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    People with Adult Celiac Disease are Shorter than their Peers


    Jefferson Adams


    • A new study shows that adults with celiac disease are shorter than their healthy counterparts.


    Image Caption: Adults with celiac disease are shorter than their healthy peers. Photo: CC--Ian D. Keating

    Celiac.com 11/14/2016 - Diagnosis of celiac disease is often delayed, sometimes into adulthood, but researchers don't have much good data on the possible consequences of such a delay.


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    There's plenty of data to show that pediatric patients with celiac disease are often short in stature. However, there's very little data on physical features, including height, of adult patients with celiac disease. A team of researchers recently set out to evaluate whether patients suffering from celiac disease are shorter in comparison with the general population without celiac disease. The research team included Abbas Esmaeilzadeh, Azita Ganji, Ladan Goshayeshi, Kamran Ghafarzadegan, Mehdi Afzal Aghayee, Homan Mosanen Mozafari, Hassan Saadatniya, Abdolrasol Hayatbakhsh, and Vahid Ghavami Ghanbarabadi.

    The team also assessed likely correlations between demographic and physical features, main complains, serum anti tTG level, and intestinal pathology damage between short versus tall stature celiac patients. They conducted a retrospective cross-sectional study on 219 adult patients diagnosed with celiac disease in the Celiac Disease Center, between June 2008 and June 2014 in Mashhad, Iran.

    All patients were between 18 and 60 years of age. The team compared the height of the study subjects against a group of 657 age- and sex-matched control cases from the healthy population. They then then compared the likely influencing factors on height such as intestinal pathology, serum level of anti-tissue transglutaminase (anti-tTG), serum vitamin D, and hemoglobin level at the time of diagnosis in short versus tall stature patients with celiac disease.

    All 65 male and 154 female celiac patients were shorter than their counterparts in the general population "(males: 168.5±8.6 to 171.3±7.2 cm, p less than 0.01 and females: 154.8±10.58 to 157.8±7.2 cm, p less than 0.01). Spearman linear correlation showed height in patient with celiac disease was correlated with serum hemoglobin (p less than 0.001, r=0.285) and bone mineral density (p less than 0.001) and not with serum vitamin D levels (p =0.024, r=0.237), but was not correlated with anti-tTG serum levels (p=0.97)."

    Celiac patients with upper and lower quartile of height in men and women had no significant difference in the anti-tTG level and degree of duodenal pathology (Marsh grade). Shorter patients more commonly experienced anemia than taller patients.

    Adults with celiac disease are definitely shorter compared with healthy adults. There is a direct correlation between height and anemia and bone mineral density. This study really drives home the importance of early detection and treatment of celiac disease.

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    Diagnosed with celiac disease at 21 years old. I am a female 5'8â€. My mom is 5´ 6" dad is 5´9". Don´t seem to fit your theory. I never eat out because of cross contamination. Keep researching. Hoping for a cure.

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    Guest Jefferson Adams

    Posted

    Diagnosed with celiac disease at 21 years old. I am a female 5'8â€. My mom is 5´ 6" dad is 5´9". Don´t seem to fit your theory. I never eat out because of cross contamination. Keep researching. Hoping for a cure.

    The article says that most, but by no means all, people with adult celiac disease are shorter than their peers. That means there will can still be tall people with adult celiac disease, just that they are the exception that proves the rule.

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    Diagnosed with celiac disease at 31 years old. I´m a 5´8" female. My mom is 5´5" dad with celiac disease was 6" and my sister who doesn´t have celiac disease is 5´5 1/2" and my niece with celiac disease is on target with her I don´t seem to fit the theory either.

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    Guest Jared M.

    Posted

    That's too bad. I´m 6´3". Maybe without celiac I could've been tall enough to be a center in basketball.

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    Diagnosed at age 70. Had food problems at age 3, slow growth until age 14. Often anemic. now 5´4". Mother 5´6" Sister 5´8" Brothers over 6´ Father 5´9". Had Lyme Disease. Endometriosis. Osteoporosis. Chemical sensitivities and allergies. Unnecessary sinus operation. Lack of stamina. Was told "it was all in my head" when I went to physicians. Have BS Public Health, MA Molecular Genetics but was too tired to go on for PhD. Now 80. Took about 8 years on gluten-free diet to recover.

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    Guest Kurt Ashton

    Posted

    I am 47 years old, and 6ft. -8".... Whoever came up with that scientific theory is off the mark!!

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    I agree with the other commenters. I'm 5'10 and have celiac disease and vitamin B12 anemia. This doesn't really seem to fit their theory.

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    Guest Jefferson Adams

    Posted

    Diagnosed with celiac disease at 31 years old. I´m a 5´8" female. My mom is 5´5" dad with celiac disease was 6" and my sister who doesn´t have celiac disease is 5´5 1/2" and my niece with celiac disease is on target with her I don´t seem to fit the theory either.

    Not picking on Alicia and Hannah specifically, but you have both misread the data here. First, it's not a theory, it is a simple data set from a large population with adult celiac disease. The data show that MOST people with adult celiac disease are shorter than their peers. It can be true that most people with celiac disease are shorter than their peers, AND true that a few rare individuals can also have adult celiac disease and be taller than their peers. BOTH things can be true. In fact, that's exactly what the data says: People with adult celiac disease who are taller than their peers are the exception, they are rare; most are shorter. The data says absolutely nothing about people without adult celiac disease, be they short or tall. I hope that helps.

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    Guest Janice Lamb

    Posted

    Diagnosed at 52. I'm 5'1, my mother was 5'4 1/2" and father 5´8" Also was anemic and had osteopenia.

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    Guest Janice Lamb

    Posted

    I'm 5'1" My mother was 5'4 1/2" and my father was 5'8". Also diagnosed at 52 years old and was anemic and had low bone density..

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    I am the only one who has been tested for celiac disease in my family. I am several inches shorter then all the women, but I am not short at 5'6".

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    Guest Jefferson Adams

    Posted

    I am the only one who has been tested for celiac disease in my family. I am several inches shorter then all the women, but I am not short at 5'6".

    The best way to think of it is this: If you had a genetically identical twin without celiac disease, you would likely be a bit shorter, regardless of how tall you both were overall.

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    Guest Jefferson Adams

    Posted

    I agree with the other commenters. I'm 5'10 and have celiac disease and vitamin B12 anemia. This doesn't really seem to fit their theory.

    Please understand that this is not a theory, but is scientifically collected data. Think of it this way: If you had an identical twin without celiac disease, your twin would likely be taller than you, say 5´11" or 6´0". It would also be true if you were both on the shorter side, i.e., twin would likely be taller.

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    My own experience with stuttering is limited. I stuttered as a child when I became nervous, upset, or self-conscious. Although I have been gluten free for many years, I haven’t noticed any impact on my inclination to stutter when upset. I don’t know if they are related, but I have also had challenges with speaking when distressed and I have noticed a substantial improvement in this area since removing gluten from my diet. Nonetheless, I have long wondered if there is a connection between gluten consumption and stuttering. Having done the research for this article, I would now encourage stutterers to try a gluten free diet for six months to see if it will reduce or eliminate their stutter. Meanwhile, I hope that some investigator out there will research this matter, publish her findings, and start the ball rolling toward getting some definitive answers to this question.
    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

    Jefferson Adams
    Celiac.com 06/14/2018 - Refractory celiac disease type II (RCDII) is a rare complication of celiac disease that has high death rates. To diagnose RCDII, doctors identify a clonal population of phenotypically aberrant intraepithelial lymphocytes (IELs). 
    However, researchers really don’t have much data regarding the frequency and significance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. Such data could provide useful comparison information for patients with RCDII, among other things.
    To that end, a research team recently set out to try to get some information about the frequency and importance of clonal T cell receptor (TCR) gene rearrangements (TCR-GRs) in small bowel (SB) biopsies of patients without RCDII. The research team included Shafinaz Hussein, Tatyana Gindin, Stephen M Lagana, Carolina Arguelles-Grande, Suneeta Krishnareddy, Bachir Alobeid, Suzanne K Lewis, Mahesh M Mansukhani, Peter H R Green, and Govind Bhagat.
    They are variously affiliated with the Department of Pathology and Cell Biology, and the Department of Medicine at the Celiac Disease Center, New York Presbyterian Hospital/Columbia University Medical Center, New York, USA. Their team analyzed results of TCR-GR analyses performed on SB biopsies at our institution over a 3-year period, which were obtained from eight active celiac disease, 172 celiac disease on gluten-free diet, 33 RCDI, and three RCDII patients and 14 patients without celiac disease. 
    Clonal TCR-GRs are not infrequent in cases lacking features of RCDII, while PCPs are frequent in all disease phases. TCR-GR results should be assessed in conjunction with immunophenotypic, histological and clinical findings for appropriate diagnosis and classification of RCD.
    The team divided the TCR-GR patterns into clonal, polyclonal and prominent clonal peaks (PCPs), and correlated these patterns with clinical and pathological features. In all, they detected clonal TCR-GR products in biopsies from 67% of patients with RCDII, 17% of patients with RCDI and 6% of patients with gluten-free diet. They found PCPs in all disease phases, but saw no significant difference in the TCR-GR patterns between the non-RCDII disease categories (p=0.39). 
    They also noted a higher frequency of surface CD3(−) IELs in cases with clonal TCR-GR, but the PCP pattern showed no associations with any clinical or pathological feature. 
    Repeat biopsy showed that the clonal or PCP pattern persisted for up to 2 years with no evidence of RCDII. The study indicates that better understanding of clonal T cell receptor gene rearrangements may help researchers improve refractory celiac diagnosis. 
    Source:
    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023