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    Impotency and Celiac Disease


    Scott Adams


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    Hyperprolactinaemia is seen in 25% of celiac patients, which causes impotence and loss of libido. This quote was taken from an abstract at the following cite: Dig Dis, 12(3):186-190 1994, May-Jun. The title of the article is Infertility, Obstetric and Gynaecological Problems in Celiac Sprue. Here are some more references:

    • Molteni N, Bardella MT, Bianchi PA. Obstetric and gynecological problems in women with untreated celiac sprue. J Clin Gastroenterol 1990; 12: 37-9.
    • Sher KS, Mayberry JF. Female fertility, obstetric and gynaecological history in celiac disease. A case control study. Digestion 1994; 55: 243-6.
    • Sher KS, Jayanthi V, Probert CS, Stewart CR, Mayberry JF. Infertility, obstetric and gynaecological problems in celiac sprue. Dig Dis 1994; 12:186-90.
    • McCann JP, Nicholls DP, Verzin JA. Adult celiac disease presenting with infertility. Ulster Med J 1988; 57: 88-9.
    • Ferguson R, Holmes GKT, Cooke WT. Celiac disease, fertility and pregnancy. Scand J Gastroenterol 1982; 17: 65-8.
    • The good news is that the overwhelming opinion was that adherence to a strict gluten free diet should and would restore fertility if the infertility was a result of celiac disease.
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    Absolutely zero mention about the effects of Celiac on WOMEN'S infertility.

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    I was looking for information regarding C.D./gluten intolerance and male sexual health... this article is too short, non-informative and all your reference articles lead back to female issues? Bleh.

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  • About Me

    In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I founded The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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  • Related Articles

    Diana Gitig Ph.D.
    Celiac.com 07/11/2011 - Is celiac disease associated with infertility? Although some reports suggest that as much of 8% of women with unexplained infertility have celiac disease, others found no correlation between the two conditions. And there is little hard evidence that celiac disease is an actual cause of infertility. To begin to bring some clarity to this issue, Khoshbaten et al. tried to determine the prevalence of celiac disease among couples with unexplained infertility in Iran. Their results are reported in the Journal of Obstetrics and Gynaecology Research.
    Infertile couples were recruited in Tabriz, Iran, between October 2006 and September 2007. After a complete evaluation of their endocrine status, one hundred couples with unexplained infertility were chosen for this study. Two hundred couples with at least one child and no reproductive problems served as controls. Thirteen infertile subjects - 5 men and 8 women - had elevated levels of tissue transglutaminase antibodies, compared to eleven controls - 4 men and 7 women. Fourteen infertile subjects and eleven controls were found to be IgA deficient; of these, three of each had elevated tissue transglutaminase IgG. Based on this serology, the researchers note that the likelihood of celiac disease in infertile patients is 2.39 times higher than in controls; the frequency of celiac disease is 8% in infertile patients, compared to 3.5% in controls.
    Only five infertile subjects and four controls with elevated tissue transglutaminase antibodies agreed to have duodenal mucosal biopsies; the remainder had no gastrointestinal complaints or other symptoms, so they opted out of the endoscopy. According to the biopsy, celiac disease was indicated in three cases of unexplained infertility compared to one case in the control group.
    Previous studies have demonstrated that men with celiac disease have an increased incidence of hypogonadism, sexual dysfunction, and poor semen quality. Women with celiac disease can have major menstrual problems. Systemic diseases like celiac can exert subtle effects on the reproductive system in both genders. A gluten free diet can alleviate infertility if it is caused by nutritional imbalances due to celiac disease, such as malabsorption of zinc, selenium, iron, and folate.
    This Iranian study, like previous studies in Finland, Italy, Israel, and the US, thus seems to come down on the side of celiac disease, as measured by serological markers, being more significantly frequent among couples with unexplained infertility than in controls.
    Source:

    Khoshbaten M, Nejad MR, Farzady L, Sharifi N, Hashemi SH, and Rostami K. Fertility disorder associated with celiac disease in males and females: fact or fiction? J. Obstet. Gynaecol. Res. 2011.

    Jefferson Adams
    Celiac.com 12/08/2011 - Researchers have shown that celiac disease and Toxoplasma gondii infection can both cause a strong neutrophil-mediated immune reaction that can have an adverse impact pregnancy outcomes.
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    After childbirth, those patients satisfied for follow-up who tested positive for anti-tissue transglutaminase submitted to biopsy specimens. The team evaluated biopsies using Marsh-Rostami classification.
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    Three patients with Marsh I, IIIa, and IIIc also positive IgG showed Toxoplasma gondii infections.
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    The results of this study show patients with positive celiac disease-serology had higher overall rates of Toxoplasma gondii infection rates than did those with negative celiac disease serology, but celiac disease did not trigger increase in proinflammatory cytokines, such as IL8.
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    Source:

    American Journal of Gastroenterology doi: 10.1038 / ajg.2010.425

    Diana Gitig Ph.D.
    Celiac.com 12/20/2011 - There has been some controversy surrounding the idea that there is a higher prevalence of undiagnosed celiac disease in people with infertility, with some studies finding it but others not. Most of these studies have been performed in Europe; only two to date have taken place in the United States. Peter Green’s group at Columbia recently tried to establish the actual prevalence of undiagnosed celiac disease in the infertile population in the United States, to determine if it would make sense to routinely screen a subgroup of infertile patients for celiac disease. Their results are published in The Journal of Reproductive Medicine.
    Study participants were recruited from the population who came to Columbia’s Center for Women’s Reproductive Care to deal with their infertility issues, which they had been coping with for at least a year. One hundred eight-eight women, ages 25-39, volunteered to participate in the study. They underwent serological screening for tissue transglutaminase (tTG IgA) and endomysial antibodies (EMA IgA), and measurement of total IgA and both IgA and IgG antigliadin antibodies was done to control for the potential IgA deficiency in some individuals. Four of the 188 patients enrolled in the study were diagnosed with celiac disease, making the prevalence of celiac disease in this population 2.1%. Yet a subgroup analysis of the prevalence of celiac disease in women with unexplained fertility revealed a prevalence of 5.9%, which achieves statistical significance.
    All four women reported suffering from gastrointestinal symptoms before their diagnosis, and they had a significantly increased prevalence of Irritable Bowel Syndrome as well. The authors admit that this is quite a small sample, and because screening was voluntary, it is also a selected population.
    But even so, they suggest that physicians should inquire about GI symptoms when patients present with infertility, and that screening for celiac is appropriate in those with unexplained infertility who complain of gastrointestinal distress. They even go so far as to posit that all women with unexplained infertility be screened for celiac, even if they don’t have gastrointestinal trouble.
    All four women conceived within ten months after starting on a gluten free diet, two naturally and two with help. And all of them went on to deliver healthy babies.
    Source:

    Choi JM, Lebwohl B, Wang J, Lee SK, Murray JA, Sauer MV, Green PH. Increased prevalence of celiac disease in patients with unexplained infertility in the United States. J Reprod Med. 2011 May-Jun; 56(5-6):199-203.

    Jefferson Adams
    Celiac.com 11/05/2012 - Over the last 40 years, studies have shown higher rates of menstrual abnormalities and pregnancy complications among women with celiac disease.
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    The research team was led by Stephanie M. Moleski, MD, of Thomas Jefferson University Hospitals in Philadelphia. Dr. Moleski presented an abstract of the study data at the American College of Gastroenterology Annual Meeting 2012.
    In the abstract, she points out that women with biopsy-proven celiac disease had significantly higher rates of fertility and pregnancy complications and gave birth to less children than those without the disease.
    Because it is an abstract, the study data and conclusions should be regarded as preliminary until they appear in a peer-reviewed journal, where they can be given a fuller context and be more widely scrutinized.
    For their study, Dr. Moleski and her colleagues recruited patients treated for celiac disease at Thomas Jefferson University Hospitals, as well as members of the National Foundation for Celiac Awareness and the Gluten Intolerance Group, to respond in an anonymous Internet-based survey about fertility and pregnancy. Women without celiac disease also completed the survey and served as a control group.
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    Sources:
    Medpagetoday.com American College of Gastroenterology, 2012; Moleski SM, et al "Infertility and pregnancy outcomes in celiac disease" ACG 2012; Abstract 15.

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    Source:
    Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2. doi: 10.1016/j.cgh.2017.06.037.