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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    FREQUENCY OF AUTOANTIBODIES IN CELIAC DISEASE


    Jefferson Adams

    Celiac.com 01/29/2010 - A team of researchers recently set out to compare levels of glutamic acid decarboxylase antibody (anti-GAD), islet cell antibody (ICA), thyroperoxidase antibody (anti-TPO), thyroglobulin antibody (anti-TG), antinuclear antibodies (FANA), antibodies to double-stranded DNA (anti-ds DNA), antibody to Sjögren syndrome A antigen (anti-SSA), antibody to Sjögren syndrome B antigen (anti-SSB), Smith antibody (anti-Sm), smooth muscle antibodies (ASMA), and antimitochondrial antibody liver-kidney microsome (AMA-LKM) in patients with celiac disease against healthy control subjects,  and autoimmune hypothyroid patients.


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     The research team included Erkan Caglar, Serdal Ugurlu, Aliye Ozenoglu, Gunay Can, Pinar Kadioglu, and Ahmet Dobrucali. They are affiliated variously with Fatih Sultan Mehmet Education and Research Hospital, the Cerrahpasa Medical Faculty at the University of Istanbul, and Ondokuz Mayis University in Samsun, Turkey. They studied a total of 31 patients with celiac disease, 34 patients with autoimmune hypothyroidism and 29 healthy subjects.

    The team used immunofluorescence to assess anti-SSA, anti-SSB, anti-Sm, anti-ds DNA, anti-GAD, anti-TPO and anti-TG were studied by Enzyme-Linked Immunosorbent Assay (ELISA), and AMA-LKM, ASMA, ANA and ICA.

    Researchers used retrospective analysis to assess clinical data and the results of free thyroxine-thyroid stimulating hormone (FT4-TSH). The team used SPSS ver 13.0 for data analysis, and the χ2 method for comparisons within groups.

    They found that the frequency of anti-SSA, anti-SSB, anti-GAD, anti-Sm, anti-ds DNA, AMA-LKM, ASMA, ANA and ICA did not differ significantly between the groups.

    They found levels of anti-TPO and anti-TG antibodies to be markedly higher (<0.001) in autoimmune hypothyroid patients as compared with other groups.

    Previous studies have shown an increased frequency of autoimmune diseases of other systems in people with celiac disease.  Autoimmune antibodies specific for other autoimmune diseases appeared no more frequent in people with celiac disease.

    Source: U.S. National Library of Medicine, National Institutes of Health


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    Has anyone checked the frequency of anticentromere antibody in people with celiac. I have the DQ8 gene, and my anticentromere B test shows sky-high.

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    Guest Peggy Detmers

    Posted

    I am a biologist with celiac disease. I have relatives with no digestive display of gluten intolerance yet suffer from a myriad of autoimmune problems that go away on a Gluten Free/Casein Free diet. As a skinny track athlete I dropped on the track from diabetes in high school, then got multiple sclerosis in college, along with migraines, fibromyalgia, mitral valve prolapse and chronic fatigue. ALL gone on a Gluten Free/Casein Free diet at 49 years old! I think the general population has all those auto-immune antibodies due to the neolithic diet. Seeds are indigestible. They evolved that way. Those undigested seed proteins in the bloodstream are causing all these syndromes. As long as my family avoids them and we remain well. Eat lean meats, no seed veggies and fruit. It WORKS!!!

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    I was wondering whether or not the celiac patients had active disease. It they didn't, then the results (no increase in auto-antibodies) would make more sense to me.

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  • Related Articles

    Jefferson Adams
    Celiac.com 10/23/2009 - Current estimates put the number of celiac disease sufferers at about 1% of the general population. However, some celiac disease experts, like Dr. Andrew Fassano, predict that up to 10% of the general population may prove to suffer from gluten intolerance.
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    Destiny Stone
    Celiac.com 03/26/2010 - Mass screening studies among the general population for celiac disease show a prevalence of approximately 0.5-1.0% in adults and in children. Yet, despite the growing numbers of newly diagnosed celiac disease patients, most cases still remain undiagnosed and therefore, untreated. In part, the masses of misdiagnosed or undiagnosed  celiac disease  patients are a result of the variety of disguises  celiac disease can have. Celiac disease can manifest into a multitude of symptoms including, but by no means exclusive to, malabsorption syndrome, diarrhea, anemia, infertility and osteoporosis.
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    Source:

    http://www.ncbi.nlm.nih.gov/pubmed/20047580

    Jefferson Adams
    Celiac.com 08/12/2011 - Although serological analysis is used in diagnosing celiac disease, histopathology is regarded as most reliable.
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    Gastroenterology doi: 10.1053/j.gastro.2010.04.007

    Jefferson Adams
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    Journal of Clinical Pathology (2011). doi:10.1136/jclinpath-2011-200372

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    fdfworld.com

    Jefferson Adams
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    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764