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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    AN UPDATE ON EVERY CELIAC DISEASE DRUG CURRENTLY IN DEVELOPMENT


    Jefferson Adams


    • Numerous drugs designed to treat celiac disease are currently in development, and more than one of them could be on the market very soon.


    Celiac.com 08/21/2015 - Here's every celiac disease treatment currently in development in a single list:

    • Image: CC--Robson#ALV003, by Alvine Pharmaceuticals, is a combination of two enzymes that break down gluten before it can provoke an immune reaction. The drug is a powder to be dissolved in water and taken before meals.

      ALV003 most recently passed a phase 2 clinical trial, results of which appeared in the June 2014 issue of Gastroenterology. Post-trial biopsies showed that ALV003 prevented intestinal damage in 34 volunteers with celiac disease who ate 2 grams of gluten each day for six weeks and also took the drug. Phase 2b, a 12-week trial, is now underway.
       
    • AN-PEP, by DSM Food Specialties, is another enzyme that degrades gluten. AN-PEP is believed to work best when taken while gluten is still in the stomach.

      Results from a small 2013 study showing AN-PEP to be safe, appeared in the World Journal of Gastroenterology. For the study, 16 people ate 7 grams of gluten every day for two weeks and half of them also ate AN-PEP, and half took a placebo. However, the placebo group did not get sick enough during the course of the study to show that the enzyme had any effect, so further study is under way.
       
    • ActoBiotics by ActoGenX uses Lactococcus lactis as an expression system to locally secrete bio-therapeutics such as cytokines, antibodies, hormones, etc.

      Early pre-clinical work with a genetically altered L. lactis secreting a peptide derived from gliadin demonstrated an in vivo suppression of gluten sensitization.

      Specifically, Huigbregtse et al. engineered L. lactis to secrete a deamidated DQ8 gliadin epitope (LL-eDQ8d) and studied the induction of Ag-specific tolerance in NOD ABo DQ8 transgenic mice [34]. Although apparently not part of the ActoGenX development program, recent work by Galipeau et al. also deserves mention in this context.

      The group treated gluten-sensitive mice with elafin, a serine protease inhibitor, delivered by the L. lactis vector, and found normalization of inflammation, improved permeability, and maintained ZO-1 expression. There is speculation that this is due to reduced deamidation of gliadin peptide.
       
    • AVX176 by Avaxia Biologics, is an investigational oral antibody drug patented to provide "Antibody Therapy for Treatment of Diseases Associated with Gluten Intolerance." The patent, which expires on May 27 2029, provides broad coverage for treating celiac disease using orally administered antibodies produced by Avaxia's proprietary platform technology.
       
    • BL-7010, by BioLineRx, is a novel co-polymer for the treatment of celiac disease, which significantly reduces the immune response triggered by gluten.

      This drug has been shown in mice to reduce the immune system response that leads to intestinal damage and villous atrophy in celiac disease. BL-7010 actually binds to the gluten protein, reducing the protein's toxicity.The drug, with the gluten molecule attached, then passes harmlessly through the digestive system to be expelled as stool.

      BL-7010 has undergone safety testing in humans and was found to be well tolerated. According to BioLineRx, testing will begin in mid-2015 to see if the drug works as expected to diminish gluten's effects on the body.

      However, BL-7010 is designed to protect only against gluten cross-contamination; it won't allow people with celiac disease to eat large amounts of gluten.
       
    • CCR9, by Chemocentryx, is a drug called vercirnon, which is also known as Traficet-EN, or CCX282B), and was originally intended for patients with moderate-to-severe Crohn's disease. CCR9 has completed one Phase 2 trial in 67 patients with celiac disease. However, despite the completion of the trial several years ago, no results relating to celiac disease have been made public or published.
       
    • Egg Yolk Enzyme. Little is known about efforts to develop a celiac treatment that uses egg yolk to coat gluten and allow it to pass through the body undetected, thus preventing an adverse gluten reaction in sensitive individuals. Like most other drugs being developed, this treatment would work to prevent reactions to small amounts of gluten, rather than as a cure. 
       
    • Larazotide Acetate by Alba Therapeutics.

      How it works: Larazotide acetate blocks a protein that carries pieces of gluten across the gut, where immune cells can see them. Fasano and his colleagues found that this carrier protein, called zonulin, is overproduced by celiac patients after they eat gluten.

      Results of the most recent phase 2 trial of larazotide acetate, published in February 2015 in Gastroenterology. The volunteers who took the drug experienced fewer days with disease symptoms during the 12 week-long study.
       
    • Nexvax2, by ImmusanT, works much like an allergy shot. Nexvax2 exposes the immune system to gluten in a controlled way so that immune cells that are usually activated get turned off or eliminated.

      So far, Nexvax2 has completed a phase 1 trial showing it to be safe. More research is being done to test whether it is effective.

      Designed to work as a vaccine, Nexvax2 combines three proprietary peptides that elicit an immune response in celiac disease patients who carry the immune recognition gene HLA-DQ2. Similar to allergy shots, the vaccine is designed to reprogram gluten-specific T cells triggered by the patient's immune response to the protein.
       
    • ZED1227 by Dr. Falk Pharma and Zedira recently announced the start of phase I clinical trials for the drug candidate ZED1227, a direct acting inhibitor of tissue transglutaminase. The small molecule targets the dysregulated transglutaminase within the small intestine in order to dampen the immune response to gluten which drives the disease process.


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    Stay tuned for updates and progress reports as these drugs work their way through their various trial phases.

    Finally, share your thoughts on all these celiac drugs in the development pipeline. Are you excited, wary, both? Let us know by commenting below.

    Source:


    Image Caption: Image: CC--Robson#
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    Article's fine. Concept's disturbing. Eating a gluten-free diet is the free, already-proven cure for celiac and gluten-intolerance. They don't have to torture mice and likely other animals to find a "cure" for something that there already is a cure for. I imagine there is $$ for the researchers here and $$ for the animal labs and $$ for the pharmaceuticals. What about all the other types of food allergies out there and what about all the GMOs headed our way that we don't really know how bodies will react to long term? Perhaps if we are mindful of what we eat and what we produce for food, we wouldn't have to turn this into a pharmaceutical company's dream. Those of us who find the gluten free diet healthy and fine, have no problem limiting what we eat and will not want to be shoved into a world where everyone is expected to take a pill and many gluten free options begin to disappear.

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    Guest avwalters

    Posted

    It's a good article, about a subject I don't really understand. I'm a celiac and I have a cure; I don't eat gluten. As long as I stick to it, I feel great. I cannot imagine risking my situation, and risking whatever side effects may appear, to take a drug so I could eat gluten.

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    Guest Lorraine Lunz

    Posted

    I react immediately to any gluten that I am exposed to, but I am too old to join any trials. I eat a !00% gluten-free diet, unless someone else cooks and says the food is gluten-free and it is not.

    I hope the younger patients will have a cure.

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    Guest Virginia Williams

    Posted

    Would love to have something to take for my celiac disease - hopefully something will be out soon - wondering if there is something out already that I do not know about - would love to know if there is.

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    Guest PamLevy

    Posted

    I have BX proven Celiac. Are there any trials I can participate in in OKC area? THAT'S what I would like to know.

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    Guest Khawaja Adeel

    Posted

    I am anxiously waiting for the outcome of the tests and availability of magical medicine. I don't know if i can be a part of any trial or not (Though I am willing and interested) as I am from Pakistan.

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    Folks, from what I understand, these drugs are not "cures" and do not mean you can go crazy and eat all the gluten you want.

     

    For most of them, they are meant to reduce symptoms from ingesting small amounts of gluten, generally from accidental ingestion/cross-contamination, etc.

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    An interesting article but I agree with Mars and Avwalters. A gluten-free diet is THE treatment for Celiac. I know that many Celiacs wish they could eat gluten products again (it's certainly what I grew up with) but on the brighter side gluten products are not, for the most part, healthy foods and in the long run we are better off without them (certainly true for me anyway).

    I would never take a pill so I could eat gluten again. Gluten is a poison to me and the pharmaceuticals could end up being the same with as yet unknown side effects. Not worth any risk IMHO.

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    Guest Jefferson

    Posted

    Article's fine. Concept's disturbing. Eating a gluten-free diet is the free, already-proven cure for celiac and gluten-intolerance. They don't have to torture mice and likely other animals to find a "cure" for something that there already is a cure for. I imagine there is $$ for the researchers here and $$ for the animal labs and $$ for the pharmaceuticals. What about all the other types of food allergies out there and what about all the GMOs headed our way that we don't really know how bodies will react to long term? Perhaps if we are mindful of what we eat and what we produce for food, we wouldn't have to turn this into a pharmaceutical company's dream. Those of us who find the gluten free diet healthy and fine, have no problem limiting what we eat and will not want to be shoved into a world where everyone is expected to take a pill and many gluten free options begin to disappear.

    Eating gluten-free does not cure celiac disease. It causes most of the symptoms to go away. If you eat gluten again, for a long enough period, the celiac disease returns. A gluten-free diet is a treatment, not a cure.

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    Ok folks, lets read the article shall we? The article does mention that the majority of the drugs are designed with the intent of assisting celiac patients with avoiding a cross-contamination reaction, not that we can just start consuming gluten in large quantities.

    For myself, as a very sensitive celiac, this could be life changing. I can't go to most places where there is a gluten-free menu (in addition with regular fare) as many kitchen staff do not have the proper training to ensure safe food handing. The fall out is simply not worth it, I get too sick, for too long to risk it. If a little pill could allow me to occasionally go out for dinner or travel more easily with my husband and child, and allow me to eat without fear, (not start eating gluten again, mind) it would enhance my quality of life beyond measure.

     

    I am not in love with big pharma by any means, and avoid medication whenever possible, however, when there is a need, there is a need. There have been MANY medical advances have improved quality of life for countless individuals the world over. Let's not forget how a short time ago people died from now treatable diseases. Its not always bad.

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    Just like many of the commenters here, I am skeptical of any medications when diet is so effective and free. However, I would like to open my social life up a bit and it would be great to be able to occasionally take a pill before going to a party or wedding reception or a professional conference or a festival or a sporting event, any activity in which people eat. And would make travel or hurricane evacuation much much easier. I don't even miss wheat anymore, but I do miss the camaraderie of socializing over a good meal. I am excited at the possibilities.

     

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    Thank you, Kris! I could not agree with you more. Great article. Please continue to keep us informed on these advances in media. I would LOVE to be able to eat at a restaurant or a friends house and not have to worry about cross contamination. I will always maintain a gluten-free diet. I have no need to eat something my body does no tolerate. However, no matter how many steps I take, eating outside my own kitchen is always a risk. If I could take a pill during those times and not have a reaction due to cross contamination or the food preparer's oversight, it would improve my quality of life. No one wants to live in a bubble.

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    Being totally gluten free (5 1/2 yrs) hasn't helped me much. Still disabled by pain, fatigue, abdominal swelling. Now, if you had a treatment for that...I would welcome it.

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    Guest Rebecca

    Posted

    Jefferson, excellent article and thank you for an update and summary in one place of the latest research on celiac treatments. I was wondering if you have a source for best digestive enzyme product for celiacs to take? My 14 year old daughter has Celiac and Hashimoto's and I believe digestive enzymes are a very important aid in a healthy life for her, just not sure if there are some better than others for people with celiac disease, there are so many on the market. (btw she is on a 100% gluten-free diet) Please let me know if you have a good reference for me. Thanks so much for all your helpful info!!

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    Guest Jefferson

    Posted

    Ok folks, lets read the article shall we? The article does mention that the majority of the drugs are designed with the intent of assisting celiac patients with avoiding a cross-contamination reaction, not that we can just start consuming gluten in large quantities.

    For myself, as a very sensitive celiac, this could be life changing. I can't go to most places where there is a gluten-free menu (in addition with regular fare) as many kitchen staff do not have the proper training to ensure safe food handing. The fall out is simply not worth it, I get too sick, for too long to risk it. If a little pill could allow me to occasionally go out for dinner or travel more easily with my husband and child, and allow me to eat without fear, (not start eating gluten again, mind) it would enhance my quality of life beyond measure.

     

    I am not in love with big pharma by any means, and avoid medication whenever possible, however, when there is a need, there is a need. There have been MANY medical advances have improved quality of life for countless individuals the world over. Let's not forget how a short time ago people died from now treatable diseases. Its not always bad.

    I agree! I think that very sensitive celiac sufferers might benefit tremendously from safe treatments that might prevent low levels gluten contamination from causing any problems. I think that would be great for many people.

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    Guest Wayne W

    Posted

    Great article, agree the eating gluten-free is not a cure. I do it but miss out on all the good stuff. I want my life back and am excited about a possible solution soon!

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    Guest Anonymouse

    Posted

    This is really exciting. If these drugs do work, we might have to get some for those times that we eat out or at someone else's house. You know, the times when you think things are gluten free, but you can't be 100% sure. I would absolutely love to have some kind of backup to make me feel safe outside the home as well.

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    Guest Jefferson

    Posted

    Jefferson, excellent article and thank you for an update and summary in one place of the latest research on celiac treatments. I was wondering if you have a source for best digestive enzyme product for celiacs to take? My 14 year old daughter has Celiac and Hashimoto's and I believe digestive enzymes are a very important aid in a healthy life for her, just not sure if there are some better than others for people with celiac disease, there are so many on the market. (btw she is on a 100% gluten-free diet) Please let me know if you have a good reference for me. Thanks so much for all your helpful info!!

    Be careful of digestive enzymes, as many do not fully degrade gluten. I did an article on this recently. The only bright spot from the article was this: "In contrast, the pure enzyme AN-PEP effectively degraded all nine epitopes in the pH range of the stomach at much lower dose."

     

    Based on that, I would consider AN-PEP, but I am not a doctor, and that's strictly a personal, not a medical, opinion. An opinion based on research, not personal experience, so definitely take it with a grain of salt and use your own judgement.

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    Eating gluten-free does not cure celiac disease. It causes most of the symptoms to go away. If you eat gluten again, for a long enough period, the celiac disease returns. A gluten-free diet is a treatment, not a cure.

    Yes, you are correct. Gluten free diet is a treatment not a "cure". Bad word choice on my part. The treatment of a gluten free diet is good enough for me for all the reasons I listed.

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    Being totally gluten free (5 1/2 yrs) hasn't helped me much. Still disabled by pain, fatigue, abdominal swelling. Now, if you had a treatment for that...I would welcome it.

    Amen!

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    Thank you. For almost 10 years I have had to order, caution, not eat, etc. because of celiac. A pill to protect against small amounts of gluten and still maintain a gluten free diet would be a blessing.

    Gluten free food is very expensive and mostly tasteless. And it is not a very healthful diet. Cure would be great but I will take protection of sorts for the moment. Report was great.

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    Guest Carolyn Huntington

    Posted

    While I cannot imagine eating gluten safely without some kind of new symptoms as there is usually a price to pay when medications are used and sometimes the side effects are worse than the original problem. Which I am sure is a big concern for everyone as our health improves so much on a gluten free diet (especially a healthy gluten-free diet). Obviously it will be very important what type of side effects go along any pill. But I for one really pray for both my daughter and I that something turns out to be very effective at least with cross contamination without causing a lot of new problems. Too often finding food that is safe and not cross contaminated eating out is still a big problem.

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    Jefferson Adams

    Celiac.com 09/10/2007 - A study published recently in the journal of Alimentary Pharmacology and Therapeutics shows that the paracellular permeability inhibitor AT-1001 effectively reduces intestinal barrier dysfunction, proinflammatory cytokine production, and gastrointestinal symptoms in people who have celiac disease. At present, a lifetime devoted to following a strict gluten-free diet is the backbone of current treatment for celiac disease. However, as researchers have come to know more about celiac disease, they’re insights are leading to developments that offer more effective prognosis and treatment of the disease.
    One of those promising new approaches involves treating celiac patients with doses of AT-1001, a paracellular permeability inhibitor that is structurally derived from a protein secreted by Vibrio cholerae. Recently, a team of medical researchers set out to assess the safety and tolerability of 12 mg doses of AT-1001 in people with celiac disease who submitted to acute gluten exposure.
    For the in-patient, double-blind, randomized placebo-controlled safety study, researchers looked at twenty men and women with celiac disease and measured intestinal permeability, through fractional excretions of lactulose and mannitol, as an exploratory measure of the efficacy of AT-1001 in treating celiac disease.
    The test subjects were men and women with age ranging from 18 to 59 years old. Each was pre-screened and referred by a gastroenterologist. Each had positive biopsy and antibody screens that indicated celiac disease. Each had also been on a gluten-free diet at least six months, was not known to be IgA deficient, and presented with anti-tTG titres of <10 EU at enrollment.
    Study shows safety and tolerability of 12 mg doses of AT-1001 in celiac disease
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    Jefferson Adams
    Celiac.com 05/19/2014 - A research team recently examined the effects of prednisolone and a gluten-free diet on mucosal epithelial cell regeneration and apoptosis in celiac disease.
    The team included Shalimar, P. Das, V. Sreenivas, S. Datta Gupta, S.K. Panda, and G.K. Makharia. They are with the Department of Gastroenterology and Human Nutrition at the All India Institute of Medical Sciences in Ansari Nagar in New Delhi, India.
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    The team conducted duodenal biopsies at the start, and at 4 and 8 weeks following treatment. They recruited six patients with functional dyspepsia as control subjects.
    The team stained all biopsies for markers of intrinsic apoptotic pathway (AIF, H2AX, p53), common apoptotic pathway (CC3, M30), apoptotic inhibitors (XIAP, Bcl2), and epithelial proliferation (Ki-67). They then compared apoptotic (AI) and proliferation indices (PI).
    Initial duodenal biopsies showed the end apoptotic products H2AX and M30 to be markedly higher.
    In comparison with those treated with GFD alone, after 4 weeks of GFD + prednisolone treatment, some markers of both intrinsic and common apoptotic pathways showed rapid decline.
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    Dig Dis Sci. 2012 Dec;57(12):3116-25. doi: 10.1007/s10620-012-2294-1. Epub 2012 Jun 30.

    Jefferson Adams
    Celiac.com 04/10/2015 - Of course, a strict gluten free diet is still the only safe and effective treatment for celiac disease. However, new drugs in development, some of which are currently being tested on humans, might allow people with celiac disease to safely eat gluten again, at least in small amounts.
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    Drugs currently under trial include an enzyme that splits the protein in wheat that triggers adverse reactions, into smaller harmless products, and another which promises to make the gut less leaky, and thus block potentially toxic substances from triggering inflammation.
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    "We also found that the bits of gluten that were presented to the T-cells have some changes caused by an enzyme in the body – transglutaminase 2", says Sollid. HLAs are proteins which act as markers, binding to fragments of other proteins, and telling T-cells how to treat them.
    So it wasn't much of a stretch for Professor Sollid's team to determine that the defective HLAs bind to fragments of gluten, causing the T-cells to treat them as bacteria or viruses.
    Basically, two HLA types present gluten remnants to the T-cells, causing the T-cells to regard the gluten as dangerous, and to trigger immune reactions that cause inflammation in the intestines, and this is what causes celiac disease.
    "We think that this is huge," Sollid said. "We understand the immune cells that are activated and why they are activated."
    At present, Professor Sollid and his group are investigating how antibodies against transglutaminase are formed.
    This is a simple, but huge moment in the annals of medicine and in the annals of celiac disease. It's a discovery that will help researchers develop new approaches to treatment, and/or a cure for celiac disease in the future.
    Source:
    Med.uio.no

  • Recent Articles

    Tammy Rhodes
    Celiac.com 04/24/2018 - Did you know in 2017 alone, the United States had OVER TENS OF THOUSANDS of people evacuate their homes due to natural disasters such as fires, floods, hurricanes, tornadoes and tsunamis? Most evacuation sites are not equipped to feed your family the safe gluten free foods that are required to stay healthy.  Are you prepared in case of an emergency? Do you have your Gluten Free Emergency Food Bag ready to grab and go?  
    I have already lived through two natural disasters. Neither of which I ever want to experience again, but they taught me a very valuable lesson, which is why I created a Gluten Free Emergency Food Bag (see link below). Here’s my story. If you’ve ever lived in or visited the Los Angeles area, you’re probably familiar with the Santa Ana winds and how bitter sweet they are. Sweet for cleaning the air and leaving the skies a brilliant crystal blue, and bitter for the power outages and potential brush fires that might ensue.  It was one of those bitter nights where the Santa Ana winds were howling, and we had subsequently lost our power. We had to drive over an hour just to find a restaurant so we could eat dinner. I remember vividly seeing the glow of a brush fire on the upper hillside of the San Gabriel Mountains, a good distance from our neighborhood. I really didn’t think much of it, given that it seemed so far from where we lived, and I was hungry! After we ate, we headed back home to a very dark house and called it a night. 
    That’s where the story takes a dangerous turn….about 3:15am. I awoke to the TV blaring loudly, along with the lights shining brightly. Our power was back on! I proceeded to walk throughout the house turning everything off at exactly the same time our neighbor, who was told to evacuate our street, saw me through our window, assuming I knew that our hillside was ablaze with flames. Flames that were shooting 50 feet into the air. I went back to bed and fell fast asleep. The fire department was assured we had left because our house was dark and quiet again. Two hours had passed.  I suddenly awoke to screams coming from a family member yelling, “fire, fire, fire”! Flames were shooting straight up into the sky, just blocks from our house. We lived on a private drive with only one way in and one way out.  The entrance to our street was full of smoke and the fire fighters were doing their best to save our neighbors homes. We literally had enough time to grab our dogs, pile into the car, and speed to safety. As we were coming down our street, fire trucks passed us with sirens blaring, and I wondered if I would ever see my house and our possessions ever again. Where do we go? Who do we turn to? Are shelters a safe option? 
    When our daughter was almost three years old, we left the West Coast and relocated to Northern Illinois. A place where severe weather is a common occurrence. Since the age of two, I noticed that my daughter appeared gaunt, had an incredibly distended belly, along with gas, stomach pain, low weight, slow growth, unusual looking stool, and a dislike for pizza, hotdog buns, crackers, Toast, etc. The phone call from our doctor overwhelmed me.  She was diagnosed with Celiac Disease. I broke down into tears sobbing. What am I going to feed my child? Gluten is everywhere.
    After being scoped at Children's Hospital of Chicago, and my daughters Celiac Disease officially confirmed, I worried about her getting all the nutrients her under nourished body so desperately needed. I already knew she had a peanut allergy from blood tests, but just assumed she would be safe with other nuts. I was so horribly wrong. After feeding her a small bite of a pistachio, which she immediately spit out, nuts would become her enemy. Her anaphylactic reaction came within minutes of taking a bite of that pistachio. She was complaining of horrible stomach cramps when the vomiting set in. She then went limp and starting welting. We called 911.
    Now we never leave home without our Epipens and our gluten free food supplies. We analyze every food label. We are hyper vigilant about cross contamination. We are constantly looking for welts and praying for no stomach pain. We are always prepared and on guard. It's just what we do now. Anything to protect our child, our love...like so many other parents out there have to do every moment of ever day!  
    Then, my second brush with a natural disaster happened, without any notice, leaving us once again scrambling to find a safe place to shelter. It was a warm and muggy summer morning, and my husband was away on a business trip leaving my young daughter and me to enjoy our summer day. Our Severe Weather Alert Radio was going off, again, as I continued getting our daughter ready for gymnastics.  Having gotten used to the (what seemed to be daily) “Severe Thunderstorm warning,” I didn’t pay much attention to it. I continued downstairs with my daughter and our dog, when I caught a glimpse out the window of an incredibly black looking cloud. By the time I got downstairs, I saw the cover to our grill literally shoot straight up into the air. Because we didn’t have a fenced in yard, I quickly ran outside and chased the cover, when subsequently, I saw my neighbor’s lawn furniture blow pass me. I quickly realized I made a big mistake going outside. As I ran back inside, I heard debris hitting the front of our home.  Our dog was the first one to the basement door! As we sat huddled in the dark corner of our basement, I was once again thinking where are we going to go if our house is destroyed. I was not prepared, and I should have been. I should have learned my lesson the first time. Once the storm passed, we quickly realized we were without power and most of our trees were destroyed. We were lucky that our house had minimal damage, but that wasn’t true for most of the area surrounding us.  We were without power for five days. We lost most of our food - our gluten free food.
    That is when I knew we had to be prepared. No more winging it. We couldn’t take a chance like that ever again. We were “lucky” one too many times. We were very fortunate that we did not lose our home to the Los Angeles wildfire, and only had minimal damage from the severe storm which hit our home in Illinois.
      
    In 2017 alone, FEMA (Federal Emergency Management Agency) had 137 natural disasters declared within the United States. According to FEMA, around 50% of the United States population isn’t prepared for a natural disaster. These disasters can happen anywhere, anytime and some without notice. It’s hard enough being a parent, let alone being a parent of a gluten free family member. Now, add a natural disaster on top of that. Are you prepared?
    You can find my Gluten Free Emergency Food Bags and other useful products at www.allergynavigator.com.  

    Jefferson Adams
    Celiac.com 04/23/2018 - A team of researchers recently set out to learn whether celiac disease patients commonly suffer cognitive impairment at the time they are diagnosed, and to compare their cognitive performance with non-celiac subjects with similar chronic symptoms and to a group of healthy control subjects.
    The research team included G Longarini, P Richly, MP Temprano, AF Costa, H Vázquez, ML Moreno, S Niveloni, P López, E Smecuol, R Mazure, A González, E Mauriño, and JC Bai. They are variously associated with the Small Bowel Section, Department of Medicine, Dr. C. Bonorino Udaondo Gastroenterology Hospital; Neurocience Cognitive and Traslational Institute (INECO), Favaloro Fundation, CONICET, Buenos Aires; the Brain Health Center (CESAL), Quilmes, Argentina; the Research Council, MSAL, CABA; and with the Research Institute, School of Medicine, Universidad del Salvador.
    The team enrolled fifty adults with symptoms and indications of celiac disease in a prospective cohort without regard to the final diagnosis.  At baseline, all individuals underwent cognitive functional and psychological evaluation. The team then compared celiac disease patients with subjects without celiac disease, and with healthy controls matched by sex, age, and education.
    Celiac disease patients had similar cognitive performance and anxiety, but no significant differences in depression scores compared with disease controls.
    A total of thirty-three subjects were diagnosed with celiac disease. Compared with the 26 healthy control subjects, the 17 celiac disease subjects, and the 17 disease control subjects, who mostly had irritable bowel syndrome, showed impaired cognitive performance (P=0.02 and P=0.04, respectively), functional impairment (P<0.01), and higher depression (P<0.01). 
    From their data, the team noted that any abnormal cognitive functions they saw in adults with newly diagnosed celiac disease did not seem not to be a result of the disease itself. 
    Their results indicate that cognitive dysfunction in celiac patients could be related to long-term symptoms from chronic disease, in general.
    Source:
    J Clin Gastroenterol. 2018 Mar 1. doi: 10.1097/MCG.0000000000001018.

    Connie Sarros
    Celiac.com 04/21/2018 - Dear Friends and Readers,
    I have been writing articles for Scott Adams since the 2002 Summer Issue of the Scott-Free Press. The Scott-Free Press evolved into the Journal of Gluten Sensitivity. I felt honored when Scott asked me ten years ago to contribute to his quarterly journal and it's been a privilege to write articles for his publication ever since.
    Due to personal health reasons and restrictions, I find that I need to retire. My husband and I can no longer travel the country speaking at conferences and to support groups (which we dearly loved to do) nor can I commit to writing more books, articles, or menus. Consequently, I will no longer be contributing articles to the Journal of Gluten Sensitivity. 
    My following books will still be available at Amazon.com:
    Gluten-free Cooking for Dummies Student's Vegetarian Cookbook for Dummies Wheat-free Gluten-free Dessert Cookbook Wheat-free Gluten-free Reduced Calorie Cookbook Wheat-free Gluten-free Cookbook for Kids and Busy Adults (revised version) My first book was published in 1996. My journey since then has been incredible. I have met so many in the celiac community and I feel blessed to be able to call you friends. Many of you have told me that I helped to change your life – let me assure you that your kind words, your phone calls, your thoughtful notes, and your feedback throughout the years have had a vital impact on my life, too. Thank you for all of your support through these years.

    Jefferson Adams
    Celiac.com 04/20/2018 - A digital media company and a label data company are teaming up to help major manufacturers target, reach and convert their desired shoppers based on dietary needs, such as gluten-free diet. The deal could bring synergy in emerging markets such as the gluten-free and allergen-free markets, which represent major growth sectors in the global food industry. 
    Under the deal, personalized digital media company Catalina will be joining forces with Label Insight. Catalina uses consumer purchases data to target shoppers on a personal base, while Label Insight works with major companies like Kellogg, Betty Crocker, and Pepsi to provide insight on food label data to government, retailers, manufacturers and app developers.
    "Brands with very specific product benefits, gluten-free for example, require precise targeting to efficiently reach and convert their desired shoppers,” says Todd Morris, President of Catalina's Go-to-Market organization, adding that “Catalina offers the only purchase-based targeting solution with this capability.” 
    Label Insight’s clients include food and beverage giants such as Unilever, Ben & Jerry's, Lipton and Hellman’s. Label Insight technology has helped the Food and Drug Administration (FDA) build the sector’s very first scientifically accurate database of food ingredients, health attributes and claims.
    Morris says the joint partnership will allow Catalina to “enhance our dataset and further increase our ability to target shoppers who are currently buying - or have shown intent to buy - in these emerging categories,” including gluten-free, allergen-free, and other free-from foods.
    The deal will likely make for easier, more precise targeting of goods to consumers, and thus provide benefits for manufacturers and retailers looking to better serve their retail food customers, especially in specialty areas like gluten-free and allergen-free foods.
    Source:
    fdfworld.com

    Jefferson Adams
    Celiac.com 04/19/2018 - Previous genome and linkage studies indicate the existence of a new disease triggering mechanism that involves amino acid metabolism and nutrient sensing signaling pathways. In an effort to determine if amino acids might play a role in the development of celiac disease, a team of researchers recently set out to investigate if plasma amino acid levels differed among children with celiac disease compared with a control group.
     
    The research team included Åsa Torinsson Naluai, Ladan Saadat Vafa, Audur H. Gudjonsdottir, Henrik Arnell, Lars Browaldh, and Daniel Agardh. They are variously affiliated with the Institute of Biomedicine, Department of Microbiology & Immunology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; the Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden; the Department of Pediatric Gastroenterology, Hepatology and Nutrition, Karolinska University Hospital and Division of Pediatrics, CLINTEC, Karolinska Institute, Stockholm, Sweden; the Department of Clinical Science and Education, Karolinska Institute, Sodersjukhuset, Stockholm, Sweden; the Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden; the Diabetes & Celiac Disease Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; and with the Nathan S Kline Institute in the U.S.A.
    First, the team used liquid chromatography-tandem mass spectrometry (LC/MS) to analyze amino acid levels in fasting plasma samples from 141 children with celiac disease and 129 non-celiac disease controls. They then crafted a general linear model using age and experimental effects as covariates to compare amino acid levels between children with celiac disease and non-celiac control subjects.
    Compared with the control group, seven out of twenty-three children with celiac disease showed elevated levels of the the following amino acids: tryptophan; taurine; glutamic acid; proline; ornithine; alanine; and methionine.
    The significance of the individual amino acids do not survive multiple correction, however, multivariate analyses of the amino acid profile showed significantly altered amino acid levels in children with celiac disease overall and after correction for age, sex and experimental effects.
    This study shows that amino acids can influence inflammation and may play a role in the development of celiac disease.
    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764