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      Frequently Asked Questions About Celiac Disease   04/07/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    NEARLY HALF OF PATIENTS WITH CELIAC DISEASE ARE OVERWEIGHT OR OBESE AT DIAGNOSIS


    Jefferson Adams

    Celiac.com 05/09/2012 - Weight loss is traditionally regarded as one of the classic symptoms of celiac disease. Recent studies suggest that people with celiac disease are far more likely to be obese than underweight at the time of presentation.


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    Photo: CC--fbellonA research team recently set out to assess the frequency of obesity in newly diagnosed celiac disease.

    The research team included Elizabeth Tucker, Kamran Rostami, Sudhakaran Prabhakaran, and Daivid Al Dulaimi. They are affiliated variously with the Institute of Health and Society of Worcester University, School of Clinical and Experimental Medicine in Worcester, the University of Birmingham, and the department of Gastroenterology at Alexandra Hospital in Redditch, in the United Kingdom.

    The research team wanted to assess the frequency of obesity in newly diagnosed celiac disease.

    To do so, they reviewed dietetic records and patient demographic of people with celiac disease, along with initial assessment date, and Body Mass Index (BMI) recorded and statistically analyzed.

    In all, they reviewed data for 187 celiac disease patients diagnosed between 1999 and 2009. Of those, 127 patients were female (68%) and 60 male (32%), a ratio of 2 to 1.

    Patients ranged in age from 18 to 87 years of age, with an average age of 54 years.

    BMI inter-quartile range (IQR) ran from 21.5 to 28.1, with an average BMI of 23.6. IQR was 21.8 to 27.3 for men, with an average BMI of 23.9.

    For females, the BMI IQR ran from 21.4 to 28.6, with an average of 23.2. Overall, 83 patients (44%) registered a BMI of 25 or above.

    The team found no significant difference gender, age or year of referral among patients with a BMI of 25 or above.

    Twenty-five patients (13 %) had a BMI of 30 or above. Of those, twenty were female, and ranged in age from 18 to 71 years old, with an average age of 56 years.

    In all, 11% of females registered a BMI of 30 or more, compared with only 3% males, a 5 to 1 ratio. Only 5 patients (3%) had a BMI below 18.5.

    They found that nearly half of those diagnosed with celiac disease registered with a BMI of 25 or over. Compared to males, females showed a wider range of BMI and were more likely to be obese, registering a BMI of 30 or more.

    Source:


    Image Caption: Photo: CC--fbellon
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    Guest Donnie

    Posted

    I've always been short and skinny, before Celiac diagnosis and after. My family members with it, were mostly overweight.

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    Guest Jenny

    Posted

    As someone recently diagnosed with celiac disease, I was actually glad to see this article. I have had active symptoms of this disease for about two years, and during those years I have steadily put on weight. I would love comments on people in the same situation and what they have done to get their weight back on track.

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    Guest suzanne gault

    Posted

    As someone recently diagnosed with celiac disease, I was actually glad to see this article. I have had active symptoms of this disease for about two years, and during those years I have steadily put on weight. I would love comments on people in the same situation and what they have done to get their weight back on track.

    My son is 18 and has been overweight most of his life. In 2010 we found out he was gluten intolerent. He is 6 feet tall and weighs 312 pounds. It has been my primary goal in life to help him lose weight. We record everything he eats and he works out at the gym at least 4 times per week. He rarely has an appetite and usually consumes 1800 calories per day...2000 on a good day. Does the gluten totally destroy the gut and the metabolism?

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    Guest cate

    Posted

    I, too, was overweight when first diagnosed - despite trying every diet going, and, really, not over-consuming in any shape or form. I also undertook regular exercise, but just kept gaining weight. On top of that I didn't have any classic symptoms of coeliac disease - I was the last person in my family to ever have 'digestive upsets'. True. But I did have a plethora of annoying and, up until that day unrelated, minor health issues. Then I had a violent reaction to an antibiotic and one of the many tests my doctor ordered was the blood test for coeliac. I laughed when she rang to tell me there was a possibility that I had coeliac disease. Wasn't that a condition of skinny, malnutritioned children? I was 48 and, well, fat! Further tests revealed major damage to my intestine and I immediately went gluten-free (I'm good at following diets), but to little avail. Nothing changed. After six months and some further research I chose to attempt the Specific Carbohydrate Diet, suspecting problems with Leaky Gut Syndrome. After a week of severe withdrawal symptoms, eating SCD became easy and I have now lost over 30kilos and have more energy and fewer health problems than I ever have in my adult life. celiac disease seems to impact people in so many ways... the image of the poorly child that I had is only one of them. Given the vast numbers of undiagnosed people we are told are out there, surely it is time for the education campaign regarding this disease to be stepped up?

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    Guest Patti

    Posted

    My son is 18 and has been overweight most of his life. In 2010 we found out he was gluten intolerent. He is 6 feet tall and weighs 312 pounds. It has been my primary goal in life to help him lose weight. We record everything he eats and he works out at the gym at least 4 times per week. He rarely has an appetite and usually consumes 1800 calories per day...2000 on a good day. Does the gluten totally destroy the gut and the metabolism?

    Yes, this happened to someone I know. He needs to have all of his vitamins and minerals checked. He probably destroyed the lining of his stomach. He cannot absorb b12 through food. He has to get b12 shots; how long and how often will depend on if his stomach can repair itself. Also, the vitamins may need to be liquid and he will have to make sure they are gluten-free.

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    Guest Marybeth

    Posted

    My sister and I both have celiac as does two of her three children. We had polar opposite symptoms. I was very skinny but my sister was obese. The more important information we need to understand is WHY, is there such broad spectrum of symptoms?

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    Guest Keena

    Posted

    I have to put in my two cents. I have worked in health care for 7 years and have in that time seen an increase in the diagnosis of celiac disease. I have personally had a lot of health issues and at the age of 36 (2 months ago) I was diagnosed with the disease myself. Even though I work in the field I was in shock. I have had most of the symptoms for 20 years and never suspected because I'm overweight. No one would ever believe I'm malnourished. We need to spread the word. This isn't a skinny persons disease. When I tell people I have I frequently get looks of shock, disbelief, and have even had people accuse me of trying to get attention or making it up. If only they understood what I've gone through and how sick I've been for years. Please help me spread the word and educate people.

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    I too was gaining weight rapidly as I aged, gaining 20 lbs. in 2 years. When I told people I had celiac disease, they'd say "I thought that made you thin?" I'd joke back, "there's no wheat in candy!" Meanwhile, after 3 years almost, I've lost about 25+ and feel like I have my life back!

     

    Let me challenge readers here: stop cheating, you are killing your small intestine, which leads to other serious things. My mother died undiagnosed at 60. She had horrendous health, never felt good, and ended up with lupus, seizures, and liver failure. She always baked bread and rolls and was so ill she'd have to lie around. I teased her as a skinny teen calling her fat. My, don't we all have a lot to learn!

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    Guest smiley100

    Posted

    I have recently been diagnosed with celiac disease. After months of being ill, my first doctor dismissed it as a stomach bug and stress from my son dying. I was 140kg, which is why I could not have it according to my doctor, so i switched doctors and made him give me the blood test and biopsy. Low and behold... he explained to me that I was so overweight because I was not getting the nutrients I needed, which is why i was so hungry and kept eating. I have been gluten-free for 9 months and I am down to 85kg. My periods went from a 29 - 75 cycle to 28, no more miscarriages (of which I have had 5), no more bad mood swings or feeling so exhausted I could barely get out of bed.

    Good luck to all, don't give up! Make your doctor do what you want, they do not have all the answers if they will not let you supply evidence!

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    Guest michele

    Posted

    When we were cave men we didn't bake bread. I don't think our bodies are meant to digest all this gluten, let alone bad carbs and processed food. My sister just got diagnosed with this. I'm getting checked asap.

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    admin
    Celiac.com 11/29/2006 – Contrary to popular beliefs (not to metion outdated medical training), this study demonstrates that 39% of those who are diagnosed with celiac disease are actually overweight rather than underweight. A full 30% of celiac disease patients were in the obese range at the time of their diagnosis. Unfortunately many medical doctors still wont even consider testing overweight patients for celiac disease because they erronously believe that the disease can only occur in individuals who are underweight. This line of reasoning is outdated and incorrect, and is also very dangerous to those who happen to have celiac disease are are overweight—which is now known to be quite common.
    For those who want to read more about this topic be sure to have a look at the following articles:
    Celiac Disease and Obesity—There is a Connection by Melissa Croda Food Cravings, Obesity and Gluten Consumption by Dr. Ron Hoggan, Ed.D.
    Below is the Abstract for the latest study, which was conducted by William Dickey, M.D., Ph.D., F.A.C.G.:

    Am J Gastroenterol. 2006;101(10):2356-2359.
    Overweight in Celiac Disease: Prevalence, Clinical Characteristics, and Effect of a Gluten-Free Diet
    Posted 11/14/2006
    William Dickey, M.D., Ph.D., F.A.C.G.; Natalie Kearney, B.Sc. Abstract:

    Background: It is well established that a minority of celiac patients present with classic symptoms due to malabsorption. However, few studies have focussed on the distribution of body mass index (BMI) in celiac populations and its relationship to clinical characteristics, or on its response to treatment.
    Methods: We reviewed BMI measurements and other clinical and pathological characteristics from a database of 371 celiac patients diagnosed over a 10-yr period and seen by a single gastroenterologist. To assess response to gluten exclusion, we compared BMI at diagnosis and after 2 yr treatment in patients with serological support for dietary compliance.
    Results: Mean BMI was 24.6 kg/m2 (range 16.3–43.5). Seventeen patients (5%) were underweight (BMI Conclusions:
    Few celiac patients are underweight at diagnosis and a large minority is overweight; these are less likely to present with classical features of diarrhea and reduced hemoglobin. Failed or delayed diagnosis of celiac disease may reflect lack of awareness of this large subgroup. The increase in weight of already overweight patients after dietary gluten exclusion is a potential cause of morbidity, and the gluten-free diet as conventionally prescribed needs to be modified accordingly.

    Jefferson Adams
    Celiac.com 12/19/2011 - Very little data has been collected about how body mass relates to celiac disease in children in the United States. Recently, a team of researchers sought to document the way celiac disease presents in children with normal and with elevated body mass index (BMI) for age, and to study BMI changes in those kids following a gluten-free diet.
    The research team included Norelle Rizkalla Reilly, Kathleen Aguilar, Benjamin G. Hassid, Jianfeng Cheng, Amy R. DeFelice, Philip Kazlow, Govind Bhagat, and Peter H. Green. They are variously affiliate with Columbia University School of Medicine.
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    To compare the results, they assessed patient height, weight, and BMI by age (z score), and grouped results by BMI as underweight, normal, or overweight.
    To be certain which of the patients were following a gluten-free diet, the team used results of serological assays, and data of noncompliant patients, which they assessed separately.
    Their analysis included only data gathered during the observation period, which they then expressed as change in height, weight, and BMI z score per month of dietary treatment.
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    Source:

    JPGN 2011;53: 528–531

    Jefferson Adams
    Celiac.com 03/04/2013 - Morbid obesity is a common medical condition. In many cases, bariatric surgery is necessary. Although for decades celiac disease has been associated with chronic diarrhea and weight loss, and other classic symptoms, recent data shows that the clinical spectrum of celiac disease is extremely wide.
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    The researchers included Federico Cuenca-Abente, Fabio Nachman, and Julio C. Bai of the Department of Surgery and Department of Medicine at Dr C. Bonorino Udaondo Gastroenterology Hospital in Buenos Aires, Argentina.
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    Interestingly, four of the five patients had no obvious symptoms. One complained of chronic diarrhea and anemia. All patients began a gluten-free diet. Due to their celiac disease diagnosis, doctors offered all five patients a purely restrictive bariatric procedure. At the time of the report, three of the patients had received a sleeve gastrectomy, while the other two were still undergoing pre-operative evaluation.
    The team's findings help to enlarge the clinical spectrum of untreated celiac disease. Even though rates of celiac disease in obese patients seems to be similar to that in the general population, the team recommends that patients with morbid obesity be tested for celiac disease in order to determine the best surgical strategy and outcome.
    Source:
    Acta Gastroenterol Latinoam 2012;42:321-324

    Jefferson Adams
    Celiac.com 04/06/2015 - Several studies have shown that many patients with celiac disease experience changes in body weight after starting a gluten-free diet, but researchers still don't have much data on rates of metabolic syndrome in this population.
    A team of researchers recently set out to assess rates of metabolic syndrome in patients with celiac at diagnosis, and at one year after starting gluten-free diet. The research team included R. Tortora, P. Capone, G. De Stefano, N. Imperatore, N. Gerbino, S. Donetto, V. Monaco, N. Caporaso, and A. Rispo. They are affiliated with the Department of Clinical Medicine and Surgery, University Federico II of Naples, Naples, Italy, or with the Department of Education and Professional Studies, King's College London, London, UK.
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    After 1 year on a gluten-free diet, the team compared the patient data to baseline, with respect to metabolic syndrome sub-categories. They found 72 vs. 48 patients exceeded waist circumference cut-off (P < 0.01; OR: 2.8); 18 vs. 4 patients had high blood pressure (P < 0.01; OR: 5.2); 25 vs. 7 patients exceeded glycemic threshold (P = 0.01; OR: 4.4); 34 vs. 32 patients with celiac disease had reduced levels of HDL cholesterol (P = 0.7); and 16 vs. 7 patients had high levels of triglycerides (P = 0.05).
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    To address this, the research team recommends an in-depth nutritional assessment for all patients with celiac disease.
    Source: 
    Aliment Pharmacol Ther. 2015;41(4):352-359.

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    admin
    WHAT IS CELIAC DISEASE?
    Celiac disease is an autoimmune condition that affects around 1% of the population. People with celiac disease suffer an autoimmune reaction when they consume wheat, rye or barley. The immune reaction is triggered by certain proteins in the wheat, rye, or barley, and, left untreated, causes damage to the small, finger-like structures, called villi, that line the gut. The damage occurs as shortening and villous flattening in the lamina propria and crypt regions of the intestines. The damage to these villi then leads to numerous other issues that commonly plague people with untreated celiac disease, including poor nutritional uptake, fatigue, and myriad other problems.
    Celiac disease mostly affects people of Northern European descent, but recent studies show that it also affects large numbers of people in Italy, China, Iran, India, and numerous other places thought to have few or no cases.
    Celiac disease is most often uncovered because people experience symptoms that lead them to get tests for antibodies to gluten. If these tests are positive, then the people usually get biopsy confirmation of their celiac disease. Once they adopt a gluten-free diet, they usually see gut healing, and major improvements in their symptoms. 
    CLASSIC CELIAC DISEASE SYMPTOMS
    Symptoms of celiac disease can range from the classic features, such as diarrhea, upset stomach, bloating, gas, weight loss, and malnutrition, among others.
    LESS OBVIOUS SYMPTOMS
    Celiac disease can often less obvious symptoms, such fatigue, vitamin and nutrient deficiencies, anemia, to name a few. Often, these symptoms are regarded as less obvious because they are not gastrointestinal in nature. You got that right, it is not uncommon for people with celiac disease to have few or no gastrointestinal symptoms. That makes spotting and connecting these seemingly unrelated and unclear celiac symptoms so important.
    NO SYMPTOMS
    Currently, most people diagnosed with celiac disease do not show symptoms, but are diagnosed on the basis of referral for elevated risk factors. 

    CELIAC DISEASE VS. GLUTEN INTOLERANCE
    Gluten intolerance is a generic term for people who have some sort of sensitivity to gluten. These people may or may not have celiac disease. Researchers generally agree that there is a condition called non-celiac gluten sensitivity. That term has largely replaced the term gluten-intolerance. What’s the difference between celiac disease and non-celiac gluten-sensitivity? 
    CELIAC DISEASE VS. NON-CELIAC GLUTEN SENSITIVITY (NCGS)
    Gluten triggers symptoms and immune reactions in people with celiac disease. Gluten can also trigger symptoms in some people with NCGS, but the similarities largely end there.

    There are four main differences between celiac disease and non-celiac gluten sensitivity:
    No Hereditary Link in NCGS
    Researchers know for certain that genetic heredity plays a major role in celiac disease. If a first-degree relative has celiac disease, then you have a statistically higher risk of carrying genetic markers DQ2 and/or DQ8, and of developing celiac disease yourself. NCGS is not known to be hereditary. Some research has shown certain genetic associations, such as some NCGS patients, but there is no proof that NCGS is hereditary. No Connection with Celiac-related Disorders
    Unlike celiac disease, NCGS is so far not associated with malabsorption, nutritional deficiencies, or a higher risk of autoimmune disorders or intestinal malignancies. No Immunological or Serological Markers
    People with celiac disease nearly always test positive for antibodies to gluten proteins. Researchers have, as yet, identified no such antobodies or serologic markers for NCGS. That means that, unlike with celiac disease, there are no telltale screening tests that can point to NCGS. Absence of Celiac Disease or Wheat Allergy
    Doctors diagnose NCGS only by excluding both celiac disease, an IgE-mediated allergy to wheat, and by the noting ongoing adverse symptoms associated with gluten consumption. WHAT ABOUT IRRITABLE BOWEL SYNDROME (IBS) AND IRRITABLE BOWEL DISEASE (IBD)?
    IBS and IBD are usually diagnosed in part by ruling out celiac disease. Many patients with irritable bowel syndrome are sensitive to gluten. Many experience celiac disease-like symptoms in reaction to wheat. However, patients with IBS generally show no gut damage, and do not test positive for antibodies to gliadin and other proteins as do people with celiac disease. Some IBS patients also suffer from NCGS.

    To add more confusion, many cases of IBS are, in fact, celiac disease in disguise.

    That said, people with IBS generally react to more than just wheat. People with NCGS generally react to wheat and not to other things, but that’s not always the case. Doctors generally try to rule out celiac disease before making a diagnosis of IBS or NCGS. 
    Crohn’s Disease and celiac disease share many common symptoms, though causes are different.  In Crohn’s disease, the immune system can cause disruption anywhere along the gastrointestinal tract, and a diagnosis of Crohn’s disease typically requires more diagnostic testing than does a celiac diagnosis.  
    Crohn’s treatment consists of changes to diet and possible surgery.  Up to 10% of Crohn's patients can have both of conditions, which suggests a genetic connection, and researchers continue to examine that connection.
    Is There a Connection Between Celiac Disease, Non-Celiac Gluten Sensitivity and Irritable Bowel Syndrome? Large Number of Irritable Bowel Syndrome Patients Sensitive To Gluten Some IBD Patients also Suffer from Non-Celiac Gluten Sensitivity Many Cases of IBS and Fibromyalgia Actually Celiac Disease in Disguise CELIAC DISEASE DIAGNOSIS
    Diagnosis of celiac disease can be difficult. 

    Perhaps because celiac disease presents clinically in such a variety of ways, proper diagnosis often takes years. A positive serological test for antibodies against tissue transglutaminase is considered a very strong diagnostic indicator, and a duodenal biopsy revealing villous atrophy is still considered by many to be the diagnostic gold standard. 
    But this idea is being questioned; some think the biopsy is unnecessary in the face of clear serological tests and obvious symptoms. Also, researchers are developing accurate and reliable ways to test for celiac disease even when patients are already avoiding wheat. In the past, patients needed to be consuming wheat to get an accurate test result. 
    Celiac disease can have numerous vague, or confusing symptoms that can make diagnosis difficult.  Celiac disease is commonly misdiagnosed by doctors. Read a Personal Story About Celiac Disease Diagnosis from the Founder of Celiac.com Currently, testing and biopsy still form the cornerstone of celiac diagnosis.
    TESTING
    There are several serologic (blood) tests available that screen for celiac disease antibodies, but the most commonly used is called a tTG-IgA test. If blood test results suggest celiac disease, your physician will recommend a biopsy of your small intestine to confirm the diagnosis.
    Testing is fairly simple and involves screening the patients blood for antigliadin (AGA) and endomysium antibodies (EmA), and/or doing a biopsy on the areas of the intestines mentioned above, which is still the standard for a formal diagnosis. Also, it is now possible to test people for celiac disease without making them concume wheat products.

    BIOPSY
    Until recently, biopsy confirmation of a positive gluten antibody test was the gold standard for celiac diagnosis. It still is, but things are changing fairly quickly. Children can now be accurately diagnosed for celiac disease without biopsy. Diagnosis based on level of TGA-IgA 10-fold or more the ULN, a positive result from the EMA tests in a second blood sample, and the presence of at least 1 symptom could avoid risks and costs of endoscopy for more than half the children with celiac disease worldwide.

    WHY A GLUTEN-FREE DIET?
    Currently the only effective, medically approved treatment for celiac disease is a strict gluten-free diet. Following a gluten-free diet relieves symptoms, promotes gut healing, and prevents nearly all celiac-related complications. 
    A gluten-free diet means avoiding all products that contain wheat, rye and barley, or any of their derivatives. This is a difficult task as there are many hidden sources of gluten found in the ingredients of many processed foods. Still, with effort, most people with celiac disease manage to make the transition. The vast majority of celiac disease patients who follow a gluten-free diet see symptom relief and experience gut healing within two years.
    For these reasons, a gluten-free diet remains the only effective, medically proven treatment for celiac disease.
    WHAT ABOUT ENZYMES, VACCINES, ETC.?
    There is currently no enzyme or vaccine that can replace a gluten-free diet for people with celiac disease.
    There are enzyme supplements currently available, such as AN-PEP, Latiglutetenase, GluteGuard, and KumaMax, which may help to mitigate accidental gluten ingestion by celiacs. KumaMax, has been shown to survive the stomach, and to break down gluten in the small intestine. Latiglutenase, formerly known as ALV003, is an enzyme therapy designed to be taken with meals. GluteGuard has been shown to significantly protect celiac patients from the serious symptoms they would normally experience after gluten ingestion. There are other enzymes, including those based on papaya enzymes.

    Additionally, there are many celiac disease drugs, enzymes, and therapies in various stages of development by pharmaceutical companies, including at least one vaccine that has received financial backing. At some point in the not too distant future there will likely be new treatments available for those who seek an alternative to a lifelong gluten-free diet. 

    For now though, there are no products on the market that can take the place of a gluten-free diet. Any enzyme or other treatment for celiac disease is intended to be used in conjunction with a gluten-free diet, not as a replacement.

    ASSOCIATED DISEASES
    The most common disorders associated with celiac disease are thyroid disease and Type 1 Diabetes, however, celiac disease is associated with many other conditions, including but not limited to the following autoimmune conditions:
    Type 1 Diabetes Mellitus: 2.4-16.4% Multiple Sclerosis (MS): 11% Hashimoto’s thyroiditis: 4-6% Autoimmune hepatitis: 6-15% Addison disease: 6% Arthritis: 1.5-7.5% Sjögren’s syndrome: 2-15% Idiopathic dilated cardiomyopathy: 5.7% IgA Nephropathy (Berger’s Disease): 3.6% Other celiac co-morditities include:
    Crohn’s Disease; Inflammatory Bowel Disease Chronic Pancreatitis Down Syndrome Irritable Bowel Syndrome (IBS) Lupus Multiple Sclerosis Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Psoriasis Rheumatoid Arthritis Scleroderma Turner Syndrome Ulcerative Colitis; Inflammatory Bowel Disease Williams Syndrome Cancers:
    Non-Hodgkin lymphoma (intestinal and extra-intestinal, T- and B-cell types) Small intestinal adenocarcinoma Esophageal carcinoma Papillary thyroid cancer Melanoma CELIAC DISEASE REFERENCES:
    Celiac Disease Center, Columbia University
    Gluten Intolerance Group
    National Institutes of Health
    U.S. National Library of Medicine
    Mayo Clinic
    University of Chicago Celiac Disease Center

    Jefferson Adams
    Celiac.com 04/17/2018 - Could the holy grail of gluten-free food lie in special strains of wheat that lack “bad glutens” that trigger the celiac disease, but include the “good glutens” that make bread and other products chewy, spongey and delicious? Such products would include all of the good things about wheat, but none of the bad things that might trigger celiac disease.
    A team of researchers in Spain is creating strains of wheat that lack the “bad glutens” that trigger the autoimmune disorder celiac disease. The team, based at the Institute for Sustainable Agriculture in Cordoba, Spain, is making use of the new and highly effective CRISPR gene editing to eliminate the majority of the gliadins in wheat.
    Gliadins are the gluten proteins that trigger the majority of symptoms for people with celiac disease.
    As part of their efforts, the team has conducted a small study on 20 people with “gluten sensitivity.” That study showed that test subjects can tolerate bread made with this special wheat, says team member Francisco Barro. However, the team has yet to publish the results.
    Clearly, more comprehensive testing would be needed to determine if such a product is safely tolerated by people with celiac disease. Still, with these efforts, along with efforts to develop vaccines, enzymes, and other treatments making steady progress, we are living in exciting times for people with celiac disease.
    It is entirely conceivable that in the not-so-distant future we will see safe, viable treatments for celiac disease that do not require a strict gluten-free diet.
    Read more at Digitaltrends.com , and at Newscientist.com