Celiac.com 06/15/2015 - It's well-documented that people with active celiac disease are more likely to have osteoporosis and increased risk of fractures. High-resolution peripheral quantitative computed tomography (HR-pQCT) allows for three-dimensional exploration of bone micro-architecture, including measurement of cortical and trabecular compartments, and providing detailed information on bone disease pathophysiology and fracture. Using HR-pQCT, research team recently set out to assess the volumetric and micro-architectural characteristics of peripheral bones. that is the distal radius and tibia, in adult pre-menopausal women with active freshly diagnosed celiac disease.
For the study, their team prospectively enrolled 31 consecutive premenopausal women with newly diagnosed celiac disease (median age 29â€…years, range: 18–49) and 22 healthy women of similar age (median age 30â€…years, range 21–41) and body mass index. Using HR-pQCT, the team was able to successfully identify significant deterioration in the micro-architecture of trabecular and cortical compartments of peripheral bones.
HR-pQCT revealed that most bone micro-architecture parameters were substantially reduced in celiac disease patients compared to a control group. Twenty-two patients showed symptomatic celiac disease. These patients had a greater bone micro-architectural deficit than those with sub-clinical celiac disease.
Impaired bone micro-architecture could be one cause of diminished bone strength and higher risk of fractures seen in many celiac patients.
The researchers are looking to conduct a follow-up of this group of patients. They want to know whether bone micro-architecture recovers with a gluten-free diet, and, if so, how quickly and to what extent.
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