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    Migraine Headaches: Gluten Triggers Severe Headaches in Sensitive Individuals


    Scott Adams


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    Neurology 2001;56:385-388.

    Celiac.com 02/15/2001 - According to a new study published in the February issue of Neurology, severe, chronic migraine headaches can be triggered in gluten-sensitive individuals who do not exclude gluten from their diets. The study examined ten patients who had a long history of chronic headaches that had recently worsened, or were resistant to treatment. Some patients had additional symptoms such as lack of balance. Dr. Marios Hadjivassiliou, from the Royal Hallamshire Hospital in Sheffield, UK, and colleagues tested each patient and found that all were sensitive to gluten. . The patients were tested and each was found to be gluten-sensitive. Additionally, MRI scans determined that each had inflammation in their central nervous systems caused by gluten-sensitivity.

    Results: Nine out of 10 patients went on a gluten-free diet, and seven of them stopped having headaches completely. The patients heightened immune responses, which are triggered by the ingestion of gluten, could be one of the factors causing the headaches. The other two patients who were on a gluten-free diet experienced significant relief, but not complete relief.

    Conclusion: According to Dr. Hadjivassiliou, removal of the trigger factor by the introduction of a gluten-free diet may be a promising therapeutic intervention for patients with chronic headaches. Further studies are needed to confirm Dr. Hadjivassilious preliminary findings.

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    Guest glojo

    Posted

    My 8 year old son went on a gluten and dairy free diet 2 weeks ago - he had chronic daily migraines and facial spasms - they have entirely disappeared - there is a definite link between your diet and migraines! It's a lot of hard work to change your eating pattern - but it so worth it! Good luck~

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    Guest Patrice

    Posted

    This article was very helpful. I've been having headaches almost daily for the past year and I'm now considering to be tested to see if I'm sensitive to gluten.

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    Great article! I had migraines 2 to 5 times a week for over 10 years and they stopped completely after a couple of days of eating gluten-free. I have been gluten-free for about 6 months and they have not come back.

     

    Is there a way to make migraines one of the common symptoms caused by an intolerance to gluten? Every list I looked at stated many symptoms but rarely said anything about migraines (or headaches in general).

     

    Also, I had an MD tell me that an intolerance to gluten cannot cause migraines or headaches. Would there be a way of informing them that, yes, it can cause migraines?

     

    Cheers

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    Wow,

    I am thrilled to know that I might have found why I have been so sick those past years. I have seen different specialists and they couldn't figure what was the reason I had those multiple symptoms (chronic migraines, constipation/diahrrea, lack of appetite, fatigue etc). Usually, the doctors I went through only said: Well, here's a prescription. That made me angry because I wanted to find the cause. I couldn't find a pattern that helped me figured what was wrong. Celiac disease makes sense since gluten is found in lots of products. I'm seeing my doctor next month and I will make sure to ask for tests I need to go through to find if I have celiac disease.

    Thanks for sharing!

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    My husband has had severe headaches and migraines for many years and medication has not helped. We went on a diet last fall that only allowed some fruits, vegetables, beef, chicken and fish. His headaches and migraines disappeared completely. Now off the strict diet, we started adding things back to our diet and through process of elimination, have determined what was causing his migraines - gluten.

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    Guest Mariateek

    Posted

    Great article I suffer with aura migraines since childhood. Yesterday I had an intense blind spots and other aura migraine symptoms. I have been gluten free for 6 months and I ate a small amount of gluten yesterday resulting in nausea intense stomach pain and an intense aura migraine. Diet is so important to our immune system.

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    Guest ken craig

    Posted

    I am a celiac and I do get migraines. These can usually be traced to accidental gluten ingestion. Thanks for the information.

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    I have had daily "atypical" Migraines on a daily basis for the past three years while under the care of a neurologist. A nerve block injection at the base of the skull helped for a short time and then several months ago a total of 31 botox injections in one setting in the back of the neck, skull, side of the head, and forehead worked for a few months. However, a repeat procedure was not really successful. Over the years I took many of the usual medications which did not help over the long run to prevent the headaches. However, the Triptans worked great for relieving/stopping the headaches once they started. The good news is that a recent endoscopy and biopsy revealed that I had celiac disease. I just recently went on the gluten free diet and my migraines basically went away after about three weeks (I still take some preventative meds in conjunction with the diet) but I have not had to take a triptan to kill a headache which I did before on almost a daily plus basis. I plan on slowly backing off the preventative meds.

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    I have had daily "atypical" Migraines on a daily basis for the past three years while under the care of a neurologist. A nerve block injection at the base of the skull helped for a short time and then several months ago a total of 31 botox injections in one setting in the back of the neck, skull, side of the head, and forehead worked for a few months. However, a repeat procedure was not really successful. Over the years I took many of the usual medications which did not help over the long run to prevent the headaches. However, the Triptans worked great for relieving/stopping the headaches once they started. The good news is that a recent endoscopy and biopsy revealed that I had celiac disease. I just recently went on the gluten free diet and my migraines basically went away after about three weeks (I still take some preventative meds in conjunction with the diet) but I have not had to take a triptan to kill a headache which I did before on almost a daily plus basis. I plan on slowly backing off the preventative meds.

    Hi Frank, I am glad to hear that you are feeling better. Did your doctor think you had celiac disease before the endoscopy? I believe it is possible I might have celiac sensitivity and had just googled celiac and migraines and found this page. I will have an endoscopy and colonoscopy next week. I plan on asking my doc if he will take the necessary biopsies to test for celiac. I just tried Topamax and I had to stop because of side effects. Good Luck!

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    Would love to believe that this is the answer for my husband's migraine problem. 13 years now and we haven't found a solution. Dr.'s all want to through a script at him and no one wants to eliminate the source. He has kept a food diary, tried preventatives (Topamax and Nortriptyline), massage therapy, chiropractor and acupuncture. Mouthguard for TMJ, special pillows and his only help is the Imitrex he takes for pain when he gets a headache. I started him gluten free yesterday (January 1) and on day two, he has a migraine. Hoping it will just take a few weeks and then they'll be gone. Don't know what to do next if it isn't gluten.

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    Guest Rochelle

    Posted

    More positive reinforcement. I have suffered from migraines since 4th grade. It was assumed the cause was hormones. Over time, they got worse, until about 10 years ago they were so bad I was put on a steady diet of narcotics to relieve the pain and allow me moderate function. They keep getting worse, with doctors throwing all manner of drugs at me just to see if they would help. The headaches are constant and daily, migraines, tension headaches, cluster headaches etc. I finally got to the end of the line, the 37 Botox injections across my head and down my neck. Supposed to last 3 months, they lasted 3 weeks, the biggest improvement i had felt in 10 years. I am now at the point of applying for disability because I can no longer work or even effectively care for my children. My sister has been bugging me about trying a gluten free diet, but i love love french bread, bagels, etc. Finally i said, why not just try it? That was four days ago. I have not had any significant headache since. I am cautious, since it is hard to credit that after more than twenty years of endless pain, it could end with such a simple solution. But it really does seem to be working. Hooray! I can barely imagine that i will be able to smile and play with my kids and not yell at them to be quiet.

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    Guest Rochelle

    Posted

    Would love to believe that this is the answer for my husband's migraine problem. 13 years now and we haven't found a solution. Dr.'s all want to through a script at him and no one wants to eliminate the source. He has kept a food diary, tried preventatives (Topamax and Nortriptyline), massage therapy, chiropractor and acupuncture. Mouthguard for TMJ, special pillows and his only help is the Imitrex he takes for pain when he gets a headache. I started him gluten free yesterday (January 1) and on day two, he has a migraine. Hoping it will just take a few weeks and then they'll be gone. Don't know what to do next if it isn't gluten.

    Tracy, your husband's story is similar to mine, I have had all kinds of meds thrown at me, mood stabilizers, antidepressants, muscle relaxers, narcotics, steroids, massage, acupuncture, magnesium creams, hormone therapy, etc. Finally did Botox, which helped a little but lasted 3 weeks instead of 3 months. The gluten free diet seems to be helping me, but it has been only 4 days so I am cautious. My point is to not give up, and don't resign yourselves to never finding the cause. There is one, and it is worth it to keep looking, although it can be incredibly difficult to be hopeful with so much pain.

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    I've had migraines for 5+years. Started on gluten free 3 weeks ago (along with caffeine, chocolate, dairy and everything else in heal your headache 1-2-3 book). I can't be positive, but I think it's the gluten-free that's helping. There are a lot of good foods out there! The key is planning. I'll take a limited diet over chronic headaches any day!

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    Guest Becky

    Posted

    More positive reinforcement. I have suffered from migraines since 4th grade. It was assumed the cause was hormones. Over time, they got worse, until about 10 years ago they were so bad I was put on a steady diet of narcotics to relieve the pain and allow me moderate function. They keep getting worse, with doctors throwing all manner of drugs at me just to see if they would help. The headaches are constant and daily, migraines, tension headaches, cluster headaches etc. I finally got to the end of the line, the 37 Botox injections across my head and down my neck. Supposed to last 3 months, they lasted 3 weeks, the biggest improvement i had felt in 10 years. I am now at the point of applying for disability because I can no longer work or even effectively care for my children. My sister has been bugging me about trying a gluten free diet, but i love love french bread, bagels, etc. Finally i said, why not just try it? That was four days ago. I have not had any significant headache since. I am cautious, since it is hard to credit that after more than twenty years of endless pain, it could end with such a simple solution. But it really does seem to be working. Hooray! I can barely imagine that i will be able to smile and play with my kids and not yell at them to be quiet.

    How are you feeling now Rochelle? I've had progressive headaches for 6 years now. I was told about gluten and am on day 6 of my gluten free diet and doing excellent. I will see after 1 month how I feel. I am not hopeful about anything since I've been let down so many times with so many medications. Nothing has seem to help over the years and started on narcotic medication for about 1-2 months this past year to help the pain.

    My headaches were like yours, constant and daily. They've found no medical reasons for them.

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    I have been gluten-free for 6 months. My everyday headaches are gone. And during my period, I only have 1 day with a small headache instead of a week and a half of severve migraine. What a difference. And my stomach pain and bloating are gone too.

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    Guest j viles

    Posted

    It is so reassuring to hear about other people like you. Also, it is encouraging to know I'm not the only one who has lost faith in doctors. Thank God for the internet... we can research and help ourselves!

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    My husband has had severe headaches and migraines for many years and medication has not helped. We went on a diet last fall that only allowed some fruits, vegetables, beef, chicken and fish. His headaches and migraines disappeared completely. Now off the strict diet, we started adding things back to our diet and through process of elimination, have determined what was causing his migraines - gluten.

    How long before he noticed a difference after changing his diet?

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    I have the reverse... I started a gluten-free diet two weeks ago and my migraines are more often and a lot worse!

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    Guest Julie

    Posted

    I am so grateful for all the information provided here. I've suffered from migraines for 26 years. My doctorsays that I'm the worst patient in the clinic. Mine are treated in a combination of medication: Topamax, Nadolol, Nortryptilyne. Unfortunately with all this I still get migraines. I avoid some food items and alcohol. I know what my triggers are. I need to keep a routine, which is a bit difficult with four children. I'm grateful that I'm not working at the present time. We are in the process of re-locating. I have suffered from chronic migraines, constipation/diarrhea, lack of appetite, fatigue etc). I also have an aura with my migraines, it's a surefire of what's coming. A severe car accident that resulted in whiplash did not help me either. My doctor diagnosed me with IBS and I'm also lactose intolerant. The info provided here do describe me here very well. I will discuss this with my doctor as I do not wish to take medication for the rest of my life. Thank you!

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    Guest Beatrice

    Posted

    I kept a diary of my headaches which were one side of my head, like a knife in the side of my brain, each pulse just excrutiating. I had these from new years eve 2007 until January 2013, when I went off gluten. I felt them in my sleep they were so bad. the occurence was once or twice a month lasting two to four days. I also had knuckle pain in my hand joints - both hands. I've not had one headache since going off gluten and my hands are back to normal. It took six weeks to completely eradicate the so called 'arthritis' in my hands for which i was prescribed heavy duty medication, so if you are only a few days in, hang in there. Give it six weeks. I've never felt better. I keep a symptom diary and can easily see the timing. One week of experimental back on gluten trial and the headache came back. Not willing to risk it again.

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    Guest Diane

    Posted

    Great to read so much hope for migraine sufferers!

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    Guest Rebecca

    Posted

    For those of you who went gluten-free and it helped your migraines, how long did it take to notice a difference? I'm on day 10 of gluten-free and haven't noticed any difference at all, I've called a few doctors and no one seems to know how long it should take.

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    For those of you who went gluten-free and it helped your migraines, how long did it take to notice a difference? I'm on day 10 of gluten-free and haven't noticed any difference at all, I've called a few doctors and no one seems to know how long it should take.

    I've been told by holistic practitioners that taking gluten out of your diet should be done for at least 6 weeks before you can tell if it works or not. It takes that long for all of the gluten to leave your system.

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    Guest Joyce

    Posted

    Wouldn't it be nice to know that it has been gluten all these years? I have suffered, like so many, from chronic headaches. My daughter looks at me and says, "You have another headache today?" But I continue on through the pain! The hope in reading these posts is a hope that I haven't felt in a long time. I have been on so many meds and herbal remedies that help for a short time, but that is it. I will definitely take a step forward to seeing if in fact all that I am going through is due to gluten.

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    Good article. I recently read the book naturally pain free, which had the elimination diet in (no gluten, dairy, sugar,chocolate, red meat ect) it. I got the book so I could find foods and herbs to relieve my chronic migraine, muscle, nerve and joint pain. After a few days on the diet I notices my chronic daily IBS symptoms were almost gone, as was my heart burn. So after a week and a half I ate some multigrain bread in the morning and yogurt around 7pm. That night I started having IBS issues heart burn, increased pins and needles sensations in my fingertips and lips. My heart rate also increased and my migraine went to severe status. Went to see my Dr today and she agrees it probably a gluten and/or lactose intolerance. It's amazing that after 3 yrs of treatments, meds and specialist this is probably the cause. I told my doctors about the IBS, tingling in lips and heart burn long ago and they just gave me meds to treat it, never considering I may have food intolerance. I have been on disability for over 2 yrs which has probably ruined my career if I'm ever able to get back in the work force. Man, am I ever glad I got that book, may have saved my sanity.

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    In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I founded The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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    But, five yearslater, I learned that there could be more than one trigger for mymigraines and unfortunately, gluten was only one of them.After two cycles of pregnancy and nursing, my hormones eventually normalized into a regular cycle.Now, that, in and of itself, amazed me, that for the first time in my life my body had learned to have a 4-week textbook cycle.But, along with those cycles came the worst migraines I had ever experienced in my life.I realized, sadly, that gluten wasn’t my only migraine trigger.I could avoid gluten, but I couldn’t avoid my cycle.Theirony of it all struck hard– the gluten free diet had made me healthyenough to have a regular cycle – a regular cycle attached with horrificmigraines.Once again, I was going from doctor to doctor,but this time (unlike the years until my celiac diagnosis), I receiveda fast diagnosis – menstrual migraine.The neurologistwho diagnosed me said that they were probably the worst type ofmigraine out there – very resistant to medication, fierce in theirstrength, and often lasting for days.Well, he hasn’t been wrong.
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    Before I go on, I dowant to say that staying on the gluten-free diet is the only option tohaving a good life at all – even though it allows the cycles that bringthe migraines.Before going gluten-free, I was sick all the time with migraines.Now I am much healthier, but do get terrible cyclical migraines.I obviously choose the latter.
    This article focuses on migraine prevention.Ido have in my cabinet some very expensive, strong prescription triptans(Amerge works the best for me) and these are a necessity…simply becauseI do not want to land up in my local emergency room with a migrainethat feels like it’s killing me.I think of the prescriptions as my rescue doses, for those times when all the prevention and care in the world fails.
    I have tried many,many preventative treatments – supplements, herbs, Chinese medicine,bioidentical hormone pills, natural hormone creams, allergy treatments,massage, chiropractic, and even acupuncture.People swearby massage and acupuncture, I tried it some, but did not perceiveenough of a benefit to continue – the expense alone was giving me amigraine.
    To date, nothing has taken away my migraines, but the following items have definitely helped.And, the good news is that every item listed is affordable and completely doable! 
    Wakeup at the same time every day.  My neurologist has a beautifulexplanation as to why this can prevent a migraine, and it surprisinglyhas nothing to do with low blood sugar!  I cannot remember his eloquentexplanation.  But, many migraine sufferers will find they get amigraine on their day off – the “Saturday Migraine”.  Usually, it’sfrom sleeping in and messing up the sensitive sleep/wake cycle.  Myalarm has one setting – for week days as well as weekends.  If I’mtired later in the day from getting up early after a late night (whichwould usually happen on a weekend), I do my best to take a nap, but Irarely sleep in. B complex.  Every migraine guide you read anywhere, always mentions theB vitamins.  As I have already posted, and others have commented,celiacs have low absorption of the B vitamins since often the damagedportion of the small intestine is where absorption of B’s shouldoccur.  This can be overcome by taking large doses of B’s.  I finallyfound a B-complex I can tolerate, and that’s Solgar B50.  They have astronger dose, Solgar B100, but the B50 works for me.  B2 is oftensingled out for migraine sufferers, and Solgar makes an isolated B2,but this doesn’t work well for me.  It may for you, and at under $10,it’s certainly worth a try – in fact, I wish I could give you some ofmy almost-full bottle to try! Magnesium.  I’ve taken magnesiumall along, but recently, from a commercial on the celiac website in themigraine section, I read about Dermamag.  (My husband joked with methat purchasing a supplement from an online Ad, was akin to finding adate on the internet, but it does look like this has been a goodthing!)  The premise behind Dermamag, is that people with migraines arenot absorbing enough magnesium through their digestive systems (soundslike a celiac to me), and that their “patented” formula is the first ofits kind to deliver it through the skin.  Well, $29 and a few dayslater, my first bottle arrived, and I must say, I’ve been quitepleased.  It does sting my skin a bit, so I apply it to wet skin, butit has definitely stopped a few days from turning into migraine daysthese past few weeks.  I’m hoping that after a few months of use, theoverall benefit will increase.  It might work just as well to soak in abath of Epsom salts every night, and it would certainly be cheaper, butyou know, that isn’t a “patented” way to increase your magnesiumlevels!!! Lemon Juice.  About three years ago I read a littleside article in an educators magazine, of all places, that women intheir mid-thirties often start experiencing terrible cyclicalheadaches.  The article blamed this on our western acidic diets andwent on to say that one of the best ways to counteract an acidic dietis to squeeze lemon in your water.  Now, that made about as much senseto me as nothing – since lemons are acidic themselves, but lemons arecheap – much cheaper than the dozens of supplements I have tried overthe years.  I have since been told that although they are acidic, theirnet effect in the body is basic (?!!) but illogical logic aside, Istarted squeezing lemons into my water that same day and for THREEMONTHS I did not have one migraine.  Of course, you have to be carefulnot to overdo it – too much acid cannot be good for a sensitivestomach.  Currently, I consume at least one lemon every day – mostpeople go to the store when they run out of milk, I go when I run outof lemons.  I honestly think that at this point in my migraine journey,without “lemon-water” I would have a migraine every day. Vitamin D.  I actually break open my vitamin D capsule and rub it on myskin every other day.  I know the latest articles are pushing 4000 IU’sof vitamin D a day and higher, but if I take that much (orally ortransdermally) I get welts on my skin.  I showed the welts to a healthcare practitioner once and he immediately said they were from excessvitamin D.  I reduced my dose and find that 2000IU every other dayseems to be optimum for me. Evening Primrose Oil (EPO) fromHemp Oil.  I think, I hope, I pray, that this oil is turning into myown personal magic bullet.  A few months ago I purchased some ManitobaHarvest Hemp Oil on the advice of a friend and went 5 weeks without amigraine.  I had previously tried a great brand of EPO in the capsuleform, but honestly couldn’t afford to take it in the doses I required. The Hemp Oil, however, brings you the EPO in a nature-made n-3:n-6:n-9fatty acid ratio.   When I ran out of the Manitoba harvest, I couldn’tfind it locally, so I bought a different brand and my migrainesreturned.  Frustrated, I gave up on it, until just two weeks ago, whensomeone I had suggested try it raved on and on how it was helping themwith PMS.  I finally found my original brand, and have been back on itfor 10 days.  The difference so far has been amazing, I don’t even feellike I could get a migraine at all!  Obviously, time will tell, but fornow I’ll continue to be hopeful.  I actually take Nordic Arctic FishOil, too, so I mix a little of each and swallow the whole nasty mess. I have friends who mix it in juice or incorporate it in their food, butI don’t want to ruin the food I’m eating, so I just take it straightand get it over with.  A word of caution – EPO has been known to causeuterine contractions, so do not take it if you are pregnant! Finally, and I will not belabor this point since I have have mentionedit in another article, I do take Solgar’s prenatal multivitamin simplybecause it’s the only multi that I can tolerate.  And, I only take halfa dose.   Calcium, magnesium, vitamin D from Solaray. 
    That’smy personal regime.  I have come up with it by research, reading,severe trial and error, and much wasting of money.  Hopefully one ofthose items can help you in your quest to become migraine free.  Asalways, I would never try more than one new thing at a time, our bodiesare too sensitive and there needs to be time for us to gauge our ownreactions.  
    Good luck, God bless, and I would love to hear of anyof your own personal successes against migraines.  Maybe, between allof us, we can beat these things, and instead of counting the yearsuntil menopause, we can enjoy the intervening years gluten AND migrainefree!!!
     

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    Jefferson Adams
    Celiac.com 06/21/2018 - Would you buy a house advertised as ‘gluten-free’? Yes, there really is such a house for sale. 
    It seems a Phoenix realtor Mike D’Elena is hoping that his trendy claim will catch the eye of a buyer hungry to avoid gluten, or, at least one with a sense of humor. D’Elena said he crafted the ads as a way to “be funny and to draw attention.” The idea, D’Elena said, is to “make it memorable.” 
    Though D’Elena’s marketing seeks to capitalizes on the gluten-free trend, he knows Celiac disease is a serious health issue for some people. “[W]e’re not here to offend anybody….this is just something we're just trying to do to draw attention and do what's best for our clients," he said. 
    Still, the signs seem to be working. D'elena had fielded six offers within a few days of listing the west Phoenix home.
    "Buying can sometimes be the most stressful thing you do in your entire life so why not have some fun with it," he said. 
    What do you think? Clever? Funny?
    Read more at Arizonafamily.com.

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    Bakery On Main started in the small bakery of a natural foods market on Main Street in Glastonbury, Connecticut. Founder Michael Smulders listened when his customers with Celiac Disease would mention the lack of good tasting, gluten-free options available to them. Upon learning this, he believed that nobody should have to suffer due to any kind of food allergy or dietary need. From then on, his mission became creating delicious and fearlessly unique gluten-free products that were clean and great tasting, while still being safe for his Celiac customers!
    Premium ingredients, bakeshop delicious recipes, and happy customers were our inspiration from the beginning— and are still the cornerstones of Bakery On Main today. We are a fiercely ethical company that believes in integrity and feels that happiness and wholesome, great tasting food should be harmonious. We strive for that in everything we bake in our dedicated gluten-free facility that is GFCO Certified and SQF Level 3 Certified. We use only natural, NON-GMO Project Verified ingredients and all of our products are certified Kosher Parve, dairy and casein free, and we have recently introduced certified Organic items as well! 
    Our passion is to bake the very best products while bringing happiness to our customers, each other, and all those we meet!
    We are available during normal business hours at: 1-888-533-8118 EST.
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    Jefferson Adams
    Celiac.com 06/20/2018 - Currently, the only way to manage celiac disease is to eliminate gluten from the diet. That could be set to change as clinical trials begin in Australia for a new vaccine that aims to switch off the immune response to gluten. 
    The trials are set to begin at Australia’s University of the Sunshine Coast Clinical Trials Centre. The vaccine is designed to allow people with celiac disease to consume gluten with no adverse effects. A successful vaccine could be the beginning of the end for the gluten-free diet as the only currently viable treatment for celiac disease. That could be a massive breakthrough for people with celiac disease.
    USC’s Clinical Trials Centre Director Lucas Litewka said trial participants would receive an injection of the vaccine twice a week for seven weeks. The trials will be conducted alongside gastroenterologist Dr. James Daveson, who called the vaccine “a very exciting potential new therapy that has been undergoing clinical trials for several years now.”
    Dr. Daveson said the investigational vaccine might potentially restore gluten tolerance to people with celiac disease.The trial is open to adults between the ages of 18 and 70 who have clinically diagnosed celiac disease, and have followed a strict gluten-free diet for at least 12 months. Anyone interested in participating can go to www.joinourtrials.com.
    Read more at the website for Australia’s University of the Sunshine Coast Clinical Trials Centre.

    Source:
    FoodProcessing.com.au

    Jefferson Adams
    Celiac.com 06/19/2018 - Could baking soda help reduce the inflammation and damage caused by autoimmune diseases like rheumatoid arthritis, and celiac disease? Scientists at the Medical College of Georgia at Augusta University say that a daily dose of baking soda may in fact help reduce inflammation and damage caused by autoimmune diseases like rheumatoid arthritis, and celiac disease.
    Those scientists recently gathered some of the first evidence to show that cheap, over-the-counter antacids can prompt the spleen to promote an anti-inflammatory environment that could be helpful in combating inflammatory disease.
    A type of cell called mesothelial cells line our body cavities, like the digestive tract. They have little fingers, called microvilli, that sense the environment, and warn the organs they cover that there is an invader and an immune response is needed.
    The team’s data shows that when rats or healthy people drink a solution of baking soda, the stomach makes more acid, which causes mesothelial cells on the outside of the spleen to tell the spleen to go easy on the immune response.  "It's most likely a hamburger not a bacterial infection," is basically the message, says Dr. Paul O'Connor, renal physiologist in the MCG Department of Physiology at Augusta University and the study's corresponding author.
    That message, which is transmitted with help from a chemical messenger called acetylcholine, seems to encourage the gut to shift against inflammation, say the scientists.
    In patients who drank water with baking soda for two weeks, immune cells called macrophages, shifted from primarily those that promote inflammation, called M1, to those that reduce it, called M2. "The shift from inflammatory to an anti-inflammatory profile is happening everywhere," O'Connor says. "We saw it in the kidneys, we saw it in the spleen, now we see it in the peripheral blood."
    O'Connor hopes drinking baking soda can one day produce similar results for people with autoimmune disease. "You are not really turning anything off or on, you are just pushing it toward one side by giving an anti-inflammatory stimulus," he says, in this case, away from harmful inflammation. "It's potentially a really safe way to treat inflammatory disease."
    The research was funded by the National Institutes of Health.
    Read more at: Sciencedaily.com

    Jefferson Adams
    Celiac.com 06/18/2018 - Celiac disease has been mainly associated with Caucasian populations in Northern Europe, and their descendants in other countries, but new scientific evidence is beginning to challenge that view. Still, the exact global prevalence of celiac disease remains unknown.  To get better data on that issue, a team of researchers recently conducted a comprehensive review and meta-analysis to get a reasonably accurate estimate the global prevalence of celiac disease. 
    The research team included P Singh, A Arora, TA Strand, DA Leffler, C Catassi, PH Green, CP Kelly, V Ahuja, and GK Makharia. They are variously affiliated with the Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Lady Hardinge Medical College, New Delhi, India; Innlandet Hospital Trust, Lillehammer, Norway; Centre for International Health, University of Bergen, Bergen, Norway; Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts; Gastroenterology Research and Development, Takeda Pharmaceuticals Inc, Cambridge, MA; Department of Pediatrics, Università Politecnica delle Marche, Ancona, Italy; Department of Medicine, Columbia University Medical Center, New York, New York; USA Celiac Disease Center, Columbia University Medical Center, New York, New York; and the Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.
    For their review, the team searched Medline, PubMed, and EMBASE for the keywords ‘celiac disease,’ ‘celiac,’ ‘tissue transglutaminase antibody,’ ‘anti-endomysium antibody,’ ‘endomysial antibody,’ and ‘prevalence’ for studies published from January 1991 through March 2016. 
    The team cross-referenced each article with the words ‘Asia,’ ‘Europe,’ ‘Africa,’ ‘South America,’ ‘North America,’ and ‘Australia.’ They defined celiac diagnosis based on European Society of Pediatric Gastroenterology, Hepatology, and Nutrition guidelines. The team used 96 articles of 3,843 articles in their final analysis.
    Overall global prevalence of celiac disease was 1.4% in 275,818 individuals, based on positive blood tests for anti-tissue transglutaminase and/or anti-endomysial antibodies. The pooled global prevalence of biopsy-confirmed celiac disease was 0.7% in 138,792 individuals. That means that numerous people with celiac disease potentially remain undiagnosed.
    Rates of celiac disease were 0.4% in South America, 0.5% in Africa and North America, 0.6% in Asia, and 0.8% in Europe and Oceania; the prevalence was 0.6% in female vs 0.4% males. Celiac disease was significantly more common in children than adults.
    This systematic review and meta-analysis showed celiac disease to be reported worldwide. Blood test data shows celiac disease rate of 1.4%, while biopsy data shows 0.7%. The prevalence of celiac disease varies with sex, age, and location. 
    This review demonstrates a need for more comprehensive population-based studies of celiac disease in numerous countries.  The 1.4% rate indicates that there are 91.2 million people worldwide with celiac disease, and 3.9 million are in the U.S.A.
    Source:
    Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2. doi: 10.1016/j.cgh.2017.06.037.