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    Complicated Celiac Disease Uncommon but Deadly


    Jefferson Adams

    Celiac.com 01/15/2014 - Complicated celiac disease is uncommon, but patients have high death rates, say a team of researchers, who recently set out to better understand the epidemiology of complications in patients with celiac disease.


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    Photo: CC--vvracerThe research team included F. Biagi, P. Gobbi, A. Marchese, E. Borsotti, F. Zingone, C. Ciacci, U. Volta, G. Caio, A. Carroccio, G. Ambrosiano, P. Mansueto, G.R. Corazza. They are affiliated with the Coeliac Centre/First Department of Internal Medicine at the Fondazione IRCCS Policlinico San Matteo at the University of Pavia in Italy.

    The team conducted a retrospective multi-center case-control study based on collection of clinical and laboratory data. They looked at incidence of complicated celiac disease among celiac patients directly diagnosed in four Italian centers.

    Their study did not include patients referred to these centers after being diagnosed with celiac disease and/or complicated celiac disease at other facilities.

    Between January of 1999 and October 2011, the team followed-up on 1840 adult celiac patients, for a total of 7364.3 person-years. They found that fourteen patients developed complications to they celiac disease.

    Five patients died by the end of the observation period in October 2011, making the rates of complicated celiac disease nine cases out of 1835 celiac patients (1/204, 0.49%, 95% CI 0.2-0.9%).

    The annual rates of complicated celiac disease in the study period was 14 out of 7364 celiac patients, or about 0.2%, 95% CI 0.1-0.31%.

    Although complications tend to occur soon after the diagnosis of celiac disease, Kaplan-Meier curve analysis showed that they can actually occur at any time after the diagnosis of celiac disease.

    Overall, complications of celiac disease in this study group were quite rare, but those patients with complications faced very high mortality rates.

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    Guest Michael S.

    Posted

    What kind of complications are you referring to? As a colon cancer survivor for over 36 years, 2 dozen incidences of kidney stones requiring several surgeries and a serious colon related issue 20 years ago (10 years before the celiac diagnosis) which left me with a permanent disability I often can't tell which one of these issues is causing the "problem of the day". I was the 1st person to have the colon resection surgery for the cancer. I was left with 6" of colon. The 1st kidney stone surgery required major surgery to remove a 5 cm. stone that did a lot of damage. The remainder of my colon ruptured in 1991 and caused a very large impacted abscess resulting in nerve problems in my legs (among other areas) and later arthritis. I am now have difficulty eating many foods. Not just those containing gluten, which I avoid religiously so if there are any other issues I need to be aware of I would be most appreciative.

    Thank you.

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    It would have been a better article if it mentioned what the complicated cases were.

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    I don't see in the article the complications you are talking about...I would like to know them. Thanks.

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    So, what are the complications?? This article gave no details!!!

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    Guest Ian geary

    Posted

    But what were the complications? More information on those would be useful.

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    American College of Gastroenterology. Hammerle C, Crowe S "Natural history and treatment of refractory celiac disease: Experience with 17 patients at a single center" ACG 2010; Abstract 235.

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    Sources:
    1. Toft M, Dietrichs E. Aggravated stuttering following subthalamic deep brain stimulation in Parkinson’s disease--two cases. BMC Neurol. 2011 Apr 8;11:44.
    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

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    Journal of Clinical Pathologyhttp://dx.doi.org/10.1136/jclinpath-2018-205023

    Jefferson Adams
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    Source:
    Alimentary Pharmacology & Therapeutics

    Jefferson Adams
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    Source:
    Gut. 2017 Feb;66(2):250-257.  doi: 10.1136/gutjnl-2015-310148.