Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Jefferson Adams
    Jefferson Adams

    Could Gluten-Sensitivity Play a Role in Acute Mania?

    Reviewed and edited by a celiac disease expert.

    The team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline.

    Could Gluten-Sensitivity Play a Role in Acute Mania? - Artistic view of how the world feels like with schizophrenia. Image: CC0 1.0--Yeenosaurus
    Caption: Artistic view of how the world feels like with schizophrenia. Image: CC0 1.0--Yeenosaurus

    Celiac.com 08/05/2019 - The relationship between mental health, gluten sensitivity, and celiac disease has not been well researched. Some studies have shown that people with schizophrenia and bipolar disorder have elevated levels of antibodies to gliadin.

    A team of researchers recently set out to examine longitudinally the levels of antibody reactivity to gliadin in acute mania. The sample included 60 individuals assessed during a hospital stay for acute mania, 39 at a 6-month follow-up, and a sample of 143 non-psychiatric control subjects. 

    Celiac.com Sponsor (A12):
    The research team included Faith Dickerson, Cassie Stallings, Andrea Origoni, Crystal Vaughan, Sunil Khushalani, and Robert Yolken. They are variously affiliated with the Stanley Research Program at Sheppard Pratt, Baltimore, MD, USA, and the Stanley Neurovirology Laboratory, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA. 

    The team used enzyme immunoassay to measure antibodies to gliadin. They used regression models to analyze the relationship between the antibodies and the clinical progress of patients with mania. 

    Using multivariate analyses, the team found that patients with mania had significantly higher levels of IgG antibodies to gliadin at baseline, but not other markers of celiac disease, compared with control subjects. 

    At the six month follow-up, however, these levels did not differ substantially from those of control subjects. 

    In patients with mania, elevated levels after six months were strongly associated with re-hospitalization in the 6-month follow-up period. 

    Based on these results, the team concludes that the monitoring and control of gluten sensitivity could be helpful in managing individuals hospitalized with acute mania.

    Stay tuned for more on this and related stories.

    Source:



    User Feedback

    Recommended Comments

    miguel54b

    Could Gluten-Sensitivity Play a Role in Acute Mania? My answer is yes. What qualify me to give that answer? My own experience and reading other experiences plus the studies out there. There should be no doubts that the damage that gluten causes affect the brain by direct or indirect way. Once gluten cause a leaky gut there is not telling what is going to happen until its happen. 

    Link to comment
    Share on other sites


    Create an account or sign in to comment

    You need to be a member in order to leave a comment

    Create an account

    Sign up for a new account in our community. It's easy!

    Register a new account

    Sign in

    Already have an account? Sign in here.

    Sign In Now

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 04/29/2009 - A team of researchers based at UK's prospective University of Highlands and Islands (UHI) have found a link between gluten and schizophrenia. According to their latest findings, proteins found in the gluten of wheat, rye and barley might play a role in triggering schizophrenia in people with a genetic risk for the condition, or in worsening symptoms in people who have the disease.
    The research team has been looking into the role played by gluten in schizophrenia and diabetes, as well as hunting for connections between the two disorders. Their research showed that the bodies of certain schizophrenia sufferers could not properly processes gluten, which led to tissue damage.
    As a result of these and other findings, researchers now consider genetic risk...


    Jefferson Adams
    Celiac.com 01/23/2013 - Can going gluten-free bring about a major improvement in mental health for some children?
    This question is addressed in recent Open Original Shared Link. In the article, Lochner talks about the challenges she faced in trying to raise her daughter who, for the first couple of years, seemed to become more and more emotionally volatile and unstable, even while her daughter's twin brother seemed just fine.
    Lochner details her trips to multiple pediatricians and behavioral therapists in an effort to get an answer for her daughter's behavior.
    Initially, the behavioral therapists pretty much dismissed her concerns and, when Lochner asked what she could do to calm her daughter down, told her to “Try distracting her…Give her a toy that makes noise. Or sit her ...


    Jefferson Adams
    Celiac.com 12/08/2014 - Many people with celiac disease report suffering from impaired cognition or "brain fog," but no good study had been done until a research team took an in-depth look at the issue. Of particular interest was the degree to which improved mental clarity in gluten-free celiac patients correlates with histological and serological measures of disease severity.
    The research team included I. T. Lichtwark, E. D. Newnham, S. R. Robinson, S. J. Shepherd, P. Hosking, P. R. Gibson, and G. W. Yelland, who are variously affiliated with the School of Psychological Sciences, Monash University, Clayton, Australia, the Eastern Health Clinical School at Monash University, Box Hill Hospital, Melbourne, Australia, the School of Health Sciences at RMIT University in Bundoora, Australia...


    Jefferson Adams
    04/22/2019 - A gluten-free diet can improve symptoms of schizophrenia in certain patients, new research suggests. In the small pilot study, Deanna L. Kelly, PharmD, professor of psychiatry, University of Maryland School of Medicine, Baltimore, and colleagues studied the effects a gluten-free diet in schizophrenia, especially in patients with elevated gluten antibodies.
    Kelly and her team set out to determine whether a gluten-free diet would improve psychiatric symptoms in this subgroup of patients with elevated AGA IgG.
    They found that schizophrenia patients with elevated gluten antibodies, specifically, elevated antigliadin antibodies (AGA IgG), who followed a gluten-free-diet for 5 weeks saw a greater reduction in negative symptoms compared counterparts on a non-gluten...


  • Recent Activity

    1. - trents replied to AlyO's topic in Parents, Friends and Loved Ones of Celiacs
      3

      Possible gluten exposure in 4yo

    2. - AlyO replied to AlyO's topic in Parents, Friends and Loved Ones of Celiacs
      3

      Possible gluten exposure in 4yo

    3. - trents replied to Hannah24's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Negative Test but I have All the Symptoms!

    4. - knitty kitty replied to Hannah24's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      5

      Negative Test but I have All the Symptoms!

    5. - trents replied to Linedancegal's topic in Introduce Yourself / Share Stuff
      2

      25 year biopsy confirmed/ate pizza with no ill effects?


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,457
    • Most Online (within 30 mins)
      7,748

    Kitty-Kat001
    Newest Member
    Kitty-Kat001
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Hannah24
    • jessiemariecar
    • Rhonda H
    • HayleyC123
    • Touche
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...