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  • Scott Adams
    Scott Adams

    Oxford Research May Lead to a Cure for Celiac Disease

    Reviewed and edited by a celiac disease expert.

    March 2000 Volume 6 Number 3 pp 337 - 342
    Robert P. Anderson, Pilar Degano, Andrew J. Godkin, Derek P. Jewell & Adrian V.S. Hill

    Celiac.com 06/25/2001 - Researchers from the Institute of Molecular Medicine and the Nuffield Department of Gastroenterology at Oxford University lead by Dr Robert Anderson have published a study regarding the toxic fraction of gluten, and the specific immune response to this fraction. To date scientists basic understanding of the mechanism that causes celiac disease has been linked to a broad immune response to a variety of gluten peptides, but researchers lacked specifics about both processes. This general understanding has now become very specific based on this new research. By subjecting 12 people with celiac disease to a gluten challenge and monitoring 51 fragments of the A-gliadin gluten protein in their bodies, researchers have determined the specific celiac disease antigen responsible for damage caused by the disorder, and the specific immune response that is caused by the antigen. The results of the study indicate that initial immune reaction to gluten was caused by only two adjacent fragments of the protein, which actually represented a single A-gliadin sequence. The immune response to this single fragment was identical in 11 out of 12 test subjects with celiac disease, and the immune response was not seen in the control subjects who did not have celiac disease. Researchers in Norway have also replicated these results.

    These findings may lead to better diagnostic tests and treatment for celiac disease, including the possibility of a vaccine or a genetically-modified version of wheat that excludes the harmful A-gliadin sequence, thus making it harmless to celiacs. Dr. Robert Anderson believes that a vaccine for celiac disease would likely involve using the toxic peptide itself, or a variation of it, to desensitize a person with the disease to the A-gliadin sequence. Further research in the area is now underway by the team.


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    Please cure my disease, I'm 15 and I want to eat pizza with my friends.

    I'm 16 and in the same boat as you, I have been gluten free over a year. If you have any questions or need some support you can talk to me.

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    You guys are breaking my heart. My 9 year old daughter is there with you....let's all pray for the cure to come soon so you guys can enjoy your youth a little more! :-)

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    You are all breaking my heart! I am 63 yrs old and have just been diagnosed and I'm now depressed facing life without all my favorite foods.... but I'm 63 not 15....Let's hope for a cure soon, as this article was from March 2000.

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    You are all breaking my heart! I am 63 yrs old and have just been diagnosed and I'm now depressed facing life without all my favorite foods.... but I'm 63 not 15....Let's hope for a cure soon, as this article was from March 2000.

    I am so nervous about eating out and I have had this since 1997. I just wish I could eat whatever I wanted like everyone else!

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    Please cure my disease, I'm 15 and I want to eat pizza with my friends.

    Have a little faith, there will be a cure. For now, there are alternatives to eating gluten products. I to have this crappy disease and chose to go around and it and not let it get me.

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  • About Me

    In 1994 I was diagnosed with celiac disease, which led me to create Celiac.com in 1995. I created this site for a single purpose: To help as many people as possible with celiac disease get diagnosed so they can begin to live happy, healthy gluten-free lives. Celiac.com was the first site on the Internet dedicated solely to celiac disease. In 1998 I founded The Gluten-Free Mall, Your Special Diet Superstore!, and I am the co-author of the book Cereal Killers, and founder and publisher of Journal of Gluten Sensitivity.

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