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    People with Celiac Disease Face Higher Risk of Thyroid Autoimmune Disorders


    Jefferson Adams

    Celiac.com 02/02/2012 - A team of researchers recently conducted a prospective controlled study on a gluten-free diet and autoimmune thyroiditis in patients with celiac disease.


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    Photo: CC - sea townThe research team included S. Metso, H. Hyytiä-Ilmonen, K. Kaukinen, H. Huhtala, P. Jaatinen, J. Salmi, J. Taurio, and P. Collin. They are affiliated with the Department of Internal Medicine at Tampere University Hospital in Tampere, Finland.

    Prior to the study, there had been contradictory data regarding the ways in which early diagnosis and a gluten-free diet might slow the progression of associated autoimmune diseases in celiac disease.

    The research team investigated the course of autoimmune thyroid diseases in newly diagnosed celiac disease patients, both before and after gluten-free dietary treatment.

    For their study, the team examined twenty-seven adults with newly diagnosed celiac disease, both at the time of diagnosis and after one year on gluten-free diet.

    They also recorded and examined previously diagnosed and subclinical autoimmune thyroid diseases. The team used ultrasound to measure thyroid gland volume and echo-genicity. They also measured autoantibodies against celiac disease and thyroiditis, and conducted thyroid function tests.

    As a control group, they enrolled twenty-seven non-celiac subjects, all of whom followed a normal, gluten-containing diet.

    The data showed that, upon diagnosis, ten of 27 celiac disease patients had either manifest (n = 7) or subclinical (n = 3) thyroid diseases. Only three of 27 control subjects (10/27 vs. 3/27, p = 0.055) had thyroid disease.

    After treatment with a gluten-free diet, thyroid volume continued to decrease significantly in the patients with celiac disease compared with the control subjects, indicating the progression of thyroid gland atrophy regardless of the gluten-free diet.

    Overall, celiac patients faced a higher risk of thyroid autoimmune disorders than non-celiac control subjects. Moreover, a gluten-free diet did not seem to stop or reverse the progression of autoimmune disease after one year.

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    Guest SandraB

    Posted

    This is disturbing, but there is at least one study which suggests that the link between celiac and thyroid disease is selenium deficiency. This is common in celiac disease because of the malabsorption problems, and it is essential for proper thyroid function. If these patients above went gluten free without taking extra selenium this hypothesis would fit well.

    Google selenium/celiac/thyroid to find the study. I am gluten sensitive and have antibodies to my thyroid, a sub-clinical auto immune problem - which I only discovered by having a private test, most people in the UK would never find out they had it unless their TSH was outside the wide parameters set here.

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    I have both Celiac and Hashimoto's hypothyroidism. I take thyroid meds, and I avoid all gluten in foods and non-food products. My niece was recently diagnosed with celiac and hypothyroid disease, too.

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    Guest Gloria Brown

    Posted

    This makes me wonder several things:

     

    1) The amount of trace gluten unwittingly entering the newly diagnosed patients? (i.e through consuming packaged products containing <20ppm of gluten, personal care products containing gluten, or airborne gluten inhaled into the oral passages and onto the digestive system from gluten-containing environments or pets, etc.)

     

    2) Co-factors also affecting their autoimmune systems? (i.e. mercury fillings)

     

    3) The affect of iodide being counteracted through salt which may contain small amounts of gluten anti-caking agents (as opposed to receiving it through SSKI potassium iodide).

     

    4) The year and location of the study, and whether radiation from Fukushima nuclear power plant leakage may have any affect?

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    I have both celiac and Hashimoto's Hypothyroidism. After six years on a gluten-free diet and still suffering from malabsorption problems, I read about an Array 4 test for gluten mimickers. After taking the test it ends up I when I eat tapioca, it has the same effect on me as wheat, barley, rye and oats. Eight months after removing tapioca from my already gluten-free diet, I am no longer suffering from the side effects of celiac disease.

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    Thank you for this information, I will definitely check on the selenium because I try to stay gluten free but still don't feel

    like I know as much as I should.

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    So now that we have studies for the thyroid disorders that may develop or have developed in celiac, what can celiacs do to better treat their thyroid issues (recognize symptoms) in a natural way and or by medical treatment?

    I would prefer natural personally.

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    I too have both thyroid and celiac and took years to diagnose because they did not show in the initial tests.

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    Guest Lori Muir

    Posted

    Part Three:

     

    I have been misdiagnosed with every non curable syndrome you can think of.... Low FODMAP AND GLUTEN FREE has saved my life...literally...

     

    Those Aussies are light years ahead of the US in terms of understanding GUT health. I have read, and researched this without the help of ANY doctors... they refuse to even discuss food intolerances as it relates to my symptoms... they just want to hand out symptom treating drugs ( That will ALWAYS make me sicker ) or operate on me...

     

    I HAVE HAD 'E-NuFF of that! LOW FODMAP Food is where it's AT! - Sincerely, Lori Muir, Birmingham, Alabama

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    I have both Celiac and Hashimoto's hypothyroidism. I take thyroid meds, and I avoid all gluten in foods and non-food products. My niece was recently diagnosed with celiac and hypothyroid disease, too.

    Hi Donnie

     

    I am having a very hard time obtaining official diagnosis but am almost 100% sure I have celiac and Hashimoto's. Am wondering what symptoms you and your niece experienced?

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    Guest Brian L

    Posted

    This study was anything but definitive. There were only 27 subjects that participated. Out of that 27, only 7 had clinical symptoms of thyroid disease with 3 having subclinical manifestations of thyroid disease. It is random writers who wish to write an article about one study that do not demonstrate any knowledge in evidence based medicine. This study was just a prospective study and its findings are hardly conclusive.

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    Sources:
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    2. Tani T, Sakai Y. Stuttering after right cerebellar infarction: a case study. J Fluency Disord. 2010 Jun;35(2):141-5. Epub 2010 Mar 15.
    3. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    4. Jäncke L, Hänggi J, Steinmetz H. Morphological brain differences between adult stutterers and non-stutterers. BMC Neurol. 2004 Dec 10;4(1):23.
    5. Kell CA, Neumann K, von Kriegstein K, Posenenske C, von Gudenberg AW, Euler H, Giraud AL. How the brain repairs stuttering. Brain. 2009 Oct;132(Pt 10):2747-60. Epub 2009 Aug 26.
    6. Galantucci S, Tartaglia MC, Wilson SM, Henry ML, Filippi M, Agosta F, Dronkers NF, Henry RG, Ogar JM, Miller BL, Gorno-Tempini ML. White matter damage in primary progressive aphasias: a diffusion tensor tractography study. Brain. 2011 Jun 11.
    7. Lundgren K, Helm-Estabrooks N, Klein R. Stuttering Following Acquired Brain Damage: A Review of the Literature. J Neurolinguistics. 2010 Sep 1;23(5):447-454.
    8. [No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 43-1988. A 52-year-old man with persistent watery diarrhea and aphasia. N Engl J Med. 1988 Oct 27;319(17):1139-48
    9. Molteni N, Bardella MT, Baldassarri AR, Bianchi PA. Celiac disease associated with epilepsy and intracranial calcifications: report of two patients. Am J Gastroenterol. 1988 Sep;83(9):992-4.
    10. http://ezinearticles.com/?Food-Allergy-and-Stuttering-Link&id=1235725 
    11. http://www.craig.copperleife.com/health/stuttering_allergies.htm 
    12. https://www.celiac.com/forums/topic/73362-any-help-is-appreciated/
    13. Ford RP. The gluten syndrome: a neurological disease. Med Hypotheses. 2009 Sep;73(3):438-40. Epub 2009 Apr 29.
    14. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illness? Lancet. 1996 Feb 10;347(8998):369-71.

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    Celiac.com 06/12/2018 - A life-long gluten-free diet is the only proven treatment for celiac disease. However, current methods for assessing gluten-free diet compliance are lack the sensitivity to detect occasional dietary transgressions that may cause gut mucosal damage. So, basically, there’s currently no good way to tell if celiac patients are suffering gut damage from low-level gluten contamination.
    A team of researchers recently set out to develop a method to determine gluten intake and monitor gluten-free dietary compliance in patients with celiac disease, and to determine its correlation with mucosal damage. The research team included ML Moreno, Á Cebolla, A Muñoz-Suano, C Carrillo-Carrion, I Comino, Á Pizarro, F León, A Rodríguez-Herrera, and C Sousa. They are variously affiliated with Facultad de Farmacia, Departamento de Microbiología y Parasitología, Universidad de Sevilla, Sevilla, Spain; Biomedal S.L., Sevilla, Spain; Unidad Clínica de Aparato Digestivo, Hospital Universitario Virgen del Rocío, Sevilla, Spain; Celimmune, Bethesda, Maryland, USA; and the Unidad de Gastroenterología y Nutrición, Instituto Hispalense de Pediatría, Sevilla, Spain.
    For their study, the team collected urine samples from 76 healthy subjects and 58 patients with celiac disease subjected to different gluten dietary conditions. To quantify gluten immunogenic peptides in solid-phase extracted urines, the team used a lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant GIPs and an LFT reader. 
    They detected GIPs in concentrated urines from healthy individuals previously subjected to gluten-free diet as early as 4-6 h after single gluten intake, and for 1-2 days afterward. The urine test showed gluten ingestion in about 50% of patients. Biopsy analysis showed that nearly 9 out of 10 celiac patients with no villous atrophy had no detectable GIP in urine, while all patients with quantifiable GIP in urine showed signs of gut damage.
    The ability to use GIP in urine to reveal gluten consumption will likely help lead to new and non-invasive methods for monitoring gluten-free diet compliance. The test is sensitive, specific and simple enough for clinical monitoring of celiac patients, as well as for basic and clinical research applications including drug development.
    Source:
    Gut. 2017 Feb;66(2):250-257. &nbsp;doi: 10.1136/gutjnl-2015-310148.