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    Adolescent Celiacs Have Elevated Levels of Anti-Thyroid and Anti-Pancreatic Autoantibodies


    Scott Adams


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    Am J Gastroenterol 2000;95:1742-1748.

    Celiac.com 09/20/2000 - A new study published in the July issue of the American Journal of Gastroenterology by Dr. Vincenzo Toscano and colleagues at the Universita La Sapienza in Rome indicates that adolescent patients with celiac disease have elevated levels of anti-thyroid and anti-pancreatic autoantibodies. The results indicate that gluten plays a key role in the observed autoimmunity, and may in some cases result in organ dysfunction.

    Previous studies have shown that antibodies directed against endocrine glands develop in a high proportion of patients who have celiac disease. In many cases a gluten-free diet is abandoned by many patients in adolescence, and the researchers studied such a group to determine whether anti-endocrine antibodies and endocrine function were affected by the presence or absence of gluten. Their study indicates that 9 of 44 celiac disease patients tested positive for at least one anti-thyroid autoantibody. The same numbers of patients tested positive for anti-pancreatic autoantibodies. Additionally, one patient was diabetic, two others exhibited preclinical hypothyroidism, and one had clinical hypothyroidism.

    Further, 10 of 19 patients on a diet containing gluten were positive for at least one antibody, in comparison with five of 25 patients on the gluten-free diet, and the distribution of autoantibodies was significantly different between the two groups. Dr. Toscanos team concludes that gluten consumption is associated with a high prevalence of anti-endocrine autoantibodies.

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    I am desperate for an answer to my question. I have celiac, but am on a liquid diet of yogurt and carnation breakfast with protein power, from gastroparesis. I don't know if they have things in it I can't have on the celiac diet, but I do not digest solid food.

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  • About Me

    In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I founded The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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  • Related Articles

    Scott Adams
    AUTHORS: Cuoco L; Certo M; Jorizzo RA; De Vitis I; Tursi A; Papa A; De Marinis L; Fedeli P; Fedeli G; Gasbarrini G
    AUTHOR AFFILIATION: Department of Internal Medicine, Catholic University S.C., Rome, Italy.
    SOURCE: Ital J Gastroenterol Hepatol 1999 May;31(4):283-7 [MEDLINE record in process]
    CITATION IDS: PMID: 10425571 UI: 99354303
    ABSTRACT: BACKGROUND AND AIMS - Celiac disease is associated with several autoimmune disorders such as insulin-dependent diabetes, Sjogrens syndrome, Addisons disease and thyroid diseases. The aim of our study was to evaluate the prevalence of celiac disease in patients affected by autoimmune thyroid diseases by means of anti-gliadin and anti-endomysial antibodies. PATIENTS: We studied 92 patients affected by autoimmune thyroid diseases (47 chronic autoimmune thyroiditis, 22 Hashimotos thyroiditis and 23 Graves disease). Ninety patients with non autoimmune thyroid disorders (51 multifollicular goitre, 28 solitary nodule and 11 papillary carcinoma) and 236 blood donors also took part in the study as control groups. METHODS: Total serum IgA were measured in all subjects to exclude selective IgA deficiency; then we measured anti-gliadin antibodies and anti-endomysial antibodies. In patients with anti-gliadin/anti-endomysial antibody positivity and/or with haematinic and laboratory signs of malabsorption we carried out gastrointestinal endoscopy with duodenal histological examination.
    RESULTS: Among the 92 patients with autoimmune thyroid disease, 4 (4.3%) showed anti-gliadin and anti-endomysial positivity and had celiac disease; among the 90 patients with non autoimmune thyroid diseases, 1 (1.1%) had celiac disease; finally, among the blood donors, 1 subject (0.4%) was anti-gliadin-anti-endomysium antibody positive and had celiac disease. Those subjects presenting with only anti-gliadin antibody positivity did not have celiac disease.
    CONCLUSIONS: These results show that the prevalence of celiac disease in patients with autoimmune thyroid diseases is significantly increased when compared with the general population (p = 0.009) but not with patients affected by non autoimmune thyroid disorders (p = 0.18). We suggest a serological screening for celiac disease in all patients with autoimmune thyroid disease measuring anti-endomysial antibodies, considering that early detection and treatment of celiac disease are effective in preventing its complications.

    Scott Adams
    The following is a list of citations where you can find more information on the relationship between hypothyroidism and celiac disease:
    The American Family Physician web page (http://www.aafp.org/afp) has an article (March 1, 1998) on detecting Celiac in a patient. It says that autoimmune thryroid diseases were found in 5.4% of celiacs. In the Feb 15,1998 issue there is an article entitled Subclinical Hypothyroidism: Deciding When to Treat. Cole DE, et al. [see Related Articles]. Neonatal severe hyperparathyroidism, secondary hyperparathyroidism, and familial hypocalciuric hypercalcemia: multiple different phenotypes associated with an inactivating Alu insertion mutation of the calcium-sensing receptor gene. Am J Med Genet. 1997 Aug 8; 71(2): 202-210. PMID: 9217223; UI: 97360195. Corazza GR, et al. [see Related Articles] Propeptide of type I procollagen is predictive of posttreatment bone mass gain in adult celiac disease. Gastroenterology. 1997 Jul; 113(1): 67-71. PMID: 9207263; UI: 97350887. Shaker JL, et al. [see Related Articles] Hypocalcemia and skeletal disease as presenting features of celiac disease. Arch Intern Med. 1997 May 12; 157(9): 1013-1016. PMID: 9140273; UI: 97285000. Moran CE, et al. [see Related Articles] Bone mineral density in patients with pancreatic insufficiency and steatorrhea. Am J Gastroenterol. 1997 May; 92(5): 867-871. PMID: 9149203; UI: 97293150. Corazza GR, et al. [see Related Articles] Influence of pattern of clinical presentation and of gluten-free diet on bone mass and metabolism in adult celiac disease. Bone. 1996 Jun; 18(6): 525-530. PMID: 8805992; UI: 96399521. Keaveny AP, et al. [see Related Articles] Bone remodeling indices and secondary hyperparathyroidism in celiac disease. Am J Gastroenterol. 1996 Jun; 91(6): 1226-1231. PMID: 8651176; UI: 96237643. Wrong O. [see Related Articles] A woman with bone pain, fractures, and malabsorption. Lancet. 1996 Mar 23; 347(9004): 829. No abstract available. PMID: 8622356; UI: 96180154. Kumar V, et al. [see Related Articles] Celiac disease and hypoparathyroidism: cross-reaction of endomysial antibodies with parathyroid tissue. Clin Diagn Lab Immunol. 1996 Mar; 3(2): 143-146. PMID: 8991626; UI: 96265434. Bertoli A, et al. [see Related Articles] A woman with bone pain, fractures, and malabsorption. Lancet. 1996 Feb 3; 347(8997): 300. No abstract available. PMID: 8569366; UI: 96158642. Rude RK, et al. [see Related Articles] Magnesium deficiency: possible role in osteoporosis associated with gluten-sensitive enteropathy. Osteoporos Int. 1996; 6(6): 453-461. PMID: 9116391; UI: 97183181. Molteni N, et al. [see Related Articles] Intestinal calcium absorption as shown by stable strontium test in celiac disease before and after gluten-free diet. Am J Gastroenterol. 1995 Nov; 90(11): 2025-2028. PMID: 7485015; UI: 96048763. Pratico G, et al. [see Related Articles] [Calcium-phosphorus metabolism in celiac disease in children]. Pediatr Med Chir. 1995 Sep; 17(5): 403-406. Italian. PMID: 8684993; UI: 96286520. Corazza GR, et al. [see Related Articles] Bone mass and metabolism in patients with celiac disease. Gastroenterology. 1995 Jul; 109(1): 122-128. PMID: 7797010; UI: 95317529. Gonzalez D, et al. [see Related Articles] Body composition and bone mineral density in untreated and treated patients with celiac disease. Bone. 1995 Feb; 16(2): 231-234. PMID: 7756052; UI: 95275602. Mazure R, et al. [see Related Articles] Bone mineral affection in asymptomatic adult patients with celiac disease. Am J Gastroenterol. 1994 Dec; 89(12): 2130-2134. PMID: 7977227; UI: 95067822. Wortsman J, et al. [see Related Articles] Case report: idiopathic hypoparathyroidism co-existing with celiac disease: immunologic studies. Am J Med Sci. 1994 Jun; 307(6): 420-427. PMID: 8198149; UI: 94256518. Bolla G, et al. [see Related Articles] [Tertiary hyperparathyroidism revealing celiac disease in adults]. Presse Med. 1994 Feb 19; 23(7): 346. French. No abstract available. PMID: 8208699; UI: 94269013. Lindh E, et al. [see Related Articles] Screening for antibodies against gliadin in patients with osteoporosis. J Intern Med. 1992 Apr; 231(4): 403-406. PMID: 1588266; UI: 92268780. Caraceni MP, et al. [see Related Articles] Bone and mineral metabolism in adult celiac disease. Am J Gastroenterol. 1988 Mar; 83(3): 274-277. PMID: 3257843; UI: 88147922

    Jefferson Adams
    Celiac.com 03/01/2010 - Common autoimmune disorders often coexist in the same subjects, and to cluster in families. A research team recently set out to quantify the risk of diagnosis of coexisting autoimmune diseases in more than 3000 index cases with clinically proven Graves' disease or Hashimoto's thyroiditis.
    The research team included Kristien Boelaert, PhD, Paul R. Newbya, Matthew J. Simmonds, PhD, Roger L. Holder, Jacqueline D. Carr-Smith, Joanne M. Heward, PhD, Nilusha Manjia, Amit Allahabadia, MD, Mary Armitage, DM, Krishna V. Chatterjee, PhD, John H. Lazarus, MD, Simon H. Pearce, PhD, Bijay Vaidya, PhD, Stephen C. Gough, PhD, and Jayne A. Franklyn, PhD.
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    Relative risks for most other coexisting autoimmune disorders were markedly increased among parents of index cases.
    This study is one of the largest so far to quantify the risk of diagnosis of coexisting autoimmune diseases among more than 3000 index cases with clinically proven Graves' disease or Hashimoto's thyroiditis.
    These results emphasize the the importance of screening for other autoimmune diagnoses when patients with autoimmune thyroid disease show new or nonspecific symptoms.
    Source:
    Am. J. Med. Volume 123, Issue 2, Pages 183.e1-183.e9 (February 2010)



    Jefferson Adams
    Celiac.com 05/07/2012 - People with celiac disease face a higher risk of developing primary hyperparathyroidism (PHPT) in the early years after their celiac disease is diagnosed, according to a new report from Sweden. The report appears in the The Journal of Clinical Endocrinology & Metabolism.
    A team of researchers recently set out to examine the risk of primary hyperparathyroidism (PHPT) in people with celiac disease. The researchers included Dr. Jonas F. Ludvigsson, Olle Kämpe, Benjamin Lebwohl, Peter H. R. Green, Shonni J. Silverberg and Anders Ekbom. They are affiliated with the Department of Pediatrics (J.F.L.) at Örebro University Hospital in Örebro, Sweden, the Clinical Epidemiology Unit (J.F.L., A.E.) of the Department of Medicine at Karolinska Institutet in Stockholm, Sweden; the Department of Medical Sciences (O.K.) at Uppsala University and University Hospital in Uppsala, Sweden; and Celiac Disease Center (B.L., P.H.R.G.), and Division of Endocrinology, Department of Medicine (S.J.S.) at Columbia University College of Physicians and Surgeons in New York city, USA.
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    A review of the data show that the increased risk of PHPT persisted after restricting the analysis to 1987 or later, which post-date changes in ICD coding. The risk for PHPT was slightly higher for women diagnosed with celiac disease after menopause than for women diagnosed earlier in life.
    Their study does not "provide any insight into the nature of the association between celiac disease and PHPT," the authors admit. They are unsure whether the association  is causal or whether celiac disease and PHPT might be tied another unidentified condition.
    Because most patients with untreated celiac disease have vitamin D and calcium deficiencies, the team expected to find a "constellation of celiac disease and elevated parathyroid hormone levels," but that they did not expect to see a connection between celiac disease with hypercalcemia and PHPT.
    The team calls for future studies to focus on thoroughly investigating the connection, so that researchers can understand all possible aspects of the link between these two conditions.
    Source:
    J Clin Endocrinol Metab 2012

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    Jefferson Adams
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    Jefferson Adams
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    Bakery On Main started in the small bakery of a natural foods market on Main Street in Glastonbury, Connecticut. Founder Michael Smulders listened when his customers with Celiac Disease would mention the lack of good tasting, gluten-free options available to them. Upon learning this, he believed that nobody should have to suffer due to any kind of food allergy or dietary need. From then on, his mission became creating delicious and fearlessly unique gluten-free products that were clean and great tasting, while still being safe for his Celiac customers!
    Premium ingredients, bakeshop delicious recipes, and happy customers were our inspiration from the beginning— and are still the cornerstones of Bakery On Main today. We are a fiercely ethical company that believes in integrity and feels that happiness and wholesome, great tasting food should be harmonious. We strive for that in everything we bake in our dedicated gluten-free facility that is GFCO Certified and SQF Level 3 Certified. We use only natural, NON-GMO Project Verified ingredients and all of our products are certified Kosher Parve, dairy and casein free, and we have recently introduced certified Organic items as well! 
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    Source:
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