team that included B. Lebwohl, J. Wang, S. K. Lee, J. A. Murray, M. V. Sauer and P. H. R. Green.
    Together, they assessed 191 women with infertility. The researchers confirmed four women with positive serum test results to have celiac disease. That's 2.1 percent of the 188 patients who completed testing. The women received nutritional counseling to adopt a gluten-free diet.
    Now, this prevalence rate was not significantly higher than the expected 1.3 percent seen in the general population.
    However, three cases of undiagnosed celiac disease were seen among the 51 women with unexplained fertility, for a significantly higher prevalence rate of 5.9 percent.
    Interestingly, all four women found to have celiac disease successfully conceived within a year of diagnosis and treatment.
    From these results, the team concludes that women with unexplained infertility face a higher risk of undiagnosed celiac disease. They also suggest that this is a risk factor that can be mitigated, and treated.
    Source:

    The Journal of Reproductive Medicine

    Jefferson Adams
    Celiac.com 03/04/2015 - Women with infertility face higher rates of celiac disease, according to a recent data analysis.
    Until now, data connecting celiac disease and infertility has been contradictory. There are currently no recommendations regarding celiac disease screening in female patients with infertility.
    A research team recently conducted a meta-analysis to find out whether women with infertility have a higher risk for celiac disease. The team included Prashant Singh MBBS; Shubhangi Arora MBBS; Suman Lal MD; Tor A. Strand MD, PhD; and Govind K. Makharia MD, DM, DNB, MNAMS.
    To source information for their analysis, the team performed a literature search using the MeSH keywords "celiac disease," "gluten," and "infertility." They based celiac diagnosis on positive patient serology and biopsies showing villous atrophy. The team extracted celiac disease data in 3 groups of women with "all cause" infertility, unexplained infertility, and a group of control subjects. They then calculated pooled odds ratio (OR) and prevalence, with 95% confidence intervals (CI).
    Of 105 relevant studies, they included five studies for calculation of pooled odds ratio. Four additional studies, where data on controls were not available, were also considered for calculation of pooled rates of celiac disease.
    The analysis showed that women with infertility had 3.5 times higher odds of having celiac disease compared with the control group (OR=3.5; 95% CI, 1.3-9; P<0.01). Similarly, odds for celiac disease in women with "unexplained infertility" were 6 times greater than for control subjects (OR=6; 95% CI, 2.4-14.6).
    Of 884 women with infertility, 20 had celiac disease indicating a pooled prevalence of 2.3% (95% CI, 1.4-3.5).
    Of 623 women with "unexplained infertility," 20 had celiac disease. The pooled prevalence of celiac disease in women with unexplained infertility was 3.2% (95% CI, 2-4.9).
    Celiac disease is more common in women with what is called "all-cause" infertility and "unexplained" infertility, than in general population.
    Infertility and unexplained infertility can point to hidden celiac disease.
    Source:
    Journal of Clinical Gastroenterology. doi: 10.1097/MCG.0000000000000285

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    Tammy Rhodes
    Celiac.com 04/24/2018 - Did you know in 2017 alone, the United States had OVER TENS OF THOUSANDS of people evacuate their homes due to natural disasters such as fires, floods, hurricanes, tornadoes and tsunamis? Most evacuation sites are not equipped to feed your family the safe gluten free foods that are required to stay healthy.  Are you prepared in case of an emergency? Do you have your Gluten Free Emergency Food Bag ready to grab and go?  
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    Jefferson Adams
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    Source:
    J Clin Gastroenterol. 2018 Mar 1. doi: 10.1097/MCG.0000000000001018.

    Connie Sarros
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    Jefferson Adams
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    fdfworld.com

    Jefferson Adams
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    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764