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      Frequently Asked Questions About Celiac Disease   04/24/2018

      This Celiac.com FAQ on celiac disease will guide you to all of the basic information you will need to know about the disease, its diagnosis, testing methods, a gluten-free diet, etc.   Subscribe to Celiac.com's FREE weekly eNewsletter   What is Celiac Disease and the Gluten-Free Diet? What are the major symptoms of celiac disease? Celiac Disease Symptoms What testing is available for celiac disease?  Celiac Disease Screening Interpretation of Celiac Disease Blood Test Results Can I be tested even though I am eating gluten free? How long must gluten be taken for the serological tests to be meaningful? The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free Is celiac inherited? Should my children be tested? Ten Facts About Celiac Disease Genetic Testing Is there a link between celiac and other autoimmune diseases? Celiac Disease Research: Associated Diseases and Disorders Is there a list of gluten foods to avoid? Unsafe Gluten-Free Food List (Unsafe Ingredients) Is there a list of gluten free foods? Safe Gluten-Free Food List (Safe Ingredients) Gluten-Free Alcoholic Beverages Distilled Spirits (Grain Alcohols) and Vinegar: Are they Gluten-Free? Where does gluten hide? Additional Things to Beware of to Maintain a 100% Gluten-Free Diet What if my doctor won't listen to me? An Open Letter to Skeptical Health Care Practitioners Gluten-Free recipes: Gluten-Free Recipes
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    LIVE BIFIDOBACTERIUM LACTIS BACTERIA BLOCKS TOXIC EFFECTS OF WHEAT GLIADIN


    Jefferson Adams

    Celiac.com 03/09/2009 - A team of researchers based in Finland recently demonstrated for the first time that B. lactis probiotic bacteria are capable of shielding epithelial cells from cellular damage caused by gliadin exposure.


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    The research team was made up of doctors K. Lindfors, T. Blomqvist, K. Juuti-Uusitalo, S. Stenman, J. Venäläinen, M. Mäki and K. Kaukinen. They are associated with the Paediatric Research Centre for the Medical School of the Finland’s University of Tampere, the Department of Peadiatrics, and the Department of Gastroenterology and Alimentary Tract Surgery at Tampere University Hospital, and the Department of Pharmacology and Toxicology of the Finland’s University of Kuopio.    

    In people with celiac disease, wheat gliadin causes serious intestinal symptoms and damages the small-bowel mucosa. Untreated, this can leave the individual at risk of developing various cancers and numerous associated conditions. Most all of this can be reversed or prevented if detected and treated early enough.

    Currently, the only effective treatment for celiac disease is a strict life-long gluten-free diet. However, a 100% gluten-free diet is nearly impossible to maintain, with so many gluten-free products containing trace amounts of gluten. Because of this, people with celiac disease face regular gluten contamination. Also because of this, acceptable alternatives are desirable.  

    Earlier studies have indicated that probiotic bacteria might be used in sourdough fermentation to induce the hydrolysis of celiac toxic gluten in food manufacturing, and thereby benefit people with celiac disease.

    Although several studies have addressed the ability of probiotic bacteria to detoxify gliadin after an extensive incubation period, the team found none that investigated whether various live probiotic bacteria can inhibit gliadin-induced toxic effects directly on epithelial cells.

    In this study the team set out to determine whether probiotics Lactobacillus fermentum or Bifidobacterium lactis might block the toxic effects of gliadin in intestinal cell culture conditions.

    To assess the degree to which live probiotics were able to block peptic-tryptic digested gliadin-induced degradation of human colon cells Caco-2, the team measured epithelial permeability by transepithelial resistance, actin cytoskeleton arrangements by the extent of membrane ruffling and expression of tight junctional protein ZO-1.

    B. lactis inhibited the gliadin-induced increase dose-dependently in epithelial permeability, and, at higher concentrations totally eliminated the gliadin-induced reduction in transepithelial resistance.

    That is, B. lactis decreased or eliminated the compromise in cell-wall resistance caused by gliadin. This means that B. lactis overcame the mechanism that gives rise to the decreased cell resistance and the increased permeability that occurs during an adverse reaction to wheat gliadin.

    The B. lactis strain also interfered with the creation of membrane ruffles in Caco-2 cells caused by gliadin exposure. Furthermore, it also shielded the tight junctions of Caco-2 cells from the toxic effects of gliadin, as shown by the way in which ZO-1 is expressed.

    The researchers concluded that live B. lactis bacteria might achieve partial to full blockage of gliadin toxicity gluten/gliadin-induced damage in the small-intestinal mucosa of people with celiac disease, and that it merits further study concerning its potential as a dietary supplement to guard against any silent damage associated with accidental gluten-contamination in celiac disease.

    Clinical and Experimental Immunology, 152: 552–558


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    Guest Anna M.

    Posted

    Great report on breaking research that may provide some relief for those dealing with celiac disease. I will pass this along to my friend, who has been following a rigorous gluten-free diet since her diagnosis. It is an immense challenge for those with celiac disease to remove gluten from their diets, and this research on B. lactis inhibiting gliadin-induced damage is hopeful news indeed.

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    Guest natrummur

    Posted

    That's a very good news! Do you think that even they will be able to eat gluten food sometimes without damage?

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    Guest tiggsy

    Posted

    This is interesting, but could be taken to mean that prodigious intakes of Activia yogurt could make one immune to the effects of gluten. I know this is not what is meant, but I'm worried that some people who may currently be resisting the gluten free diet may take this as an excuse, with very bad long term results.

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    This is interesting, but could be taken to mean that prodigious intakes of Activia yogurt could make one immune to the effects of gluten. I know this is not what is meant, but I'm worried that some people who may currently be resisting the gluten free diet may take this as an excuse, with very bad long term results.

    I do not believe this is an excuse to dive into gluten containing foods. However, with so much hidden "gluten" in processed foods it may help if you are in doubt of the safety of a food or as a prevention - "just in case" you've been exposed without knowing.

    I plan on using B lactis for extra security. Thanks for the info.

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    I've been taking this bacteria in a product. It seems to help me a lot...I feel better and hope that it is really working!

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    Guest fghdf

    Posted

    So what's the follow-up on this? Anyone been taking B.Lactis successfully to fight effects of celiac?

     

    Also, they measure bacteria quantities in units of cfu/ml (e.g. 1000000 cfu/ml). How does that translate into what's on the nutrition label? It sounds like a unit of concentration, not quantity.

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    So what's the follow-up on this? Anyone been taking B.Lactis successfully to fight effects of celiac?

     

    Also, they measure bacteria quantities in units of cfu/ml (e.g. 1000000 cfu/ml). How does that translate into what's on the nutrition label? It sounds like a unit of concentration, not quantity.

    cfu/mL simply translates to "colony forming units per mL". Each "colony forming unit" is basically one individual bacterium that has the potential of forming an individual colony when it divides. Anyway, its the standard way a scientist measures the total number of bacteria in a bacterial culture.

    And yes, it is a unit of concentration that is used to obtain quantity. So, for example, 1000000 cfu/mL would mean that there are 1000000 cfu (bacteria) in one mL of the mixture containing the bacterial species. So if we had 10 mL of the stuff, there would be 10000000 bacteria in that 10 mL.

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    The researchers were very clear in the amount that needed to be taken to achieve the desired effect: "The two lowest concentrations (105 and 106 cfu/ml) of B. lactis were ineffective in inhibiting gliadin-induced membrane ruffle formation, while the highest concentration (107 cfu/ml) was significantly protective (P < 0·0005). B. lactis at a concentration of 107 cfu/ml was even more protective against gliadin-induced damage than L. fermentum at the same concentration, as only 25·7% of the cellular edge was covered by membrane ruffles, in contrast to 34·1% in L. fermentum-supplemented cells. Supplementation of the Caco-2 cell cultures with 107 cfu/ml of B. lactis was able to reduce the percentage of membrane ruffling to the level of the PT-BSA control (P = 0·5)."

     

    Bottom Line: a minimum of 107 cfu/ml of B. lactis

     

    Also, with the recent study from Columbia University (See NY Times from 2015/05/19) that concluded that a lot of probiotics contain gluten.

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    admin
    Author: Auricchio S; De Ritis G; De Vincenzi M; Silano V.
    Source: J Pediatr Gastroenterol Nutr, 1985 Dec, 4:6, 923-30.
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    Jefferson Adams
    Celiac.com 06/15/2008 - Many people with celiac disease have stories to tell about the about how difficult it can be to get a getting a proper diagnosis. Celiac disease can mimic so many other conditions. Irritable Bowel Syndrome (IBS) is one of those conditions. The symptoms for Irritable Bowel Syndrome and for celiac disease are often similar as a result the diagnosis of celiac disease can be delayed or missed and misdiagnosed as irritable bowel syndrome.
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    2.    Recent advances in Coeliac Disease by D.A. van Heel and J. West, published in Gut 2006 55, pp 1037-1046
    3.    Coeliac Society of the UK


    Jefferson Adams
    Celiac.com 01/16/2012 - Should there be mass screening for celiac disease? Currently, there is no consensus among scientists or among public policy makers in favor of mass screening for celiac disease as a public health intervention. Advocacy for mass celiac disease screening remains somewhat controversial.
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    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229548/

    Jefferson Adams
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    Jefferson Adams
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    fdfworld.com

    Jefferson Adams
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    Source:
    PLoS One. 2018; 13(3): e0193764. doi: & 10.1371/journal.pone.0193764