Celiac.com 01/29/2010 - A team of researchers recently set out to compare levels of glutamic acid decarboxylase antibody (anti-GAD), islet cell antibody (ICA), thyroperoxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), antinuclear antibodies (FANA), antibodies to double-stranded DNA (anti-ds DNA), antibody to Sjögren syndrome A antigen (anti-SSA), antibody to Sjögren syndrome B antigen (anti-SSB), Smith antibody (anti-Sm), smooth muscle antibodies (ASMA), and antimitochondrial antibody liver-kidney microsome (AMA-LKM) in patients with celiac disease against healthy control subjects, and autoimmune hypothyroid patients.
The team used immunofluorescence to assess anti-SSA, anti-SSB, anti-Sm, anti-ds DNA, anti-GAD, anti-TPO and anti-TG were studied by Enzyme-Linked Immunosorbent Assay (ELISA), and AMA-LKM, ASMA, ANA and ICA.
Researchers used retrospective analysis to assess clinical data and the results of free thyroxine-thyroid stimulating hormone (FT4-TSH). The team used SPSS ver 13.0 for data analysis, and the Ï‡2 method for comparisons within groups.
They found that the frequency of anti-SSA, anti-SSB, anti-GAD, anti-Sm, anti-ds DNA, AMA-LKM, ASMA, ANA and ICA did not differ significantly between the groups.
They found levels of anti-TPO and anti-TG antibodies to be markedly higher (<0.001) in autoimmune hypothyroid patients as compared with other groups.
Previous studies have shown an increased frequency of autoimmune diseases of other systems in people with celiac disease. Autoimmune antibodies specific for other autoimmune diseases appeared no more frequent in people with celiac disease.
Source: U.S. National Library of Medicine, National Institutes of Health