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    • Scott Adams

      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    Is a Vaccine for Celiac Disease Just Around the Corner?


    Jefferson Adams

    Celiac.com 03/30/2012 - A company called Microtest Laboratories is manufacturing doses of what they claim may be the first effective vaccine treatment for celiac disease. At this point, the only treatment for celiac disease is to avoid gluten in the diet.


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    Photo: CC-R/DV/RSOther companies are working on vaccines for celiac disease, and several working trials are underway. However, this new drug's creator, ImmusanT, based in Cambridge says that, unlike other vaccines, which prevent an infection, their drug, Nexvax2 works by changing the immune system so it no longer attacks gluten.

    Production on Nexvax2, began last week, Steven G. Richter, Microtest’s president and science director, told a local reporter. So far, ImmusanT has raised $20 million in investor capital to bring the vaccine to market.

    Regarding the path from concept to manufacturing for Nexvax2, Richter says that the process has been anything but straightforward. "It's arty process," he told a local reporter, "you have to develop protocols for all the manufacturing and plans to do all of the work aseptically. You have to get all those protocols and plans approved through the regulatory process. Then you have to do the work.”

    Microtest is initially manufacturing 9,000 vials for ImmusanT: two 3,000-dose batches of vaccine and a 3,000-dose batch of inert placebo to be used in the clinical trial. Richter says that the control group contains everything except the active vaccine.

    ImmusanT is looking to start the first clinical trials in the second quarter of this year by testing the doses on people with celiac disease. The full article, in Massliveonline.com quotes Leslie J. Williams, president and CEO of ImmusanT, as saying that “The test will be if it [the vaccine] induces a tolerance for gluten in the diet."

    The report says that Williams and the company hope to get the vaccine commercially available by 2017. Will the company succeed? Will they have a successful vaccine available in just five short years? Let us know what you think.



    Image Caption: Photo: CC-R/DV/RS
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    As much as they like to call these vaccines, their own site's explanation begins with calling it "one of an emerging class of therapeutic vaccines based on the same principles as traditional desensitization therapy for allergic conditions using whole proteins"

     

    People get way too excited about a celiac "vaccine" while the term itself doesn't even strictly fit what the companies are doing.

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    Guest Emilio

    Posted

    This is unbelievable, do you guys think this is going to happen? I'm excited for this, I'll be doing research on this everyday if I have to. I doubt it will happen but reading this gave me hope.

     

    I would just donate my body to test all of these things to find a cure for celiac disease. I wish I was one of the people tested. Hopefully in the future there will be a cure for all of us.. give it your best Microtest Laboratories.

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    Guest Jared M.

    Posted

    I hope this research goes well. The bread, crackers and pizza I can live without. But I would really like to be able to drink a good IPA again. The sorghum beers are horrible. I am quickly growing tired of ciders. I would definitely pay for this treatment if it works.

     

    I have also contacted ImmusanT about participation in the clinical trials.

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    I have celiac. That would be wonderful. I have gained weight and there is no explanation.

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    Guest Cathi

    Posted

    Good Article. " It works by changing the immune system so it no longer attacks gluten". My Question is, " What will be the side effects of this turning off the body's ability to fight Gluten?" Will there still be destruction some place else and maybe worse? So, many times a pill is created to help one thing only to find out that it created another problem some place else in the body. Frankly, I am worried.

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    Guest Linda Haas

    Posted

    Can't wait to hear more about the progress made on this vaccine....it sounds very promising!

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    Guest Michele

    Posted

    I posted a link to this article on a celiac facebook page I belong to and the initial response was very positive. Several people want to volunteer for the trials, for the sake of their children. There was some controversy about how they are actually doing the clinical trials knowing that there is a possibility your are 'poisoning' yourself by eating gluten while on the vaccine (which may be a placebo). Curious as to how the drug companies are handling the testing with an oath of not to cause harm.

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    Guest Sonja

    Posted

    I'm 61, diagnosed last summer, after so many doctors for min 30 years that something is very wrong medically with me, my "no results, it's all in your head," or better one "why do you want to be sick, enjoy life?" 5 years sounds great, although I wish it can be sooner. Wishing you all the best, it's not easy, today I got my results from, hemocode nutrition test, so little dood to eat, until last summer I didn't know that any of this exist, celiac is serious disease especially is discovered so late.

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    Guest muriel weadick

    Posted

    This is what all celiacs have been waiting for, and I am sure I am not alone in wishing the company success.Although it sounds too good to be true, let us remain optimistic. If the drug does become available in 5 years in the US, we in Canada will likely not be allowed to access it for several years after that! Too bad the company does not have a partner on this side of the border!

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    Guest VHill

    Posted

    My thought on this is that we may want to look at the root of the problem - why are people having reactions to gluten? Is it due to the genetic modification of grains or other similar possibilities? If so, I don't think a vaccination may be the best solution. I really feel for those with this problem, as I have an intolarance (not Celiac) so I can relate, but sometimes drugs and quick fixes may not be the best solution. It seems as if there is a lot of research going on to find a drug or vaccine for cancer and other chronic illnesses, but what about stepping back and looking at all of the fake food and other artficial substances we put in our bodies. Everyone wants a quick fix to their problems and I don't know if this is the right perspective.

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    Thanks but no thanks. I'll remain a celiac and continue to eat healthy. While trying to fix one problem, some will end up with far worse problems.

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    My thought on this is that we may want to look at the root of the problem - why are people having reactions to gluten? Is it due to the genetic modification of grains or other similar possibilities? If so, I don't think a vaccination may be the best solution. I really feel for those with this problem, as I have an intolarance (not Celiac) so I can relate, but sometimes drugs and quick fixes may not be the best solution. It seems as if there is a lot of research going on to find a drug or vaccine for cancer and other chronic illnesses, but what about stepping back and looking at all of the fake food and other artficial substances we put in our bodies. Everyone wants a quick fix to their problems and I don't know if this is the right perspective.

    I agree with you re fake food/artificial substance that goes into bodies daily. A vaccination is just more chemicals going into our bodies. If you have celiac than you must have other allergies too, at least I do and so do all the others with celiac that I know. This is a genetic problem, or so they say, so how do they determine who gets the vaccine and when? Why would anyone want to put more artificial ingredients into their bodies not really knowing what side effects will occur 5-10 years down the road? I suffered long enough before being diagnosed and the last thing I want to do is to take a chance of poisoning myself. All natural food is good enough for me!

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    Guest Cheryl

    Posted

    Totally agree with vhill seems like a ploy to poison people with GMO foods that come up with a supposed "cure". Eat healthy whole foods this is not a curse its a wake up call to be healthy if you didn't have celiac you'd probably be eating processed crap.

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    Guest Suzanne

    Posted

    This would be great. I am very happy to follow a Gluten free diet forever as I am happy with the food that I can create at home. However the thing that makes it hard is getting ill from the tiniest bit of cross contamination from a restaurant or a food that doesn't list gluten in the ingredients. A vaccine like this would make it easier to eat out and go on vacation.

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    Guest Loren

    Posted

    This would be great. I am very happy to follow a Gluten free diet forever as I am happy with the food that I can create at home. However the thing that makes it hard is getting ill from the tiniest bit of cross contamination from a restaurant or a food that doesn't list gluten in the ingredients. A vaccine like this would make it easier to eat out and go on vacation.

    Suzanne, I totally agree with you. It's the littlest things that make us sick and we never know where it came from. Yes real pizza and bread would be great. But to not get sick from cross contamination. I would go for that.

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    Good Article. " It works by changing the immune system so it no longer attacks gluten". My Question is, " What will be the side effects of this turning off the body's ability to fight Gluten?" Will there still be destruction some place else and maybe worse? So, many times a pill is created to help one thing only to find out that it created another problem some place else in the body. Frankly, I am worried.

    I agree!

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    Guest Celi Acsprue

    Posted

    I agree. Gluten free foods may be the best we can do. How will this 'vaccination' help us not be allergic to gluten?

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    Guest Chris

    Posted

    I think it's a great idea! I would be willing to let them make money off of me if it works.

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    Guest Donna

    Posted

    Good Article. " It works by changing the immune system so it no longer attacks gluten". My Question is, " What will be the side effects of this turning off the body's ability to fight Gluten?" Will there still be destruction some place else and maybe worse? So, many times a pill is created to help one thing only to find out that it created another problem some place else in the body. Frankly, I am worried.

    Absolutely agree with you, Cathi. There is always a problem and side effects with ANY drug! My question is this: WHAT ELSE will be shut off? Will we be even MORE susceptible to other illnesses? I am worried as well!

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    Guest Donda

    Posted

    I posted a link to this article on a celiac facebook page I belong to and the initial response was very positive. Several people want to volunteer for the trials, for the sake of their children. There was some controversy about how they are actually doing the clinical trials knowing that there is a possibility your are 'poisoning' yourself by eating gluten while on the vaccine (which may be a placebo). Curious as to how the drug companies are handling the testing with an oath of not to cause harm.

    I'm thrilled with the possibility of this coming to market. I agree that the introduction of a new treatment may include the potential for side effects. However, with the advancements in genetics, it's likely that the "vaccine" would target only the reaction to gluten. It will be interesting to read further about the science behind the process. In reference to the question about the oath to do no harm, just to share, that oath was originally made to various Greek gods and has been adapted over the years to include various terms including "keeping the best interest of the patient". In that regard, some may choose to say that a small group who volunteers for the clinical trial in order to ensure that millions of others can be protected, is a form of keeping the best interest of the patient. I would volunteer in order to allow my two children to have the option to avoid cross contamination even while maintaining a gluten-free diet. Kudos to the researchers and company! Fear not, we will pay for the “vaccineâ€. If you want to boost shareholders' value you can start a waiting list for the “vaccine†to show the investors the level of interest. (I want to ensure funding stays strong on the project!) You could also consider expanding the waiting list by offerring a referral credit. I'd advise lobbying insurance companies now so it will be covered sooner. Speak their language, show them the costs avoidance that would result from the treatment of related complications such as Type 1 Diabetes and other autoimmune diseases that often follow the development of celiac disease.

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  • Related Articles

    Scott Adams

    Digestion 2002;66(3):178-85
    PMID: 12481164
    Ciacci C, Cirillo M, Cavallaro R, Mazzacca G.
    Department of Internal Medicine, Gastrointestinal Unit, Federico II University of Naples, Naples, Italy.
    Celiac.com 01/12/2003 - Background and Aims: Celiac disease is the most common severe food intolerance in the Western world and is due to gluten ingestion in genetically susceptible children and adults. Intestinal biopsy is the golden standard for evaluation of mucosal damage associated with celiac disease. Gluten-free diet is the key treatment for celiac disease. Data on the long-term control of celiac disease are few and limited to small series of patients. The study reports data on the control of celiac disease and on its correlates in a large cohort of celiac adults during long-term treatment with gluten-free diet.
    Methods: The study cohort comprises 91 men and 299 women having undergone treatment with a gluten-free diet for at least 2 years and with complete records for visits at the time of diagnosis of celiac disease (baseline). Data collection included gender, age, education, weight, bowel habit, blood hemoglobin, plasma albumin and cholesterol, serum antiendomysium antibodies (EMA), dietary compliance to gluten-free diet (coded as good, low, or very low), and intestinal damage at biopsy (coded as absent, mild, or severe).
    Results: The duration of follow-up was 6.9 +/- 7.5 years (mean +/- SD, range 2-22 years). At follow-up visit, intestinal damage was absent in 170 patients (43.6%), mild in 127 (32.6%), and severe in 93 (23.8%). At follow-up, intestinal damage was significantly associated with dietary compliance, EMA, and plasma albumin (follow-up value and change value from baseline to follow-up). Baseline education significantly predicted dietary compliance and intestinal damage at follow-up.
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    Jefferson Adams

    Celiac.com 07/30/2007 - A study published in the journal Clinical Gastroenterology and Hepatology suggests that a newly proposed system of classifying duodenal pathology on celiac disease provides an improved inter-observation than the less Marsh-Oberhuber classification, and offers an advance towards making a simpler, better, more valid diagnosis of celiac disease. Celiac disease is presently classified according to the Marsh-Oberhuber system of classifying duodenal lesions.
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    Jefferson Adams
    Celiac.com 02/18/2008 - A greater awareness of celiac disease, coupled with better and more accurate tests for celiac disease have helped to bring about a situation where most people currently diagnosed with celiac disease show no symptoms at the time of their diagnosis. Currently, most people diagnosed with celiac disease do not show symptoms, but are diagnosed on the basis of referral for elevated risk factors. This finding has caused doctors to call for an adjustment to screening procedures for high-risk populations.
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    Jefferson Adams
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    The team found that patients with persistently high anti-tTG antibody levels commonly showed abnormal duodenal histology (P < 0.001), low ferritin (P < 0.01) and poor adherence to the GFD (P < 0.001).
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    From these results, the team advocates the use of anti-tTG antibody concentrations to monitor newly diagnosed and established patients with celiac disease, and to target dietary intervention accordingly to reduce the risk of long-term problems.

    Alimentary Pharmacology & Therapeutics. 2009;30(3):236-244.


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    Jefferson Adams
    Celiac.com 05/18/2018 - Across the country, colleges and universities are rethinking the way they provide food services for students with food allergies and food intolerance. In some cases, that means major renovations. In other cases, it means creating completely new dining and food halls. To document both their commitment and execution of gluten-free and allergen-free dining, these new food halls are frequently turning to auditing and accreditation firms, such as Kitchens with Confidence.
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    When accompanied by diarrhea, vomiting can be a painful experience that would leave you exhausted. It also results in malnutrition and the patient experiences weight loss (not in a good way though). If you experience uncontrolled vomiting, report the matter to a physician to manage the condition.
    Bloating
    Since coeliac disease damages the small intestine, bloating is another common system. This is due to inflammation of the digestive tract. In a study with more than a 1,000 participants, almost 73% of the people reported bloating after ingesting gluten. 
    Bloating can be managed by eliminating gluten from the diet which is why a gluten-free diet is necessary for people suffering from celiac disease.
    Fatigue
    Constant feeling of tiredness and low energy levels is another common symptom associated with celiac disease. If you experience a lack of energy after in taking gluten, then you need to consult a physician to diagnose the condition. Now fatigue can also result from inefficient thyroid function, infections, and depression (a symptom of the coeliac disease). However, almost 51% of celiac patients suffer from fatigue in a study.
    Itchy Rash
    Now the chances of getting a rash after eating gluten are slim, but the symptom has been associated with celiac disease in the past. The condition can cause dermatitis herpetiformis, which causes a blistering skin rash that occurs around the buttocks, knees, and elbows. 
    A study found out that almost 17% of patients suffering from celiac disease might develop dermatitis herpetiformis due to lack of right treatment. Make sure you schedule an online appointment with your dermatologist or visit the nearest healthcare facility to prevent worsening of symptoms.
    Even with such common symptoms, diagnosing the condition is imperative for a quick recovery and to mitigate the long-term risks associated with celiac disease. 
    Sources:
    ncbi.nlm.nih.gov  Celiac.com ncbi.nlm.nih.gov  mendfamily.com